| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Shilei Song, Qingmei Nie, Zhifang Li, Gang D. Curcumin improves neurofunctions of 6-OHDA-induced parkinsonian rats. Pathology, research and practice. vol 212. issue 4. 2017-01-27. PMID:26922613. |
however, the potential effect of cm on 6-ohda-injured substantia nigra (sn) needs to be investigated. |
2017-01-27 |
2023-08-13 |
rat |
| E R Mingazov, M V Ugrumo. Gene expression of proteins of the vesicle cycle in dopaminergic neurons in modeling of Parkinson's disease. Doklady. Biochemistry and biophysics. vol 468. issue 1. 2017-01-25. PMID:27417722. |
it was shown that there is a compensatory increase in gene expression of proteins responsible for exocytosis at the preclinical stage of parkinson's disease (pd) in the in substantia nigra (sn) in mice. |
2017-01-25 |
2023-08-13 |
mouse |
| Joana Jesus-Ribeiro, João Sargento-Freitas, Mário Sousa, Fernando Silva, António Freire, Cristina Januári. Substantia nigra hyperechogenicity does not correlate with motor features in Parkinson's disease. Journal of the neurological sciences. vol 364. 2017-01-06. PMID:27084206. |
the evaluation of hyperechogenicity of the substantia nigra (sn) by transcranial sonography (tcs) is validated for the diagnosis of parkinson's disease (pd). |
2017-01-06 |
2023-08-13 |
Not clear |
| Shuei Sugama, Yoshihiko Kakinum. Loss of dopaminergic neurons occurs in the ventral tegmental area and hypothalamus of rats following chronic stress: Possible pathogenetic loci for depression involved in Parkinson's disease. Neuroscience research. vol 111. 2016-12-29. PMID:27142317. |
in our previous study, we demonstrated the first evidence that solely chronic restraint stress (rs) induced the da neuronal loss in the substantia nigra (sn). |
2016-12-29 |
2023-08-13 |
rat |
| Helder Henrique Alves Medeiros, Melquisedec Abiaré Dantas Santana, Mariana Dias Leite, Luisa Alves Pereira Aquino, Marília Abero Sá de Barros, Nayana Tânia Galvão, Fernando Vagner Lobo Ladd, Judney Cley Cavalcante, Miriam Stela Maris Oliveira Costa, Jeferson Souza Cavalcante, Expedito Silva Nasciment. The cytoarchitectonic and TH-immunohistochemical characterization of the dopamine cell groups in the substantia nigra, ventral tegmental area and retrorubral field in a bat (Artibeus planirostris). Neuroscience research. vol 112. 2016-12-28. PMID:27349153. |
the dopamine (da) neurons of the retrorubral field (rrf - a8), the substantia nigra (sn - a9), and the ventral tegmental area (vta - a10) have been implicated in motor regulation, reward, aversion, cognition, and several neuropsychiatric disorders. |
2016-12-28 |
2023-08-13 |
Not clear |
| Jun Wang, Weina Bi, Wei Zhao, Merina Varghese, Rick J Koch, Ruth H Walker, Roshantha A Chandraratna, Martin E Sanders, Amanda Janesick, Bruce Blumberg, Libby Ward, Lap Ho, Giulio M Pasinett. Selective brain penetrable Nurr1 transactivator for treating Parkinson's disease. Oncotarget. vol 7. issue 7. 2016-12-21. PMID:26862735. |
oral administration of irx4204 can activate nuclear receptor nurr1 downstream signaling in the substantia nigra (sn) andattenuate neurochemical and motor deficits in a rat model of pd. |
2016-12-21 |
2023-08-13 |
rat |
| Heung Deok Kim, Kyoung Hoon Jeong, Un Ju Jung, Sang Ryong Ki. Myricitrin Ameliorates 6-Hydroxydopamine-Induced Dopaminergic Neuronal Loss in the Substantia Nigra of Mouse Brain. Journal of medicinal food. vol 19. issue 4. 2016-12-16. PMID:26991235. |
our results found no significant neuroprotective effect of 30 mg/kg myricitrin on 6-hydroxydopamine (6-ohda)-induced neurotoxicity in the substantia nigra (sn) of mice. |
2016-12-16 |
2023-08-13 |
mouse |
| Shuai Zhang, Si-Yuan Shao, Xiu-Yun Song, Cong-Yuan Xia, Ya-Nan Yang, Pei-Cheng Zhang, Nai-Hong Che. Protective effects of Forsythia suspense extract with antioxidant and anti-inflammatory properties in a model of rotenone induced neurotoxicity. Neurotoxicology. vol 52. 2016-12-13. PMID:26408940. |
gavage administration of fs8 (50 and 200mg/kg, but not 10mg/kg) for 25 days significantly improved the behavior function, decreased the loss of dopaminergic neurons in substantia nigra (sn), and maintained the level of dopamine in striatum after unilateral infusion of rotenone in sn. |
2016-12-13 |
2023-08-13 |
Not clear |
| Won-Ho Shin, Min-Tae Jeon, Eunju Leem, So-Yoon Won, Kyoung Hoon Jeong, Sang-Joon Park, Catriona McLean, Sung Joong Lee, Byung Kwan Jin, Un Ju Jung, Sang Ryoung Ki. Induction of microglial toll-like receptor 4 by prothrombin kringle-2: a potential pathogenic mechanism in Parkinson's disease. Scientific reports. vol 5. 2016-12-13. PMID:26440368. |
in the present study, we first observed that the levels of pkr-2 and microglial tlr4 were increased in the substantia nigra (sn) of patients with pd. |
2016-12-13 |
2023-08-13 |
mouse |
| Chenhui Ji, Guo-Fang Xue, Cao Lijun, Peng Feng, Dongfang Li, Lin Li, Guanglai Li, Christian Hölsche. A novel dual GLP-1 and GIP receptor agonist is neuroprotective in the MPTP mouse model of Parkinson's disease by increasing expression of BNDF. Brain research. vol 1634. 2016-12-13. PMID:26453833. |
the number of tyrosine hydroxylase (th) positive neurons in the substantia nigra (sn) was reduced by mptp and increased by da-jc1. |
2016-12-13 |
2023-08-13 |
mouse |
| Jennifer C Arnold, Michael F Salvator. Exercise-Mediated Increase in Nigral Tyrosine Hydroxylase Is Accompanied by Increased Nigral GFR-α1 and EAAC1 Expression in Aging Rats. ACS chemical neuroscience. vol 7. issue 2. 2016-12-13. PMID:26599339. |
in aging, there is loss of tyrosine hydroxylase (th) and the glial cell line-derived neurotrophic factor (gdnf) receptor, gfr-α1, in the substantia nigra (sn). |
2016-12-13 |
2023-08-13 |
rat |
| E Sanzaro, F Iemol. Transcranial sonography in movement disorders: an interesting tool for diagnostic perspectives. Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology. vol 37. issue 3. 2016-12-13. PMID:26650802. |
in most patients with idiopathic parkinson disease, a markedly hyperechogenic substantia nigra (sn) was detected on at least one side. |
2016-12-13 |
2023-08-13 |
human |
| Y Pang, S Lin, C Wright, J Shen, K Carter, A Bhatt, L-W Fa. Intranasal insulin protects against substantia nigra dopaminergic neuronal loss and alleviates motor deficits induced by 6-OHDA in rats. Neuroscience. vol 318. 2016-12-13. PMID:26777890. |
protection of substantia nigra (sn) dopaminergic (da) neurons by neurotrophic factors (ntfs) is one of the promising strategies in parkinson's disease (pd) therapy. |
2016-12-13 |
2023-08-13 |
human |
| Hai-Yan Zhou, Qian Sun, Yu-Yan Tan, Yun-Yun Hu, Wei-Wei Zhan, Dun-Hui Li, Ying Wang, Qin Xiao, Jun Liu, Sheng-Di Che. Substantia nigra echogenicity correlated with clinical features of Parkinson's disease. Parkinsonism & related disorders. vol 24. 2016-12-13. PMID:26842545. |
transcranial sonography can display structural alterations in the substantia nigra (sn) of patients with parkinson's disease (pd), and is considered to be a potential useful tool for the diagnosis of pd. |
2016-12-13 |
2023-08-13 |
Not clear |
| K Botsakis, S Theodoritsi, K Grintzalis, F Angelatou, I Antonopoulos, C D Georgiou, M Margarity, N A Matsokis, N T Panagopoulo. 17β-Estradiol/N-acetylcysteine interaction enhances the neuroprotective effect on dopaminergic neurons in the weaver model of dopamine deficiency. Neuroscience. vol 320. 2016-12-13. PMID:26852701. |
in the present study, long-term treatment (from p1 to p21) with 17β-estradiol (17β-estradiol) significantly protected the dopaminergic neurons in the substantia nigra (sn) of weaver mouse by 54%, as was detected by immunohistochemical experiments, using the specific antibody against tyrosine hydroxylase (th). |
2016-12-13 |
2023-08-13 |
mouse |
| T V Tarasova, O A Lytkina, A Yu Roman, S O Bachurin, A A Ustyugo. The role of alpha-synuclein in the development of the dopaminergic neurons in the substantia nigra and ventral tegmental area. Doklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sections. vol 466. 2016-12-13. PMID:27021360. |
the progressive loss of dopaminergic (da) neurons is characteristic of pd and the most severe damage occurs in the substantia nigra (sn). |
2016-12-13 |
2023-08-13 |
Not clear |
| Heung Deok Kim, Kyoung Hoon Jeong, Un Ju Jung, Sang Ryong Ki. Naringin treatment induces neuroprotective effects in a mouse model of Parkinson's disease in vivo, but not enough to restore the lesioned dopaminergic system. The Journal of nutritional biochemistry. vol 28. 2016-11-07. PMID:26878791. |
moreover, similar to the effects in rat brains, this treatment induced the activation of mammalian target of rapamycin complex 1 (mtorc1), which is well known as an important survival factor for da neurons, and inhibited microglial activation in the substantia nigra (sn) of mouse brains treated with 6-ohda. |
2016-11-07 |
2023-08-13 |
mouse |
| Kyoko Takano, Naoko Shiba, Keiko Wakui, Tomomi Yamaguchi, Noriko Aida, Yuji Inaba, Yoshimitsu Fukushima, Tomoki Kosh. Elevation of neuron specific enolase and brain iron deposition on susceptibility-weighted imaging as diagnostic clues for beta-propeller protein-associated neurodegeneration in early childhood: Additional case report and review of the literature. American journal of medical genetics. Part A. vol 170A. issue 2. 2016-10-25. PMID:26481852. |
brain magnetic resonance imaging (mri) shows iron deposition in the bilateral globus pallidus (gp) and substantia nigra (sn). |
2016-10-25 |
2023-08-13 |
Not clear |
| Pingping Song, Shanshan Li, Hao Wu, Ruize Gao, Guanhua Rao, Dongmei Wang, Ziheng Chen, Biao Ma, Hongxia Wang, Nan Sui, Haiteng Deng, Zhuohua Zhang, Tieshan Tang, Zheng Tan, Zehan Han, Tieyuan Lu, Yushan Zhu, Quan Che. Parkin promotes proteasomal degradation of p62: implication of selective vulnerability of neuronal cells in the pathogenesis of Parkinson's disease. Protein & cell. vol 7. issue 2. 2016-10-25. PMID:26746706. |
mutations or inactivation of parkin, an e3 ubiquitin ligase, are associated with familial form or sporadic parkinson's disease (pd), respectively, which manifested with the selective vulnerability of neuronal cells in substantia nigra (sn) and striatum (str) regions. |
2016-10-25 |
2023-08-13 |
mouse |
| Manoj A Upadhya, Gajanan P Shelkar, Nishikant K Subhedar, Dadasaheb M Kokar. CART modulates the effects of levodopa in rat model of Parkinson's disease. Behavioural brain research. vol 301. 2016-10-20. PMID:26771081. |
parkinson's disease (pd) is an age-related disorder characterized by a progressive degeneration of dopaminergic neurons of substantia nigra (sn). |
2016-10-20 |
2023-08-13 |
rat |