| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ana Tereza Di Lorenzo Alho, Claudia Kimie Suemoto, Lívia Polichiso, Edilaine Tampellini, Kátia Cristina de Oliveira, Mariana Molina, Glaucia Aparecida Bento Santos, Camila Nascimento, Renata Elaine Paraizo Leite, Renata Eloah de Lucena Ferreti-Rebustini, Alexandre Valotta da Silva, Ricardo Nitrini, Carlos Augusto Pasqualucci, Wilson Jacob-Filho, Helmut Heinsen, Lea Tenenholz Grinber. Three-dimensional and stereological characterization of the human substantia nigra during aging. Brain structure & function. vol 221. issue 7. 2017-09-29. PMID:26386691. |
the substantia nigra (sn), the source of major dopaminergic pathways in the brain, is particularly vulnerable to changes in the progression of several age-related neurodegenerative diseases. |
2017-09-29 |
2023-08-13 |
human |
| E V Kryukova, I V Shelukhina, A A Kolacheva, A Kh Alieva, M I Shadrina, P A Slominsky, I E Kasheverov, Y N Utkin, M V Ugrumov, V I Tsetli. [Possible involvement of neuronal nicotinic acetylcholine receptors in compensatory brain mechanisms at early stages of Parkinson's disease]. Biomeditsinskaia khimiia. vol 63. issue 3. 2017-09-12. PMID:28781257. |
quantitative determination of nachr in the striatum and substantia nigra (sn) was performed using the radioactive derivatives of epibatidine, -conotoxin mii, and -bungarotoxin as ligands. |
2017-09-12 |
2023-08-13 |
mouse |
| Stefania Romeo, Flora Vitale, Cristina Viaggi, Stefano di Marco, Gabriella Aloisi, Irene Fasciani, Carla Pardini, Ilaria Pietrantoni, Mattia Di Paolo, Serena Riccitelli, Rita Maccarone, Claudia Mattei, Marta Capannolo, Mario Rossi, Annamaria Capozzo, Giovanni U Corsini, Eugenio Scarnati, Luca Lozzi, Francesca Vaglini, Roberto Maggi. Fluorescent light induces neurodegeneration in the rodent nigrostriatal system but near infrared LED light does not. Brain research. vol 1662. 2017-09-05. PMID:28263713. |
we investigated the effects of continuous artificial light exposure on the mouse substantia nigra (sn). |
2017-09-05 |
2023-08-13 |
mouse |
| Konstantinos Botsakis, Theodora Mourtzi, Vasiliki Panagiotakopoulou, Malamati Vreka, Georgios T Stathopoulos, Iosif Pediaditakis, Ioannis Charalampopoulos, Achilleas Gravanis, Foteini Delis, Katerina Antoniou, Dimitrios Zisimopoulos, Christos D Georgiou, Nikolaos T Panagopoulos, Nikolaos Matsokis, Fevronia Angelato. BNN-20, a synthetic microneurotrophin, strongly protects dopaminergic neurons in the "weaver" mouse, a genetic model of dopamine-denervation, acting through the TrkB neurotrophin receptor. Neuropharmacology. vol 121. 2017-09-05. PMID:28461162. |
using the "weaver" mouse, a genetic model of pd, which exhibits progressive dopaminergic neurodegeneration in the substantia nigra (sn), we have shown that long-term administration (p1-p21) of bnn-20 almost fully protected the dopaminergic neurons and their terminals, via i) a strong anti-apoptotic effect, probably mediated through the tropomyosin receptor kinase b (trkb) neurotrophin receptor's pi3k-akt-nf-κb signaling pathway, ii) by exerting an efficient antioxidant effect, iii) by inducing significant anti-inflammatory activity and iv) by restoring brain-derived neurotrophic factor (bdnf) levels. |
2017-09-05 |
2023-08-13 |
mouse |
| Elisa Mariani, Flavia Frabetti, Andrea Tarozzi, Maria Chiara Pelleri, Fabrizio Pizzetti, Raffaella Casade. Meta-Analysis of Parkinson's Disease Transcriptome Data Using TRAM Software: Whole Substantia Nigra Tissue and Single Dopamine Neuron Differential Gene Expression. PloS one. vol 11. issue 9. 2017-08-25. PMID:27611585. |
in this study we used the software tram (transcriptome mapper) to analyse publicly available microarray data of a total of 151 pd patients and 130 healthy controls substantia nigra (sn) samples, to identify chromosomal segments and gene loci differential expression. |
2017-08-25 |
2023-08-13 |
Not clear |
| Rajib Paul, Amarendranath Choudhury, Sanjeev Kumar, Anirudha Giri, Rajat Sandhir, Anupom Bora. Cholesterol contributes to dopamine-neuronal loss in MPTP mouse model of Parkinson's disease: Involvement of mitochondrial dysfunctions and oxidative stress. PloS one. vol 12. issue 2. 2017-08-25. PMID:28170429. |
altered antioxidant homeostasis and mitochondrial functions are the key mechanisms in loss of dopaminergic neurons in the substantia nigra (sn) region of the midbrain in pd. |
2017-08-25 |
2023-08-13 |
mouse |
| D Luke Fischer, Christopher J Kemp, Allyson Cole-Strauss, Nicole K Polinski, Katrina L Paumier, Jack W Lipton, Kathy Steece-Collier, Timothy J Collier, Daniel J Buhlinger, Caryl E Sortwel. Subthalamic Nucleus Deep Brain Stimulation Employs trkB Signaling for Neuroprotection and Functional Restoration. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 37. issue 28. 2017-08-18. PMID:28607168. |
in preclinical models, stn dbs provides neuroprotection for substantia nigra (sn) dopamine neurons and increases bdnf in the nigrostriatal system and primary motor cortex. |
2017-08-18 |
2023-08-13 |
rat |
| Ajit Ray, Maltesh Kambali, Vijayalakshmi Ravindranat. Thiol Oxidation by Diamide Leads to Dopaminergic Degeneration and Parkinsonism Phenotype in Mice: A Model for Parkinson's Disease. Antioxidants & redox signaling. vol 25. issue 5. 2017-08-10. PMID:27121974. |
a single unilateral administration of the thiol oxidant, diamide (1.45 μmol) into substantia nigra (sn) of mice leads to locomotor deficits and degeneration of dopaminergic (da) neurons in sn pars compacta (snpc). |
2017-08-10 |
2023-08-13 |
mouse |
| Won-Jin Moon, Ju-Yeon Park, Won-Sung Yun, Ji Yeong Jeon, Yeon Sil Moon, Heejin Kim, Ki-Chang Kwak, Jong-Min Lee, Seol-Heui Ha. A Comparison of Substantia Nigra T1 Hyperintensity in Parkinson's Disease Dementia, Alzheimer's Disease and Age-Matched Controls: Volumetric Analysis of Neuromelanin Imaging. Korean journal of radiology. vol 17. issue 5. 2017-08-08. PMID:27587951. |
neuromelanin loss of substantia nigra (sn) can be visualized as a t1 signal reduction on t1-weighted high-resolution imaging. |
2017-08-08 |
2023-08-13 |
Not clear |
| Jiawen Yuan, Jinpeng Ren, Ying Wang, Xiao He, Yuwu Zha. Acteoside Binds to Caspase-3 and Exerts Neuroprotection in the Rotenone Rat Model of Parkinson's Disease. PloS one. vol 11. issue 9. 2017-08-08. PMID:27632381. |
parkinson's disease (pd) is characterized by the progressive degeneration of the dopaminergic neurons in the substantia nigra (sn) region. |
2017-08-08 |
2023-08-13 |
rat |
| Seyedeh Shohreh Ebrahimi, Shahrbanoo Oryan, Esmael Izadpanah, Kambiz Hassanzade. Thymoquinone exerts neuroprotective effect in animal model of Parkinson's disease. Toxicology letters. vol 276. 2017-08-08. PMID:28526446. |
dopamine levels of dopaminergic areas in the substantia nigra (sn) and striatum (st) measured using high-performance liquid chromatography. |
2017-08-08 |
2023-08-13 |
rat |
| Elisabeth G Hain, Charlotte Klein, Tonia Munder, Juergen Braun, Kerstin Riek, Susanne Mueller, Ingolf Sack, Barbara Steine. Dopaminergic Neurodegeneration in the Mouse Is Associated with Decrease of Viscoelasticity of Substantia Nigra Tissue. PloS one. vol 11. issue 8. 2017-07-31. PMID:27526042. |
thus, the objective of this study was to evaluate (1) the validity of mre to detect viscoelastic changes in small and specific brain regions: the substantia nigra (sn), midbrain and hippocampus in a mouse model of pd, and (2) if the induced dopaminergic neurodegeneration and inflammation in the sn is reflected by local changes in viscoelasticity. |
2017-07-31 |
2023-08-13 |
mouse |
| Dandan Luo, Ying Shi, Jun Wang, Qing Lin, Yi Sun, Keqiang Ye, Qiao Yan, Hai Zhan. 7,8-dihydroxyflavone protects 6-OHDA and MPTP induced dopaminergic neurons degeneration through activation of TrkB in rodents. Neuroscience letters. vol 620. 2017-07-24. PMID:27019033. |
the results demonstrated that treatment with 7,8-dhf in drinking water for four weeks (two weeks before 6-ohda+two weeks after 6-ohda lesion) significantly improved dopamine-mediated behaviors in 6-ohda rat model, and prevented the loss of dopaminergic neurons in the substantia nigra (sn). |
2017-07-24 |
2023-08-13 |
mouse |
| Efrat Lasser-Katz, Alon Simchovitz, Wei-Hua Chiu, Wolfgang H Oertel, Ronit Sharon, Hermona Soreq, Jochen Roeper, Joshua A Goldber. Mutant α-Synuclein Overexpression Induces Stressless Pacemaking in Vagal Motoneurons at Risk in Parkinson's Disease. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 37. issue 1. 2017-07-24. PMID:28053029. |
α-synuclein overexpression (asox) drives the formation of toxic aggregates in neurons vulnerable in parkinson's disease (pd), including dopaminergic neurons of the substantia nigra (sn) and cholinergic neurons of the dorsal motor nucleus of the vagus (dmv). |
2017-07-24 |
2023-08-13 |
mouse |
| Kab-Tae Park, Jong Cheol Shon, Ji-Eun Kim, Gyu Hwan Park, Hyun Jin Choi, Kwang-Hyeon Li. Sulfatides Primarily Exist in the Substantia Nigra Region of Mouse Brain Tissue. Lipids. vol 52. issue 2. 2017-07-20. PMID:28078602. |
to this end, substantia nigra (sn), caudate putamen (cpu), hippocampus (hip), hypothalamus (hyp), and cortex (cx) tissues of mice were analyzed using direct infusion nanoelectrospray-ion trap mass spectrometry and multivariate analyses. |
2017-07-20 |
2023-08-13 |
mouse |
| Shih-Ying Wu, Yun-Wen Chen, Sheng-Feng Tsai, Sheng-Nan Wu, Yao-Hsiang Shih, Ya-Fen Jiang-Shieh, Ting-Ting Yang, Yu-Min Ku. Estrogen ameliorates microglial activation by inhibiting the Kir2.1 inward-rectifier K(+) channel. Scientific reports. vol 6. 2017-07-19. PMID:26960267. |
by comparing microglia and dopaminergic (da) neurons in the substantia nigra (sn) of male and female mice of different ages, we found that the degrees of microglial activation and da neuron loss increased with age in both genders, but were more pronounced in males, as were peripheral lipopolysaccharide (lps)-induced microglial activation and da neuron loss. |
2017-07-19 |
2023-08-13 |
mouse |
| Johanna Duda, Christina Pötschke, Birgit Lis. Converging roles of ion channels, calcium, metabolic stress, and activity pattern of Substantia nigra dopaminergic neurons in health and Parkinson's disease. Journal of neurochemistry. vol 139 Suppl 1. 2017-07-14. PMID:26865375. |
dopamine-releasing neurons within the substantia nigra (sn da) are particularly vulnerable to degeneration compared to other dopaminergic neurons. |
2017-07-14 |
2023-08-13 |
Not clear |
| Waqqas M Shams, Christian Sanio, Matthew G Quinlan, Wayne G Brak. 17β-Estradiol infusions into the dorsal striatum rapidly increase dorsal striatal dopamine release in vivo. Neuroscience. vol 330. 2017-07-11. PMID:27256507. |
the present study investigated the in vivo effects of e2 infused into the ds, medial prefrontal cortex (mpfc) or the substantia nigra (sn) on dorsal striatal da release. |
2017-07-11 |
2023-08-13 |
rat |
| Hong Jiang, Jun Wang, Jack Rogers, Junxia Xi. Brain Iron Metabolism Dysfunction in Parkinson's Disease. Molecular neurobiology. vol 54. issue 4. 2017-07-07. PMID:27039308. |
understanding how iron accumulates in the substantia nigra (sn) and why it specifically targets dopaminergic (daergic) neurons is particularly warranted for pd, as this knowledge may provide new therapeutic avenues for a more targeted neurotherapeutic strategy for this disease. |
2017-07-07 |
2023-08-13 |
Not clear |
| Hiroaki Fujita, Keisuke Suzuki, Ayaka Numao, Yuji Watanabe, Tomoyuki Uchiyama, Tomoyuki Miyamoto, Masayuki Miyamoto, Koichi Hirat. Usefulness of Cardiac MIBG Scintigraphy, Olfactory Testing and Substantia Nigra Hyperechogenicity as Additional Diagnostic Markers for Distinguishing between Parkinson's Disease and Atypical Parkinsonian Syndromes. PloS one. vol 11. issue 11. 2017-07-04. PMID:27812167. |
we aimed to evaluate the utility of the combined use of cardiac 123i-metaiodobenzylguanidine (mibg) scintigraphy, olfactory testing, and substantia nigra (sn) hyperechogenicity on transcranial sonography (tcs) in differentiating parkinson's disease (pd) from atypical parkinsonian syndromes (apss), such as multiple system atrophy (msa) and progressive supranuclear palsy (psp). |
2017-07-04 |
2023-08-13 |
Not clear |