All Relations between sn and Substantia nigra

Publication Sentence Publish Date Extraction Date Species
Megan E Straley, Wesley Van Oeffelen, Sarah Theze, Aideen M Sullivan, Siobhain M O'Mahony, John F Cryan, Gerard W O'Keeff. Distinct alterations in motor & reward seeking behavior are dependent on the gestational age of exposure to LPS-induced maternal immune activation. Brain, behavior, and immunity. vol 63. 2018-01-30. PMID:27266391. mesodiencephalic dopaminergic neurons in the ventral tegmental area (vta) regulate motivation and reward, whereas those in the substantia nigra (sn) are essential for motor control. 2018-01-30 2023-08-13 rat
M Barro. The ventral tegmentum and dopamine: A new wave of diversity. Neuroscience. vol 282. 2018-01-26. PMID:25453764. projection systems arising from the ventral tegmental area (vta) and the substantia nigra (sn) have a critical role in a broad range of functions, as well as in the etiology, symptoms and treatment of neurological and psychiatric diseases. 2018-01-26 2023-08-13 human
Yannick Vermeiren, Peter P De Dey. Targeting the norepinephrinergic system in Parkinson's disease and related disorders: The locus coeruleus story. Neurochemistry international. vol 102. 2018-01-25. PMID:27899296. for almost half a century, the motor aspects have been attributed to lewy pathology (lp) predominantly in the substantia nigra (sn), causing a major loss of dopaminergic neurons. 2018-01-25 2023-08-13 Not clear
Daniela Frosini, Roberto Ceravolo, Michela Tosetti, Ubaldo Bonuccelli, Mirco Cosottin. Nigral involvement in atypical parkinsonisms: evidence from a pilot study with ultra-high field MRI. Journal of neural transmission (Vienna, Austria : 1996). vol 123. issue 5. 2018-01-23. PMID:26943945. ten healthy subjects (hs) and 15 patients with atypical parkinsonisms underwent 7-t susceptibility-weighted-imaging mr to evaluate substantia nigra (sn). 2018-01-23 2023-08-13 human
S K Tahajjul Taufique, Vinod Kuma. Differential activation and tyrosine hydroxylase distribution in the hippocampal, pallial and midbrain brain regions in response to cognitive performance in Indian house crows exposed to abrupt light environment. Behavioural brain research. vol 314. 2018-01-18. PMID:27478138. further, under ll, th- immunoreactive neurons were reduced in number in midbrain dopamine synthesis sites, the venteral tegmental area (vta) and substantia nigra (sn), with a negative correlation of co-localized zenk/th- immunoreactive cells on errors during the association tasks. 2018-01-18 2023-08-13 Not clear
Jason Langley, Daniel E Huddleston, Michael Merritt, Xiangchuan Chen, Rebecca McMurray, Michael Silver, Stewart A Factor, Xiaoping H. Diffusion tensor imaging of the substantia nigra in Parkinson's disease revisited. Human brain mapping. vol 37. issue 7. 2018-01-16. PMID:27029026. to analyze diffusion tensor imaging (dti) data in the substantia nigra (sn) using a more consistent region of interest (roi) defined by neuromelanin-sensitive mri in order to assess parkinson's disease (pd) related changes in diffusion characteristics in the sn. 2018-01-16 2023-08-13 Not clear
Ting Xu, Junjun Zhou, Jie Zhu, Shuai Zhang, Ning Zhang, Yan Zhao, Chunchun Ding, Xue Shi, Jihong Ya. Carnosic acid protects non-alcoholic fatty liver-induced dopaminergic neuron injury in rats. Metabolic brain disease. vol 32. issue 2. 2018-01-12. PMID:27957651. furthermore, ca treated-animals displayed an increase in the contents of dopamine (da) and its metabolites 3,4-dihydroxyphenylacelic acid (dopac) and elevated the expressions of tyrosine hydroxylase (th)-positive neurons in the substantia nigra (sn) as well as the th protein in the striatum. 2018-01-12 2023-08-13 rat
Hannah Jang, Sehwan Kim, Jae Man Lee, Yong-Seok Oh, Sang Myun Park, Sang Ryong Ki. Montelukast treatment protects nigral dopaminergic neurons against microglial activation in the 6-hydroxydopamine mouse model of Parkinson's disease. Neuroreport. vol 28. issue 5. 2018-01-12. PMID:28178069. in the present study, our results showed that treatment with montelukast could protect da neurons against 6-hydroxydopamine (6-ohda)-induced neurotoxicity and its administration significantly attenuated the production of neurotoxic cytokines such as tumor necrosis factor-α (tnfα) and interleukin-1β (il-1β) from activated microglia in the substantia nigra (sn) and striatum following 6-ohda treatment. 2018-01-12 2023-08-13 mouse
S Favaretto, U Walter, C Baracchini, S Pompanin, C Bussè, G Zorzi, M Ermani, A Cagni. Accuracy of transcranial brain parenchyma sonography in the diagnosis of dementia with Lewy bodies. European journal of neurology. vol 23. issue 8. 2018-01-09. PMID:27132982. transcranial sonography (tcs) of the brain parenchyma is used to visualize alterations in the substantia nigra (sn) and it is applied for early diagnosis of parkinson's disease. 2018-01-09 2023-08-13 Not clear
Joanna Kalaani, Joëlle Roche, Eva Hamade, Bassam Badran, Mohamed Jaber, Afsaneh Gaillard, Laetitia Presto. Axon guidance molecule expression after cell therapy in a mouse model of Parkinson's disease. Restorative neurology and neuroscience. vol 34. issue 6. 2018-01-09. PMID:27858721. others and we have previously shown that transplantation of ventral mesencephalic fetal cells into substantia nigra (sn) in an animal model of pd enables anatomical and functional repair of the degenerated pathway. 2018-01-09 2023-08-13 mouse
Peijian Yue, Lin Gao, Xuejing Wang, Xuebing Ding, Junfang Ten. Intranasal Administration of GDNF Protects Against Neural Apoptosis in a Rat Model of Parkinson's Disease Through PI3K/Akt/GSK3β Pathway. Neurochemical research. vol 42. issue 5. 2018-01-09. PMID:28247332. the numbers of th-positive neurons in the 6-ohda-injected lesioned substantia nigra (sn) decreased significantly compared with the sham group. 2018-01-09 2023-08-13 rat
Hwon Heo, Jae-Bum Ahn, Hyeong Hun Lee, Euna Kwon, Jun-Won Yun, Hyeonjin Kim, Byeong-Cheol Kan. Neurometabolic profiles of the substantia nigra and striatum of MPTP-intoxicated common marmosets: An in vivo proton MRS study at 9.4 T. NMR in biomedicine. vol 30. issue 2. 2018-01-08. PMID:28028868. given the strong coupling between the substantia nigra (sn) and striatum (str) in the early stage of parkinson's disease (pd), yet only a few studies reported to date that have simultaneously investigated the neurochemistry of these two brain regions in vivo, we performed longitudinal metabolic profiling in the sn and str of 1-methyl-1,2,3,6-tetrahydropyridine (mptp)-intoxicated common marmoset monkey models of pd (n = 10) by using proton mrs ( 2018-01-08 2023-08-13 monkey
Rajib Paul, Banashree Chetia Phukan, Arokiasamy Justin Thenmozhi, Thamilarasan Manivasagam, Pallab Bhattacharya, Anupom Bora. Melatonin protects against behavioral deficits, dopamine loss and oxidative stress in homocysteine model of Parkinson's disease. Life sciences. vol 192. 2018-01-08. PMID:29138117. our previous study established the involvement of oxidative stress in the substantia nigra (sn) of hcy rat model of pd; however, the role of antioxidants, such as melatonin, was not tested in this model. 2018-01-08 2023-08-13 rat
Sean L Hammond, Ashley N Leek, Evan H Richman, Ronald B Tjalken. Cellular selectivity of AAV serotypes for gene delivery in neurons and astrocytes by neonatal intracerebroventricular injection. PloS one. vol 12. issue 12. 2018-01-08. PMID:29244806. brains were then systematically analyzed for gfp expression at 3 or 6 weeks post-infection in various regions, including the olfactory bulb, striatum, cortex, hippocampus, substantia nigra (sn) and cerebellum. 2018-01-08 2023-08-13 mouse
Kirsten E Schoonover, Lesley A McCollum, Rosalinda C Robert. Protein Markers of Neurotransmitter Synthesis and Release in Postmortem Schizophrenia Substantia Nigra. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 42. issue 2. 2018-01-05. PMID:27550734. the substantia nigra (sn) provides the largest dopaminergic input to the brain, projects to the striatum (the primary locus of action for antipsychotic medication), and receives gabaergic and glutamatergic inputs. 2018-01-05 2023-08-13 human
Gian D Pal, Bichun Ouyang, Geidy Serrano, Holly A Shill, Christopher Goetz, Glenn Stebbins, Leo Verhagen Metman, Erika Driver-Dunckley, Shyamal H Mehta, John N Caviness, Marwan N Sabbagh, Charles H Adler, Thomas G Beac. Comparison of neuropathology in Parkinson's disease subjects with and without deep brain stimulation. Movement disorders : official journal of the Movement Disorder Society. vol 32. issue 2. 2017-12-29. PMID:27911008. the aim of this postmortem study was to compare, in parkinson's disease subjects with and without bilateral subthalamic nucleus deep brain stimulation (stn-dbs), the loss of pigmented neurons within the substantia nigra and pathological alpha-synuclein density within the sn and other brain regions. 2017-12-29 2023-08-13 human
Maikel Kronbauer, Vinicia Garzela Metz, Karine Roversi, Veronica Tironi Dias, Caren Tatiane de David Antoniazzi, Raquel Cristine da Silva Barcelos, Marilise E Burge. Influence of magnesium supplementation on movement side effects related to typical antipsychotic treatment in rats. Behavioural brain research. vol 320. 2017-12-27. PMID:27816557. sub-chronic haloperidol was related to orofacial dyskinesia (od) and catalepsy development, increased generation of reactive species (rs) and levels of protein carbonyl (pc) in cortex, striatum and substantia nigra (sn) in all experimental protocols. 2017-12-27 2023-08-13 rat
Jennifer C Arnold, Mark A Cantu, Ella A Kasanga, Vicki A Nejtek, Evan V Papa, Nicoleta Bugnariu, Michael F Salvator. Aging-related limit of exercise efficacy on motor decline. PloS one. vol 12. issue 11. 2017-12-26. PMID:29176896. one mechanism of aging-related motor decline may be decreased expression of gdnf family receptor, gfrα-1, which is decreased in substantia nigra (sn) between 12 and 30 months old. 2017-12-26 2023-08-13 rat
Neha Sharma, Bimla Nehr. Apocyanin, a Microglial NADPH Oxidase Inhibitor Prevents Dopaminergic Neuronal Degeneration in Lipopolysaccharide-Induced Parkinson's Disease Model. Molecular neurobiology. vol 53. issue 5. 2017-12-22. PMID:26081143. lps when injected into the substantia nigra (sn) reproduced the characteristic hallmark features of pd in rats. 2017-12-22 2023-08-13 rat
Juliann D Jaumotte, Stephanie L Wyrostek, Michael J Zigmon. Protection of cultured dopamine neurons from MPP(+) requires a combination of neurotrophic factors. The European journal of neuroscience. vol 44. issue 1. 2017-12-22. PMID:27098376. parkinson's disease is a progressive neurodegenerative disorder, caused in part by the loss of dopamine (da) neurons in the substantia nigra (sn). 2017-12-22 2023-08-13 rat