| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jason Langley, Daniel E Huddleston, Xiangchuan Chen, Jan Sedlacik, Nishant Zachariah, Xiaoping H. A multicontrast approach for comprehensive imaging of substantia nigra. NeuroImage. vol 112. 2016-01-11. PMID:25731994. |
we characterize the contrast behavior of substantia nigra (sn) in both magnetization transfer (mt) imaging, which is believed to be sensitive to neuromelanin (nm), and susceptibility weighted imaging (swi). |
2016-01-11 |
2023-08-13 |
Not clear |
| Yi Pang, Lu-Tai Tien, Hobart Zhu, Juying Shen, Camilla F Wright, Tembra K Jones, Samir A Mamoon, Abhay J Bhatt, Zhengwei Cai, Lir-Wan Fa. Interleukin-1 receptor antagonist reduces neonatal lipopolysaccharide-induced long-lasting neurobehavioral deficits and dopaminergic neuronal injury in adult rats. International journal of molecular sciences. vol 16. issue 4. 2016-01-11. PMID:25898410. |
this is evidenced by a sustained activation of microglia and elevated interleukin-1β (il-1β) levels, as well as reduced tyrosine hydroxylase (th) expression in the substantia nigra (sn) of p70 rat brain. |
2016-01-11 |
2023-08-13 |
rat |
| Neil A Harrison, Mara Cercignani, Valerie Voon, Hugo D Critchle. Effects of inflammation on hippocampus and substantia nigra responses to novelty in healthy human participants. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 40. issue 4. 2016-01-05. PMID:25154706. |
the dopaminergic substantia nigra (sn) is implicated in the drive to explore novel stimuli and situations. |
2016-01-05 |
2023-08-13 |
human |
| Arman Rahimmi, Farnoosh Khosrobakhsh, Esmael Izadpanah, Mohammad Raman Moloudi, Kambiz Hassanzade. N-acetylcysteine prevents rotenone-induced Parkinson's disease in rat: An investigation into the interaction of parkin and Drp1 proteins. Brain research bulletin. vol 113. 2016-01-04. PMID:25732239. |
dopamine levels of dopaminergic areas in rat brain including substantia nigra (sn) and striatum (st) were assessed using high performance liquid chromatography analysis to measure the loss of dopamine. |
2016-01-04 |
2023-08-13 |
rat |
| Lijuan Bai, Xique Zhang, Xiaohong Li, Na Liu, Fan Lou, Honglei Ma, Xiaoguang Luo, Yan Re. Somatostatin prevents lipopolysaccharide-induced neurodegeneration in the rat substantia nigra by inhibiting the activation of microglia. Molecular medicine reports. vol 12. issue 1. 2015-12-31. PMID:25777539. |
in the present study, a model of pd was generated by injecting lipopolysaccharide (lps) into the substantia nigra (sn) of rats in order to investigate the effects of sst on lps-induced degeneration of da in vivo. |
2015-12-31 |
2023-08-13 |
rat |
| E Dragicevic, J Schiemann, B Lis. Dopamine midbrain neurons in health and Parkinson's disease: emerging roles of voltage-gated calcium channels and ATP-sensitive potassium channels. Neuroscience. vol 284. 2015-12-30. PMID:25450964. |
da midbrain neurons within the substantia nigra (sn) and the ventral tegmental area (vta) exhibit a variety of distinct axonal projections and cellular properties, and are differentially affected in diseases like schizophrenia, attention deficit hyperactivity disorder, and parkinson's disease (pd). |
2015-12-30 |
2023-08-13 |
Not clear |
| L-H You, F Li, L Wang, S-E Zhao, S-M Wang, L-L Zhang, L-H Zhang, X-L Duan, P Yu, Y-Z Chan. Brain iron accumulation exacerbates the pathogenesis of MPTP-induced Parkinson's disease. Neuroscience. vol 284. 2015-12-22. PMID:25301748. |
brain iron levels are significantly increased in parkinson's disease (pd) and iron deposition is observed in the substantia nigra (sn) of pd patients. |
2015-12-22 |
2023-08-13 |
mouse |
| Kyoung Hoon Jeong, Min-Tae Jeon, Heung Deok Kim, Un Ju Jung, Min Cheol Jang, Jin Woo Chu, Seung Jun Yang, Il Yoon Choi, Myung-Sook Choi, Sang Ryong Ki. Nobiletin protects dopaminergic neurons in the 1-methyl-4-phenylpyridinium-treated rat model of Parkinson's disease. Journal of medicinal food. vol 18. issue 4. 2015-12-22. PMID:25325362. |
our results showed that nobiletin treatment at 10 mg/kg bw, but not at 1 or 20 mg/kg bw, significantly protected da neurons in the substantia nigra (sn) of mpp(+)-treated rats. |
2015-12-22 |
2023-08-13 |
rat |
| S Mitra, N Chakrabarti, S S Dutta, S Ray, P Bhattacharya, P Sinha, A Bhattacharyy. Gender-specific brain regional variation of neurons, endogenous estrogen, neuroinflammation and glial cells during rotenone-induced mouse model of Parkinson's disease. Neuroscience. vol 292. 2015-12-16. PMID:25592425. |
rotenone (rt) produces reactive oxygen species (ros) by inhibiting the mitochondrial electron transport chain; causing dopaminergic (da) cell death in the substantia nigra (sn) and simulates other models of induced parkinson's disease (pd). |
2015-12-16 |
2023-08-13 |
mouse |
| M D Sconce, M J Churchill, C Moore, C K Meshu. Intervention with 7,8-dihydroxyflavone blocks further striatal terminal loss and restores motor deficits in a progressive mouse model of Parkinson's disease. Neuroscience. vol 290. 2015-12-15. PMID:25655214. |
animals treated with mptp and 7,8-dhf also demonstrated increased levels of, a sprouting-associated protein, superior cervical ganglion-10 (scg10), phosphorylated trkb (ptrkb), and phosphorylated extracellular signal-regulated kinase 1/2 (perk1/2) within the dl striatum and substantia nigra (sn) compared to the 4-week mptp-treated animals. |
2015-12-15 |
2023-08-13 |
mouse |
| Xiang-Yun Li, Guang-Hai Mei, Qiang Dong, Yu Zhang, Zhuang-Li Guo, Jing-Jing Su, Yu-Ping Tang, Xue-Hong Jin, Hou-Guang Zhou, Yan-Yan Huan. Enhanced Neuroprotective Effects of Coadministration of Tetrandrine with Glutathione in Preclinical Model of Parkinson's Disease. Parkinson's disease. vol 2015. 2015-12-15. PMID:26664824. |
levels in the redox system, dopamine (da) metabolism, dopaminergic neuronal survival, and apoptosis of the substantia nigra (sn) and striatum, as well as the rotational behavior of animals were examined after a 50-day administration of gsh + tet (or gsh) and/or l-3,4-dihydroxyphenylalanine (l-dopa) to pd rats. |
2015-12-15 |
2023-08-13 |
rat |
| Wei Fang, Guodong Gao, Haikang Zhao, Yi Xia, Xiaodong Guo, Nan Li, Yuqian Li, Yang Yang, Lei Chen, Qiang Wang, Lihong L. Role of the Akt/GSK-3β/CRMP-2 pathway in axon degeneration of dopaminergic neurons resulting from MPP+ toxicity. Brain research. vol 1602. 2015-12-14. PMID:25150591. |
earlier reports suggest that the main pathological change in pd is due to apoptosis of dopaminergic neuronal soma in the substantia nigra (sn). |
2015-12-14 |
2023-08-13 |
Not clear |
| Kanji Matsukawa, Kei Ishii, Tomoko Ishida, Atsushi Nagai, Nan Lian. Stimulation of the mesencephalic ventral tegmental area blunts the sensitivity of cardiac baroreflex in decerebrate cats. Autonomic neuroscience : basic & clinical. vol 189. 2015-12-14. PMID:25600884. |
we have examined for the first time whether electrical stimulation of the mesencephalic ventral tegmental area (vta) or the substantia nigra (sn) was capable of suppressing cardiac baroreflex sensitivity in decerebrate cats. |
2015-12-14 |
2023-08-13 |
Not clear |
| Jeffrey Graham, Douglas Hobson, Arjuna Ponnampala. High affinity hemoglobin and Parkinson's disease. Medical hypotheses. vol 83. issue 6. 2015-12-08. PMID:25468785. |
parkinson's disease (pd) is a neurodegenerative disorder characterized by the loss of dopaminergic neurons in the substantia nigra (sn) region of the midbrain. |
2015-12-08 |
2023-08-13 |
human |
| Anna I Blazejewska, Ali M Al-Radaideh, Sam Wharton, Su Yin Lim, Richard W Bowtell, Cris S Constantinescu, Penny A Gowlan. Increase in the iron content of the substantia nigra and red nucleus in multiple sclerosis and clinically isolated syndrome: a 7 Tesla MRI study. Journal of magnetic resonance imaging : JMRI. vol 41. issue 4. 2015-12-07. PMID:24841344. |
to study iron deposition in the substantia nigra (sn) and red nuclei (rn), in patients with clinically isolated syndrome (cis) and relapsing remitting ms (rrms) and healthy controls (hc). |
2015-12-07 |
2023-08-13 |
Not clear |
| Jürgen Berg, Manfred Roch, Jennifer Altschüler, Christine Winter, Anne Schwerk, Andreas Kurtz, Barbara Steine. Human adipose-derived mesenchymal stem cells improve motor functions and are neuroprotective in the 6-hydroxydopamine-rat model for Parkinson's disease when cultured in monolayer cultures but suppress hippocampal neurogenesis and hippocampal memory function when cultured in spheroids. Stem cell reviews and reports. vol 11. issue 1. 2015-12-04. PMID:25120226. |
in the present study we compared monolayer-cultured (amsc) and spheroid (smsc) msc following transplantation into the substantia nigra (sn) of 6-ohda lesioned rats regarding effects on the local microenvironment, degeneration of dopaminergic neurons, neurogenesis in the hippocampal dg as well as motor and memory function in the 6-ohda-rat model for pd. |
2015-12-04 |
2023-08-13 |
human |
| S Reimão, P Pita Lobo, D Neutel, L Correia Guedes, M Coelho, M M Rosa, J Ferreira, D Abreu, N Gonçalves, C Morgado, R G Nunes, J Campos, J J Ferreir. Substantia nigra neuromelanin magnetic resonance imaging in de novo Parkinson's disease patients. European journal of neurology. vol 22. issue 3. 2015-12-03. PMID:25534480. |
depigmentation of the substantia nigra (sn) and locus coeruleus (lc) is a conspicuous pathological feature of parkinson's disease (pd) and is related to the loss of neuromelanin, whose paramagnetic properties result in high signal on specific t1-weighted magnetic resonance imaging (mri). |
2015-12-03 |
2023-08-13 |
Not clear |
| Jolanta Konieczny, Anna Czarnecka, Kinga Kamińska, Tomasz Lenda, Przemysław Nowa. Decreased behavioral response to intranigrally administered GABAA agonist muscimol in the lactacystin model of Parkinson's disease may result from partial lesion of nigral non-dopamine neurons: comparison to the classical neurotoxin 6-OHDA. Behavioural brain research. vol 283. 2015-12-02. PMID:25655509. |
therefore, our study was aimed to examine the toxic effect of intranigral administration of lactacystin on da and non-da neurons in the rat substantia nigra (sn), compared to the classic neurotoxin 6-ohda. |
2015-12-02 |
2023-08-13 |
rat |
| Dong-Hee Choi, Ji-Hye Kim, Joo-Ha Seo, Jongmin Lee, Wahn Soo Choi, Yoon-Seong Ki. Matrix metalloproteinase-3 causes dopaminergic neuronal death through Nox1-regenerated oxidative stress. PloS one. vol 9. issue 12. 2015-12-01. PMID:25536219. |
direct overexpression of autoactivated mmp3 (actmmp3) in n27 cells or in rat substantia nigra (sn) increased expression of nox1. |
2015-12-01 |
2023-08-13 |
mouse |
| Ariana Q Farrand, Rebecca A Gregory, Michael D Scofield, Kristi L Helke, Heather A Boge. Effects of aging on glutamate neurotransmission in the substantia nigra of Gdnf heterozygous mice. Neurobiology of aging. vol 36. issue 3. 2015-11-24. PMID:25577412. |
although the cause of nigrostriatal degeneration is unknown, one theory is that excess glutamate from the subthalamic nucleus results in excitotoxic events in the substantia nigra (sn). |
2015-11-24 |
2023-08-13 |
mouse |