| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ping-Yue Pan, Xianting Li, Jing Wang, James Powell, Qian Wang, Yuanxi Zhang, Zhaoyu Chen, Bridget Wicinski, Patrick Hof, Timothy A Ryan, Zhenyu Yu. Parkinson's Disease-Associated LRRK2 Hyperactive Kinase Mutant Disrupts Synaptic Vesicle Trafficking in Ventral Midbrain Neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 37. issue 47. 2017-12-04. PMID:29054882. |
parkinson's disease (pd) is characterized pathologically by the selective loss of substantia nigra (sn) dopaminergic (daergic) neurons. |
2017-12-04 |
2023-08-13 |
Not clear |
| Neda Valian, Abolhassan Ahmadiani, Leila Dargah. Escalating Methamphetamine Regimen Induces Compensatory Mechanisms, Mitochondrial Biogenesis, and GDNF Expression, in Substantia Nigra. Journal of cellular biochemistry. vol 118. issue 6. 2017-11-28. PMID:27862224. |
so, we evaluated the effects of repeated escalating ma regimen on transcriptional factors involved in mitochondrial biogenesis and glial-derived neurotrophic factor (gdnf) expression in substantia nigra (sn) and striatum of rat. |
2017-11-28 |
2023-08-13 |
rat |
| Young C Chung, Won-Ho Shin, Jeong Y Baek, Eun J Cho, Hyung H Baik, Sang R Kim, So-Yoon Won, Byung K Ji. CB2 receptor activation prevents glial-derived neurotoxic mediator production, BBB leakage and peripheral immune cell infiltration and rescues dopamine neurons in the MPTP model of Parkinson's disease. Experimental & molecular medicine. vol 48. issue 1. 2017-11-20. PMID:27534533. |
the mechanisms underlying cb2 receptor-mediated neuroprotection of dopamine neurons in the substantia nigra (sn) were evaluated in the mptp mouse model of parkinson's disease (pd) by immunohistochemical staining (tyrosine hydroxylase, macrophage ag complex-1, glial fibrillary acidic protein, myeloperoxidase (mpo), and cd3 and cd68), real-time pcr and a fluorescein isothiocyanate-labeled albumin assay. |
2017-11-20 |
2023-08-13 |
mouse |
| Inga B Fricke, Thomas Viel, Maik M Worlitzer, Franziska M Collmann, Alexis Vrachimis, Andreas Faust, Lydia Wachsmuth, Cornelius Faber, Frédéric Dollé, Michael T Kuhlmann, Klaus Schäfers, Sven Hermann, Jens C Schwamborn, Andreas H Jacob. 6-hydroxydopamine-induced Parkinson's disease-like degeneration generates acute microgliosis and astrogliosis in the nigrostriatal system but no bioluminescence imaging-detectable alteration in adult neurogenesis. The European journal of neuroscience. vol 43. issue 10. 2017-11-16. PMID:26950181. |
parkinson's disease is a slowly progressing neurodegenerative disorder caused by loss of dopaminergic neurons in the substantia nigra (sn), leading to severe impairment in motor and non-motor functions. |
2017-11-16 |
2023-08-13 |
mouse |
| Thomas Walker, Christos Michaelides, Antigoni Ekonomou, Kalotina Geraki, Harold G Parkes, Maria Suessmilch, Amy H Herlihy, William R Crum, Po-Wah S. Dissociation between iron accumulation and ferritin upregulation in the aged substantia nigra: attenuation by dietary restriction. Aging. vol 8. issue 10. 2017-11-16. PMID:27743512. |
iron accumulation was concomitant with increased ferritin immunoreactivity in basal ganglia regions except in the substantia nigra (sn). |
2017-11-16 |
2023-08-13 |
Not clear |
| Dandan Chen, Wenyu Fu, Wenxin Zhuang, Cui Lv, Fengjie Li, Xin Wan. Therapeutic effects of intranigral transplantation of mesenchymal stem cells in rat models of Parkinson's disease. Journal of neuroscience research. vol 95. issue 3. 2017-11-13. PMID:27617772. |
this study tests the therapeutic effect of transplantation of rat bone marrow mesenchymal stem cells (mscs) into the substantia nigra (sn) of the pd rat. |
2017-11-13 |
2023-08-13 |
rat |
| Jolanta Konieczny, Anna Czarnecka, Tomasz Lenda, Kinga Kamińska, Lucyna Antkiewicz-Michalu. The significance of rotational behavior and sensitivity of striatal dopamine receptors in hemiparkinsonian rats: A comparative study of lactacystin and 6-OHDA. Neuroscience. vol 340. 2017-11-07. PMID:27826109. |
a growing body of evidence indicates that impairment of the ubiquitin-proteasome (ups) system in the substantia nigra (sn) plays an important role in the pathogenesis of parkinson's disease (pd). |
2017-11-07 |
2023-08-13 |
rat |
| Kyung Moon Lee, Yujeong Lee, Hye Jeong Chun, Ah Hyun Kim, Ju Yeon Kim, Joo Yeon Lee, Akihito Ishigami, Jaewon Le. Neuroprotective and anti-inflammatory effects of morin in a murine model of Parkinson's disease. Journal of neuroscience research. vol 94. issue 10. 2017-11-03. PMID:27265894. |
parkinson's disease (pd) is one of the most common neurodegenerative disorders and is characterized by loss of dopaminergic neurons in the substantia nigra (sn). |
2017-11-03 |
2023-08-13 |
mouse |
| J Osacka, L Horvathova, Z Majercikova, Alexander Kis. Eff ect of a single asenapine treatment on Fos expression in the brain catecholamine-synthesizing neurons: impact of a chronic mild stress preconditioning. Endocrine regulations. vol 51. issue 2. 2017-11-03. PMID:28609288. |
fos protein expression in catecholamine-synthesizing neurons of the substantia nigra (sn) pars compacta (snc, a8), pars reticulata (snr, a9), and pars lateralis (snl), the ventral tegmental area (vta, a10), the locus coeruleus (lc, a6) and subcoeruleus (slc), the ventrolateral pons (pon-a5), the nucleus of the solitary tract (nts-a2), the area postrema (ap), and the ventrolateral medulla (vlm-a1) was quantitatively evaluated aft er a single administration of asenapine (ase) (designated for schizophrenia treatment) in male wistar rats preconditioned with a chronic unpredictable variable mild stress (cms) for 21 days. |
2017-11-03 |
2023-08-13 |
rat |
| J Gao, X-Y Kang, S Sun, L Li, B-L Zhang, Y-Q Li, D-S Ga. Transcription factor Six2 mediates the protection of GDNF on 6-OHDA lesioned dopaminergic neurons by regulating Smurf1 expression. Cell death & disease. vol 7. 2017-10-31. PMID:27148690. |
glial cell line-derived neurotrophic factor (gdnf) has strong neuroprotective and neurorestorative effects on dopaminergic (da) neurons in the substantia nigra (sn); however, the underlying molecular mechanisms remain to be fully elucidated. |
2017-10-31 |
2023-08-13 |
Not clear |
| Merja H Voutilainen, Francesca De Lorenzo, Polina Stepanova, Susanne Bäck, Li-Ying Yu, Päivi Lindholm, Eeva Pörsti, Mart Saarma, Pekka T Männistö, Raimo K Tuomine. Evidence for an Additive Neurorestorative Effect of Simultaneously Administered CDNF and GDNF in Hemiparkinsonian Rats: Implications for Different Mechanism of Action. eNeuro. vol 4. issue 1. 2017-10-31. PMID:28303260. |
parkinson's disease (pd) is a neurodegenerative disorder associated with a progressive loss of dopaminergic (daergic) neurons of the substantia nigra (sn) and the accumulation of intracellular inclusions containing α-synuclein. |
2017-10-31 |
2023-08-13 |
rat |
| Zhi-Yong Wang, Hui Lian, Li Zhou, Yi-Min Zhang, Qing-Qing Cai, Li-Fei Zheng, Jin-Xia Zh. Altered Expression of D1 and D2 Dopamine Receptors in Vagal Neurons Innervating the Gastric Muscularis Externa in a Parkinson's Disease Rat Model. Journal of Parkinson's disease. vol 6. issue 2. 2017-10-30. PMID:27164043. |
parkinson's disease (pd) is characterized by dopaminergic neuron degeneration in the substantia nigra (sn) accompanied by pathology of the dorsal motor nucleus of the vagus (dmv). |
2017-10-30 |
2023-08-13 |
rat |
| Ting-Ting Huang, Dong-Lin Hao, Bo-Na Wu, Lun-Lin Mao, Jin Zhan. Uric acid demonstrates neuroprotective effect on Parkinson's disease mice through Nrf2-ARE signaling pathway. Biochemical and biophysical research communications. vol 493. issue 4. 2017-10-30. PMID:28986252. |
we showed that uric acid improved behavioral performances and cognition of pd mice, increased th-positive dopaminergic neurons and decreased gfap-positive astrocytes in substantia nigra (sn). |
2017-10-30 |
2023-08-13 |
mouse |
| Chi Wang Ip, Laura-Christin Klaus, Akua A Karikari, Naomi P Visanji, Jonathan M Brotchie, Anthony E Lang, Jens Volkmann, James B Kopric. AAV1/2-induced overexpression of A53T-α-synuclein in the substantia nigra results in degeneration of the nigrostriatal system with Lewy-like pathology and motor impairment: a new mouse model for Parkinson's disease. Acta neuropathologica communications. vol 5. issue 1. 2017-10-25. PMID:28143577. |
aav1/2-driven overexpression of human mutated a53t-α-synuclein in rat and monkey substantia nigra (sn) induces degeneration of nigral dopaminergic neurons and decreases striatal dopamine and tyrosine hydroxylase (th). |
2017-10-25 |
2023-08-13 |
mouse |
| Hyein Kim, Hojin Kang, Yunjong Lee, Chi-Hu Park, Areum Jo, Rin Khang, Joo-Ho Shi. Identification of transketolase as a target of PARIS in substantia nigra. Biochemical and biophysical research communications. vol 493. issue 2. 2017-10-23. PMID:28939041. |
the overexpression of paris selectively leads to the loss of dopaminergic neurons (dn) and mitochondrial abnormalities in the substantia nigra (sn) of parkinson's disease (pd) models. |
2017-10-23 |
2023-08-13 |
mouse |
| Anamitra Ghosh, Monica R Langley, Dilshan S Harischandra, Matthew L Neal, Huajun Jin, Vellareddy Anantharam, Joy Joseph, Timothy Brenza, Balaji Narasimhan, Arthi Kanthasamy, Balaraman Kalyanaraman, Anumantha G Kanthasam. Mitoapocynin Treatment Protects Against Neuroinflammation and Dopaminergic Neurodegeneration in a Preclinical Animal Model of Parkinson's Disease. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology. vol 11. issue 2. 2017-10-18. PMID:26838361. |
mito-apo showed excellent brain bioavailability and also markedly attenuated mptp-induced oxidative markers in the substantia nigra (sn). |
2017-10-18 |
2023-08-13 |
mouse |
| Qiang Guan, Meihua Wang, Hanqing Chen, Liu Yang, Zhiqiang Yan, Xijin Wan. Aging-related 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neurochemial and behavioral deficits and redox dysfunction: improvement by AK-7. Experimental gerontology. vol 82. 2017-10-16. PMID:27235848. |
furthermore, we observed that mptp treatment resulted in significant reduction in gsh content and significant increase in mda content and sirt2 expression in the substantia nigra (sn) of aging mice, while it did not do so in young animals. |
2017-10-16 |
2023-08-13 |
mouse |
| Joanna A Korecka, Elizabeth B Moloney, Ruben Eggers, Barbara Hobo, Sanny Scheffer, Nienke Ras-Verloop, R Jeroen Pasterkamp, Dick F Swaab, August B Smit, Ronald E van Kesteren, Koen Bossers, Joost Verhaage. Repulsive Guidance Molecule a (RGMa) Induces Neuropathological and Behavioral Changes That Closely Resemble Parkinson's Disease. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 37. issue 39. 2017-10-10. PMID:28842419. |
in line with this, rgma induced selective degeneration of dopaminergic neurons in the substantia nigra (sn) and affected the integrity of the nigrostriatal system. |
2017-10-10 |
2023-08-13 |
mouse |
| Shida Zhou, Xinxing Du, Junxia Xie, Jun Wan. Interleukin-6 regulates iron-related proteins through c-Jun N-terminal kinase activation in BV2 microglial cell lines. PloS one. vol 12. issue 7. 2017-10-06. PMID:28672025. |
parkinson's disease (pd) is a common neurodegenerative disorder characterized by the loss of dopaminergic (da) neurons in the substantia nigra (sn) and subsequent da depletion in the striatum. |
2017-10-06 |
2023-08-13 |
Not clear |
| Daniel Tibussek, Christin Rademacher, Julian Caspers, Bernd Turowski, Jörg Schaper, Gerald Antoch, Dirk Kle. Gadolinium Brain Deposition after Macrocyclic Gadolinium Administration: A Pediatric Case-Control Study. Radiology. vol 285. issue 1. 2017-10-05. PMID:28640695. |
si was measured on unenhanced t1-weighted mr images for the following five regions of interest (rois): the dentate nucleus (dn), pons, substantia nigra (sn), pulvinar thalami, and globus pallidus (gp). |
2017-10-05 |
2023-08-13 |
Not clear |