| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Nancy G Hernandez-Chan, Michael J Bannon, Carlos E Orozco-Barrios, Lourdes Escobedo, Sergio Zamudio, Fidel De la Cruz, Jose L Gongora-Alfaro, Juan Armendáriz-Borunda, David Reyes-Corona, Armando J Espadas-Alvarez, Yazmin M Flores-Martínez, Jose Ayala-Davila, Maria E Hernandez-Gutierrez, Lenin Pavón, Refugio García-Villegas, Rasajna Nadella, Daniel Martinez-Fon. Neurotensin-polyplex-mediated brain-derived neurotrophic factor gene delivery into nigral dopamine neurons prevents nigrostriatal degeneration in a rat model of early Parkinson's disease. Journal of biomedical science. vol 22. 2016-04-18. PMID:26198255. |
the reduction of bdnf expression in parkinson's disease substantia nigra (sn) might contribute to the death of dopaminergic neurons because inhibiting bdnf expression in the sn causes parkinsonism in the rat. |
2016-04-18 |
2023-08-13 |
rat |
| Vincent Prinz, Anna-Maria Hetzer, Susanne Müller, Mustafa Balkaya, Christoph Leithner, Golo Kronenberg, Matthias Endre. MRI heralds secondary nigral lesion after brain ischemia in mice: a secondary time window for neuroprotection. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. vol 35. issue 12. 2016-04-11. PMID:26126863. |
cerebral ischemia in the territory of the middle cerebral artery (mca) can induce delayed neuronal cell death in the ipsilateral substantia nigra (sn) remote from the primary ischemic lesion. |
2016-04-11 |
2023-08-13 |
mouse |
| Anke A Dijkstra, Angela Ingrassia, Renee X de Menezes, Ronald E van Kesteren, Annemieke J M Rozemuller, Peter Heutink, Wilma D J van de Ber. Evidence for Immune Response, Axonal Dysfunction and Reduced Endocytosis in the Substantia Nigra in Early Stage Parkinson's Disease. PloS one. vol 10. issue 6. 2016-04-08. PMID:26087293. |
to elucidate molecular mechanisms underlying neuronal dysfunction and alpha-synuclein pathology in the premotor phase of pd, we investigated the transcriptome of the substantia nigra (sn) of well-characterized ilbd, pd donors and age-matched controls with braak alpha-synuclein stage ranging from 0-6. |
2016-04-08 |
2023-08-13 |
human |
| Jia-Jia Xiao, Ming Yin, Ze-Jian Wang, Xiao-Ping Wan. Transplanted Neural Stem Cells: Playing a Neuroprotective Role by Ceruloplasmin in the Substantia Nigra of PD Model Rats? Oxidative medicine and cellular longevity. vol 2015. 2016-04-08. PMID:26146528. |
although mounting evidence suggests that ceruloplasmin (cp) deficiency and iron deposition are pivotal factors responsible for exacerbating demise of dopaminergic neurons in the substantia nigra (sn) of the parkinsonism and neural stem cells (nscs) are believed to be excellent candidates for compensating the lost dopaminergic neurons, there are few researches to explore the change of cp expression and of iron deposition in the pathological microenvironment of sn after nscs transplantation and the ability of grafted nscs to differentiate directionally into dopaminergic neurons under the changed homeostasis. |
2016-04-08 |
2023-08-13 |
rat |
| Perdita Cheshire, Scott Ayton, Kelly L Bertram, Helen Ling, Abi Li, Catriona McLean, Glenda M Halliday, Sean S O'Sullivan, Tamas Revesz, David I Finkelstein, Elsdon Storey, David R William. Serotonergic markers in Parkinson's disease and levodopa-induced dyskinesias. Movement disorders : official journal of the Movement Disorder Society. vol 30. issue 6. 2016-04-07. PMID:25649148. |
we obtained brain tissue from 44 pd cases and 17 age-matched controls and assessed monoamine levels and the serotonin and dopamine transporters in the striatum, and the extent of dopaminergic and serotonergic cell preservation in the substantia nigra (sn) and the dorsal raphe nuclei (drn), respectively. |
2016-04-07 |
2023-08-13 |
Not clear |
| Lian-Kun Song, Kai-Li Ma, Yu-He Yuan, Zheng Mu, Xiu-Yun Song, Fei Niu, Ning Han, Nai-Hong Che. Targeted Overexpression of α-Synuclein by rAAV2/1 Vectors Induces Progressive Nigrostriatal Degeneration and Increases Vulnerability to MPTP in Mouse. PloS one. vol 10. issue 6. 2016-04-06. PMID:26114655. |
the targeted overexpression of α-syn in the substantia nigra (sn) mediated by viral vectors may provide a better alternative to recapitulate the neurodegenerative features of pd. |
2016-04-06 |
2023-08-13 |
mouse |
| Sofia Reimão, Patrícia Pita Lobo, Dulce Neutel, Leonor Correia Guedes, Miguel Coelho, Mário M Rosa, Pedro Azevedo, Joana Ferreira, Daisy Abreu, Nilza Gonçalves, Rita G Nunes, Jorge Campos, Joaquim J Ferreir. Substantia nigra neuromelanin-MR imaging differentiates essential tremor from Parkinson's disease. Movement disorders : official journal of the Movement Disorder Society. vol 30. issue 7. 2016-04-04. PMID:25758364. |
magnetic resonance imaging (mri) studies have been able to identify neuromelanin changes in the substantia nigra (sn) of pd patients, but they have thus far not been investigated in et. |
2016-04-04 |
2023-08-13 |
Not clear |
| Andrea Pilotto, Rezzak Yilmaz, Daniela Ber. Developments in the role of transcranial sonography for the differential diagnosis of parkinsonism. Current neurology and neuroscience reports. vol 15. issue 7. 2016-03-31. PMID:26008814. |
in this review, we highlight recent evidence supporting tcs as a reliable method in the differential diagnosis of parkinsonism, combining substantia nigra (sn), basal ganglia and ventricular system findings. |
2016-03-31 |
2023-08-13 |
Not clear |
| Guillaume Grolez, Caroline Moreau, Bernard Sablonnière, Guillaume Garçon, Jean-Christophe Devedjian, Sayah Meguig, Patrick Gelé, Christine Delmaire, Regis Bordet, Luc Defebvre, Ioav Z Cabantchik, David Devo. Ceruloplasmin activity and iron chelation treatment of patients with Parkinson's disease. BMC neurology. vol 15. 2016-03-29. PMID:25943368. |
growing body of evidence suggests that parkinson's disease (pd) is associated with oxidative damage via iron accumulation in the substantia nigra (sn). |
2016-03-29 |
2023-08-13 |
Not clear |
| R M Santiago, F S Tonin, J Barbiero, T Zaminelli, S L Boschen, R Andreatini, C Da Cunha, M M S Lima, M A B F Vita. The nonsteroidal antiinflammatory drug piroxicam reverses the onset of depressive-like behavior in 6-OHDA animal model of Parkinson's disease. Neuroscience. vol 300. 2016-03-29. PMID:25999296. |
considering the potential neuroprotective effect of nonsteroidal antiinflammatory drugs in neurodegenerative diseases, the objective of the present study was to investigate the effects of piroxicam on depressive-like behavior in male wistar rats lesioned with 6-hydroxydopamine (6-ohda) in the substantia nigra (sn). |
2016-03-29 |
2023-08-13 |
rat |
| K Hikishima, K Ando, Y Komaki, K Kawai, R Yano, T Inoue, T Itoh, M Yamada, S Momoshima, H J Okano, H Okan. Voxel-based morphometry of the marmoset brain: In vivo detection of volume loss in the substantia nigra of the MPTP-treated Parkinson's disease model. Neuroscience. vol 300. 2016-03-29. PMID:26012491. |
movement dysfunction in parkinson's disease (pd) is caused by the degeneration of dopaminergic (da) neurons in the substantia nigra (sn). |
2016-03-29 |
2023-08-13 |
monkey |
| Jun Wang, Mingxia Bi, Junxia Xi. Ceruloplasmin is Involved in the Nigral Iron Accumulation of 6-OHDA-Lesioned Rats. Cellular and molecular neurobiology. vol 35. issue 5. 2016-03-28. PMID:25656940. |
elevated iron levels in the substantia nigra (sn) participate in neuronal death in parkinson's disease (pd), while the mechanisms underlying the increased iron are still unknown. |
2016-03-28 |
2023-08-13 |
rat |
| R T Bartus, J H Kordower, E M Johnson, L Brown, B R Kruegel, Y Chu, T L Baumann, A E Lang, C W Olanow, C D Herzo. Post-mortem assessment of the short and long-term effects of the trophic factor neurturin in patients with α-synucleinopathies. Neurobiology of disease. vol 78. 2016-03-28. PMID:25841760. |
less than 1% of substantia nigra (sn) neurons stained for neurturin in the shorter-term cases. |
2016-03-28 |
2023-08-13 |
human |
| Yingjun Liu, Qinbo Zhou, Mi Tang, Ning Fu, Wei Shao, Shuzhen Zhang, Yanqing Yin, Rong Zeng, Xiaomin Wang, Gang Hu, Jiawei Zho. Upregulation of alphaB-crystallin expression in the substantia nigra of patients with Parkinson's disease. Neurobiology of aging. vol 36. issue 4. 2016-03-17. PMID:25683516. |
the underlying mechanisms of the characteristic neurodegeneration in the substantia nigra (sn) are still not fully understood. |
2016-03-17 |
2023-08-13 |
mouse |
| Cristiane Batassini, Núbia Broetto, Lucas Silva Tortorelli, Milene Borsoi, Caroline Zanotto, Fabiana Galland, Tadeu Mello Souza, Marina Concli Leite, Carlos-Alberto Gonçalve. Striatal Injury with 6-OHDA Transiently Increases Cerebrospinal GFAP and S100B. Neural plasticity. vol 2015. 2016-03-09. PMID:26090233. |
herein, we induced a parkinson's disease (pd) model via a 6-ohda intrastriatal injection in rats and investigated the changes in gfap and s100b using elisa in the substantia nigra (sn), striatum, and cerebrospinal fluid on the 1st, 7th, and 21st days following the injection. |
2016-03-09 |
2023-08-13 |
rat |
| Shinki Murakami, Ikuko Miyazaki, Ko Miyoshi, Masato Asanum. Long-Term Systemic Exposure to Rotenone Induces Central and Peripheral Pathology of Parkinson's Disease in Mice. Neurochemical research. vol 40. issue 6. 2016-03-07. PMID:25894684. |
here, we recorded the serial immunohistochemical changes in neurons and glial cells of the striatum, substantia nigra (sn), olfactory bulb (ob), thoracic cord (thc) and ascending colon (ac) induced by 1-, 3- and 6-week administration of rotenone (50 mg/kg/day) infused subcutaneously in c57bl mice using an osmotic pump. |
2016-03-07 |
2023-08-13 |
mouse |
| Hong-Ying Zhang, Hui Tang, Wen-Xin Chen, Gong-Jun Ji, Jing Ye, Ning Wang, Jing-Tao Wu, Bing Gua. Mapping the functional connectivity of the substantia nigra, red nucleus and dentate nucleus: A network analysis hypothesis associated with the extrapyramidal system. Neuroscience letters. vol 606. 2016-03-01. PMID:26342496. |
this study aimed to examine the functional networks related to the extrapyramidal system using a temporal oscillation signal correlation analysis method based on critical nodes in the substantia nigra (sn), red nucleus (rn) and dentate nucleus (dn). |
2016-03-01 |
2023-08-13 |
human |
| Johann Lambeck, Wolf-Dirk Niesen, Matthias Reinhard, Reinhard Matthias, Cornelius Weiller, Matthias Dose, Dose Matthias, Birgit Zucker, Zucker Birgi. Substantia nigra hyperechogenicity in hypokinetic Huntington's disease patients. Journal of neurology. vol 262. issue 3. 2016-02-29. PMID:25572159. |
substantia nigra (sn) hyperechogenicity can be detected by transcranial sonography (tcs) to assist the early diagnosis of idiopathic parkinson's disease (ipd). |
2016-02-29 |
2023-08-13 |
Not clear |
| M D Sconce, M J Churchill, R E Greene, C K Meshu. Intervention with exercise restores motor deficits but not nigrostriatal loss in a progressive MPTP mouse model of Parkinson's disease. Neuroscience. vol 299. 2016-02-29. PMID:25943481. |
we found that after 4 weeks of mptp treatment, mice that volunteered to exercise had behavioral recovery in several measures despite the loss of 73% and 53% tyrosine hydroxylase (th) within the dorsolateral (dl) striatum and the substantia nigra (sn), respectively which was equivalent to the loss seen in the mice that did not exercise but were also administered mptp for 4 weeks. |
2016-02-29 |
2023-08-13 |
mouse |
| Yiming Xiao, Vladimir S Fonov, Silvain Beriault, Ian Gerard, Abbas F Sadikot, G Bruce Pike, D Louis Collin. Patch-based label fusion segmentation of brainstem structures with dual-contrast MRI for Parkinson's disease. International journal of computer assisted radiology and surgery. vol 10. issue 7. 2016-02-23. PMID:25249471. |
while many automatic volumetric segmentation methods have been proposed for the lentiform nucleus, few have attempted to identify the key brainstem substructures including the subthalamic nucleus (stn), substantia nigra (sn), and red nucleus (rn) due to their small size and poor contrast in conventional t1w mri. |
2016-02-23 |
2023-08-13 |
Not clear |