| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Toomas Toomsoo, Inga Liepelt-Scarfone, Daniela Berg, Riina Kerner, Allan-Hermann Pool, Liis Kadastik-Eerme, Inna Rubanovits, Toomas Asser, Pille Tab. Effect of Age on Substantia Nigra Hyper-echogenicity in Parkinson's Disease Patients and Healthy Controls. Ultrasound in medicine & biology. vol 45. issue 1. 2019-06-19. PMID:30482710. |
substantia nigra (sn) hyper-echogenicity (sn+) describes an enlargement (>90th percentile) of the area of echogenicity at the anatomic site of the sn in the midbrain detected by transcranial sonography. |
2019-06-19 |
2023-08-13 |
Not clear |
| Cong Zhang, Liyan Hou, Jie Yang, Yuning Che, Fuqiang Sun, Huihua Li, Qingshan Wan. 2,5-Hexanedione induces dopaminergic neurodegeneration through integrin α Cell death & disease. vol 9. issue 2. 2019-06-10. PMID:29352205. |
2,5-hexanedione induces dopaminergic neurodegeneration through integrin α recent study demonstrated that chronic exposure to solvents increases the risk of parkinson's disease (pd), the second most common neurodegenerative disorder characterized by progressive dopaminergic neurodegeneration in the substantia nigra (sn). |
2019-06-10 |
2023-08-13 |
rat |
| Ying Chen, Qianhang Shao, Yu-He Yuan, Nai-Hong Che. Prion-like propagation of α-synuclein in the gut-brain axis. Brain research bulletin. vol 140. 2019-05-30. PMID:29894766. |
the progression of pd includes the degenerative loss of dopaminergic (da) neurons and aggregation of α-synuclein in the substantia nigra (sn). |
2019-05-30 |
2023-08-13 |
Not clear |
| Rüyal Tan, Funda Bölükbaşi Hatip, Öznur Açikalin, Atsushi Yamauchi, Yasufumi Kataoka, Izzettin Hatip-Al-Khati. Effect of varenicline on behavioral deficits in a rat model of Parkinson's disease induced by unilateral 6-hydroxydopamine lesion of substantia nigra. Behavioural pharmacology. vol 29. issue 4. 2019-05-29. PMID:29064842. |
a unilateral lesion of the substantia nigra (sn) has been used as a reliable model of pd. |
2019-05-29 |
2023-08-13 |
rat |
| Hedi An, Xiaoyan Zeng, Tengfei Niu, Gaiying Li, Jie Yang, Lanlan Zheng, Wei Zhou, Hong Liu, Miaomiao Zhang, Dongya Huang, Jianqi L. Quantifying iron deposition within the substantia nigra of Parkinson's disease by quantitative susceptibility mapping. Journal of the neurological sciences. vol 386. 2019-05-28. PMID:29406966. |
iron deposition within the substantia nigra (sn) has been postulated to play a vital role in parkinson's disease (pd). |
2019-05-28 |
2023-08-13 |
Not clear |
| Mohammad Saee. Genomic convergence of locus-based GWAS meta-analysis identifies AXIN1 as a novel Parkinson's gene. Immunogenetics. vol 70. issue 9. 2019-05-21. PMID:29923028. |
these were further investigated for gene expression in substantia nigra (sn) of pd and control subjects on geo datasets. |
2019-05-21 |
2023-08-13 |
human |
| Wei-Zhong Zhao, Hsiang-Tsui Wang, Hui-Ju Huang, Yu-Li Lo, Anya Maan-Yuh Li. Neuroprotective Effects of Baicalein on Acrolein-induced Neurotoxicity in the Nigrostriatal Dopaminergic System of Rat Brain. Molecular neurobiology. vol 55. issue 1. 2019-05-08. PMID:28866823. |
in the present study, the neuroprotective effect of baicalein (a phenolic flavonoid in the dried root of scutellaria baicalensis georgi) on acrolein-induced neurodegeneration of nigrostriatal dopaminergic system was investigated using local infusion of acrolein in the substantia nigra (sn) of rat brain. |
2019-05-08 |
2023-08-13 |
rat |
| Clifford M Cassidy, Fabio A Zucca, Ragy R Girgis, Seth C Baker, Jodi J Weinstein, Madeleine E Sharp, Chiara Bellei, Alice Valmadre, Nora Vanegas, Lawrence S Kegeles, Gary Brucato, Un Jung Kang, David Sulzer, Luigi Zecca, Anissa Abi-Dargham, Guillermo Horg. Neuromelanin-sensitive MRI as a noninvasive proxy measure of dopamine function in the human brain. Proceedings of the National Academy of Sciences of the United States of America. vol 116. issue 11. 2019-05-06. PMID:30796187. |
neuromelanin-sensitive mri (nm-mri) purports to detect the content of neuromelanin (nm), a product of dopamine metabolism that accumulates with age in dopamine neurons of the substantia nigra (sn). |
2019-05-06 |
2023-08-13 |
human |
| İsmail Ünal, Ebru Emekli-Alturfa. Fishing for Parkinson's Disease: A review of the literature. Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia. vol 62. 2019-04-24. PMID:30660479. |
parkinson's disease (pd), the second most common neurodegenerative disorder in the world, is due to the damage or death of cells that produce dopamine in the region called the substantia nigra (sn). |
2019-04-24 |
2023-08-13 |
human |
| Eugene Bok, Young Cheul Chung, Ki-Suk Kim, Hyung Hwan Baik, Won-Ho Shin, Byung Kwan Ji. Modulation of M1/M2 polarization by capsaicin contributes to the survival of dopaminergic neurons in the lipopolysaccharide-lesioned substantia nigra in vivo. Experimental & molecular medicine. vol 50. issue 7. 2019-04-11. PMID:29968707. |
lps was unilaterally injected into the substantia nigra (sn) in the absence or presence of cap or capsazepine (czp, a trpv1 antagonist). |
2019-04-11 |
2023-08-13 |
rat |
| Megha Verma, Jay S Schneide. siRNA-mediated knockdown of B3GALT4 decreases GM1 ganglioside expression and enhances vulnerability for neurodegeneration. Molecular and cellular neurosciences. vol 95. 2019-04-11. PMID:30611881. |
reduced levels of brain gangliosides gd1a, gd1b, gt1b and to a lesser extent gm1 have been found in substantia nigra (sn) from parkinson's disease (pd) patients, along with decreased gene expression for key enzymes (b3galt4, st3gal2) involved in synthesis of these gangliosides. |
2019-04-11 |
2023-08-13 |
Not clear |
| Michael F Salvatore, Vicki A Nejtek, Habibeh Khoshboue. Prolonged increase in ser31 tyrosine hydroxylase phosphorylation in substantia nigra following cessation of chronic methamphetamine. Neurotoxicology. vol 67. 2019-04-08. PMID:29782882. |
in the rodent pd 6-ohda model, nigrostriatal lesion decreases th protein in both striatum and substantia nigra (sn). |
2019-04-08 |
2023-08-13 |
mouse |
| Elisabeth G Hain, Maria Sparenberg, Justyna Rasińska, Charlotte Klein, Levent Akyüz, Barbara Steine. Indomethacin promotes survival of new neurons in the adult murine hippocampus accompanied by anti-inflammatory effects following MPTP-induced dopamine depletion. Journal of neuroinflammation. vol 15. issue 1. 2019-04-08. PMID:29803225. |
parkinson's disease (pd) is characterized by dopaminergic cell loss and inflammation in the substantia nigra (sn) leading to motor deficits but also to hippocampus-associated non-motor symptoms such as spatial learning and memory deficits. |
2019-04-08 |
2023-08-13 |
mouse |
| Yoon-Sang Oh, Do-Young Kwon, Joong-Seok Kim, Moon-Ho Park, Daniela Ber. Transcranial sonographic findings may predict prognosis of gastroprokinetic drug-induced parkinsonism. Parkinsonism & related disorders. vol 46. 2019-04-01. PMID:29111425. |
transcranial sonography (tcs) of the substantia nigra (sn) has been widely used to diagnose pd and differentiate parkinsonism types. |
2019-04-01 |
2023-08-13 |
Not clear |
| Qifang Yang, Lina Zhou, Chen Liu, Daihong Liu, Yang Zhang, Chang Li, Yongning Shang, Xin Wei, Chuanming Li, Jian Wan. Brain iron deposition in type 2 diabetes mellitus with and without mild cognitive impairment-an in vivo susceptibility mapping study. Brain imaging and behavior. vol 12. issue 5. 2019-04-01. PMID:29297155. |
the susceptibility values of the bilateral parietal cortex, frontal white matter, caudate nucleus (cn), putamen (pu), globus pallidus, thalamus, red nucleus, substantia nigra (sn), hippocampus (hp) and dentate nucleus were analyzed and correlated with the neuropsychological cognitive scores. |
2019-04-01 |
2023-08-13 |
Not clear |
| Fangfang Dou, Xinkun Chu, Bei Zhang, Liang Liang, Guoqiang Lu, Jianqing Ding, Shengdi Che. EriB targeted inhibition of microglia activity attenuates MPP Molecular brain. vol 11. issue 1. 2019-04-01. PMID:30563578. |
with the progressive and selective degeneration of dopaminergic (da) neurons, proinflammatory cytokines are elevated in the substantia nigra (sn) of pd patients. |
2019-04-01 |
2023-08-13 |
mouse |
| Katarzyna Kuter, Manuela Kratochwil, Klemencja Berghauzen-Maciejewska, Urszula Głowacka, Michiru D Sugawa, Krystyna Ossowska, Norbert A Denche. Adaptation within mitochondrial oxidative phosphorylation supercomplexes and membrane viscosity during degeneration of dopaminergic neurons in an animal model of early Parkinson's disease. Biochimica et biophysica acta. vol 1862. issue 4. 2019-03-28. PMID:26844379. |
in parkinson's disease (pd) motor symptoms are not observed until loss of 70% of dopaminergic neurons in substantia nigra (sn), preventing early diagnosis. |
2019-03-28 |
2023-08-13 |
rat |
| Gwan Ui Hong, Jin Whan Cho, Soo Youl Kim, Joo Ho Shin, Jai Youl R. Inflammatory mediators resulting from transglutaminase 2 expressed in mast cells contribute to the development of Parkinson's disease in a mouse model. Toxicology and applied pharmacology. vol 358. 2019-03-22. PMID:30195017. |
this study aimed to investigate the role of transglutaminase 2 (tg2) expressed in mast cells in substantia nigra (sn) in parkinson's disease (pd) model or human pd patients. |
2019-03-22 |
2023-08-13 |
mouse |
| Monica R Langley, Shivani Ghaisas, Muhammet Ay, Jie Luo, Bharathi N Palanisamy, Huajun Jin, Vellareddy Anantharam, Arthi Kanthasamy, Anumantha G Kanthasam. Manganese exposure exacerbates progressive motor deficits and neurodegeneration in the MitoPark mouse model of Parkinson's disease: Relevance to gene and environment interactions in metal neurotoxicity. Neurotoxicology. vol 64. 2019-03-21. PMID:28595911. |
the neurodegenerative changes were accompanied by enhanced oxidative damage in the striatum and substantia nigra (sn) of mitopark mice treated with mn. |
2019-03-21 |
2023-08-13 |
mouse |
| Cynthia A Kelm-Nelson, Michael A Trevino, Michelle R Ciucc. Quantitative Analysis of Catecholamines in the Pink1 -/- Rat Model of Early-onset Parkinson's Disease. Neuroscience. vol 379. 2019-03-18. PMID:29496635. |
catecholamine concentrations in the striatum (sr), substantia nigra (sn), and locus coeruleus (lc) were analyzed to test the hypothesis that behavioral deficits would correlate to altered protein levels. |
2019-03-18 |
2023-08-13 |
rat |