| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jeongah Kim, Sangwon Jang, Mijung Choi, Sooyoung Chung, Youngshik Choe, Han Kyoung Choe, Gi Hoon Son, Kunsoo Rhee, Kyungjin Ki. Abrogation of the Circadian Nuclear Receptor REV-ERBα Exacerbates 6-Hydroxydopamine-Induced Dopaminergic Neurodegeneration. Molecules and cells. vol 41. issue 8. 2018-12-17. PMID:30078232. |
parkinson's disease (pd) is a neurodegenerative disease characterized by progressive degeneration of dopaminergic (daergic) neurons, particularly in the substantia nigra (sn). |
2018-12-17 |
2023-08-13 |
mouse |
| Debashis Dutta, Nilufar Ali, Emili Banerjee, Raghavendra Singh, Amit Naskar, Ramesh Kumar Paidi, Kochupurackal P Mohanakuma. Low Levels of Prohibitin in Substantia Nigra Makes Dopaminergic Neurons Vulnerable in Parkinson's Disease. Molecular neurobiology. vol 55. issue 1. 2018-12-11. PMID:28062948. |
since substantia nigra (sn) and ventral tegmental area (vta) dopaminergic neurons are, respectively, susceptible or largely unaffected in parkinson's disease (pd), we searched for protein(s) that regulates this differential sensitivity. |
2018-12-11 |
2023-08-13 |
mouse |
| Benjamín Garzón, Rouslan Sitnikov, Lars Bäckman, Grégoria Kalpouzo. Automated segmentation of midbrain structures with high iron content. NeuroImage. vol 170. 2018-12-11. PMID:28602813. |
the substantia nigra (sn), the subthalamic nucleus (stn), and the red nucleus (rn) are midbrain structures of ample interest in many neuroimaging studies, which may benefit from the availability of automated segmentation methods. |
2018-12-11 |
2023-08-13 |
human |
| Huai-Hsuan Tseng, Jeremy J Watts, Michael Kiang, Ivonne Suridjan, Alan A Wilson, Sylvain Houle, Pablo M Rusjan, Romina Mizrah. Nigral Stress-Induced Dopamine Release in Clinical High Risk and Antipsychotic-Naïve Schizophrenia. Schizophrenia bulletin. vol 44. issue 3. 2018-12-11. PMID:29036383. |
striatal da function results from the activity of midbrain da neurons projecting mainly from the substantia nigra (sn). |
2018-12-11 |
2023-08-13 |
Not clear |
| Hansol Lee, Sun-Yong Baek, Se Young Chun, Jae-Hyeok Lee, HyungJoon Ch. Specific visualization of neuromelanin-iron complex and ferric iron in the human post-mortem substantia nigra using MR relaxometry at 7T. NeuroImage. vol 172. 2018-12-11. PMID:29162523. |
neuromelanin (nm) is an endogenous iron chelating molecule of pigmented neurons in the human substantia nigra (sn). |
2018-12-11 |
2023-08-13 |
human |
| Paul W Hook, Sarah A McClymont, Gabrielle H Cannon, William D Law, A Jennifer Morton, Loyal A Goff, Andrew S McCallio. Single-Cell RNA-Seq of Mouse Dopaminergic Neurons Informs Candidate Gene Selection for Sporadic Parkinson Disease. American journal of human genetics. vol 102. issue 3. 2018-12-11. PMID:29499164. |
these data facilitated unbiased identification of da neuron subpopulations through their unique transcriptional profiles, including a postnatal neuroblast population and substantia nigra (sn) da neurons. |
2018-12-11 |
2023-08-13 |
mouse |
| Cybelle Façanha Barreto Medeiros-Linard, Belmira Lara da Silveira Andrade-da-Costa, Ricielle Lopes Augusto, Adriana Sereniki, Maria Teresa Sales Trevisan, Renata de Cássia Ribas Perreira, Francisco Thiago Correia de Souza, Glauber Ruda Feitoza Braz, Claudia Jacques Lagranha, Ivone Antônia de Souza, Almir Gonçalves Wanderley, Soraya S Smailli, Simone Sette Lopes Lafayett. Anacardic Acids from Cashew Nuts Prevent Behavioral Changes and Oxidative Stress Induced by Rotenone in a Rat Model of Parkinson's Disease. Neurotoxicity research. vol 34. issue 2. 2018-12-11. PMID:29520721. |
lipoperoxidation levels and total superoxide dismutase (t-sod) activity, as well as cytoplasmic and mitochondrial sod gene expression, were assessed in the substantia nigra (sn), striatum, and cerebral cortex. |
2018-12-11 |
2023-08-13 |
rat |
| Li Cheng, Lin Chen, Xinbing Wei, Yimeng Wang, Zhiping Ren, Shenglan Zeng, Xiumei Zhang, Haitao Wen, Chengjiang Gao, Huiqing Li. NOD2 promotes dopaminergic degeneration regulated by NADPH oxidase 2 in 6-hydroxydopamine model of Parkinson's disease. Journal of neuroinflammation. vol 15. issue 1. 2018-11-26. PMID:30157869. |
in parkinson's disease (pd), loss of striatal dopaminergic (da) terminals and degeneration of da neurons in the substantia nigra (sn) are associated with inflammation. |
2018-11-26 |
2023-08-13 |
Not clear |
| Courtney A Bouchet, Megan A Miner, Esteban C Loetz, Adam J Rosberg, Holly S Hake, Caroline E Farmer, Mykola Ostrovskyy, Nathan Gray, Benjamin N Greenwoo. Activation of Nigrostriatal Dopamine Neurons during Fear Extinction Prevents the Renewal of Fear. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 43. issue 3. 2018-11-20. PMID:28976945. |
da neurons originating in the substantia nigra (sn) projecting to the dorsal striatum (ds) are traditionally viewed in the context of motor behavior, but growing data implicate this nigrostriatal circuit in emotion. |
2018-11-20 |
2023-08-13 |
Not clear |
| Yi-Ting Wang, Hui-Ching Lin, Wei-Zhong Zhao, Hui-Ju Huang, Yu-Li Lo, Hsiang-Tsui Wang, Anya Maan-Yuh Li. Acrolein acts as a neurotoxin in the nigrostriatal dopaminergic system of rat: involvement of α-synuclein aggregation and programmed cell death. Scientific reports. vol 7. 2018-11-16. PMID:28401906. |
clinical studies report significant increases in acrolein (an α,β-unsaturated aldehyde) in the substantia nigra (sn) of patients with parkinson's disease (pd). |
2018-11-16 |
2023-08-13 |
rat |
| Hande Parlak, Ayse Ozkan, Sayra Dilmac, Gamze Tanriover, Ozlem Ozsoy, Aysel Aga. Neuronal nitric oxide synthase phosphorylation induced by docosahexaenoic acid protects dopaminergic neurons in an experimental model of Parkinson's disease. Folia histochemica et cytobiologica. vol 56. issue 1. 2018-11-16. PMID:29577226. |
the aim of this study was to investigate if the dha acts on neurons of substantia nigra (sn) by phosphorylation of neuronal nitric oxide synthase (nnos) in an experimental mouse model of pd. |
2018-11-16 |
2023-08-13 |
mouse |
| Joanna Motyl, Joanna B Strosznajde. Sphingosine kinase 1/sphingosine-1-phosphate receptors dependent signalling in neurodegenerative diseases. The promising target for neuroprotection in Parkinson's disease. Pharmacological reports : PR. vol 70. issue 5. 2018-11-16. PMID:30138818. |
pd is characterized by selective loss of dopaminergic (da) neurons in the substantia nigra (sn), with an enigmatic cause in most individuals. |
2018-11-16 |
2023-08-13 |
Not clear |
| Matteo Martino, Paola Magioncalda, Hua Yu, Xiaojing Li, Qiang Wang, Yajing Meng, Wei Deng, Yinfei Li, Mingli Li, Xiaohong Ma, Timothy Lane, Niall W Duncan, Georg Northoff, Tao L. Abnormal Resting-State Connectivity in a Substantia Nigra-Related Striato-Thalamo-Cortical Network in a Large Sample of First-Episode Drug-Naïve Patients With Schizophrenia. Schizophrenia bulletin. vol 44. issue 2. 2018-11-14. PMID:28605528. |
the aim of this study was therefore to test dopamine-related substantia nigra (sn)-based striato-thalamo-cortical resting-state functional connectivity (fc) in scz. |
2018-11-14 |
2023-08-13 |
Not clear |
| Xiao-Yu Cheng, Si-Yue Li, Cheng-Jie Mao, Mei-Xia Wang, Jing Chen, Fen Wang, Guang-Hui Wang, Wen-Bin Deng, Xiao-Kang Li, Chun-Feng Li. Serum Response Factor Promotes Dopaminergic Neuron Survival via Activation of Beclin 1-Dependent Autophagy. Neuroscience. vol 371. 2018-11-09. PMID:29196028. |
here, we report decreased srf levels in the substantia nigra (sn) of rotenone-treated rats that was associated with the loss of tyrosine hydroxylase (th)-positive neurons. |
2018-11-09 |
2023-08-13 |
rat |
| Luqing Wei, Xiao Hu, Yonggui Yuan, Weiguo Liu, Hong Che. Abnormal ventral tegmental area-anterior cingulate cortex connectivity in Parkinson's disease with depression. Behavioural brain research. vol 347. 2018-11-05. PMID:29530489. |
the present study used resting-state fmri and seed-based functional connectivity of putative dopaminergic midbrain regions (i.e., substantia nigra (sn) and ventral tegmental area (vta)) to investigate the circuit-related abnormalities in pd with depression. |
2018-11-05 |
2023-08-13 |
Not clear |
| Yuyan Tan, Elaine Delvaux, Jennifer Nolz, Paul D Coleman, Shengdi Chen, Diego Mastroen. Upregulation of histone deacetylase 2 in laser capture nigral microglia in Parkinson's disease. Neurobiology of aging. vol 68. 2018-10-16. PMID:29803514. |
to address the role of hdac2 in specific cell classes, and in disease, we examined glial protein and mrna levels in the substantia nigra (sn) of parkinson's disease (pd) and normal controls (ncs) by immunohistochemistry and laser captured microdissection followed by quantitative real time polymerase chain reaction. |
2018-10-16 |
2023-08-13 |
human |
| Mohammed Abdel-Rahman, Rania A Galhom, Wael Amin Nasr El-Din, Mona H Mohammed Ali, Alaa El-Din Saad Abdel-Hami. Therapeutic efficacy of olfactory stem cells in rotenone induced Parkinsonism in adult male albino rats. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 103. 2018-10-15. PMID:29864896. |
rotenone; widely used insecticide has a neurodegenerative effect on the dopaminergic cells of substantia nigra (sn) of midbrain producing parkinsonism. |
2018-10-15 |
2023-08-13 |
rat |
| Lu-Tai Tien, Yih-Jing Lee, Yi Pang, Silu Lu, Jonathan W Lee, Chih-Hsueh Tseng, Abhay J Bhatt, Renate D Savich, Lir-Wan Fa. Neuroprotective Effects of Intranasal IGF-1 against Neonatal Lipopolysaccharide-Induced Neurobehavioral Deficits and Neuronal Inflammation in the Substantia Nigra and Locus Coeruleus of Juvenile Rats. Developmental neuroscience. vol 39. issue 6. 2018-09-28. PMID:28787734. |
moreover, lps exposure caused injury to central catecholaminergic neurons, as indicated by a reduction of tyrosine hydroxylase (th) immunoreactivity in the substantia nigra (sn), ventral tegmental area (vta) and olfactory bulb (ob), and brain noradrenergic neurons, as indicated by a reduction of th immunoreactivity in the locus coeruleus (lc) of the p21 rat brain. |
2018-09-28 |
2023-08-13 |
human |
| Chun Huang, Fengqin Lin, Guoqing Wang, Disheng Lu, Qin Wu, Jie Liu, Jingshan Shi, Feng Zhan. Tetrahydroxystilbene Glucoside Produces Neuroprotection against 6-OHDA-Induced Dopamine Neurotoxicity. Oxidative medicine and cellular longevity. vol 2018. 2018-09-18. PMID:29576855. |
parkinson's disease (pd) was one of the most common neurodegenerative diseases with a slow and progressive loss of dopamine (da) neurons in the midbrain substantia nigra (sn). |
2018-09-18 |
2023-08-13 |
Not clear |
| Neha Sharma, Bimla Nehr. Curcumin affords neuroprotection and inhibits α-synuclein aggregation in lipopolysaccharide-induced Parkinson's disease model. Inflammopharmacology. vol 26. issue 2. 2018-09-05. PMID:29027056. |
an animal model of pd was established by injecting lipopolysaccharide (lps, 5 µg/5 µl pbs) into the substantia nigra (sn) of rats which was followed by curcumin administration (40 mg/kg b.wt (i.p.)) |
2018-09-05 |
2023-08-13 |
rat |