| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Guohua Zhang, Chengguo Zhang, Yuhu Zhang, Yukai Wang, Kun Nie, Bin Zhang, Haiqun Xie, Jiancong Lu, Lijuan Wan. The effects of striatal silent lacunar infarction on the substantia nigra and movement disorders in Parkinson's disease: A follow-up study. Parkinsonism & related disorders. vol 43. 2018-06-12. PMID:28688982. |
striatal silent lacunar infarction (ssli) is associated with structural changes to the substantia nigra (sn), detectable by diffusion kurtosis imaging (dki). |
2018-06-12 |
2023-08-13 |
Not clear |
| Daniela Frosini, Mirco Cosottini, Graziella Donatelli, Mauro Costagli, Laura Biagi, Claudio Pacchetti, Michele Terzaghi, Pietro Cortelli, Dario Arnaldi, Enrica Bonanni, Michela Tosetti, Ubaldo Bonuccelli, Roberto Ceravol. Seven tesla MRI of the substantia nigra in patients with rapid eye movement sleep behavior disorder. Parkinsonism & related disorders. vol 43. 2018-06-12. PMID:28781201. |
susceptibility-weighted imaging of the substantia nigra (sn) both at 7 and 3 tesla (t) has shown high accuracy in distinguishing patients with parkinson's disease (pd) and healthy subjects (hs). |
2018-06-12 |
2023-08-13 |
human |
| Hongmei Cao, Jie Shi, Bingqing Cao, Bei Kang, Ming Zhang, Qiumin Q. Evaluation of the Braak staging of brain pathology with Neuroscience letters. vol 660. 2018-06-11. PMID:28844732. |
in this study, we investigated the metabolites of medulla oblongata, substantia nigra (sn), putamen, and motor cortex by measuring n-acetylaspartate (naa), choline-containing compounds (cho) and creatine (cr) in 22 patients of pd and 15 age-matched healthy controls, using single-voxel |
2018-06-11 |
2023-08-13 |
Not clear |
| Christine Winter, Dana M Greene, Paraskevi Mavrogiorgou, Helge Schaper, Reinhard Sohr, Abel Bult-Ito, Georg Jucke. Altered serotonergic and GABAergic neurotransmission in a mice model of obsessive-compulsive disorder. Behavioural brain research. vol 337. 2018-06-08. PMID:28916503. |
the neurochemical investigation of several brain regions of the corticostriato-thalamocortical circuity, i.e., nucleus caudatus (cpu), nucleus accumbens (nac), globus pallidus (gp), hippocampus (hpc), amygdala (am), ventral tegmental area (vta) and substantia nigra (sn) was performed by electrochemical (serotonin and dopamine) and fluorescence (glutamate and gaba) hplc detection. |
2018-06-08 |
2023-08-13 |
mouse |
| Poonam Thakur, Ludivine S Breger, Martin Lundblad, Oi Wan Wan, Bengt Mattsson, Kelvin C Luk, Virginia M Y Lee, John Q Trojanowski, Anders Björklun. Modeling Parkinson's disease pathology by combination of fibril seeds and α-synuclein overexpression in the rat brain. Proceedings of the National Academy of Sciences of the United States of America. vol 114. issue 39. 2018-06-05. PMID:28900002. |
this study was designed to generate a more faithful model of parkinson's disease by injecting human α-syn fibril seeds into the rat substantia nigra (sn), in combination with adenoassociated virus (aav)-mediated overexpression of human α-syn, at levels that, by themselves, are unable to induce acute dopamine (da) neurodegeneration. |
2018-06-05 |
2023-08-13 |
human |
| Antonio Martin-Bastida, Sara Pietracupa, Paola Piccin. Neuromelanin in parkinsonian disorders: an update. The International journal of neuroscience. vol 127. issue 12. 2018-06-04. PMID:28460588. |
neuromelanin (nm) is a dark pigment that accumulates linearly with aging in substantia nigra (sn) and locus coeruleus (lc). |
2018-06-04 |
2023-08-13 |
Not clear |
| Sujung Yeo, Backil Sung, Yeon-Mi Hong, Maurits van den Noort, Peggy Bosch, Sook-Hyun Lee, Jongbeom Song, Sang-Kyun Park, Sabina Li. Decreased expression of serum- and glucocorticoid-inducible kinase 1 (SGK1) promotes alpha-synuclein increase related with down-regulation of dopaminergic cell in the Substantia Nigra of chronic MPTP-induced Parkinsonism mice and in SH-SY5Y cells. Gene. vol 661. 2018-05-30. PMID:29604467. |
parkinson's disease (pd) is a chronically progressive neurodegenerative disease, with its main pathological hallmarks being a dramatic loss of dopaminergic neurons predominantly in the substantia nigra (sn), and the formations of intracytoplasmic lewy bodies and dystrophic neurites. |
2018-05-30 |
2023-08-13 |
mouse |
| Wei-Lan Yin, Wei-Guo Yin, Bai-Sheng Huang, Li-Xiang W. Neuroprotective effects of lentivirus-mediated cystathionine-beta-synthase overexpression against 6-OHDA-induced parkinson's disease rats. Neuroscience letters. vol 657. 2018-05-28. PMID:28764908. |
parkinson's disease (pd) is age-related neurodegenerative disorder by a progressive loss of dopaminergic(da) neurons in the substantia nigra (sn) and striatum, which is at least partly associated with α-synuclein protein accumulation in these neurons. |
2018-05-28 |
2023-08-13 |
rat |
| Lijin Wang, Hongyu Yang, Qingqing Wang, Qiaohui Zhang, Zhangjing Wang, Qunwei Zhang, Siying Wu, Huangyuan L. Paraquat and MPTP induce alteration in the expression profile of long noncoding RNAs in the substantia nigra of mice: Role of the transcription factor Nrf2. Toxicology letters. vol 291. 2018-05-23. PMID:29627306. |
pq caused lncrna expression profiling alteration in the substantia nigra (sn) through an interaction with nrf2, thus changing the nr_027648/zc3h14/cybb and nr_030777/zfp326/cpne5 mrna pathways. |
2018-05-23 |
2023-08-13 |
mouse |
| Jae-Hyeok Lee, Sun-Yong Baek, YoungKyu Song, Sujeong Lim, Hansol Lee, Minh Phuong Nguyen, Eun-Joo Kim, Gi Yeong Huh, Se Young Chun, HyungJoon Ch. The Neuromelanin-related T2* Contrast in Postmortem Human Substantia Nigra with 7T MRI. Scientific reports. vol 6. 2018-05-21. PMID:27596274. |
high field magnetic resonance imaging (mri)-based delineation of the substantia nigra (sn) and visualization of its inner cellular organization are promising methods for the evaluation of morphological changes associated with neurodegenerative diseases; however, corresponding mr contrasts must be matched and validated with quantitative histological information. |
2018-05-21 |
2023-08-13 |
human |
| Zhi-Fen Dong, Cai-Shan Wang, Ying-Chun Zhang, Ying Zhang, Yu-Jing Sheng, Hua Hu, Wei-Feng Luo, Chun-Feng Li. Transcranial Sonographic Alterations of Substantia Nigra and Third Ventricle in Parkinson's Disease with or without Dementia. Chinese medical journal. vol 130. issue 19. 2018-05-21. PMID:28937033. |
numerous studies have demonstrated that patients with parkinson's disease (pd) have a higher prevalence of substantia nigra (sn) hyperechogenicity compared with controls. |
2018-05-21 |
2023-08-13 |
Not clear |
| Yu Zhang, Kevin Michel-Herve Larcher, Bratislav Misic, Alain Daghe. Anatomical and functional organization of the human substantia nigra and its connections. eLife. vol 6. 2018-05-14. PMID:28826495. |
we investigated the anatomical and functional organization of the human substantia nigra (sn) using diffusion and functional mri data from the human connectome project. |
2018-05-14 |
2023-08-13 |
human |
| XiaoLong Hu, Qi Song, Xin Li, DanDan Li, Qiao Zhang, WeiHong Meng, QingChun Zha. Neuroprotective effects of Kukoamine A on neurotoxin-induced Parkinson's model through apoptosis inhibition and autophagy enhancement. Neuropharmacology. vol 117. 2018-05-03. PMID:28238714. |
parkinson's disease (pd) is characterized by the loss of dopaminergic neurons in substantia nigra (sn). |
2018-05-03 |
2023-08-13 |
Not clear |
| Jaung-Geng Lin, Chao-Jung Chen, Han-Bin Yang, Yi-Hung Chen, Shih-Ya Hun. Electroacupuncture Promotes Recovery of Motor Function and Reduces Dopaminergic Neuron Degeneration in Rodent Models of Parkinson's Disease. International journal of molecular sciences. vol 18. issue 9. 2018-05-03. PMID:28837077. |
the pathological hallmark of pd is a progressive loss of dopaminergic neurons in the substantia nigra (sn) pars compacta in the brain, ultimately resulting in severe striatal dopamine deficiency and the development of primary motor symptoms (e.g., resting tremor, bradykinesia) in pd. |
2018-05-03 |
2023-08-13 |
mouse |
| Margherita Fabbri, Sofia Reimão, Miguel Carvalho, Rita G Nunes, Daisy Abreu, Leonor Correia Guedes, Raquel Bouça, Patricia P Lobo, Catarina Godinho, Miguel Coelho, Nilza C Gonçalves, Mario Miguel Rosa, Angelo Antonini, Joaquim J Ferreir. Substantia Nigra Neuromelanin as an Imaging Biomarker of Disease Progression in Parkinson's Disease. Journal of Parkinson's disease. vol 7. issue 3. 2018-04-30. PMID:28671143. |
a specific t1-weighted magnetic resonance imaging (mri) sequence has been shown to detect substantia nigra (sn) neuromelanin (nm) signal changes that accurately discriminate parkinson's disease (pd) patients from controls, even in early disease stages. |
2018-04-30 |
2023-08-13 |
Not clear |
| Agnete Prydz, Katja Stahl, Maja Puchades, Nina Davarpaneh, Maria Nadeem, Ole Petter Ottersen, Vidar Gundersen, Mahmood Amiry-Moghadda. Subcellular expression of aquaporin-4 in substantia nigra of normal and MPTP-treated mice. Neuroscience. vol 359. 2018-04-30. PMID:28735099. |
further, mri studies of patients with parkinson's disease (pd) point to an excessive water accumulation in the substantia nigra (sn). |
2018-04-30 |
2023-08-13 |
mouse |
| Anita Jagota, Ushodaya Matta. Daily chronomics of proteomic profile in aging and rotenone-induced Parkinson's disease model in male Wistar rat and its modulation by melatonin. Biogerontology. vol 18. issue 4. 2018-04-24. PMID:28577110. |
to identify biomarkers of aging and pd chronomics of proteomic day-night profiles in suprachiasmatic nucleus (scn), pineal and substantia nigra (sn) in 3 month (m), 12, 24 m and ripd rat model were studied at two time points i.e. |
2018-04-24 |
2023-08-13 |
rat |
| Qi-Min Wang, Yu-Yu Xu, Shang Liu, Ze-Gang M. Isradipine attenuates MPTP-induced dopamine neuron degeneration by inhibiting up-regulation of L-type calcium channels and iron accumulation in the substantia nigra of mice. Oncotarget. vol 8. issue 29. 2018-04-23. PMID:28521299. |
the aim of this study is to investigate the effects of l-type calcium channels (ltccs) on mptp-induced dopamine (da) neuron degeneration and iron accumulation in the substantia nigra (sn) of mice. |
2018-04-23 |
2023-08-13 |
mouse |
| Hojin Kang, Rin Khang, Sangwoo Ham, Ga Ram Jeong, Hyojung Kim, Minkyung Jo, Byoung Dae Lee, Yun Il Lee, Areum Jo, ChiHu Park, Hyein Kim, Jeongkon Seo, Sun Ha Paek, Yun-Song Lee, Jeong-Yun Choi, Yunjong Lee, Joo-Ho Shi. Activation of the ATF2/CREB-PGC-1α pathway by metformin leads to dopaminergic neuroprotection. Oncotarget. vol 8. issue 30. 2018-04-23. PMID:28611284. |
the widely prescribed anti-diabetic medicine metformin is effective in preventing neurodegeneration in animal models; however, despite the significant potential of metformin for treating pd, the therapeutic effects and molecular mechanisms underlying dopaminergic neuroprotection by metformin are largely unknown.in this study, we found that metformin induced substantial proteomic changes, especially in metabolic and mitochondrial pathways in the substantia nigra (sn). |
2018-04-23 |
2023-08-13 |
Not clear |
| Fatemeh Nouri Emamzade. Role of Apolipoproteins and α-Synuclein in Parkinson's Disease. Journal of molecular neuroscience : MN. vol 62. issue 3-4. 2018-04-23. PMID:28695482. |
the main pathological feature of this disease is the loss of more than 80% of dopamine-producing neurons in the substantia nigra (sn). |
2018-04-23 |
2023-08-13 |
Not clear |