| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Baihui Huang, Shihao Wu, Zhengbo Wang, Longjiao Ge, Joshua D Rizak, Jing Wu, Jiali Li, Lin Xu, Longbao Lv, Yong Yin, Xintian Hu, Hao L. Phosphorylated α-Synuclein Accumulations and Lewy Body-like Pathology Distributed in Parkinson's Disease-Related Brain Areas of Aged Rhesus Monkeys Treated with MPTP. Neuroscience. vol 379. 2019-03-18. PMID:29592843. |
here, pathological changes in the substantia nigra (sn) and pd-related brain areas were measured in aged monkeys treated with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp) utilizing a modeling-recovery-remodeling strategy. |
2019-03-18 |
2023-08-13 |
monkey |
| Juciano Gasparotto, Camila Tiefensee Ribeiro, Rafael Calixto Bortolin, Nauana Somensi, Thallita Kelly Rabelo, Alice Kunzler, Natália Cabral Souza, Matheus Augusto de Bittencourt Pasquali, José Claudio Fonseca Moreira, Daniel Pens Gelai. Targeted inhibition of RAGE in substantia nigra of rats blocks 6-OHDA-induced dopaminergic denervation. Scientific reports. vol 7. issue 1. 2019-03-15. PMID:28821831. |
in this study, we used the multimodal blocker of rage fps-zm1, which has become available recently, to selectively inhibit rage in the substantia nigra (sn) of rats intracranially injected with 6-hydroxydopamine (6-ohda). |
2019-03-15 |
2023-08-13 |
rat |
| Mohammad Raziya Banu, Muhammed Ibrahim, K Prabhu, Srinivasagam Rajasanka. Ameliorative Effect of Withaferin A on Ageing-Mediated Impairment in the Dopamine System and Its Associated Behavior of Wistar Albino Rat. Pharmacology. vol 103. issue 3-4. 2019-03-14. PMID:30544122. |
the hplc assay revealed significant decline in the levels of da and homovanillic acid (hva) in substantia nigra (sn) and striatum (st) of aged rat. |
2019-03-14 |
2023-08-13 |
rat |
| Qian Zhang, Chengwu Li, Ting Zhang, Yaping Ge, Xiaojuan Han, Sifan Sun, Jianhua Ding, Ming Lu, Gang H. Deletion of Kir6.2/SUR1 potassium channels rescues diminishing of DA neurons via decreasing iron accumulation in PD. Molecular and cellular neurosciences. vol 92. 2019-03-05. PMID:30171894. |
k-atp channels in mature substantia nigra (sn) dopaminergic (da) neurons are composed of inwardly rectifying potassium channel (kir) subunit 6.2 and sulfonylurea receptor 1 (sur1). |
2019-03-05 |
2023-08-13 |
mouse |
| Sebastian Hormigo, Dolores E López, Antonio Cardoso, Gladys Zapata, Jacqueline Sepúlveda, Orlando Castellan. Direct and indirect nigrofugal projections to the nucleus reticularis pontis caudalis mediate in the motor execution of the acoustic startle reflex. Brain structure & function. vol 223. issue 6. 2019-02-28. PMID:29574585. |
since the basal ganglia circuits control movement and action selection, we hypothesize that their output via the substantia nigra (sn) may interplay with the asr primary circuit by providing inputs to pnc. |
2019-02-28 |
2023-08-13 |
rat |
| Katarzyna Kuter, Łukasz Olech, Urszula Głowack. Prolonged Dysfunction of Astrocytes and Activation of Microglia Accelerate Degeneration of Dopaminergic Neurons in the Rat Substantia Nigra and Block Compensation of Early Motor Dysfunction Induced by 6-OHDA. Molecular neurobiology. vol 55. issue 4. 2019-02-26. PMID:28466266. |
progressive degeneration of dopaminergic neurons in the substantia nigra (sn) is the underlying cause of parkinson's disease (pd). |
2019-02-26 |
2023-08-13 |
rat |
| Shan Zhang, Shu Chen, Anmin Liu, Jungang Wan, Lingwen Tang, Niandong Zheng, Yi Xion. Inhibition of BDNF production by MPP Neuroscience letters. vol 675. 2019-02-22. PMID:29030221. |
the observation of reduced level of bdnf in the substantia nigra (sn) of parkinson's disease (pd) patients suggests its important role in neuron protection in pd pathogenesis. |
2019-02-22 |
2023-08-13 |
Not clear |
| Eugene L Boshoff, Edward J R Fletcher, Susan Dut. Fibroblast growth factor 20 is protective towards dopaminergic neurons in vivo in a paracrine manner. Neuropharmacology. vol 137. 2019-02-20. PMID:29698669. |
we set out to examine whether manipulation of the fgf20 system affected nigrostriatal tract integrity in rats, to identify which fibroblast growth factor receptors (fgfrs) might reside on dopaminergic neurons and to discover the source of endogenous fgf20 in the substantia nigra (sn). |
2019-02-20 |
2023-08-13 |
human |
| Junjie Zeng, Wu Xing, Weihua Liao, Xiaoyi Wan. Magnetic resonance imaging, susceptibility weighted imaging and quantitative susceptibility mapping findings of pantothenate kinase-associated neurodegeneration. Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia. vol 59. 2019-02-12. PMID:30392836. |
the qsm values were higher in the bilateral central gp, bilateral peripheral gp, and bilateral substantia nigra (sn) and lower in the left red nucleus (rn) compared with the healthy controls. |
2019-02-12 |
2023-08-13 |
human |
| Jeong Yeob Baek, Jae Yeong Jeong, Kyoung In Kim, So-Yoon Won, Young Cheul Chung, Jin Han Nam, Eun Ju Cho, Tae-Beom Ahn, Eugene Bok, Won-Ho Shin, Byung Kwan Ji. Inhibition of Microglia-Derived Oxidative Stress by Ciliary Neurotrophic Factor Protects Dopamine Neurons In Vivo from MPP⁺ Neurotoxicity. International journal of molecular sciences. vol 19. issue 11. 2019-02-11. PMID:30423807. |
we demonstrated that capsaicin (cap), an agonist of transient receptor potential vanilloid subtype 1 (trpv1), inhibits microglia activation and microglia-derived oxidative stress in the substantia nigra (sn) of mpp⁺-lesioned rat. |
2019-02-11 |
2023-08-13 |
human |
| M Caleb Bagley, Måns Ekelöf, Kylie Rock, Heather Patisaul, David C Muddima. IR-MALDESI mass spectrometry imaging of underivatized neurotransmitters in brain tissue of rats exposed to tetrabromobisphenol A. Analytical and bioanalytical chemistry. vol 410. issue 30. 2019-02-08. PMID:30317443. |
three neurotransmitters of interest were studied in three selected regions of the brain: caudate putamen, substantia nigra (sn), and dorsal raphe. |
2019-02-08 |
2023-08-13 |
rat |
| Nao Chuhma, Susana Mingote, Leora Yetnikoff, Abigail Kalmbach, Thong Ma, Samira Ztaou, Anna-Claire Sienna, Sophia Tepler, Jean-Francois Poulin, Mark Ansorge, Rajeshwar Awatramani, Un Jung Kang, Stephen Raypor. Dopamine neuron glutamate cotransmission evokes a delayed excitation in lateral dorsal striatal cholinergic interneurons. eLife. vol 7. 2019-02-05. PMID:30295607. |
the da neurons mediating these excitatory signals are in the substantia nigra (sn). |
2019-02-05 |
2023-08-13 |
mouse |
| Mei Liu, Eun-Joo Shin, Duy-Khanh Dang, Chun-Hui Jin, Phil Ho Lee, Ji Hoon Jeong, Seok-Joo Park, Yong-Sun Kim, Bin Xing, Tao Xin, Guoying Bing, Hyoung-Chun Ki. Trichloroethylene and Parkinson's Disease: Risk Assessment. Molecular neurobiology. vol 55. issue 7. 2019-02-04. PMID:29270919. |
following 8 months of tce treatment, there was a progressive and selective loss of 50% of the dopaminergic neurons in mouse substantia nigra (sn) and about 50% loss of dopamine and 72% loss of 3,4-dihydroxyphenylacetic acid in the striatum, respectively. |
2019-02-04 |
2023-08-13 |
mouse |
| Stefan Theodor Schwarz, Olivier Mougin, Yue Xing, Anna Blazejewska, Nin Bajaj, Dorothee P Auer, Penny Gowlan. Parkinson's disease related signal change in the nigrosomes 1-5 and the substantia nigra using T2* weighted 7T MRI. NeuroImage. Clinical. vol 19. 2019-01-21. PMID:29872633. |
previous work has proven that iron dependent mri scans can detect the largest nigrosome (n1) within the substantia nigra (sn) pars compacta and changes in pd. |
2019-01-21 |
2023-08-13 |
Not clear |
| Johanna Duda, Michael Fauler, Jan Gründemann, Birgit Lis. Cell-Specific RNA Quantification in Human SN DA Neurons from Heterogeneous Post-mortem Midbrain Samples by UV-Laser Microdissection and RT-qPCR. Methods in molecular biology (Clifton, N.J.). vol 1723. 2019-01-16. PMID:29344870. |
all these issues were considered for comparative gene expression analysis in dopamine (da) midbrain neurons of the substantia nigra (sn) from controls and parkinson's disease (pd) specimens, as the preferential degeneration of sn da neurons in the pathological hallmark of pd. |
2019-01-16 |
2023-08-13 |
human |
| Sehwan Kim, Gyeong Joon Moon, Yong-Seok Oh, Jungha Park, Won-Ho Shin, Jae Yeong Jeong, Kwang Shik Choi, Byung Kwan Jin, Nikolai Kholodilov, Robert E Burke, Hyung-Jun Kim, Chang Man Ha, Seok-Geun Lee, Sang Ryong Ki. Protection of nigral dopaminergic neurons by AAV1 transduction with Rheb(S16H) against neurotoxic inflammation in vivo. Experimental & molecular medicine. vol 50. issue 2. 2019-01-15. PMID:29422542. |
our observations showed that rheb(s16h) transduction played a role in the neuroprotection of the nigrostriatal da system against pkr-2-induced neurotoxic inflammation, even though there were similar levels of pro-inflammatory cytokines, such as tumor necrosis factor-alpha (tnf-α) and interleukin-1-beta (il-1β), in the aav1-rheb(s16h)-treated substantia nigra (sn) compared to the sn treated with pkr-2 alone; the neuroprotective effects may be mediated by the activation of neurotrophic signaling pathways following rheb(s16h) transduction of nigral da neurons. |
2019-01-15 |
2023-08-13 |
Not clear |
| Won Sik Eum, Min Jea Shin, Chi Hern Lee, Hyeon Ji Yeo, Eun Ji Yeo, Yeon Joo Choi, Hyun Jung Kwon, Duk-Soo Kim, Oh Shin Kwon, Keun Wook Lee, Kyu Hyung Han, Jinseu Park, Dae Won Kim, Soo Young Cho. Neuroprotective effects of Tat-ATOX1 protein against MPP Biochimie. vol 156. 2019-01-09. PMID:30352250. |
neuroprotective effects of tat-atox1 protein against mpp parkinson's disease (pd), a neurodegenerative disorder, is characterized by a loss of dopaminergic neurons in the substantia nigra (sn) of the brain and it is well known that the pathogenesis of pd is related to a number of risk factors including oxidative stress. |
2019-01-09 |
2023-08-13 |
Not clear |
| Jay S Schneide. Altered expression of genes involved in ganglioside biosynthesis in substantia nigra neurons in Parkinson's disease. PloS one. vol 13. issue 6. 2018-12-31. PMID:29902255. |
the present study examined the extent to which deficits in gene expression of key biosynthetic enzymes involved in synthesis of gm1 and gd1b (b3galt4) and gd1a and gt1b (st3gal2) exist in neuromelanin-containing neurons in the pd substantia nigra (sn). |
2018-12-31 |
2023-08-13 |
human |
| Ying Jiang, Zhentang Cao, Huizi Ma, Guihong Wang, Xuemei Wang, Zhan Wang, Yaqin Yang, Huiqing Zhao, Genliang Liu, Longling Li, Tao Fen. Auricular Vagus Nerve Stimulation Exerts Antiinflammatory Effects and Immune Regulatory Function in a 6-OHDA Model of Parkinson's Disease. Neurochemical research. vol 43. issue 11. 2018-12-19. PMID:30311182. |
the aim of this study was to evaluate the effects of auricular vagus nerve stimulation (avns) on substantia nigra (sn) dopaminergic neurodegeneration and the associated neuroinflammation and immune responses in a rat pd model. |
2018-12-19 |
2023-08-13 |
rat |
| Yan Zhou, Jialei Zhu, Yang Lv, Chenghuan Song, Jianhua Ding, Ming Xiao, Ming Lu, Gang H. Kir6.2 Deficiency Promotes Mesencephalic Neural Precursor Cell Differentiation via Regulating miR-133b/GDNF in a Parkinson's Disease Mouse Model. Molecular neurobiology. vol 55. issue 11. 2018-12-17. PMID:29564810. |
the loss of dopaminergic (da) neurons in the substantia nigra (sn) is a major feature in the pathology of parkinson's disease (pd). |
2018-12-17 |
2023-08-13 |
mouse |