| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Qing He, Yan-hua Li, Si-si Guo, Ying Wang, Wei Lin, Qiong Zhang, Jian Wang, Cun-gen Ma, Bao-Guo Xia. Inhibition of Rho-kinase by Fasudil protects dopamine neurons and attenuates inflammatory response in an intranasal lipopolysaccharide-mediated Parkinson's model. The European journal of neuroscience. vol 43. issue 1. 2016-10-17. PMID:26565388. |
microglia activation and inflammatory factors in brain microenvironment are associated with degeneration of neurons in the substantia nigra (sn) of parkinson's disease (pd) patients and various pd models. |
2016-10-17 |
2023-08-13 |
Not clear |
| K Berghauzen-Maciejewska, J Wardas, B Kosmowska, H Domin, M Śmiałowska, U Głowacka, K Ossowsk. Adaptive down-regulation of the serotonin transporter in the 6-hydroxydopamine-induced rat model of preclinical stages of Parkinson's disease and after chronic pramipexole treatment. Neuroscience. vol 314. 2016-10-13. PMID:26628402. |
intrastriatal 6-ohda injections decreased the number of dopaminergic, but not serotonergic neurons in the dr. 6-ohda reduced the dat binding in the cp, and sert binding in the nigrostriatal system (cp, substantia nigra (sn)), limbic system (ventral tegmental area (vta), nucleus accumbens (nac), amygdala, prefrontal cortex (pfcx), habenula, hippocampus) and dr. a significant positive correlation was found between dat and sert binding in the cp. |
2016-10-13 |
2023-08-13 |
rat |
| Weibo Shi, Chunling Ma, Qian Qi, Lizhe Liu, Haitao Bi, Bin Cong, Yingmin L. The effect of different durations of morphine exposure on mesencephalic dopaminergic neurons in morphine dependent rats. Neurotoxicology. vol 51. 2016-10-12. PMID:26386147. |
therefore, this study investigated th changes in dopaminergic neurons of the ventral tegmental area (vta) and substantia nigra (sn), as well as the morphine effects on dopaminergic neurons induced by different durations of morphine dependence. |
2016-10-12 |
2023-08-13 |
rat |
| Sarah J Stednitz, Briana Freshner, Samantha Shelton, Tori Shen, Donovan Black, Ethan Gahta. Selective toxicity of L-DOPA to dopamine transporter-expressing neurons and locomotor behavior in zebrafish larvae. Neurotoxicology and teratology. vol 52. issue Pt A. 2016-10-12. PMID:26546233. |
the primary neuropathology in pd involves the death of dopaminergic cells in the substantia nigra (sn), an anatomical region of the brain implicated in dopamine production and voluntary motor control. |
2016-10-12 |
2023-08-13 |
zebrafish |
| Susanne Pirker, Laura Perju-Dumbrava, Gabor G Kovacs, Tatiana Traub-Weidinger, Walter Pirke. Progressive Dopamine Transporter Binding Loss in Autopsy-Confirmed Corticobasal Degeneration. Journal of Parkinson's disease. vol 5. issue 4. 2016-09-29. PMID:26485425. |
there is neuronal loss in affected cortical regions and in the substantia nigra (sn). |
2016-09-29 |
2023-08-13 |
Not clear |
| S Reimão, S Ferreira, R G Nunes, P Pita Lobo, D Neutel, D Abreu, N Gonçalves, J Campos, J J Ferreir. Magnetic resonance correlation of iron content with neuromelanin in the substantia nigra of early-stage Parkinson's disease. European journal of neurology. vol 23. issue 2. 2016-09-27. PMID:26518135. |
magnetic resonance (mr) studies have demonstrated a significant reduction of neuromelanin in the substantia nigra (sn) of parkinson's disease (pd) patients with high accuracy for differential diagnosis compared to non-pd controls and essential tremor. |
2016-09-27 |
2023-08-13 |
Not clear |
| Paula Trujillo, Alex K Smith, Paul E Summers, Luca M Mainardi, Sergio Cerutti, Seth A Smith, Antonella Cost. High-resolution quantitative imaging of the substantia nigra. Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference. vol 2015. 2016-09-26. PMID:26737519. |
there is a growing interest in identifying neuroimaging-based biomarkers for parkinson's disease (pd), a progressive neurodegenerative disorder in which the major pathologic substrate is the loss of pigmented dopaminergic neurons in the substantia nigra (sn). |
2016-09-26 |
2023-08-13 |
human |
| Neha Sharma, Monika Kapoor, Bimla Nehr. Apocyanin, NADPH oxidase inhibitor prevents lipopolysaccharide induced α-synuclein aggregation and ameliorates motor function deficits in rats: Possible role of biochemical and inflammatory alterations. Behavioural brain research. vol 296. 2016-09-15. PMID:26367469. |
for the establishment of pd model lps (5 μg/5 μl pbs) was injected into the substantia nigra (sn) of rats. |
2016-09-15 |
2023-08-13 |
rat |
| Michaela E Johnson, Yoon Lim, Manjula Senthilkumaran, Xin-Fu Zhou, Larisa Bobrovskay. Investigation of tyrosine hydroxylase and BDNF in a low-dose rotenone model of Parkinson's disease. Journal of chemical neuroanatomy. vol 70. 2016-09-02. PMID:26562783. |
rearing behaviour decreased by week 3 in the rotenone group (p<0.01), with further decreases in rearing by week 4 (p<0.001); however, th remained unchanged in the substantia nigra (sn) and striatum; th levels were also unaltered in other catecholaminergic cell groups of the brainstem such as a1c1 neurons or locus coeruleus. |
2016-09-02 |
2023-08-13 |
rat |
| Shuke Nie, Yan Xu, Guiqin Chen, Kai Ma, Chao Han, Zhenli Guo, Zhentao Zhang, Keqiang Ye, Xuebing Ca. Small molecule TrkB agonist deoxygedunin protects nigrostriatal dopaminergic neurons from 6-OHDA and MPTP induced neurotoxicity in rodents. Neuropharmacology. vol 99. 2016-08-30. PMID:26282118. |
dopaminergic neurons loss in the substantia nigra (sn) and dopamine (da) content loss in the striatum correlate well with disease severity in parkinson's disease (pd). |
2016-08-30 |
2023-08-13 |
mouse |
| Eunju Leem, Kyoung Hoon Jeong, So-Yoon Won, Won-Ho Shin, Sang Ryong Ki. Prothrombin Kringle-2: A Potential Inflammatory Pathogen in the Parkinsonian Dopaminergic System. Experimental neurobiology. vol 25. issue 4. 2016-08-30. PMID:27574481. |
moreover, inhibition of microglial activation following minocycline treatment, which has anti-inflammatory activity, protects da neurons from pkr-2-induced neurotoxicity in the substantia nigra (sn) in vivo. |
2016-08-30 |
2023-08-13 |
mouse |
| Patricia Tagliaferro, Tatyana Kareva, Tinmarla F Oo, Olga Yarygina, Nikolai Kholodilov, Robert E Burk. An early axonopathy in a hLRRK2(R1441G) transgenic model of Parkinson disease. Neurobiology of disease. vol 82. 2016-08-24. PMID:26192625. |
we have shown that as human bac transgenic hlrrk2(r1441g) mice age, they exhibit two abnormalities in the nigrostriatal dopaminergic system: an axonopathy and a diminished number of dendrites in the substantia nigra (sn). |
2016-08-24 |
2023-08-13 |
mouse |
| Maj Schneider Thomsen, Michelle Vandborg Andersen, Pia Rægaard Christoffersen, Malene Duedal Jensen, Jacek Lichota, Torben Moo. Neurodegeneration with inflammation is accompanied by accumulation of iron and ferritin in microglia and neurons. Neurobiology of disease. vol 81. 2016-08-22. PMID:25801802. |
chronic inflammation in the substantia nigra (sn) accompanies conditions with progressive neurodegeneration. |
2016-08-22 |
2023-08-13 |
rat |
| Christina Poetschke, Elena Dragicevic, Johanna Duda, Julia Benkert, Antonios Dougalis, Roberta DeZio, Terrance P Snutch, Joerg Striessnig, Birgit Lis. Compensatory T-type Ca2+ channel activity alters D2-autoreceptor responses of Substantia nigra dopamine neurons from Cav1.3 L-type Ca2+ channel KO mice. Scientific reports. vol 5. 2016-08-19. PMID:26381090. |
the preferential degeneration of substantia nigra dopamine midbrain neurons (sn da) causes the motor-symptoms of parkinson's disease (pd). |
2016-08-19 |
2023-08-13 |
mouse |
| Ning Yao, Yanhong Wu, Yan Zhou, Lili Ju, Yujun Liu, Rongkai Ju, Deyi Duan, Qunyuan X. Lesion of the locus coeruleus aggravates dopaminergic neuron degeneration by modulating microglial function in mouse models of Parkinson׳s disease. Brain research. vol 1625. 2016-08-15. PMID:26342895. |
the degeneration of noradrenergic neurons in the locus coeruleus (lc) commonly occurs in patients with parkinson's disease (pd), which is characterized by a selective injury of dopaminergic neurons in the substantia nigra (sn). |
2016-08-15 |
2023-08-13 |
mouse |
| Sarah Y Branch, Cang Chen, Ramaswamy Sharma, James D Lechleiter, Senlin Li, Michael J Beckstea. Dopaminergic Neurons Exhibit an Age-Dependent Decline in Electrophysiological Parameters in the MitoPark Mouse Model of Parkinson's Disease. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 36. issue 14. 2016-08-15. PMID:27053209. |
dopaminergic neurons of the substantia nigra (sn) play a vital role in everyday tasks, such as reward-related behavior and voluntary movement, and excessive loss of these neurons is a primary hallmark of parkinson's disease (pd). |
2016-08-15 |
2023-08-13 |
mouse |
| Naying He, Huawei Ling, Bei Ding, Juan Huang, Yong Zhang, Zhongping Zhang, Chunlei Liu, Kemin Chen, Fuhua Ya. Region-specific disturbed iron distribution in early idiopathic Parkinson's disease measured by quantitative susceptibility mapping. Human brain mapping. vol 36. issue 11. 2016-08-09. PMID:26249218. |
the inter-group differences of susceptibility and r2* value in deep grey matter nuclei, namely head of caudate nucleus (cn), putamen (put), global pallidus (gp), substantia nigra (sn), and red nucleus (rn), and the correlations between regional iron deposition and the clinical features were explored in forty-four early pd patients and 35 gender and age-matched healthy controls. |
2016-08-09 |
2023-08-13 |
Not clear |
| Jun-Jun Zhou, Shen-Yu Zhai, Hui-Nan Zhang, Yue-Hua Wang, Xiao-Ping P. Neuroprotective effects of 3-O-demethylswertipunicoside against MPTP-induced Parkinson's disease in vivo and its antioxidant properties in vitro. Brain research. vol 1624. 2016-08-04. PMID:26210618. |
in the 1-methyl-4-phenyl-1,2,3,6- tetrahydropyridine (mptp)-treated mouse model of parkinson's disease (pd), 3-ods dose-dependently improved motor coordination (as shown by rotarod test), increased the contents of dopamine (da) and its metabolites in the striatum, and increased the number of tyrosine hydroxylase (th)-positive neurons in the substantia nigra (sn). |
2016-08-04 |
2023-08-13 |
mouse |
| Hao Li, Xiaoguang Lei, Ting Yan, Hongwei Li, Baihui Huang, Ling Li, Liqi Xu, Li Liu, Nanhui Chen, Longbao Lü, Yuanye Ma, Lin Xu, Jiali Li, Zhengbo Wang, Baorong Zhang, Xintian H. The temporary and accumulated effects of transcranial direct current stimulation for the treatment of advanced Parkinson's disease monkeys. Scientific reports. vol 5. 2016-08-03. PMID:26220760. |
in addition, c-fos staining showed tdcs treatment effects activated the neurons both in m1 and substantia nigra (sn). |
2016-08-03 |
2023-08-13 |
monkey |
| Hiroshi Kawaguchi, Hitoshi Shimada, Fumitoshi Kodaka, Masayuki Suzuki, Hitoshi Shinotoh, Shigeki Hirano, Jeff Kershaw, Yuichi Inoue, Masaki Nakamura, Taeko Sasai, Mina Kobayashi, Tetsuya Suhara, Hiroshi It. Principal Component Analysis of Multimodal Neuromelanin MRI and Dopamine Transporter PET Data Provides a Specific Metric for the Nigral Dopaminergic Neuronal Density. PloS one. vol 11. issue 3. 2016-08-03. PMID:26954690. |
the loss of dopaminergic (da) neurons in the substantia nigra (sn) is a major pathophysiological feature of patients with parkinson's disease (pd). |
2016-08-03 |
2023-08-13 |
human |