| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Nadya Pyatigorskaya, Rahul Gaurav, Dario Arnaldi, Smaranda Leu-Semenescu, Lydia Yahia-Cherif, Romain Valabregue, Marie Vidailhet, Isabelle Arnulf, Stephane Lehéric. Magnetic Resonance Imaging Biomarkers to Assess Substantia Nigra Damage in Idiopathic Rapid Eye Movement Sleep Behavior Disorder. Sleep. vol 40. issue 11. 2018-03-26. PMID:28958075. |
at pd onset, 40 to 70% of the dopaminergic neurons in the substantia nigra (sn) are already lost. |
2018-03-26 |
2023-08-13 |
human |
| Yukari Suda, Naoko Kuzumaki, Michiko Narita, Yusuke Hamada, Masahiro Shibasaki, Kenichi Tanaka, Hideki Tamura, Takashi Kawamura, Takashige Kondo, Akihiro Yamanaka, Minoru Narit. Effect of ghrelin on the motor deficit caused by the ablation of nigrostriatal dopaminergic cells or the inhibition of striatal dopamine receptors. Biochemical and biophysical research communications. vol 496. issue 4. 2018-03-22. PMID:29378186. |
this receptor has recently been found in the substantia nigra (sn) to control dopamine (da)-related physiological functions. |
2018-03-22 |
2023-08-13 |
Not clear |
| Neha Sharma, Sheetal Sharma, Bimla Nehr. Curcumin protects dopaminergic neurons against inflammation-mediated damage and improves motor dysfunction induced by single intranigral lipopolysaccharide injection. Inflammopharmacology. vol 25. issue 3. 2018-03-08. PMID:28409389. |
altered microglial functions and increased inflammatory profile of the cns have severe behavioral consequences. in the current investigation, a single injection of lps (5 ug/5 µl pbs) was injected into the substantia nigra (sn) of rats, and curcumin [40 mg/kg b.wt (i.p.)] |
2018-03-08 |
2023-08-13 |
rat |
| Jing Zou, Zhaoyu Chen, Xiaobo Wei, Zhigang Chen, Yongmei Fu, Xiaoyan Yang, Dan Chen, Rui Wang, Peter Jenner, Jia-Hong Lu, Min Li, Zhuohua Zhang, Beisha Tang, Kunlin Jin, Qing Wan. Cystatin C as a potential therapeutic mediator against Parkinson's disease via VEGF-induced angiogenesis and enhanced neuronal autophagy in neurovascular units. Cell death & disease. vol 8. issue 6. 2018-03-06. PMID:28569795. |
the injections of cys c were administered to the right substantia nigra (sn) of a53t snca transgenic mice to measure the effects of cys c in transgenic a53t snca mice. |
2018-03-06 |
2023-08-13 |
mouse |
| M Q Xie, Z C Chen, P Zhang, H J Huang, T T Wang, Y-Q Ding, S S Qi, C Zhang, S X Chen, P Zhou, C C Shao, M Liao, C Y Su. Newborn dopaminergic neurons are associated with the migration and differentiation of SVZ-derived neural progenitors in a 6-hydroxydopamin-injected mouse model. Neuroscience. vol 352. 2018-03-05. PMID:28385636. |
previous studies have indicated that there is a low level of neurogenesis in the substantia nigra (sn) of adult mice. |
2018-03-05 |
2023-08-13 |
mouse |
| Qing Gao, Zhou Ou, Teng Jiang, You-Yong Tian, Jun-Shan Zhou, Liang Wu, Jian-Quan Shi, Ying-Dong Zhan. Azilsartan ameliorates apoptosis of dopaminergic neurons and rescues characteristic parkinsonian behaviors in a rat model of Parkinson's disease. Oncotarget. vol 8. issue 15. 2018-03-05. PMID:28445961. |
loss of dopaminergic neurons within the substantia nigra (sn) is a pathological hallmark of parkinson's disease (pd), which leads to the onset of motor symptoms. |
2018-03-05 |
2023-08-13 |
rat |
| Xiaofei Zhao, Jun Wang, Song Hu, Renping Wang, Yongjun Mao, Junxia Xi. Neuroprotective effect of resveratrol on rotenone-treated C57BL/6 mice. Neuroreport. vol 28. issue 9. 2018-03-05. PMID:28471847. |
the aim of the present study was to investigate whether resveratrol could reduce nigral iron levels to prevent the degeneration of dopaminergic neurons in the substantia nigra (sn) of c57bl/6 mice induced by rotenone. |
2018-03-05 |
2023-08-13 |
mouse |
| P Abate, A C Reyes-Guzmán, K Hernández-Fonseca, M Ménde. Prenatal ethanol exposure modifies locomotor activity and induces selective changes in Met-enk expression in adolescent rats. Neuropeptides. vol 62. 2018-03-01. PMID:27889070. |
met-enk content was quantitated by radioimmunoassay in several regions: ventral tegmental area [vta], nucleus accumbens [nacc], prefrontal cortex [pfc], substantia nigra [sn], caudate-putamen [cp], amygdala, hypothalamus and hippocampus. |
2018-03-01 |
2023-08-13 |
rat |
| Lanying Song, Marissa McMackin, Andy Nguyen, Gino Cortopass. Parkin deficiency accelerates consequences of mitochondrial DNA deletions and Parkinsonism. Neurobiology of disease. vol 100. 2018-02-22. PMID:28042097. |
parkinson's disease (pd) is a neurodegenerative condition caused by age-related death of dopaminergic (da) neurons in the substantia nigra (sn). |
2018-02-22 |
2023-08-13 |
mouse |
| Hojin Kang, Areum Jo, Hyein Kim, Rin Khang, Ji-Yeong Lee, Hanna Kim, Chi-Hu Park, Jeong-Yun Choi, Yunjong Lee, Joo-Ho Shi. PARIS reprograms glucose metabolism by HIF-1α induction in dopaminergic neurodegeneration. Biochemical and biophysical research communications. vol 495. issue 4. 2018-02-22. PMID:29287724. |
our previous study found that paris (znf746) transcriptionally suppressed transketolase (tkt), a key enzyme in pentose phosphate pathway (ppp) in the substantia nigra (sn) of aav-paris injected mice. |
2018-02-22 |
2023-08-13 |
mouse |
| Isabel C Duarte, Sónia Afonso, Helena Jorge, Ricardo Cayolla, Carlos Ferreira, Miguel Castelo-Branc. Tribal love: the neural correlates of passionate engagement in football fans. Social cognitive and affective neuroscience. vol 12. issue 5. 2018-02-12. PMID:28338882. |
we found recruitment of amygdala and reward regions, including the ventral tegmental area (vta) and substantia nigra (sn), as well as other limbic regions involved in emotional cognition, for 'positive vs neutral' and 'positive vs negative' conditions. |
2018-02-12 |
2023-08-13 |
human |
| A D Surowka, M Töpperwien, M Bernhardt, J D Nicolas, M Osterhoff, T Salditt, D Adamek, M Szczerbowska-Boruchowsk. Combined in-situ imaging of structural organization and elemental composition of substantia nigra neurons in the elderly. Talanta. vol 161. 2018-02-07. PMID:27769419. |
human dopaminergic system in general, and substantia nigra (sn) neurons, in particular, are implicated in the pathologies underlying the human brain aging. |
2018-02-07 |
2023-08-13 |
human |
| Wenzhong Zhang, Li Zhang, Limin Liu, Xiaomin Wan. Time course study of fractional anisotropy in the substantia nigra of a parkinsonian rat model induced by 6-OHDA. Behavioural brain research. vol 328. 2018-02-07. PMID:28390876. |
this study was thus designed to characterize the detailed time course of fa in the substantia nigra (sn). |
2018-02-07 |
2023-08-13 |
rat |
| Jaspal Patil, Ashok Matte, Hans Nissbrandt, Carina Mallard, Mats Sandber. Sustained Effects of Neonatal Systemic Lipopolysaccharide on IL-1β and Nrf2 in Adult Rat Substantia Nigra Are Partly Normalized by a Spirulina-Enriched Diet. Neuroimmunomodulation. vol 23. issue 4. 2018-02-05. PMID:27931028. |
neonatal infection can sensitize the adult substantia nigra (sn) to secondary insults, causing a decrease in antioxidant capacity which may lead to parkinson's disease in adults. |
2018-02-05 |
2023-08-13 |
rat |
| Megan E Straley, Wesley Van Oeffelen, Sarah Theze, Aideen M Sullivan, Siobhain M O'Mahony, John F Cryan, Gerard W O'Keeff. Distinct alterations in motor & reward seeking behavior are dependent on the gestational age of exposure to LPS-induced maternal immune activation. Brain, behavior, and immunity. vol 63. 2018-01-30. PMID:27266391. |
mesodiencephalic dopaminergic neurons in the ventral tegmental area (vta) regulate motivation and reward, whereas those in the substantia nigra (sn) are essential for motor control. |
2018-01-30 |
2023-08-13 |
rat |
| M Barro. The ventral tegmentum and dopamine: A new wave of diversity. Neuroscience. vol 282. 2018-01-26. PMID:25453764. |
projection systems arising from the ventral tegmental area (vta) and the substantia nigra (sn) have a critical role in a broad range of functions, as well as in the etiology, symptoms and treatment of neurological and psychiatric diseases. |
2018-01-26 |
2023-08-13 |
human |
| Yannick Vermeiren, Peter P De Dey. Targeting the norepinephrinergic system in Parkinson's disease and related disorders: The locus coeruleus story. Neurochemistry international. vol 102. 2018-01-25. PMID:27899296. |
for almost half a century, the motor aspects have been attributed to lewy pathology (lp) predominantly in the substantia nigra (sn), causing a major loss of dopaminergic neurons. |
2018-01-25 |
2023-08-13 |
Not clear |
| Daniela Frosini, Roberto Ceravolo, Michela Tosetti, Ubaldo Bonuccelli, Mirco Cosottin. Nigral involvement in atypical parkinsonisms: evidence from a pilot study with ultra-high field MRI. Journal of neural transmission (Vienna, Austria : 1996). vol 123. issue 5. 2018-01-23. PMID:26943945. |
ten healthy subjects (hs) and 15 patients with atypical parkinsonisms underwent 7-t susceptibility-weighted-imaging mr to evaluate substantia nigra (sn). |
2018-01-23 |
2023-08-13 |
human |
| S K Tahajjul Taufique, Vinod Kuma. Differential activation and tyrosine hydroxylase distribution in the hippocampal, pallial and midbrain brain regions in response to cognitive performance in Indian house crows exposed to abrupt light environment. Behavioural brain research. vol 314. 2018-01-18. PMID:27478138. |
further, under ll, th- immunoreactive neurons were reduced in number in midbrain dopamine synthesis sites, the venteral tegmental area (vta) and substantia nigra (sn), with a negative correlation of co-localized zenk/th- immunoreactive cells on errors during the association tasks. |
2018-01-18 |
2023-08-13 |
Not clear |
| Jason Langley, Daniel E Huddleston, Michael Merritt, Xiangchuan Chen, Rebecca McMurray, Michael Silver, Stewart A Factor, Xiaoping H. Diffusion tensor imaging of the substantia nigra in Parkinson's disease revisited. Human brain mapping. vol 37. issue 7. 2018-01-16. PMID:27029026. |
to analyze diffusion tensor imaging (dti) data in the substantia nigra (sn) using a more consistent region of interest (roi) defined by neuromelanin-sensitive mri in order to assess parkinson's disease (pd) related changes in diffusion characteristics in the sn. |
2018-01-16 |
2023-08-13 |
Not clear |