| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jui-Chih Chang, Shey-Lin Wu, Ko-Hung Liu, Ya-Hui Chen, Chieh-Sen Chuang, Fu-Chou Cheng, Hong-Lin Su, Yau-Huei Wei, Shou-Jen Kuo, Chin-San Li. Allogeneic/xenogeneic transplantation of peptide-labeled mitochondria in Parkinson's disease: restoration of mitochondria functions and attenuation of 6-hydroxydopamine-induced neurotoxicity. Translational research : the journal of laboratory and clinical medicine. vol 170. 2016-08-02. PMID:26730494. |
we injected mitochondria into the medial forebrain bundle (mfb) of the pd rats after subjecting the nigrostriatal pathway to a unilateral 6-ohda lesion for 21 days, and we verified the effectiveness of the mitochondrial graft in enhancing mitochondrial function in the soma of the substantia nigra (sn) neuron through mitochondrial transport dynamics in the nigrostriatal circuit. |
2016-08-02 |
2023-08-13 |
rat |
| Joaquín Fernández-Irigoyen, María Victoria Zelaya, Estela Perez-Valderrama, Enrique Santamarí. New insights into the human brain proteome: Protein expression profiling of deep brain stimulation target areas. Journal of proteomics. vol 127. issue Pt B. 2016-08-01. PMID:25845585. |
the nucleus basalis of meynert (nbm) and substantia nigra (sn) are considered target areas to apply dbs. |
2016-08-01 |
2023-08-13 |
human |
| Simon Schafferer, Rimpi Khurana, Violetta Refolo, Serena Venezia, Edith Sturm, Paolo Piatti, Clara Hechenberger, Hubert Hackl, Roman Kessler, Michaela Willi, Ronald Gstir, Anne Krogsdam, Alexandra Lusser, Werner Poewe, Gregor K Wenning, Alexander Hüttenhofer, Nadia Stefanov. Changes in the miRNA-mRNA Regulatory Network Precede Motor Symptoms in a Mouse Model of Multiple System Atrophy: Clinical Implications. PloS one. vol 11. issue 3. 2016-08-01. PMID:26962858. |
we investigated the expression patterns of mirnas and their mrna targets in substantia nigra (sn) and striatum, two brain regions that undergo neurodegeneration at a later stage in the msa model, by microarray and rna-seq analysis, respectively. |
2016-08-01 |
2023-08-13 |
mouse |
| Udaiyappan Janakiraman, Thamilarasan Manivasagam, Arokiasamy Justin Thenmozhi, Musthafa Mohamed Essa, Rajamani Barathidasan, Chidambaram SaravanaBabu, Gilles J Guillemin, Mohammed A S Kha. Influences of Chronic Mild Stress Exposure on Motor, Non-Motor Impairments and Neurochemical Variables in Specific Brain Areas of MPTP/Probenecid Induced Neurotoxicity in Mice. PloS one. vol 11. issue 1. 2016-07-26. PMID:26765842. |
injections (once in 3.5 days for 5 weeks) of mptp/p or exposure to cms for 4 weeks, the behavioural (motor and non-motor) impairments, levels and expressions of dopamine (da), serotonin (5-ht), daergic markers such as tyrosine hydroxylase (th), dopamine transporter (dat), vesicular monoamine transporters-2 (vmat 2) and α-synuclein in nigrostriatal (striatum (st) and substantia nigra (sn)) and extra-nigrostriatal (hippocampus, cortex and cerebellum) tissues were analysed. |
2016-07-26 |
2023-08-13 |
mouse |
| Ninni Persson, Jianlin Wu, Qing Zhang, Ting Liu, Jing Shen, Ruyi Bao, Mingfei Ni, Tian Liu, Yi Wang, Pascal Spincemaill. Age and sex related differences in subcortical brain iron concentrations among healthy adults. NeuroImage. vol 122. 2016-07-21. PMID:26216277. |
in 183 healthy volunteers (44.7 ± 14.2 years, range 20-69, ♀ 49%), in vivo quantitative susceptibility mapping (qsm) at 1.5t was performed to estimate brain iron accumulation in the following regions of interest (rois): caudate nucleus (cd), putamen (pt), globus pallidus (gp), thalamus (th), pulvinar (pul), red nucleus (rn), substantia nigra (sn) and the cerebellar dentate nuclei (dn). |
2016-07-21 |
2023-08-13 |
human |
| Sofia Reimão, Patrícia Pita Lobo, Dulce Neutel, Leonor Correia Guedes, Miguel Coelho, Mario M Rosa, Joana Ferreira, Daisy Abreu, Nilza Gonçalves, Carlos Morgado, Rita G Nunes, Jorge Campos, Joaquim J Ferreir. Quantitative Analysis Versus Visual Assessment of Neuromelanin MR Imaging for the Diagnosis of Parkinson's disease. Journal of Parkinson's disease. vol 5. issue 3. 2016-07-21. PMID:26406136. |
specific mr sequences have been able to identify the loss of neuromelanin in the substantia nigra (sn) of early stage parkinson's disease (pd) patients. |
2016-07-21 |
2023-08-13 |
Not clear |
| Robert D Abbott, G Webster Ross, Helen Petrovitch, Kamal H Masaki, Lenore J Launer, James S Nelson, Lon R White, Caroline M Tanne. Midlife milk consumption and substantia nigra neuron density at death. Neurology. vol 86. issue 6. 2016-07-20. PMID:26658906. |
to examine the relationship between midlife milk intake and parkinson disease (pd) incidence through associations with substantia nigra (sn) neuron density and organochlorine pesticide exposure in decedent brains from the honolulu-asia aging study. |
2016-07-20 |
2023-08-13 |
Not clear |
| Anne Grünewald, Karolina A Rygiel, Philippa D Hepplewhite, Christopher M Morris, Martin Picard, Doug M Turnbul. Mitochondrial DNA Depletion in Respiratory Chain-Deficient Parkinson Disease Neurons. Annals of neurology. vol 79. issue 3. 2016-07-19. PMID:26605748. |
to determine the extent of respiratory chain abnormalities and investigate the contribution of mtdna to the loss of respiratory chain complexes (ci-iv) in the substantia nigra (sn) of idiopathic parkinson disease (ipd) patients at the single-neuron level. |
2016-07-19 |
2023-08-13 |
Not clear |
| Jacqueline A Bayliss, Moyra B Lemus, Romana Stark, Vanessa V Santos, Aiysha Thompson, Daniel J Rees, Sandra Galic, John D Elsworth, Bruce E Kemp, Jeffrey S Davies, Zane B Andrew. Ghrelin-AMPK Signaling Mediates the Neuroprotective Effects of Calorie Restriction in Parkinson's Disease. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 36. issue 10. 2016-07-19. PMID:26961958. |
cr attenuated the mptp-induced loss of substantia nigra (sn) dopamine neurons and striatal dopamine turnover in ghrelin wt but not ko mice, demonstrating that ghrelin mediates cr's neuroprotective effect. |
2016-07-19 |
2023-08-13 |
mouse |
| Joshua E Albright, Iva Stojkovska, Abir A Rahman, Connor J Brown, Brad E Morriso. Nestin-positive/SOX2-negative cells mediate adult neurogenesis of nigral dopaminergic neurons in mice. Neuroscience letters. vol 615. 2016-07-14. PMID:26806039. |
the primary clinical motor symptoms of parkinson's disease (pd) result from loss of dopaminergic (da) neurons in the substantia nigra (sn). |
2016-07-14 |
2023-08-13 |
mouse |
| Linlin Pang, Jin Wang, Wanmei Huang, Songchao Gu. [A study of divalent metal transporter 1 and ferroportin 1 in brain of rats with manganese-induced parkinsonism]. Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases. vol 33. issue 4. 2016-07-12. PMID:26506769. |
to study the changes in the expression of divalent metal transporter 1 (dmt1) and ferroportin 1 (fp1) in the substantia nigra (sn) of rats with manganese-induced parkinsonism. |
2016-07-12 |
2023-08-13 |
rat |
| Regina Esterhammer, Klaus Seppi, Eva Reiter, Bernadette Pinter, Christoph Mueller, Christian Kremser, Tanja Zitzelsberger, Michael Nocker, Christoph Scherfler, Werner Poewe, Michael Schock. Potential of Diffusion Tensor Imaging and Relaxometry for the Detection of Specific Pathological Alterations in Parkinson's Disease (PD). PloS one. vol 10. issue 12. 2016-07-01. PMID:26713760. |
rois were drawn to delineate caudate nucleus (cn), putamen (pu), globus pallidus (gp) and substantia nigra (sn) on the co-registered maps. |
2016-07-01 |
2023-08-13 |
human |
| Marcio S Medeiros, Arthur Schumacher-Schuh, Andreia Machado Cardoso, Guilherme Vargas Bochi, Jucimara Baldissarelli, Aline Kegler, Daniel Santana, Carolina Maria Martins Behle Soares Chaves, Maria Rosa Chitolina Schetinger, Rafael Noal Moresco, Carlos R M Rieder, Michele Rechia Figher. Iron and Oxidative Stress in Parkinson's Disease: An Observational Study of Injury Biomarkers. PloS one. vol 11. issue 1. 2016-06-30. PMID:26751079. |
parkinson's disease (pd) is characterized by progressive motor impairment attributed to progressive loss of dopaminergic neurons in the substantia nigra (sn) pars compacta. |
2016-06-30 |
2023-08-13 |
cat |
| Ji Zhang, Beibei Yang, Hongbin Sun, Yan Zhou, Mengdi Liu, Jianhua Ding, Feng Fang, Yi Fan, Gang H. Aquaporin-4 deficiency diminishes the differential degeneration of midbrain dopaminergic neurons in experimental Parkinson's disease. Neuroscience letters. vol 614. 2016-06-29. PMID:26748031. |
parkinson's disease (pd) is primarily due to the progressive, selective and irreversible loss of dopaminergic (da) neurons in the substantia nigra (sn). |
2016-06-29 |
2023-08-13 |
mouse |
| Yan-Hua Li, Qing He, Jie-zhong Yu, Chun-yun Liu, Ling Feng, Zhi Chai, Qing Wang, Hong-zhen Zhang, Guang-Xian Zhang, Bao-guo Xiao, Cun-gen M. Lipoic acid protects dopaminergic neurons in LPS-induced Parkinson's disease model. Metabolic brain disease. vol 30. issue 5. 2016-06-24. PMID:26084861. |
our results for the first time showed that la administration improved motor dysfunction, protected dopaminergic neurons loss, and decreased α-synuclein accumulation in the substantia nigra (sn) area of brain. |
2016-06-24 |
2023-08-13 |
Not clear |
| Mayur S Parmar, Juliann D Jaumotte, Michael J Zigmond, Jane E Cavanaug. ERK1, 2, and 5 expression and activation in dopaminergic brain regions during postnatal development. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. vol 46. 2016-06-20. PMID:26363522. |
in the striatum (str) and ventral mesencephalon regions of the substantia nigra (sn) and ventral tegmental area (vta), erk5 expression and activation were high during early postnatal days and declined with aging. |
2016-06-20 |
2023-08-13 |
Not clear |
| M S Li, Y L Peng, J H Jiang, H X Xue, P Wang, P J Zhang, R W Han, M Chang, R Wan. Neuropeptide S Increases locomotion activity through corticotropin-releasing factor receptor 1 in substantia nigra of mice. Peptides. vol 71. 2016-06-17. PMID:26239581. |
here, we found that npsr protein of mouse was distributed in the substantia nigra (sn) and globus pallidus (lgp) by immunohistochemical analysis. |
2016-06-17 |
2023-08-13 |
mouse |
| Yukiko Ogura, Takeshi Izumi, Mitsuhiro Yoshioka, Toshiya Matsushim. Dissociation of the neural substrates of foraging effort and its social facilitation in the domestic chick. Behavioural brain research. vol 294. 2016-06-14. PMID:26235329. |
as the ascending dopaminergic projections include the mesolimbic and nigrostriatal pathways, we targeted our lesions at the medial striatum (mst) and substantia nigra (sn). |
2016-06-14 |
2023-08-13 |
chicken |
| Jun-yu Li, Shan-shan Ma, Qiao-ying Huang, Ming-tao L. [The Function of Neuroinflammation in Parkinson Disease]. Sheng li ke xue jin zhan [Progress in physiology]. vol 46. issue 3. 2016-06-10. PMID:26521481. |
parkinson disease (pd) is the second most common neurodegenerative disorder, characterized by a progressive loss of dopaminergic neurons in the substantia nigra (sn). |
2016-06-10 |
2023-08-13 |
Not clear |
| Jonathan Murray Lovell, Judith Mylius, Henning Scheich, Michael Brosc. Stimulation of the Dopaminergic Midbrain as a Behavioral Reward in Instrumentally Conditioned Monkeys. Brain stimulation. vol 8. issue 5. 2016-06-09. PMID:26070295. |
since the mesocortical dopaminergic system of rodents has several differences to that found in primate species, including humans, there is the need for more exhaustively studying causative relationships between activation/stimulation of the ventral tegmental area (vta) and substantia nigra (sn) and behavior in monkeys. |
2016-06-09 |
2023-08-13 |
monkey |