| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| YuYing Huang, JunFang Chen, Ying Chen, YingHan Zhuang, Mu Sun, Thomas Behnisc. The neurotoxin 1-methyl-4-phenylpyridinium (MPP(+)) alters hippocampal excitatory synaptic transmission by modulation of the GABAergic system. Frontiers in cellular neuroscience. vol 9. 2015-08-24. PMID:26300734. |
a common view is that mptp is metabolized to 1-methyl-4-phenylpyridinium ion (mpp(+)) to induce its neurodegenerative effects on dopaminergic neurons in the substantia nigra (sn). |
2015-08-24 |
2023-08-13 |
mouse |
| Marina A Gruden, Tatiana V Davydova, Victor B Narkevich, Valentina G Fomina, Chao Wang, Vladimir S Kudrin, Ludmilla A Morozova-Roche, Robert D E Sewel. Noradrenergic and serotonergic neurochemistry arising from intranasal inoculation with α-synuclein aggregates which incite parkinsonian-like symptoms. Behavioural brain research. vol 279. 2015-08-20. PMID:25446742. |
levels of noradrenaline (na), serotonin (5-ht) and 5-hydroxyindoleacetic acid (5-hiaa) were detected using hplc with electrochemical detection in the substantia nigra (sn) and striatum. |
2015-08-20 |
2023-08-13 |
mouse |
| Liang Tan, Hongfei Ge, Jun Tang, Chuhua Fu, Wangsheng Duanmu, Yujie Chen, Rong Hu, Jianfeng Sui, Xin Liu, Hua Fen. Amantadine preserves dopamine level and attenuates depression-like behavior induced by traumatic brain injury in rats. Behavioural brain research. vol 279. 2015-08-20. PMID:25447294. |
the da concentration in the striatum of the injured rats, as well as the degeneration and apoptosis of dopaminergic neurons in the substantia nigra (sn), were checked along with the depression-like behavior. |
2015-08-20 |
2023-08-13 |
rat |
| Lucía F Cardo, Eliecer Coto, René Ribacoba, Manuel Menéndez, Germán Moris, Esther Suárez, Victoria Alvare. MiRNA profile in the substantia nigra of Parkinson's disease and healthy subjects. Journal of molecular neuroscience : MN. vol 54. issue 4. 2015-08-14. PMID:25284245. |
our aim was to characterize the level of mirnas in the substantia nigra (sn) of pd patients and healthy donors. |
2015-08-14 |
2023-08-13 |
human |
| Beatriz Raposo Corradini, Priscila Iamashita, Edilaine Tampellini, José Marcelo Farfel, Lea Tenenholz Grinberg, Carlos Alberto Moreira-Filh. Complex network-driven view of genomic mechanisms underlying Parkinson's disease: analyses in dorsal motor vagal nucleus, locus coeruleus, and substantia nigra. BioMed research international. vol 2014. 2015-08-12. PMID:25525598. |
to study the molecular mechanisms involved in idiopathic pd we conducted a comparative study of transcriptional interaction networks in the dorsal motor vagal nucleus (va), locus coeruleus (lc), and substantia nigra (sn) of idiopathic pd in braak stages 4-5 (pd) and disease-free controls (ct) using postmortem samples. |
2015-08-12 |
2023-08-13 |
Not clear |
| Yuka Hama, Ichiro Yabe, Koichi Wakabayashi, Takahiro Kano, Makoto Hirotani, Yuriko Iwakura, Jun Utsumi, Hidenao Sasak. Level of plasma neuregulin-1 SMDF is reduced in patients with idiopathic Parkinson's disease. Neuroscience letters. vol 587. 2015-08-10. PMID:25524406. |
parkinson's disease (pd) is characterised by the progressive loss of dopaminergic neurons, neurons that are regulated by the development, protection and function of neuregulin-1 (nrg1)-erbb4 signals, in the substantia nigra (sn). |
2015-08-10 |
2023-08-13 |
Not clear |
| Lanying Song, Gino Cortopass. Mitochondrial complex I defects increase ubiquitin in substantia nigra. Brain research. vol 1594. 2015-08-04. PMID:25446449. |
parkinson׳s disease (pd) is the second most common neurodegenerative disorder in the developed world, and is characterized by the loss of dopaminergic (da) neurons in the substantia nigra (sn) of midbrain. |
2015-08-04 |
2023-08-13 |
mouse |
| J A D Dela Cruz, R Schmidt-Kastner, J A A Stevens, H W M Steinbusch, B P F Rutte. Differential distribution of hypoxia-inducible factor 1-beta (ARNT or ARNT2) in mouse substantia nigra and ventral tegmental area. Journal of chemical neuroanatomy. vol 61-62. 2015-07-31. PMID:25017895. |
in the current study, we analyzed the hif-1 beta subunit, as formed by aryl hydrocarbon receptor nuclear translocator (arnt) or arnt2, in the mouse substantia nigra (sn) and the ventral tegmental area (vta). |
2015-07-31 |
2023-08-13 |
mouse |
| Xiangchuan Chen, Daniel E Huddleston, Jason Langley, Sinyeob Ahn, Christopher J Barnum, Stewart A Factor, Allan I Levey, Xiaoping H. Simultaneous imaging of locus coeruleus and substantia nigra with a quantitative neuromelanin MRI approach. Magnetic resonance imaging. vol 32. issue 10. 2015-07-30. PMID:25086330. |
quantitative mri of neuromelanin (nm) containing structures (referred to as nm-mri) in the brainstem, namely the locus coeruleus (lc) and substantia nigra (sn), may assist with the early detection of parkinson's disease (pd) and alzheimer's disease (ad) as well as differential diagnosis in the early disease stages. |
2015-07-30 |
2023-08-13 |
Not clear |
| Kim-Ann Saal, Jan C Koch, Lars Tatenhorst, Eva M Szegő, Vinicius Toledo Ribas, Uwe Michel, Mathias Bähr, Lars Tönges, Paul Lingo. AAV.shRNA-mediated downregulation of ROCK2 attenuates degeneration of dopaminergic neurons in toxin-induced models of Parkinson's disease in vitro and in vivo. Neurobiology of disease. vol 73. 2015-07-29. PMID:25283984. |
parkinson's disease (pd) is a neurodegenerative disorder with prominent neuronal cell death in the substantia nigra (sn) and other parts of the brain. |
2015-07-29 |
2023-08-13 |
rat |
| Wataru Sako, Nagahisa Murakami, Yuishin Izumi, Ryuji Kaj. MRI can detect nigral volume loss in patients with Parkinson's disease: evidence from a meta-analysis. Journal of Parkinson's disease. vol 4. issue 3. 2015-07-27. PMID:24577503. |
parkinson's disease (pd) involves the degeneration of dopaminergic neurons in substantia nigra (sn) compacta. |
2015-07-27 |
2023-08-12 |
Not clear |
| Zhi-Yong Wang, Hui Lian, Qing-Qing Cai, Hai-Yan Song, Xiao-Li Zhang, Li Zhou, Yi-Min Zhang, Li-Fei Zheng, Jin-Xia Zh. No direct projection is observed from the substantia nigra to the dorsal vagus complex in the rat. Journal of Parkinson's disease. vol 4. issue 3. 2015-07-27. PMID:24613863. |
parkinson's disease (pd) is a neurodegenerative disorder that is characterized by degeneration of dopaminergic neurons in the substantia nigra (sn). |
2015-07-27 |
2023-08-12 |
rat |
| Patrik Fazio, Per Svenningsson, Anton Forsberg, Erik G Jönsson, Nahid Amini, Ryuji Nakao, Sangram Nag, Christer Halldin, Lars Farde, Andrea Varron. Quantitative Analysis of ¹⁸F-(E)-N-(3-Iodoprop-2-Enyl)-2β-Carbofluoroethoxy-3β-(4'-Methyl-Phenyl) Nortropane Binding to the Dopamine Transporter in Parkinson Disease. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. vol 56. issue 5. 2015-07-24. PMID:25791993. |
(18)f-(e)-n-(3-iodoprop-2-enyl)-2β-carbofluoroethoxy-3β-(4'-methyl-phenyl) nortropane ((18)f-fe-pe2i) is a recently developed radioligand for the in vivo quantification of the dopamine transporter (dat) in the striatum and substantia nigra (sn). |
2015-07-24 |
2023-08-13 |
Not clear |
| Haiyin Wu, Brian O'Neill, Dawn D Han, Keerthi Thirtamara-Rajamani, Yanlin Wang, Howard H G. Restoration of cocaine stimulation and reward by reintroducing wild type dopamine transporter in adult knock-in mice with a cocaine-insensitive dopamine transporter. Neuropharmacology. vol 86. 2015-07-14. PMID:24835281. |
in the current study, we expanded the aav-datwt infected areas to cover the olfactory tubercle (tu) and the ventral midbrain (vmb) containing the ventral tegmental area (vta) and substantia nigra (sn) in addition to cpu and nac with multiple injections. |
2015-07-14 |
2023-08-13 |
mouse |
| Sachin P Patil, Pankaj D Jain, Jayant S Sancheti, Priya J Ghumatkar, Rufi Tambe, Sadhana Sathay. Neuroprotective and neurotrophic effects of Apigenin and Luteolin in MPTP induced parkinsonism in mice. Neuropharmacology. vol 86. 2015-07-14. PMID:25087727. |
tyrosine hydroxylase (th), glial fibrillary acidic protein (gfap) and brain derived neurotrophic factor (bdnf) were evaluated in substantia nigra (sn) region of the brain by immunostaining. |
2015-07-14 |
2023-08-13 |
mouse |
| Lucía F Cardo, Eliecer Coto, René Ribacoba, Ignacio F Mata, Germán Moris, Manuel Menéndez, Victoria Alvare. The screening of the 3'UTR sequence of LRRK2 identified an association between the rs66737902 polymorphism and Parkinson's disease. Journal of human genetics. vol 59. issue 6. 2015-07-13. PMID:24758914. |
we found a significant lower level of the lrrk2 transcript in the substantia nigra (sn) of pd postmortem donors (n=9) who were rs66737902 c carriers (p=0.01). |
2015-07-13 |
2023-08-13 |
Not clear |
| Mahalakshmi Subramaniam, Daniel Althof, Suzana Gispert, Jochen Schwenk, Georg Auburger, Akos Kulik, Bernd Fakler, Jochen Roepe. Mutant α-synuclein enhances firing frequencies in dopamine substantia nigra neurons by oxidative impairment of A-type potassium channels. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 34. issue 41. 2015-07-08. PMID:25297088. |
parkinson disease (pd) is an α-synucleinopathy resulting in the preferential loss of highly vulnerable dopamine (da) substantia nigra (sn) neurons. |
2015-07-08 |
2023-08-13 |
mouse |
| Mahmoud M Iravani, Mona Sadeghian, Sarah Rose, Peter Jenne. Loss of locus coeruleus noradrenergic neurons alters the inflammatory response to LPS in substantia nigra but does not affect nigral cell loss. Journal of neural transmission (Vienna, Austria : 1996). vol 121. issue 12. 2015-07-07. PMID:24781752. |
we examine if destruction of the locus coeruleus with n-(2-chloroethyl)-n-ethyl-2-bromobenzylamine (dsp-4) alters dopaminergic cell loss in substantia nigra (sn) initiated by lipopolysaccharide (lps) in the rat through an effect on glial cell activation. |
2015-07-07 |
2023-08-13 |
rat |
| Xiqi Liu, Rushing Shao, Meng Li, Guofeng Yan. Edaravone protects neurons in the rat substantia nigra against 6-hydroxydopamine-induced oxidative stress damage. Cell biochemistry and biophysics. vol 70. issue 2. 2015-07-02. PMID:24948472. |
to investigate the mechanism of the neuroprotective effect of edaravone in substantia nigra (sn) of the 6-ohda-induced rat model of parkinson's disease. |
2015-07-02 |
2023-08-13 |
rat |
| Hongcai Wang, Yan Chen, Jinbo Chen, Zhentao Zhang, Wansheng Lao, Xizhi Li, Jinsha Huang, Tao Wan. Cell cycle regulation of DNA polymerase beta in rotenone-based Parkinson's disease models. PloS one. vol 9. issue 10. 2015-06-23. PMID:25303312. |
the cell cycle was reactivated in cyclin d-expressing dopaminergic neurons from the substantia nigra (sn) of rats following stereotactic (st) infusion of rotenone. |
2015-06-23 |
2023-08-13 |
rat |