| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Guangxin Chen, Juxiong Liu, Liqiang Jiang, Xin Ran, Dewei He, Yuhang Li, Bingxu Huang, Wei Wang, Shoupeng F. Galangin Reduces the Loss of Dopaminergic Neurons in an LPS-Evoked Model of Parkinson's Disease in Rats. International journal of molecular sciences. vol 19. issue 1. 2018-08-20. PMID:29267220. |
parkinson's disease (pd) is caused by the loss of dopaminergic (da) neurons in the midbrain substantia nigra (sn). |
2018-08-20 |
2023-08-13 |
rat |
| Lin Kooi Ong, Zidan Zhao, Murielle Kluge, Clifford TeBay, Katarzyna Zalewska, Phillip W Dickson, Sarah J Johnson, Michael Nilsson, Frederick R Walke. Reconsidering the role of glial cells in chronic stress-induced dopaminergic neurons loss within the substantia nigra? Friend or foe? Brain, behavior, and immunity. vol 60. 2018-08-16. PMID:27717686. |
exposure to psychological stress is known to seriously disrupt the operation of the substantia nigra (sn) and may in fact initiate the loss of dopaminergic neurons within the sn. |
2018-08-16 |
2023-08-13 |
mouse |
| Amit Khairnar, Jana Ruda-Kucerova, Nikoletta Szabó, Eva Drazanova, Anas Arab, Birgit Hutter-Paier, Joerg Neddens, Peter Latta, Zenon Starcuk, Irena Rektorov. Early and progressive microstructural brain changes in mice overexpressing human α-Synuclein detected by diffusion kurtosis imaging. Brain, behavior, and immunity. vol 61. 2018-08-10. PMID:27923670. |
we found increases in mk in 3mo tnwt-61 mice in the striatum and thalamus but not in the substantia nigra (sn), hippocampus, or sensorimotor cortex, even though the immunoreactivity of human α-syn was similar or even higher in the latter regions. |
2018-08-10 |
2023-08-13 |
mouse |
| Neil A Kelly, Kimberly H Wood, Jane B Allendorfer, Matthew P Ford, C Scott Bickel, Jon Marstrander, Amy W Amara, Thomas Anthony, Marcas M Bamman, Frank M Skidmor. High-Intensity Exercise Acutely Increases Substantia Nigra and Prefrontal Brain Activity in Parkinson's Disease. Medical science monitor : international medical journal of experimental and clinical research. vol 23. 2018-08-09. PMID:29273705. |
results an effect of acute exercise was observed as an increased alff signal within the right ventromedial prefrontal cortex (pfc), left ventrolateral pfc, and bilaterally within the substantia nigra (sn). |
2018-08-09 |
2023-08-13 |
human |
| Vedad Delic, Jeddidiah W D Griffin, Sandra Zivkovic, Yumeng Zhang, Tam-Anh Phan, Henry Gong, Dale Chaput, Christian Reynes, Vinh B Dinh, Josean Cruz, Eni Cvitkovic, Devon Placides, Ernide Frederic, Hamed Mirzaei, Stanley M Stevens, Umesh Jinwal, Daniel C Lee, Patrick C Bradsha. Individual Amino Acid Supplementation Can Improve Energy Metabolism and Decrease ROS Production in Neuronal Cells Overexpressing Alpha-Synuclein. Neuromolecular medicine. vol 19. issue 2-3. 2018-08-06. PMID:28620826. |
parkinson's disease (pd) is a neurodegenerative disorder characterized by alpha-synuclein accumulation and loss of dopaminergic neurons in the substantia nigra (sn) region of the brain. |
2018-08-06 |
2023-08-13 |
human |
| Kert Mätlik, Helena Vihinen, Ali Bienemann, Jaan Palgi, Merja H Voutilainen, Sigrid Booms, Maria Lindahl, Eija Jokitalo, Mart Saarma, Henri J Huttunen, Mikko Airavaara, Urmas Arumä. Intrastriatally Infused Exogenous CDNF Is Endocytosed and Retrogradely Transported to Substantia Nigra. eNeuro. vol 4. issue 1. 2018-07-31. PMID:28275710. |
these da neurons have been suggested to transport striatal cdnf retrogradely to the substantia nigra (sn). |
2018-07-31 |
2023-08-13 |
human |
| Qing Ye, Xiaolei Yuan, Jie Zhou, Canxing Yuan, Xuming Yan. Effect of Zishenpingchan granule prepared from Chinese medicinal substances on the c-Jun N-terminal protein kinase pathway in micewith Parkinson's disease induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan. vol 37. issue 2. 2018-07-31. PMID:29960635. |
to investigate the regulatory mechanism of the c-jun n-terminal protein kinase (jnk)signaling pathway in substantia nigra (sn) dopaminergic neurons inflammation and apoptosis, andthe neuroprotective effect of zishenpingchan granules in mice with parkinson's disease (pd) inducedby 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp). |
2018-07-31 |
2023-08-13 |
mouse |
| Ai Yan Sheng, Ying Chun Zhang, Yu Jing Sheng, Cai Shan Wang, Ying Zhang, Hua Hu, Wei Feng Luo, CHun-Feng LI. Transcranial sonography image characteristics in different Parkinson's disease subtypes. Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology. vol 38. issue 10. 2018-07-30. PMID:28726052. |
in accordance with several previous studies, we detected substantia nigra (sn) by tcs in 85.4% of patients with idiopathic pd; we concluded that pigd patients had more serious disease than td and indeterminate pd group (p < 0.05). |
2018-07-30 |
2023-08-13 |
Not clear |
| Panagiotis Perdikaris, Martha Tsarouchi, Eleni Fanarioti, Evangelos Natsaridis, Ada Mitsacos, Panagiotis Giompre. Long lasting effects of chronic WIN55,212-2 treatment on mesostriatal dopaminergic and cannabinoid systems in the rat brain. Neuropharmacology. vol 129. 2018-07-27. PMID:29113897. |
acute and chronic administration of win55,212-2 decreased dopamine transporter (dat) binding and mrna levels, as well as tyrosine hydroxylase (th) mrna expression in the substantia nigra (sn) and ventral tegmental area (vta). |
2018-07-27 |
2023-08-13 |
rat |
| Ori J Lieberman, Se Joon Choi, Ellen Kanter, Anastasia Saverchenko, Micah D Frier, Giulia M Fiore, Min Wu, Jyothisri Kondapalli, Enrico Zampese, D James Surmeier, David Sulzer, Eugene V Mosharo. α-Synuclein-Dependent Calcium Entry Underlies Differential Sensitivity of Cultured SN and VTA Dopaminergic Neurons to a Parkinsonian Neurotoxin. eNeuro. vol 4. issue 6. 2018-07-25. PMID:29177188. |
parkinson's disease (pd) is a debilitating neurodegenerative disease characterized by a loss of dopaminergic neurons in the substantia nigra (sn). |
2018-07-25 |
2023-08-13 |
mouse |
| Frauke Knossalla, Zacharias Kohl, Jürgen Winkler, Stefan Schwab, Thomas Schenk, Tobias Engelhorn, Arnd Doerfler, Philipp Gölit. High-resolution diffusion tensor-imaging indicates asymmetric microstructural disorganization within substantia nigra in early Parkinson's disease. Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia. vol 50. 2018-07-25. PMID:29366621. |
parkinson's disease (pd) is characterised by neuropathological degenerative changes in the substantia nigra (sn). |
2018-07-25 |
2023-08-13 |
Not clear |
| Silvia Favaretto, Uwe Walter, Claudio Baracchini, Annachiara Cagni. Transcranial Sonography in Neurodegenerative Diseases with Cognitive Decline. Journal of Alzheimer's disease : JAD. vol 61. issue 1. 2018-07-13. PMID:29103031. |
transcranial sonography (tcs) of the brain parenchyma detects alterations in the substantia nigra (sn), raphe nuclei and basal ganglia; this technique has been established as a tool for the early diagnosis of parkinson's disease and differential diagnosis from atypical parkinsonian syndromes. |
2018-07-13 |
2023-08-13 |
Not clear |
| Babita Singh, Shivani Pandey, Satyndra Kumar Yadav, Rajesh Verma, Surya Pratap Singh, Abbas Ali Mahd. Role of ethanolic extract of Bacopa monnieri against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) induced mice model via inhibition of apoptotic pathways of dopaminergic neurons. Brain research bulletin. vol 135. 2018-07-05. PMID:29032054. |
there was a significant reduction in tyrosine hydroxylase (th) immunoreactivity in the substantia nigra (sn) in mptp treated group, which was considerably restored by the use of bm extract. |
2018-07-05 |
2023-08-13 |
mouse |
| C Requejo, J A Ruiz-Ortega, H Bengoetxea, A García-Blanco, E Herrán, A Aristieta, M Igartua, J L Pedraz, L Ugedo, R M Hernández, J V Lafuent. Morphological Changes in a Severe Model of Parkinson's Disease and Its Suitability to Test the Therapeutic Effects of Microencapsulated Neurotrophic Factors. Molecular neurobiology. vol 54. issue 10. 2018-07-02. PMID:27844282. |
the aim of the present work was to assess the morphological changes along the rostro-caudal axis of caudo-putamen complex and substantia nigra (sn) in the referred model in order to test the suitability of a severe model to evaluate new neurorestorative therapies. |
2018-07-02 |
2023-08-13 |
rat |
| Caroline Cristiano Real, Priscila Crespo Garcia, Luiz R G Britt. Treadmill Exercise Prevents Increase of Neuroinflammation Markers Involved in the Dopaminergic Damage of the 6-OHDA Parkinson's Disease Model. Journal of molecular neuroscience : MN. vol 63. issue 1. 2018-06-27. PMID:28801819. |
parkinson's disease (pd) involves loss of dopaminergic neurons in the substantia nigra (sn), which can be correlated to neuroinflammatory changes with the aging of the nervous system. |
2018-06-27 |
2023-08-13 |
rat |
| Jose V Lafuente, Catalina Requejo, Alejandro Carrasco, Harkaitz Bengoetxe. Nanoformulation: A Useful Therapeutic Strategy for Improving Neuroprotection and the Neurorestorative Potential in Experimental Models of Parkinson's Disease. International review of neurobiology. vol 137. 2018-06-25. PMID:29132545. |
in addition to a remarkable depletion of dopamine in the nigrostriatal system, the administration of 6-ohda into mfb induces some other neuropathological changes such as an increase of glial fibrillary acidic protein (gfap) positive cells in substantia nigra (sn) as well as in striatum. |
2018-06-25 |
2023-08-13 |
rat |
| Satyndra Kumar Yadav, Shivani Pandey, Babita Sing. Role of estrogen and levodopa in 1-methyl-4-pheny-l-1, 2, 3, 6-tetrahydropyridine (mptp)-induced cognitive deficit in Parkinsonian ovariectomized mice model: A comparative study. Journal of chemical neuroanatomy. vol 85. 2018-06-22. PMID:28711564. |
the recovery of dopamine neurons in the substantia nigra (sn) region was estimated by immunostaining of tyrosine hydroxylase (th). |
2018-06-22 |
2023-08-13 |
mouse |
| Shu-Yang Yu, Chen-Jie Cao, Li-Jun Zuo, Ze-Jie Chen, Teng-Hong Lian, Fang Wang, Yang Hu, Ying-Shan Piao, Li-Xia Li, Peng Guo, Li Liu, Qiu-Jin Yu, Rui-Dan Wang, Piu Chan, Sheng-di Chen, Xiao-Min Wang, Wei Zhan. Clinical features and dysfunctions of iron metabolism in Parkinson disease patients with hyper echogenicity in substantia nigra: a cross-sectional study. BMC neurology. vol 18. issue 1. 2018-06-19. PMID:29343241. |
however, the relationship between hyper echogenicity in substantia nigra (sn) and clinical symptoms of pd patients remains unknown, and the role of dysfunction of iron metabolism on the pathogenesis of sn hyper echogenicity is unclear. |
2018-06-19 |
2023-08-13 |
Not clear |
| R D Abbott, J S Nelson, G W Ross, J H Uyehara-Lock, C M Tanner, K H Masaki, L J Launer, L R White, H Petrovitc. Marinesco bodies and substantia nigra neuron density in Parkinson's disease. Neuropathology and applied neurobiology. vol 43. issue 7. 2018-06-14. PMID:28626918. |
marinesco bodies (mb) are intranuclear inclusions in pigmented neurons of the substantia nigra (sn). |
2018-06-14 |
2023-08-13 |
Not clear |
| Thomas P Wellings, Alan M Brichta, Rebecca Li. Altered neurofilament protein expression in the lateral vestibular nucleus in Parkinson's disease. Experimental brain research. vol 235. issue 12. 2018-06-14. PMID:28929183. |
in pd, reduced expression of npnfp in substantia nigra (sn) neurons is believed to contribute to dysfunction. |
2018-06-14 |
2023-08-13 |
Not clear |