| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Krzysztof Sadowski, Małgorzata Serafin-Król, Karol Szlachta, Andrzej Friedma. Basal ganglia echogenicity in tauopathies. Journal of neural transmission (Vienna, Austria : 1996). vol 122. issue 6. 2016-02-22. PMID:25204278. |
echogenicity of the substantia nigra (sn) and lenticular nucleus (ln) were assessed. |
2016-02-22 |
2023-08-13 |
Not clear |
| Carsten Saft, Rainer Hoffmann, Katrin Strassburger-Krogias, Thomas Lücke, Saskia H Meves, Gisa Ellrichmann, Christos Krogia. Echogenicity of basal ganglia structures in different Huntington's disease phenotypes. Journal of neural transmission (Vienna, Austria : 1996). vol 122. issue 6. 2016-02-22. PMID:25503829. |
size of echogenic area of substantia nigra (sn) correlated positively with cag repeat and bradykinesia subscore, and negatively with age of onset and chorea subscore. |
2016-02-22 |
2023-08-13 |
human |
| Diego Iacono, Maria Geraci-Erck, Marcie L Rabin, Charles H Adler, Geidy Serrano, Thomas G Beach, Roger Kurla. Parkinson disease and incidental Lewy body disease: Just a question of time? Neurology. vol 85. issue 19. 2016-02-22. PMID:26468408. |
to quantify the loss of pigmented neurons in the substantia nigra (sn) of autopsy-confirmed parkinson disease (pd) and incidental lewy body disease (ilbd) vs age-matched controls (c). |
2016-02-22 |
2023-08-13 |
Not clear |
| Petr Dusek, Per M Roos, Tomasz Litwin, Susanne A Schneider, Trond Peder Flaten, Jan Aaset. The neurotoxicity of iron, copper and manganese in Parkinson's and Wilson's diseases. Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS). vol 31. 2016-02-19. PMID:24954801. |
in parkinson's disease local dysregulation of iron metabolism in the substantia nigra (sn) seems to be related to neurodegeneration with an increase in sn iron concentration, accompanied by decreased sn cu and ceruloplasmin concentrations and increased free cu concentrations and decreased ferroxidase activity in the cerebrospinal fluid. |
2016-02-19 |
2023-08-13 |
Not clear |
| Kazumasa Wakamatsu, Keisuke Tabuchi, Makoto Ojika, Fabio A Zucca, Luigi Zecca, Shosuke It. Norepinephrine and its metabolites are involved in the synthesis of neuromelanin derived from the locus coeruleus. Journal of neurochemistry. vol 135. issue 4. 2016-02-16. PMID:26156066. |
in order to elucidate the chemical structure of black to brown pigments, neuromelanins (nms), in the substantia nigra (sn) and the locus coeruleus (lc) in the central nervous system of humans and other mammalian species during aging, chemical degradative methods are powerful tools. |
2016-02-16 |
2023-08-13 |
Not clear |
| Kazumasa Wakamatsu, Keisuke Tabuchi, Makoto Ojika, Fabio A Zucca, Luigi Zecca, Shosuke It. Norepinephrine and its metabolites are involved in the synthesis of neuromelanin derived from the locus coeruleus. Journal of neurochemistry. vol 135. issue 4. 2016-02-16. PMID:26156066. |
using the chemical degradation methods for the determination of catechols in neuromelanin (nm), we have shown that dopamine (da), 3,4-dihydroxyphenylacetic acid (dopac), 3,4-dihydroxyphenylethanol (dope), and 3,4-dihydroxyphenylalanine (dopa) are mainly responsible for the structure of nm from substantia nigra (sn), while norepinephrine (ne), 3,4-dihydroxymandelic acid (doma), and 3,4-dihydroxyphenylethylene glycol (dopeg) are additionally responsible for the structure of nm from locus coeruleus (lc). |
2016-02-16 |
2023-08-13 |
Not clear |
| Angela E P Bouwmans, Albert F G Leentjens, Werner H Mess, Wim E J Webe. Abnormal Echogenicity of the Substantia Nigra, Raphe Nuclei, and Third-Ventricle Width as Markers of Cognitive Impairment in Parkinsonian Disorders: A Cross-Sectional Study. Parkinson's disease. vol 2016. 2016-02-16. PMID:26881179. |
this study assesses whether abnormal echogenicity of the substantia nigra (sn) and raphe nuclei (rn) and the diameter of third ventricle are markers of cognitive impairment in patients with pd and other forms of parkinsonism. |
2016-02-16 |
2023-08-13 |
Not clear |
| Xijin Wang, Qiang Guan, Meihua Wang, Liu Yang, Jie Bai, Zhiqiang Yan, Yuhong Zhang, Zhenguo Li. Aging-related rotenone-induced neurochemical and behavioral deficits: role of SIRT2 and redox imbalance, and neuroprotection by AK-7. Drug design, development and therapy. vol 9. 2016-02-15. PMID:26089639. |
there was also aging-related rotenone-induced increase in substantia nigra (sn) sirt2 expression in the rats. |
2016-02-15 |
2023-08-13 |
rat |
| Stefan Jean-Pierre Haas, Xiaolai Zhou, Venissa Machado, Andreas Wree, Kerstin Krieglstein, Björn Spitta. Expression of Tgfβ1 and Inflammatory Markers in the 6-hydroxydopamine Mouse Model of Parkinson's Disease. Frontiers in molecular neuroscience. vol 9. 2016-02-12. PMID:26869879. |
parkinson's disease (pd) is a neurodegenerative disorder that is characterized by loss of midbrain dopaminergic (mda) neurons in the substantia nigra (sn). |
2016-02-12 |
2023-08-13 |
mouse |
| Gregory Robison, Brendan Sullivan, Jason R Cannon, Yulia Pushka. Identification of dopaminergic neurons of the substantia nigra pars compacta as a target of manganese accumulation. Metallomics : integrated biometal science. vol 7. issue 5. 2016-02-08. PMID:25695229. |
here, x-ray fluorescence microscopy determined the metal content and distribution in the substantia nigra (sn) of the rodent brain. |
2016-02-08 |
2023-08-13 |
Not clear |
| Furong Huang, Jin Fan, Jing Lu. The neural basis of novelty and appropriateness in processing of creative chunk decomposition. NeuroImage. vol 113. 2016-02-08. PMID:25797834. |
we found that novelty processing involved functional areas for procedural memory (caudate), mental rewarding (substantia nigra, sn), and visual-spatial processing, whereas appropriateness processing was mediated by areas for declarative memory (hippocampus), emotional arousal (amygdala), and orthography recognition. |
2016-02-08 |
2023-08-13 |
human |
| Y Y Tyurina, A M Polimova, E Maciel, V A Tyurin, V I Kapralova, D E Winnica, A S Vikulina, M R M Domingues, J McCoy, L H Sanders, H Bayır, J T Greenamyre, V E Kaga. LC/MS analysis of cardiolipins in substantia nigra and plasma of rotenone-treated rats: Implication for mitochondrial dysfunction in Parkinson's disease. Free radical research. vol 49. issue 5. 2016-02-03. PMID:25740198. |
as rotenone acts as an inhibitor of mitochondrial respiratory complex i, we employed oxidative lipidomics to assess oxidative metabolism of a mitochondria-specific phospholipid, cardiolipin (cl), in substantia nigra (sn) of exposed animals. |
2016-02-03 |
2023-08-13 |
rat |
| Douglas G Walker, Lih-Fen Lue, Geidy Serrano, Charles H Adler, John N Caviness, Lucia I Sue, Thomas G Beac. Altered Expression Patterns of Inflammation-Associated and Trophic Molecules in Substantia Nigra and Striatum Brain Samples from Parkinson's Disease, Incidental Lewy Body Disease and Normal Control Cases. Frontiers in neuroscience. vol 9. 2016-02-02. PMID:26834537. |
dopaminergic neurons in the substantia nigra (sn) pars compacta, whose loss results in the clinical symptoms associated with pd, are particularly susceptible to inflammatory damage and oxidative stress. |
2016-02-02 |
2023-08-13 |
human |
| R Khang, C Park, J-H Shi. Dysregulation of parkin in the substantia nigra of db/db and high-fat diet mice. Neuroscience. vol 294. 2016-01-28. PMID:25779963. |
parkinson's disease (pd) is characterized by selective loss of dopaminergic neurons in the substantia nigra (sn). |
2016-01-28 |
2023-08-13 |
mouse |
| Chen Liu, Chuanming Li, Jun Yang, Li Gui, Lu Zhao, Alan C Evans, Xuntao Yin, Jian Wan. Characterizing brain iron deposition in subcortical ischemic vascular dementia using susceptibility-weighted imaging: An in vivo MR study. Behavioural brain research. vol 288. 2016-01-27. PMID:25862942. |
the phase shift value of the bilateral hippocampus (hp), caudate nucleus (cn), globus pallidus (gp), putamen (pu), thalamus (th), red nucleus (rn), substantia nigra (sn), anterior cingulate cortex (acc), posterior cingulate (pcc), parietal cortex (pc) and frontal white matter (fwm) were examined and correlated with neuropsychological scores for sivd patients. |
2016-01-27 |
2023-08-13 |
Not clear |
| Wolfgang M Pauli, Tobias Larsen, Sven Collette, Julian M Tyszka, Ben Seymour, John P O'Dohert. Distinct Contributions of Ventromedial and Dorsolateral Subregions of the Human Substantia Nigra to Appetitive and Aversive Learning. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 35. issue 42. 2016-01-25. PMID:26490862. |
the role of neurons in the substantia nigra (sn) and ventral tegmental area (vta) of the midbrain in contributing to the elicitation of reward prediction errors during appetitive learning has been well established. |
2016-01-25 |
2023-08-13 |
human |
| Jong H Yoon, Paul Larson, Anthony Grandelis, Christian La, Edward Cui, Cameron S Carter, Michael J Minzenber. Delay Period Activity of the Substantia Nigra during Proactive Control of Response Selection as Determined by a Novel fMRI Localization Method. Journal of cognitive neuroscience. vol 27. issue 6. 2016-01-23. PMID:25514657. |
the substantia nigra (sn), an element of the bg, has figured prominently in current models of response selection. |
2016-01-23 |
2023-08-13 |
human |
| Md Shahaduzzaman, Kevin Nash, Charles Hudson, Masroor Sharif, Bethany Grimmig, Xiaoyang Lin, Ge Bai, Hui Liu, Kenneth E Ugen, Chuanhai Cao, Paula C Bickfor. Anti-human α-synuclein N-terminal peptide antibody protects against dopaminergic cell death and ameliorates behavioral deficits in an AAV-α-synuclein rat model of Parkinson's disease. PloS one. vol 10. issue 2. 2016-01-20. PMID:25658425. |
fisher 344 rats were injected with raav vector into the right substantia nigra (sn), while control rats received an aav vector expressing green fluorescent protein (gfp). |
2016-01-20 |
2023-08-13 |
human |
| Shengli Xu, Piu Cha. Interaction between Neuromelanin and Alpha-Synuclein in Parkinson's Disease. Biomolecules. vol 5. issue 2. 2016-01-18. PMID:26057626. |
parkinson's disease (pd) is a very common neurodegenerative disorder characterized by the accumulation of α-synuclein (α-syn) into lewy body (lb) inclusions and the loss of neuronmelanin (nm) containing dopamine (da) neurons in the substantia nigra (sn). |
2016-01-18 |
2023-08-13 |
Not clear |
| Guohua Zhang, Yuhu Zhang, Chengguo Zhang, Yukai Wang, Guixian Ma, Kun Nie, Haiqun Xie, Jianping Liu, Lijuan Wan. Diffusion Kurtosis Imaging of Substantia Nigra Is a Sensitive Method for Early Diagnosis and Disease Evaluation in Parkinson's Disease. Parkinson's disease. vol 2015. 2016-01-15. PMID:26770867. |
to diagnose parkinson disease (pd) in an early stage and accurately evaluate severity, it is important to develop a sensitive method for detecting structural changes in the substantia nigra (sn). |
2016-01-15 |
2023-08-13 |
Not clear |