| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jiri Blahuta, Tomas Soukup, Monika Jelinkova, Petra Bartova, Petr Cermak, Roman Herzig, David Skoloudi. A new program for highly reproducible automatic evaluation of the substantia nigra from transcranial sonographic images. Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia. vol 158. issue 4. 2015-11-23. PMID:23640029. |
recent studies report increased echogenicity of the substantia nigra (sn) in patients with parkinson's disease (pd) using transcranial sonography (tcs). |
2015-11-23 |
2023-08-12 |
human |
| Rémy Liechti, Angélique D Ducray, Pia Jensen, Stefano Di Santo, Stefanie Seiler, Charlotte H Jensen, Morten Meyer, Hans Rudolf Widme. Characterization of fetal antigen 1/delta-like 1 homologue expressing cells in the rat nigrostriatal system: effects of a unilateral 6-hydroxydopamine lesion. PloS one. vol 10. issue 2. 2015-11-20. PMID:25723595. |
fa1/dlk1-ir cells were predominantly distributed in the substantia nigra (sn) pars compacta (snc) and in the ventral tegmental area. |
2015-11-20 |
2023-08-13 |
rat |
| Hanqing Chen, Xijin Wang, Meihua Wang, Liu Yang, Zhiqiang Yan, Yuhong Zhang, Zhenguo Li. Behavioral and Neurochemical Deficits in Aging Rats with Increased Neonatal Iron Intake: Silibinin's Neuroprotection by Maintaining Redox Balance. Frontiers in aging neuroscience. vol 7. 2015-11-20. PMID:26578951. |
furthermore, we found that the neonatal iron supplementation resulted in significant increase in malondialdehyde (mda) and decrease in glutathione (gsh) in the substantia nigra (sn) of the aging male and female rats. |
2015-11-20 |
2023-08-13 |
rat |
| V Annese, C Barcia, F Ros-Bernal, A Gómez, C M Ros, V De Pablos, E Fernández-Villalba, M E De Stefano, M-T Herrer. Evidence of oligodendrogliosis in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced Parkinsonism. Neuropathology and applied neurobiology. vol 39. issue 2. 2015-11-13. PMID:22443457. |
mice and nonhuman primates administered with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp) represent elective experimental models of parkinsonism, in which degeneration of the nigrostriatal dopaminergic pathway is associated with prominent neuroinflammation, characterized by activated microglia and astrocytes in both substantia nigra (sn) and striatum. |
2015-11-13 |
2023-08-12 |
mouse |
| Michaela E Johnson, Larisa Bobrovskay. An update on the rotenone models of Parkinson's disease: their ability to reproduce the features of clinical disease and model gene-environment interactions. Neurotoxicology. vol 46. 2015-11-12. PMID:25514659. |
parkinson's disease (pd) is the second most common neurodegenerative disorder that is characterized by two major neuropathological hallmarks: the degeneration of dopaminergic neurons in the substantia nigra (sn) and the presence of lewy bodies in the surviving sn neurons, as well as other regions of the central and peripheral nervous system. |
2015-11-12 |
2023-08-13 |
Not clear |
| Gemma M Parkinson, Christopher V Dayas, Doug W Smit. Increased mitochondrial DNA deletions in substantia nigra dopamine neurons of the aged rat. Current aging science. vol 7. issue 3. 2015-10-26. PMID:25612740. |
the dopaminergic neurons of the substantia nigra (sn), which constitute the origin of the nigrostriatal system, are vulnerable to age-related degenerative processes. |
2015-10-26 |
2023-08-13 |
human |
| J Sun, N J Cairns, J S Perlmutter, R H Mach, J X. Regulation of dopamine D₃ receptor in the striatal regions and substantia nigra in diffuse Lewy body disease. Neuroscience. vol 248. 2015-10-20. PMID:23732230. |
in this study, a novel d₃-preferring radioligand [(3)h]wc-10 and a d₂-preferring radioligand [(3)h]raclopride were used and the absolute densities of the dopamine d₃ and d₂ receptors were determined in the striatal regions and substantia nigra (sn) from postmortem brains from five cases of dlbd, which included dementia with lewy bodies (dlb, n=4) and parkinson disease dementia (pdd, n=1). |
2015-10-20 |
2023-08-12 |
Not clear |
| Guanghui Zhu, Ganping Chen, Lu Shi, Jenny Feng, Yan Wang, Chaohui Ye, Wenke Feng, Jianlou Niu, Zhifeng Huan. PEGylated rhFGF-2 conveys long-term neuroprotection and improves neuronal function in a rat model of Parkinson's disease. Molecular neurobiology. vol 51. issue 1. 2015-10-20. PMID:24930088. |
the in vivo data showed that, compared with native rhfgf-2, pegylated rhfgf-2 was more efficacious in preventing 6-ohda-induced lesion upon tyrosine hydroxylase-positive neurons in the substantia nigra (sn), improving the apomorphine-induced rotational behavior and the 6-ohda-induced decline in tissue concentration of dopamine (da) and its metabolites. |
2015-10-20 |
2023-08-13 |
human |
| Yuqiang Lv, Zheng Zhang, Lin Hou, Li Zhang, Jinyu Zhang, Yuehua Wang, Cun Liu, Pingping Xu, Lu Liu, Xiaoying Gai, Tingxiu L. Phytic acid attenuates inflammatory responses and the levels of NF-κB and p-ERK in MPTP-induced Parkinson's disease model of mice. Neuroscience letters. vol 597. 2015-10-19. PMID:25929185. |
motor behavior test and tyrosine hydroxylase (th) immunohistochemistry method showed pa significantly inhibited mptp-induced dopaminergic cell loss in the substantia nigra (sn). |
2015-10-19 |
2023-08-13 |
mouse |
| Jolanta Konieczny, Danuta Jantas, Tomasz Lenda, Helena Domin, Anna Czarnecka, Katarzyna Kuter, Maria Śmiałowska, Władysław Lasoń, Elżbieta Lorenc-Koc. Lack of neuroprotective effect of celastrol under conditions of proteasome inhibition by lactacystin in in vitro and in vivo studies: implications for Parkinson's disease. Neurotoxicity research. vol 26. issue 3. 2015-10-13. PMID:24842651. |
the animal study was performed on male wistar rats injected unilaterally with lactacystin (5 μg/2 μl) into the substantia nigra (sn) pars compacta. |
2015-10-13 |
2023-08-13 |
mouse |
| Xiaoli Zhang, Yun Li, Chenzhe Liu, Ruifang Fan, Ping Wang, Lifei Zheng, Feng Hong, Xiaoyan Feng, Yue Zhang, Lisheng Li, Jinxia Zh. Alteration of enteric monoamines with monoamine receptors and colonic dysmotility in 6-hydroxydopamine-induced Parkinson's disease rats. Translational research : the journal of laboratory and clinical medicine. vol 166. issue 2. 2015-10-08. PMID:25766133. |
rats microinjected with 6-hydroxydopamine (6-ohda) into the bilateral substantia nigra (sn) exhibit constipation, but the role of monoamines and their receptors is not clear. |
2015-10-08 |
2023-08-13 |
rat |
| M M Migliore, R Ortiz, S Dye, R B Campbell, M M Amiji, B L Waszcza. Neurotrophic and neuroprotective efficacy of intranasal GDNF in a rat model of Parkinson's disease. Neuroscience. vol 274. 2015-10-07. PMID:24845869. |
glial cell line-derived neurotrophic factor (gdnf) exerts neurotrophic and neuroprotective effects on substantia nigra (sn) dopamine neurons and has great therapeutic potential for parkinson's disease (pd). |
2015-10-07 |
2023-08-13 |
rat |
| Qingshan Wang, Esteban Oyarzabal, Belinda Wilson, Li Qian, Jau-Shyong Hon. Substance P enhances microglial density in the substantia nigra through neurokinin-1 receptor/NADPH oxidase-mediated chemotaxis in mice. Clinical science (London, England : 1979). vol 129. issue 8. 2015-10-05. PMID:26223840. |
the substantia nigra (sn) contains the highest density of microglia among different brain regions. |
2015-10-05 |
2023-08-13 |
mouse |
| Fan Yang, Yunhui Liu, Jie Tu, Jun Wan, Jie Zhang, Bifeng Wu, Shanping Chen, Jiawei Zhou, Yangling Mu, Liping Wan. Activated astrocytes enhance the dopaminergic differentiation of stem cells and promote brain repair through bFGF. Nature communications. vol 5. 2015-10-02. PMID:25517983. |
light activation of transplanted astrocytes in the substantia nigra (sn) also upregulates bfgf levels in vivo and promotes the regenerative effects of co-transplanted stem cells. |
2015-10-02 |
2023-08-13 |
mouse |
| Julia Kraemmer, Gabor G Kovacs, Laura Perju-Dumbrava, Susanne Pirker, Tatiana Traub-Weidinger, Walter Pirke. Correlation of striatal dopamine transporter imaging with post mortem substantia nigra cell counts. Movement disorders : official journal of the Movement Disorder Society. vol 29. issue 14. 2015-09-21. PMID:25048738. |
only limited data are available on the relationship between striatal dopamine transporter binding and dopaminergic cell loss in the substantia nigra (sn). |
2015-09-21 |
2023-08-13 |
human |
| b' Selva Moheb Saadat, \\xc4\\xb0rfan De\\xc4\\x9firmenci, Serhat \\xc3\\x96zkan, Faruk Saydam, Zeynep \\xc3\\x96zdemir K\\xc3\\xb6ro\\xc4\\x9flu, Ertu\\xc4\\x9frul \\xc3\\x87olak, Hasan Veysi G\\xc3\\xbcne\\xc5\\x9. Is the 1254T>C polymorphism in the DMT1 gene associated with Parkinson\'s disease? Neuroscience letters. vol 594. 2015-09-14. PMID:25817364.' |
the main pathological characteristic of pd is the death of dopaminergic neurons in the substantia nigra (sn) pars compacta. |
2015-09-14 |
2023-08-13 |
Not clear |
| Qian Wang, Hui Zhang, Ming Liu, Zuofeng Zhang, Zifeng Wei, Na Sun, Tongyao Mao, Yuxin Zhan. [P38 MAPK signaling pathway regulates nuclear factor-κB and inducible nitric oxide synthase expressions in the substantia nigra in a mouse model of Parkinson's disease]. Nan fang yi ke da xue xue bao = Journal of Southern Medical University. vol 34. issue 8. 2015-09-01. PMID:25176090. |
to investigate the role of p38 mitogen-activated protein kinase (p38 mapk) signaling pathway in regulating the expression of nuclear factor-κb (nf-κb) and inducible nitric oxide synthase (inos) in the substantia nigra (sn) of a mouse model of parkinson's disease (pd). |
2015-09-01 |
2023-08-13 |
mouse |
| Max C Keuken, Birte U Forstman. A probabilistic atlas of the basal ganglia using 7 T MRI. Data in brief. vol 4. 2015-08-31. PMID:26322322. |
the atlas includes six subcortical nuclei: the striatum (str), the globus pallidus internal and external segment (gpi/e), the subthalamic nucleus (stn), the substantia nigra (sn), and the red nucleus (rn). |
2015-08-31 |
2023-08-13 |
Not clear |
| A Harkavyi, N Rampersaud, P S Whitto. Neuroprotection by Exendin-4 Is GLP-1 Receptor Specific but DA D3 Receptor Dependent, Causing Altered BrdU Incorporation in Subventricular Zone and Substantia Nigra. Journal of neurodegenerative diseases. vol 2013. 2015-08-28. PMID:26316987. |
in the present study, we determined the effects of ex-4 on cellular brdu incorporation in the rat subventricular zone (svz) and substantia nigra (sn). |
2015-08-28 |
2023-08-13 |
rat |
| Rita Kumari, J B Senthil Kumar, Pratibha Mehta Luthr. Post-lesion administration of 7-NI attenuated motor and non-motor deficits in 6-OHDA induced bilaterally lesioned female rat model of Parkinson's disease. Neuroscience letters. vol 589. 2015-08-27. PMID:25528406. |
sprague-dawley female rats with bilateral intraventricular injection of either 6-ohda (10.5μg) (n=8-11/group) or saline (sham; n=8/group) at substantia nigra (sn) were provided with 7-ni (30mg/kg/day) intraperitoneal, once a day during the 3 consecutive days of short term treatment. |
2015-08-27 |
2023-08-13 |
rat |