| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Byung-Wook Kim, Kyoung Hoon Jeong, Jae-Hong Kim, Myungwon Jin, Jong-Heon Kim, Maan-Gee Lee, Dong-Kug Choi, So-Yoon Won, Catriona McLean, Min-Tae Jeon, Ho-Won Lee, Sang Ryong Kim, Kyoungho Su. Pathogenic Upregulation of Glial Lipocalin-2 in the Parkinsonian Dopaminergic System. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 36. issue 20. 2017-06-26. PMID:27194339. |
here, we report for the first time that lcn2 expression is increased in the substantia nigra (sn) of patients with pd. |
2017-06-26 |
2023-08-13 |
mouse |
| Antje Biesemeier, Oliver Eibl, Santhana Eswara, Jean-Nicolas Audinot, Tom Wirtz, Gianni Pezzoli, Fabio A Zucca, Luigi Zecca, Ulrich Schraermeye. Elemental mapping of Neuromelanin organelles of human Substantia Nigra: correlative ultrastructural and chemical analysis by analytical transmission electron microscopy and nano-secondary ion mass spectrometry. Journal of neurochemistry. vol 138. issue 2. 2017-06-23. PMID:27121280. |
neuromelanin (nm) is a compound which highly accumulates mainly in catecholamine neurons of the substantia nigra (sn), and is contained in organelles (nm-containing organelles) with lipid bodies and proteins. |
2017-06-23 |
2023-08-13 |
human |
| Federica Marcuzzi, Silvia Zucchelli, Maria Bertuzzi, Claudio Santoro, Gianluca Tell, Piero Carninci, Stefano Gustincic. Isoforms of the Erythropoietin receptor in dopaminergic neurons of the Substantia Nigra. Journal of neurochemistry. vol 139. issue 4. 2017-06-15. PMID:27488413. |
in the brain, epor has been shown to protect several neuronal cell types from cell death, including the a9 dopaminergic neurons (da) of the substantia nigra (sn). |
2017-06-15 |
2023-08-13 |
mouse |
| Nivedita Bhattacharjee, Muhammed Khairujjaman Mazumder, Rajib Paul, Amarendranath Choudhury, Sabanum Choudhury, Anupom Bora. L-DOPA treatment in MPTP-mouse model of Parkinson's disease potentiates homocysteine accumulation in substantia nigra. Neuroscience letters. vol 628. 2017-06-13. PMID:27283777. |
in rodent, elevated level of hcy in brain or infusion of the same directly into the substantia nigra (sn) potentiates dopaminergic neurodegeneration. |
2017-06-13 |
2023-08-13 |
mouse |
| Lin-Hao You, Zhen Li, Xiang-Lin Duan, Bao-Lu Zhao, Yan-Zhong Chang, Zhen-Hua Sh. Mitochondrial ferritin suppresses MPTP-induced cell damage by regulating iron metabolism and attenuating oxidative stress. Brain research. vol 1642. 2017-05-22. PMID:27017962. |
here, we found that methyl-4-phenyl-1, 2, 3, 6-tetra-pyridine (mptp) significantly upregulated mtft in the mouse hippocampus, substantia nigra (sn) and striatum. |
2017-05-22 |
2023-08-13 |
mouse |
| Yuta Masaki, Yasuhiko Izumi, Atsuko Matsumura, Akinori Akaike, Toshiaki Kum. Protective effect of Nrf2-ARE activator isolated from green perilla leaves on dopaminergic neuronal loss in a Parkinson's disease model. European journal of pharmacology. vol 798. 2017-05-15. PMID:28167258. |
parkinson's disease (pd) is a neurodegenerative disorder characterized by a selective loss of dopaminergic neurons in the substantia nigra (sn), and oxidative stress is thought to contribute to the pathogenesis. |
2017-05-15 |
2023-08-13 |
mouse |
| Chuang Guo, Li-Juan Hao, Zhao-Hui Yang, Rui Chai, Shuai Zhang, Yu Gu, Hui-Ling Gao, Man-Li Zhong, Tao Wang, Jia-Yi Li, Zhan-You Wan. Deferoxamine-mediated up-regulation of HIF-1α prevents dopaminergic neuronal death via the activation of MAPK family proteins in MPTP-treated mice. Experimental neurology. vol 280. 2017-04-28. PMID:26996132. |
accumulating evidence suggests that an abnormal accumulation of iron in the substantia nigra (sn) is one of the defining characteristics of parkinson's disease (pd). |
2017-04-28 |
2023-08-13 |
mouse |
| Dong-Hee Choi, Ji-Hye Kim, Sung Min Kim, Kyuree Kang, Dong Wook Han, Jongmin Le. Therapeutic Potential of Induced Neural Stem Cells for Parkinson's Disease. International journal of molecular sciences. vol 18. issue 1. 2017-04-28. PMID:28117752. |
parkinson's disease (pd) is a chronic, neurodegenerative disorder that results from the loss of cells in the substantia nigra (sn) which is located in the midbrain. |
2017-04-28 |
2023-08-13 |
mouse |
| Xuan Yan, Dian-Feng Liu, Xiang-Yang Zhang, Dong Liu, Shi-Yao Xu, Guang-Xin Chen, Bing-Xu Huang, Wen-Zhi Ren, Wei Wang, Shou-Peng Fu, Ju-Xiong Li. Vanillin Protects Dopaminergic Neurons against Inflammation-Mediated Cell Death by Inhibiting ERK1/2, P38 and the NF-κB Signaling Pathway. International journal of molecular sciences. vol 18. issue 2. 2017-04-20. PMID:28208679. |
in vivo, we firstly established rat models of pd by unilateral injection of lps into substantia nigra (sn), and then examined the role of vanillin in motor dysfunction, microglial activation and degeneration of dopaminergic neurons. |
2017-04-20 |
2023-08-13 |
rat |
| Silvia Paola Caminiti, Luca Presotto, Damiano Baroncini, Valentina Garibotto, Rosa Maria Moresco, Luigi Gianolli, Maria Antonietta Volonté, Angelo Antonini, Daniela Peran. Axonal damage and loss of connectivity in nigrostriatal and mesolimbic dopamine pathways in early Parkinson's disease. NeuroImage. Clinical. vol 14. 2017-04-20. PMID:28409113. |
a progressive loss of dopamine neurons in the substantia nigra (sn) is considered the main feature of idiopathic parkinson's disease (pd). |
2017-04-20 |
2023-08-13 |
Not clear |
| Xiao-Huan Li, Chun-Fang Dai, Long Chen, Wei-Tao Zhou, Hui-Li Han, Zhi-Fang Don. 7,8-dihydroxyflavone Ameliorates Motor Deficits Via Suppressing α-synuclein Expression and Oxidative Stress in the MPTP-induced Mouse Model of Parkinson's Disease. CNS neuroscience & therapeutics. vol 22. issue 7. 2017-04-17. PMID:27079181. |
parkinson disease (pd) is a neurodegenerative disease characterized by the loss of dopaminergic neurons in the substantia nigra (sn) and diminished dopamine content in the striatum, which is at least partly associated with α-synuclein protein overexpression in these neurons. |
2017-04-17 |
2023-08-13 |
mouse |
| Satoshi Okuyama, Tomoki Semba, Nobuki Toyoda, Francesco Epifano, Salvatore Genovese, Serena Fiorito, Vito Alessandro Taddeo, Atsushi Sawamoto, Mitsunari Nakajima, Yoshiko Furukaw. Auraptene and Other Prenyloxyphenylpropanoids Suppress Microglial Activation and Dopaminergic Neuronal Cell Death in a Lipopolysaccharide-Induced Model of Parkinson's Disease. International journal of molecular sciences. vol 17. issue 10. 2017-04-07. PMID:27763495. |
in patients with parkinson's disease (pd), hyperactivated inflammation in the brain, particularly microglial hyperactivation in the substantia nigra (sn), is reported to be one of the triggers for the delayed loss of dopaminergic neurons and sequential motor functional impairments. |
2017-04-07 |
2023-08-13 |
mouse |
| Qiong Zhang, Yong-Fei Zhao, Jian-Ying Xi, Wen-Bo Yu, Bao-Guo Xia. Rho kinase II interference by small hairpin RNA ameliorates 1‑methyl‑4‑phenyl‑1,2,3,6‑tetrahydropyridine‑induced parkinsonism in mice. Molecular medicine reports. vol 14. issue 6. 2017-04-07. PMID:27840922. |
to elucidate the importance of rockii in the pathogenesis of dopaminergic (da) neuron loss and to investigate the efficacy of rock inhibitors in pd, rockii expression in the substantia nigra (sn) of mice was silenced through the injection of a lentivirus‑based small hairpin rna system. |
2017-04-07 |
2023-08-13 |
mouse |
| F Marxreiter, A Storch, J Winkle. [Cellular replacement strategies and adult neurogenesis in idiopathic Parkinson's disease]. Der Nervenarzt. vol 87. issue 8. 2017-03-15. PMID:27389601. |
motor symptoms are associated with a distinct striatal dopaminergic deficit resulting from axonal dysfunction and neuronal loss in the substantia nigra (sn). |
2017-03-15 |
2023-08-13 |
Not clear |
| Can Zhao, Hui Li, Xian-Jing Zhao, Zheng-Xia Liu, Ping Zhou, Ying Liu, Mei-Jiang Fen. Heat shock protein 60 affects behavioral improvement in a rat model of Parkinson's disease grafted with human umbilical cord mesenchymal stem cell-derived dopaminergic-like neurons. Neurochemical research. vol 41. issue 6. 2017-03-06. PMID:26758268. |
parkinson's disease (pd) is a neurodegenerative disorder that is caused by a loss of dopaminergic (daergic) neurons in mesencephalic substantia nigra (sn). |
2017-03-06 |
2023-08-13 |
human |
| Cornelius J H M Klemann, Gerard J M Martens, Geert Poelmans, Jasper E Visse. Validity of the MPTP-Treated Mouse as a Model for Parkinson's Disease. Molecular neurobiology. vol 53. issue 3. 2017-03-01. PMID:25676140. |
parkinson's disease (pd) is characterized by dopaminergic (da) neuron death in the substantia nigra (sn) and subsequent striatal adaptations. |
2017-03-01 |
2023-08-13 |
mouse |
| Yaohui Ni, Hua Huang, Yaqin Chen, Maohong Cao, Hongzhi Zhou, Yuanyuan Zhan. Investigation of Long Non-coding RNA Expression Profiles in the Substantia Nigra of Parkinson's Disease. Cellular and molecular neurobiology. vol 37. issue 2. 2017-02-23. PMID:27151187. |
substantia nigra (sn) is thought to be the most vulnerable area in this process. |
2017-02-23 |
2023-08-13 |
human |
| Se Won Oh, Na-Young Shin, Jae Jung Lee, Seung-Koo Lee, Phil Hyu Lee, Soo Mee Lim, Jin Woo Ki. Correlation of 3D FLAIR and Dopamine Transporter Imaging in Patients With Parkinsonism. AJR. American journal of roentgenology. vol 207. issue 5. 2017-02-20. PMID:27489952. |
the purpose of this study is to evaluate direct in vivo visualization of nigrosome-1 in substantia nigra (sn) with 3d flair imaging and its diagnostic value in predicting the intactness of presynaptic dopaminergic function of the nigrostriatal pathway. |
2017-02-20 |
2023-08-13 |
Not clear |
| Jae Hyeon Park, Youn Sun Park, Hyun Chul Ko. Progressive loss of nigrostriatal dopaminergic neurons induced by inflammatory responses to fipronil. Toxicology letters. vol 258. 2017-02-07. PMID:27313094. |
after stereotaxic injection of fpn in the substantia nigra (sn), the number of tyrosine hydroxylase (th)-positive neurons and the levels of th expression in the sn decreased at 7days, and a significant decrease was observed at 14days with a subsequent reduction in striatal th expression. |
2017-02-07 |
2023-08-13 |
rat |
| Guohua Zhang, Yuhu Zhang, Chengguo Zhang, Yukai Wang, Guixian Ma, Kun Nie, Haiqun Xie, Jianping Liu, Lijuan Wan. Striatal silent lacunar infarction is associated with changes to the substantia nigra in patients with early-stage Parkinson's disease: A diffusion kurtosis imaging study. Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia. vol 33. 2017-02-01. PMID:27499120. |
a recent study has shown that striatal silent infarction may occur secondary to the degeneration of dopaminergic neurons in the substantia nigra (sn) of mice. |
2017-02-01 |
2023-08-13 |
mouse |