| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Lei Tang, Nana Xu, Mengyao Huang, Wei Yi, Xuan Sang, Mingting Shao, Ye Li, Zhao-Zhe Hao, Ruifeng Liu, Yuhui Shen, Feng Yue, Xialin Liu, Chuan Xu, Sheng Li. A primate nigrostriatal atlas of neuronal vulnerability and resilience in a model of Parkinson's disease. Nature communications. vol 14. issue 1. 2023-11-18. PMID:37980356. |
here we generated high-quality profiles for 250,173 cells from the substantia nigra (sn) and putamen (pt) of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp)-induced parkinsonian macaques and matched controls. |
2023-11-18 |
2023-11-20 |
human |
| Qiong Liu, Juan Chen, Jin Xue, Xun Zhou, Yun Tian, Qiao Xiao, Wen Huang, Yongcheng Pan, Xiaoxia Zhou, Jian Li, Yuwen Zhao, Hongxu Pan, Yige Wang, Runcheng He, Yaqin Xiang, Tian Tu, Qian Xu, Qiying Sun, Jieqiong Tan, Xinxiang Yan, Jinchen Li, Jifeng Guo, Lu Shen, Ranhui Duan, Beisha Tang, Zhenhua Li. GGC expansions in NOTCH2NLC contribute to Parkinson disease and dopaminergic neuron degeneration. European journal of neurology. 2023-11-17. PMID:37975799. |
the role of ggc repeat expansions within notch2nlc in parkinson's disease (pd) and the substantia nigra (sn) dopaminergic neuron remains unclear. |
2023-11-17 |
2023-11-20 |
Not clear |
| Xinping Kuai, Dandan Shao, Shengyu Wang, Pu-Yeh Wu, Yan Wu, Xuexue Wan. Neuromelanin-sensitive MRI of the substantia nigra distinguishes bipolar from unipolar depression. Cerebral cortex (New York, N.Y. : 1991). 2023-11-13. PMID:37955650. |
in this study, we evaluated whether neuromelanin-mr signal and volume changes in the substantia nigra (sn) can be used as potential biomarkers to differentiate bd-ii from ud. |
2023-11-13 |
2023-11-20 |
human |
| Nicole Burkert, Shoumik Roy, Max Häusler, Dominik Wuttke, Sonja Müller, Johanna Wiemer, Helene Hollmann, Marvin Oldrati, Jorge Ramirez-Franco, Julia Benkert, Michael Fauler, Johanna Duda, Jean-Marc Goaillard, Christina Pötschke, Moritz Münchmeyer, Rosanna Parlato, Birgit Lis. Deep learning-based image analysis identifies a DAT-negative subpopulation of dopaminergic neurons in the lateral Substantia nigra. Communications biology. vol 6. issue 1. 2023-11-10. PMID:37950046. |
using dlap, we identified a small subpopulation of th-positive neurons (~5%), mainly located in the very lateral substantia nigra (sn), that was immunofluorescence-negative for the plasmalemmal dopamine transporter (dat), with ~40% smaller cell bodies. |
2023-11-10 |
2023-11-20 |
mouse |
| Pasquale Esposito, Cloudia Rodriguez, Michelle Gandelman, Jacky Liang, Nafissa Ismai. CD46 expression in the central nervous system of male and female pubescent mice. Journal of neuroimmunology. vol 385. 2023-11-09. PMID:37944208. |
therefore, the current study investigated if cd46 is expressed in the substantia nigra (sn) and caudate putamen (cp) of pubescent cd1 mice and examined the acute effects of pubertal antimicrobial and lipopolysaccharide (lps) treatment on cd46 expression in the brain. |
2023-11-09 |
2023-11-20 |
mouse |
| Hojin Kang, Soojeong Park, Areum Jo, Xiaobo Mao, Manoj Kumar, Chi-Hu Park, Jee-Yin Ahn, Yunjong Lee, Jeong-Yun Choi, Yun-Song Lee, Valina L Dawson, Ted M Dawson, Tae-In Kam, Joo-Ho Shi. PARIS undergoes liquid-liquid phase separation and poly(ADP-ribose)-mediated solidification. EMBO reports. vol 24. issue 11. 2023-11-06. PMID:37870275. |
furthermore, sds-resistant paris species are observed in the substantia nigra (sn) of aged mice overexpressing wild-type paris, but not with a par binding-deficient paris mutant. |
2023-11-06 |
2023-11-08 |
mouse |
| Julia J Meerman, Juliette Legler, Aldert H Piersma, Remco H S Westerink, Harm J Heusinkvel. An Adverse Outcome Pathway for Chemical-induced Parkinson's disease: Calcium is Key. Neurotoxicology. 2023-11-05. PMID:37926220. |
pd symptoms are caused by loss of function and ultimately death of dopaminergic neurons in the substantia nigra (sn). |
2023-11-05 |
2023-11-08 |
human |
| Eduarda Monteiro Fidelis, Anne Suely P Savall, Jhuly Dornelles Mello, Caroline Brandão Quines, Antônio Alvenir Comis-Neto, Tuane Bazanella Sampaio, Cristiane Casagrande Denardin, Daiana Silva de Ávila, Suzan Gonçalves Rosa, Simone Pinto. Purple pitanga extract (Eugenia uniflora) attenuates oxidative stress induced by MPTP. Metabolic brain disease. 2023-11-03. PMID:37921949. |
after 24 h, mptp (0.1 mg/10µl/nostril) or vehicle was administered bilaterally into the animal's nostrils, and 6 h later, the olfactory bulb (ob), striatum (st), and substantia nigra (sn) were collected to evaluate the oxidative stress parameters. |
2023-11-03 |
2023-11-08 |
rat |
| Hyungwoo Lee, Kijeong Lee, Young Dae Kim, Hyo Suk Nam, Hye Sun Lee, Sunghee Cho, Ji Hoe He. Association between substantia nigra degeneration and functional outcome in patients with basal ganglia infarction. European journal of neurology. 2023-10-30. PMID:37903090. |
cerebral infarction in the basal ganglia may cause secondary and delayed neuronal degeneration in the substantia nigra (sn). |
2023-10-30 |
2023-11-08 |
Not clear |
| Isaac Colvett, Anah Gilmore, Samuel Guzman, Aurélie Ledreux, Jorge E Quintero, Dhanunjaya Rao Ginjupally, Julie A Gurwell, John T Slevin, Zain Guduru, Greg A Gerhardt, Craig G van Horne, Ann-Charlotte Granhol. Recipient Reaction and Composition of Autologous Sural Nerve Tissue Grafts into the Human Brain. Journal of clinical medicine. vol 12. issue 19. 2023-10-14. PMID:37834764. |
we present data from four participants who received autologous transplantation of small pieces of sural nerve tissue into either the basal forebrain containing the nucleus basalis of meynert (nbm) or the midbrain substantia nigra (sn). |
2023-10-14 |
2023-10-15 |
human |
| Heba M Mansour, Ahmed F Mohamed, Mahmoud M Khattab, Aiman S El-Khati. Pazopanib ameliorates rotenone-induced Parkinsonism in rats by suppressing multiple regulated cell death mechanisms. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2023-10-11. PMID:37820786. |
parkinson's disease (pd) is characterized by motor impairments and progressive dopaminergic neuronal death in the substantia nigra (sn). |
2023-10-11 |
2023-10-15 |
rat |
| Min Wang, Taole Li, Rong Gao, Yu Zhang, Yanqing Ha. Identifying the potential genes in alpha synuclein driving ferroptosis of Parkinson's disease. Scientific reports. vol 13. issue 1. 2023-10-06. PMID:37803093. |
parkinson's disease (pd) is a common neurodegenerative disease with aggregation of α-synuclein (α-syn) in substantia nigra (sn). |
2023-10-06 |
2023-10-15 |
Not clear |
| Jie Zhang, Jia Li, Cheng-Xi Liu, Huan Gui, Cheng-Dong Yuan, Yi Zhan. The role of intracerebral dopamine D1 and D2 receptors in sleep-wake cycles and general anesthesia. Ibrain. vol 8. issue 1. 2023-10-03. PMID:37786416. |
dopamine (da), a monoamine neurotransmitter, is synthesized and released mainly by neurons in the ventral tegmental area and the substantia nigra (sn) pars compacta of the midbrain. |
2023-10-03 |
2023-10-07 |
Not clear |
| Nina I Uspalenko, Alexei A Mosentsov, Natalia V Khmil, Lyubov L Pavlik, Natalia V Belosludtseva, Natalia V Khunderyakova, Maria I Shigaeva, Vasilisa P Medvedeva, Anton E Malkov, Valentina F Kitchigina, Galina D Mironov. Uridine as a Regulator of Functional and Ultrastructural Changes in the Brain of Rats in a Model of 6-OHDA-Induced Parkinson's Disease. International journal of molecular sciences. vol 24. issue 18. 2023-09-28. PMID:37762607. |
using a model of parkinson's disease (pd) induced by the bilateral injection of neurotoxin 6-hydroxydopamine (6-ohda) into rat brain substantia nigra (sn), we showed uridine to exert a protective effect associated with activation of the mitochondrial atp-dependent potassium (mitok-atp) channel. |
2023-09-28 |
2023-10-07 |
rat |
| Xv-Shen Ding, Li Gao, Zheng Han, Simona Eleuteri, Wei Shi, Yun Shen, Zi-Yao Song, Mingming Su, Qian Yang, Yan Qu, David K Simon, Xue-Lian Wang, Bao Wan. Ferroptosis in Parkinson's Disease: Molecular Mechanisms and Therapeutic Potential. Ageing research reviews. 2023-09-24. PMID:37742785. |
parkinson's disease (pd) is characterized by the progressive loss of dopaminergic neurons in the substantia nigra (sn), leading to motor and non-motor symptoms. |
2023-09-24 |
2023-10-07 |
Not clear |
| Amin A Hafi. The neuroprotective effect of vitamin D in Parkinson's disease: association or causation. Nutritional neuroscience. 2023-09-21. PMID:37731327. |
parkinson's disease (pd) is a chronic neurodegenerative disease (ndd) due to the degeneration of dopaminergic neurons (dns) in the substantia nigra (sn). |
2023-09-21 |
2023-10-07 |
Not clear |
| Shanshan Hu, Xiaorong Huang, Jian Huang, Ying Qian, Yingbiao Tian, Ye Xiao, Xiaolan Qi, Xiaoxian Zhou, Zhusheng Yang, Zehui Che. Iron chelation prevents nigrostriatal neurodegeneration in a chronic methamphetamine mice model. Neurotoxicology. 2023-09-17. PMID:37717738. |
importantly, we demonstrated that meth increased iron deposition in the nigrostriatal system, including the substantia nigra (sn) and caudate putamen (cpu). |
2023-09-17 |
2023-10-07 |
mouse |
| Lei Liu, Yange Cui, Yan-Zhong Chang, Peng Y. Ferroptosis-related factors in the substantia nigra are associated with Parkinson's disease. Scientific reports. vol 13. issue 1. 2023-09-16. PMID:37717088. |
despite this superficial connection, the possible role(s) of ferroptosis-related (fr) proteins in dopaminergic neurons and/or glial cells in the substantia nigra (sn) in pd have not been examined in depth. |
2023-09-16 |
2023-10-07 |
human |
| Hong Cheng, Jingyu Wang, Yahui Zhang, Yingle Tang, Lin Zhu, Yan Tao, Wen Lu, Haifan Yang, Weiyi Zhu, Xin Tang, Xinran Qia. The mechanism of LZ-8-mediated immune response in the mouse model of Parkinson's disease. Journal of neuroimmunology. vol 383. 2023-09-11. PMID:37696167. |
parkinson's disease (pd) is associated with microscopic changes in the brain, particularly substantia nigra (sn). |
2023-09-11 |
2023-10-07 |
mouse |
| Kenji Ishibashi, Masanori Kurihara, Ryoko Ihara, Mana Higashihara, Atsushi Iwata, Kenji Ishi. Detailed Assessment of 18F-THK5351 Distribution Pattern in the Midbrain: Comparison With Progressive Supranuclear Palsy and Corticobasal Syndrome. Clinical nuclear medicine. vol 48. issue 10. 2023-09-08. PMID:37682599. |
18f-thk5351 preferentially accumulates around the substantia nigra (sn) and periaqueductal gray (pg) in the midbrain under healthy conditions and exhibits a "trimodal pattern." |
2023-09-08 |
2023-10-07 |
Not clear |