| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Cybelle Façanha Barreto Medeiros-Linard, Belmira Lara da Silveira Andrade-da-Costa, Ricielle Lopes Augusto, Adriana Sereniki, Maria Teresa Sales Trevisan, Renata de Cássia Ribas Perreira, Francisco Thiago Correia de Souza, Glauber Ruda Feitoza Braz, Claudia Jacques Lagranha, Ivone Antônia de Souza, Almir Gonçalves Wanderley, Soraya S Smailli, Simone Sette Lopes Lafayett. Anacardic Acids from Cashew Nuts Prevent Behavioral Changes and Oxidative Stress Induced by Rotenone in a Rat Model of Parkinson's Disease. Neurotoxicity research. vol 34. issue 2. 2018-12-11. PMID:29520721. |
lipoperoxidation levels and total superoxide dismutase (t-sod) activity, as well as cytoplasmic and mitochondrial sod gene expression, were assessed in the substantia nigra (sn), striatum, and cerebral cortex. |
2018-12-11 |
2023-08-13 |
rat |
| Li Cheng, Lin Chen, Xinbing Wei, Yimeng Wang, Zhiping Ren, Shenglan Zeng, Xiumei Zhang, Haitao Wen, Chengjiang Gao, Huiqing Li. NOD2 promotes dopaminergic degeneration regulated by NADPH oxidase 2 in 6-hydroxydopamine model of Parkinson's disease. Journal of neuroinflammation. vol 15. issue 1. 2018-11-26. PMID:30157869. |
in parkinson's disease (pd), loss of striatal dopaminergic (da) terminals and degeneration of da neurons in the substantia nigra (sn) are associated with inflammation. |
2018-11-26 |
2023-08-13 |
Not clear |
| Courtney A Bouchet, Megan A Miner, Esteban C Loetz, Adam J Rosberg, Holly S Hake, Caroline E Farmer, Mykola Ostrovskyy, Nathan Gray, Benjamin N Greenwoo. Activation of Nigrostriatal Dopamine Neurons during Fear Extinction Prevents the Renewal of Fear. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 43. issue 3. 2018-11-20. PMID:28976945. |
da neurons originating in the substantia nigra (sn) projecting to the dorsal striatum (ds) are traditionally viewed in the context of motor behavior, but growing data implicate this nigrostriatal circuit in emotion. |
2018-11-20 |
2023-08-13 |
Not clear |
| Yi-Ting Wang, Hui-Ching Lin, Wei-Zhong Zhao, Hui-Ju Huang, Yu-Li Lo, Hsiang-Tsui Wang, Anya Maan-Yuh Li. Acrolein acts as a neurotoxin in the nigrostriatal dopaminergic system of rat: involvement of α-synuclein aggregation and programmed cell death. Scientific reports. vol 7. 2018-11-16. PMID:28401906. |
clinical studies report significant increases in acrolein (an α,β-unsaturated aldehyde) in the substantia nigra (sn) of patients with parkinson's disease (pd). |
2018-11-16 |
2023-08-13 |
rat |
| Hande Parlak, Ayse Ozkan, Sayra Dilmac, Gamze Tanriover, Ozlem Ozsoy, Aysel Aga. Neuronal nitric oxide synthase phosphorylation induced by docosahexaenoic acid protects dopaminergic neurons in an experimental model of Parkinson's disease. Folia histochemica et cytobiologica. vol 56. issue 1. 2018-11-16. PMID:29577226. |
the aim of this study was to investigate if the dha acts on neurons of substantia nigra (sn) by phosphorylation of neuronal nitric oxide synthase (nnos) in an experimental mouse model of pd. |
2018-11-16 |
2023-08-13 |
mouse |
| Joanna Motyl, Joanna B Strosznajde. Sphingosine kinase 1/sphingosine-1-phosphate receptors dependent signalling in neurodegenerative diseases. The promising target for neuroprotection in Parkinson's disease. Pharmacological reports : PR. vol 70. issue 5. 2018-11-16. PMID:30138818. |
pd is characterized by selective loss of dopaminergic (da) neurons in the substantia nigra (sn), with an enigmatic cause in most individuals. |
2018-11-16 |
2023-08-13 |
Not clear |
| Matteo Martino, Paola Magioncalda, Hua Yu, Xiaojing Li, Qiang Wang, Yajing Meng, Wei Deng, Yinfei Li, Mingli Li, Xiaohong Ma, Timothy Lane, Niall W Duncan, Georg Northoff, Tao L. Abnormal Resting-State Connectivity in a Substantia Nigra-Related Striato-Thalamo-Cortical Network in a Large Sample of First-Episode Drug-Naïve Patients With Schizophrenia. Schizophrenia bulletin. vol 44. issue 2. 2018-11-14. PMID:28605528. |
the aim of this study was therefore to test dopamine-related substantia nigra (sn)-based striato-thalamo-cortical resting-state functional connectivity (fc) in scz. |
2018-11-14 |
2023-08-13 |
Not clear |
| Xiao-Yu Cheng, Si-Yue Li, Cheng-Jie Mao, Mei-Xia Wang, Jing Chen, Fen Wang, Guang-Hui Wang, Wen-Bin Deng, Xiao-Kang Li, Chun-Feng Li. Serum Response Factor Promotes Dopaminergic Neuron Survival via Activation of Beclin 1-Dependent Autophagy. Neuroscience. vol 371. 2018-11-09. PMID:29196028. |
here, we report decreased srf levels in the substantia nigra (sn) of rotenone-treated rats that was associated with the loss of tyrosine hydroxylase (th)-positive neurons. |
2018-11-09 |
2023-08-13 |
rat |
| Luqing Wei, Xiao Hu, Yonggui Yuan, Weiguo Liu, Hong Che. Abnormal ventral tegmental area-anterior cingulate cortex connectivity in Parkinson's disease with depression. Behavioural brain research. vol 347. 2018-11-05. PMID:29530489. |
the present study used resting-state fmri and seed-based functional connectivity of putative dopaminergic midbrain regions (i.e., substantia nigra (sn) and ventral tegmental area (vta)) to investigate the circuit-related abnormalities in pd with depression. |
2018-11-05 |
2023-08-13 |
Not clear |
| Yuyan Tan, Elaine Delvaux, Jennifer Nolz, Paul D Coleman, Shengdi Chen, Diego Mastroen. Upregulation of histone deacetylase 2 in laser capture nigral microglia in Parkinson's disease. Neurobiology of aging. vol 68. 2018-10-16. PMID:29803514. |
to address the role of hdac2 in specific cell classes, and in disease, we examined glial protein and mrna levels in the substantia nigra (sn) of parkinson's disease (pd) and normal controls (ncs) by immunohistochemistry and laser captured microdissection followed by quantitative real time polymerase chain reaction. |
2018-10-16 |
2023-08-13 |
human |
| Mohammed Abdel-Rahman, Rania A Galhom, Wael Amin Nasr El-Din, Mona H Mohammed Ali, Alaa El-Din Saad Abdel-Hami. Therapeutic efficacy of olfactory stem cells in rotenone induced Parkinsonism in adult male albino rats. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 103. 2018-10-15. PMID:29864896. |
rotenone; widely used insecticide has a neurodegenerative effect on the dopaminergic cells of substantia nigra (sn) of midbrain producing parkinsonism. |
2018-10-15 |
2023-08-13 |
rat |
| Lu-Tai Tien, Yih-Jing Lee, Yi Pang, Silu Lu, Jonathan W Lee, Chih-Hsueh Tseng, Abhay J Bhatt, Renate D Savich, Lir-Wan Fa. Neuroprotective Effects of Intranasal IGF-1 against Neonatal Lipopolysaccharide-Induced Neurobehavioral Deficits and Neuronal Inflammation in the Substantia Nigra and Locus Coeruleus of Juvenile Rats. Developmental neuroscience. vol 39. issue 6. 2018-09-28. PMID:28787734. |
moreover, lps exposure caused injury to central catecholaminergic neurons, as indicated by a reduction of tyrosine hydroxylase (th) immunoreactivity in the substantia nigra (sn), ventral tegmental area (vta) and olfactory bulb (ob), and brain noradrenergic neurons, as indicated by a reduction of th immunoreactivity in the locus coeruleus (lc) of the p21 rat brain. |
2018-09-28 |
2023-08-13 |
human |
| Chun Huang, Fengqin Lin, Guoqing Wang, Disheng Lu, Qin Wu, Jie Liu, Jingshan Shi, Feng Zhan. Tetrahydroxystilbene Glucoside Produces Neuroprotection against 6-OHDA-Induced Dopamine Neurotoxicity. Oxidative medicine and cellular longevity. vol 2018. 2018-09-18. PMID:29576855. |
parkinson's disease (pd) was one of the most common neurodegenerative diseases with a slow and progressive loss of dopamine (da) neurons in the midbrain substantia nigra (sn). |
2018-09-18 |
2023-08-13 |
Not clear |
| Neha Sharma, Bimla Nehr. Curcumin affords neuroprotection and inhibits α-synuclein aggregation in lipopolysaccharide-induced Parkinson's disease model. Inflammopharmacology. vol 26. issue 2. 2018-09-05. PMID:29027056. |
an animal model of pd was established by injecting lipopolysaccharide (lps, 5 µg/5 µl pbs) into the substantia nigra (sn) of rats which was followed by curcumin administration (40 mg/kg b.wt (i.p.)) |
2018-09-05 |
2023-08-13 |
rat |
| Guangxin Chen, Juxiong Liu, Liqiang Jiang, Xin Ran, Dewei He, Yuhang Li, Bingxu Huang, Wei Wang, Shoupeng F. Galangin Reduces the Loss of Dopaminergic Neurons in an LPS-Evoked Model of Parkinson's Disease in Rats. International journal of molecular sciences. vol 19. issue 1. 2018-08-20. PMID:29267220. |
parkinson's disease (pd) is caused by the loss of dopaminergic (da) neurons in the midbrain substantia nigra (sn). |
2018-08-20 |
2023-08-13 |
rat |
| Lin Kooi Ong, Zidan Zhao, Murielle Kluge, Clifford TeBay, Katarzyna Zalewska, Phillip W Dickson, Sarah J Johnson, Michael Nilsson, Frederick R Walke. Reconsidering the role of glial cells in chronic stress-induced dopaminergic neurons loss within the substantia nigra? Friend or foe? Brain, behavior, and immunity. vol 60. 2018-08-16. PMID:27717686. |
exposure to psychological stress is known to seriously disrupt the operation of the substantia nigra (sn) and may in fact initiate the loss of dopaminergic neurons within the sn. |
2018-08-16 |
2023-08-13 |
mouse |
| Amit Khairnar, Jana Ruda-Kucerova, Nikoletta Szabó, Eva Drazanova, Anas Arab, Birgit Hutter-Paier, Joerg Neddens, Peter Latta, Zenon Starcuk, Irena Rektorov. Early and progressive microstructural brain changes in mice overexpressing human α-Synuclein detected by diffusion kurtosis imaging. Brain, behavior, and immunity. vol 61. 2018-08-10. PMID:27923670. |
we found increases in mk in 3mo tnwt-61 mice in the striatum and thalamus but not in the substantia nigra (sn), hippocampus, or sensorimotor cortex, even though the immunoreactivity of human α-syn was similar or even higher in the latter regions. |
2018-08-10 |
2023-08-13 |
mouse |
| Neil A Kelly, Kimberly H Wood, Jane B Allendorfer, Matthew P Ford, C Scott Bickel, Jon Marstrander, Amy W Amara, Thomas Anthony, Marcas M Bamman, Frank M Skidmor. High-Intensity Exercise Acutely Increases Substantia Nigra and Prefrontal Brain Activity in Parkinson's Disease. Medical science monitor : international medical journal of experimental and clinical research. vol 23. 2018-08-09. PMID:29273705. |
results an effect of acute exercise was observed as an increased alff signal within the right ventromedial prefrontal cortex (pfc), left ventrolateral pfc, and bilaterally within the substantia nigra (sn). |
2018-08-09 |
2023-08-13 |
human |
| Vedad Delic, Jeddidiah W D Griffin, Sandra Zivkovic, Yumeng Zhang, Tam-Anh Phan, Henry Gong, Dale Chaput, Christian Reynes, Vinh B Dinh, Josean Cruz, Eni Cvitkovic, Devon Placides, Ernide Frederic, Hamed Mirzaei, Stanley M Stevens, Umesh Jinwal, Daniel C Lee, Patrick C Bradsha. Individual Amino Acid Supplementation Can Improve Energy Metabolism and Decrease ROS Production in Neuronal Cells Overexpressing Alpha-Synuclein. Neuromolecular medicine. vol 19. issue 2-3. 2018-08-06. PMID:28620826. |
parkinson's disease (pd) is a neurodegenerative disorder characterized by alpha-synuclein accumulation and loss of dopaminergic neurons in the substantia nigra (sn) region of the brain. |
2018-08-06 |
2023-08-13 |
human |
| Kert Mätlik, Helena Vihinen, Ali Bienemann, Jaan Palgi, Merja H Voutilainen, Sigrid Booms, Maria Lindahl, Eija Jokitalo, Mart Saarma, Henri J Huttunen, Mikko Airavaara, Urmas Arumä. Intrastriatally Infused Exogenous CDNF Is Endocytosed and Retrogradely Transported to Substantia Nigra. eNeuro. vol 4. issue 1. 2018-07-31. PMID:28275710. |
these da neurons have been suggested to transport striatal cdnf retrogradely to the substantia nigra (sn). |
2018-07-31 |
2023-08-13 |
human |