Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
Stéphane Lehéricy, Eric Bardinet, Cyril Poupon, Marie Vidailhet, Chantal Françoi. 7 Tesla magnetic resonance imaging: a closer look at substantia nigra anatomy in Parkinson's disease. Movement disorders : official journal of the Movement Disorder Society. vol 29. issue 13. 2015-06-22. PMID:25308960. |
until recently, imaging made only a modest contribution to detecting neurodegenerative changes in the substantia nigra (sn) directly. |
2015-06-22 |
2023-08-13 |
human |
Gesthimani Samiotaki, Camilo Acosta, Shutao Wang, Elisa E Konofago. Enhanced delivery and bioactivity of the neurturin neurotrophic factor through focused ultrasound-mediated blood--brain barrier opening in vivo. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. vol 35. issue 4. 2015-06-16. PMID:25586140. |
the brain's ascending nigrostriatal pathway is severely damaged in parkinson's disease (pd), and therefore the substantia nigra (sn) and striatal caudoputamen (cp) were selected as the target areas. |
2015-06-16 |
2023-08-13 |
Not clear |
Sabine Krabbe, Johanna Duda, Julia Schiemann, Christina Poetschke, Gaby Schneider, Eric R Kandel, Birgit Liss, Jochen Roeper, Eleanor H Simpso. Increased dopamine D2 receptor activity in the striatum alters the firing pattern of dopamine neurons in the ventral tegmental area. Proceedings of the National Academy of Sciences of the United States of America. vol 112. issue 12. 2015-06-15. PMID:25675529. |
here, we show that in vivo, both the firing rate (tonic activity) and burst firing (phasic activity) of identified midbrain da neurons are impaired in the ventral tegmental area (vta), but not in the substantia nigra (sn), of d2r-oe mice. |
2015-06-15 |
2023-08-13 |
mouse |
Diego Iacono, Maria Geraci-Erck, Hui Peng, Marcie L Rabin, Roger Kurla. Reduced Number of Pigmented Neurons in the Substantia Nigra of Dystonia Patients? Findings from Extensive Neuropathologic, Immunohistochemistry, and Quantitative Analyses. Tremor and other hyperkinetic movements (New York, N.Y.). vol 5. 2015-06-13. PMID:26069855. |
previous neuropathologic studies have reported generically defined neuronal loss in various cerebral regions of dys brains, mostly in the basal ganglia (bg), and specifically in the substantia nigra (sn). |
2015-06-13 |
2023-08-13 |
Not clear |
L P Voitenko, A G Nikonenk. [Modification of experimental rotenone model of Parkinson's disease]. Fiziolohichnyi zhurnal (Kiev, Ukraine : 1994). vol 61. issue 1. 2015-06-11. PMID:26040040. |
a modification of experimental model of parkinson's disease is proposed presuming the stereotaxic infusion of rotenone solution using a special device into the cental part of substantia nigra (sn) pars compacta of adult wistar rats. |
2015-06-11 |
2023-08-13 |
rat |
S P Patil, P D Jain, P J Ghumatkar, R Tambe, S Sathay. Neuroprotective effect of metformin in MPTP-induced Parkinson's disease in mice. Neuroscience. vol 277. 2015-06-08. PMID:25108167. |
dopaminergic degeneration was evaluated by analyzing the tyrosine hydroxylase (th) by immunostaining and nissl staining of the substantia nigra (sn) region of the brain. |
2015-06-08 |
2023-08-13 |
mouse |
Ye Lee Jun, Chang-Hwan Bae, Dongsoo Kim, Sungtae Koo, Seungtae Ki. Korean Red Ginseng protects dopaminergic neurons by suppressing the cleavage of p35 to p25 in a Parkinson's disease mouse model. Journal of ginseng research. vol 39. issue 2. 2015-06-05. PMID:26045688. |
the present study investigated a possible role of korean red ginseng (krg) in suppressing dopaminergic neuronal cell death and the cleavage of p35 to p25 in the substantia nigra (sn) and striatum (st) using a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp)-induced parkinson's disease mouse model. |
2015-06-05 |
2023-08-13 |
mouse |
Annamaria Lanzillotta, Vanessa Porrini, Arianna Bellucci, Marina Benarese, Caterina Branca, Edoardo Parrella, Pier Franco Spano, Marina Pizz. NF-κB in Innate Neuroprotection and Age-Related Neurodegenerative Diseases. Frontiers in neurology. vol 6. 2015-06-04. PMID:26042083. |
constitutive knockout of c-rel shatters the resilience of substantia nigra (sn) dopaminergic (da) neurons to aging and induces a parkinsonian like pathology in mice. |
2015-06-04 |
2023-08-13 |
mouse |
Vladimir Miletić, David Ozretić, Maja Relj. Parkinsonian syndrome and ataxia as a presenting finding of acquired hepatocerebral degeneration. Metabolic brain disease. vol 29. issue 1. 2015-06-02. PMID:24390157. |
predilection brain regions for manganese deposits are globus pallidum (gp) and substantia nigra (sn). |
2015-06-02 |
2023-08-12 |
Not clear |
Govindasamy Pushpavathi Selvakumar, Udaiyappan Janakiraman, Musthafa Mohamed Essa, Arokiasamy Justin Thenmozhi, Thamilarasan Manivasaga. Escin attenuates behavioral impairments, oxidative stress and inflammation in a chronic MPTP/probenecid mouse model of Parkinson's disease. Brain research. vol 1585. 2015-06-02. PMID:24657313. |
parkinson's disease (pd) is a progressive neurodegenerative disorder that results mainly due to the death of dopaminergic neurons in the substantia nigra (sn), and subsequently has an effect on one's motor function and coordination. |
2015-06-02 |
2023-08-12 |
mouse |
Karlijn J Doorn, Tim Moors, Benjamin Drukarch, Wilma Dj van de Berg, Paul J Lucassen, Anne-Marie van Da. Microglial phenotypes and toll-like receptor 2 in the substantia nigra and hippocampus of incidental Lewy body disease cases and Parkinson's disease patients. Acta neuropathologica communications. vol 2. 2015-05-29. PMID:25099483. |
next to α-synuclein deposition, microglial activation is a prominent pathological feature in the substantia nigra (sn) of parkinson's disease (pd) patients. |
2015-05-29 |
2023-08-13 |
Not clear |
Alice Grison, Silvia Zucchelli, Alice Urzì, Ilaria Zamparo, Dejan Lazarevic, Giovanni Pascarella, Paola Roncaglia, Alejandro Giorgetti, Paula Garcia-Esparcia, Christina Vlachouli, Roberto Simone, Francesca Persichetti, Alistair R R Forrest, Yoshihide Hayashizaki, Paolo Carloni, Isidro Ferrer, Claudia Lodovichi, Charles Plessy, Piero Carninci, Stefano Gustincic. Mesencephalic dopaminergic neurons express a repertoire of olfactory receptors and respond to odorant-like molecules. BMC genomics. vol 15. 2015-05-28. PMID:25164183. |
the mesencephalic dopaminergic (mda) cell system is composed of two major groups of projecting cells in the substantia nigra (sn) (a9 neurons) and the ventral tegmental area (vta) (a10 cells). |
2015-05-28 |
2023-08-13 |
Not clear |
Stefanie L O'Neal, Jang-Won Lee, Wei Zheng, Jason R Canno. Subacute manganese exposure in rats is a neurochemical model of early manganese toxicity. Neurotoxicology. vol 44. 2015-05-27. PMID:25117542. |
the current study used high performance liquid chromatography to quantify neurotransmitter levels in rat striatum (str), substantia nigra (sn), and hippocampus (hp). |
2015-05-27 |
2023-08-13 |
rat |
P Abate, K Hernández-Fonseca, A C Reyes-Guzmán, I G Barbosa-Luna, M Ménde. Prenatal ethanol exposure alters met-enkephalin expression in brain regions related with reinforcement: possible mechanism for ethanol consumption in offspring. Behavioural brain research. vol 274. 2015-05-26. PMID:25150040. |
met-enk content was assessed in the ventral tegmental area [vta], nucleus accumbens [nacc], prefrontal cortex [pfc], substantia nigra [sn], caudate-putamen [cp], amygdala, hypothalamus and hippocampus. |
2015-05-26 |
2023-08-13 |
rat |
Nina Daschil, Christian Humpe. Nifedipine and nimodipine protect dopaminergic substantia nigra neurons against axotomy-induced cell death in rat vibrosections via modulating inflammatory responses. Brain research. vol 1581. 2015-05-21. PMID:25038562. |
however, nimodipine and nifedipine significantly enhanced the survival of dopaminergic substantia nigra (sn) but not ventral tegmental area (vta) neurons, while nicardipine, isradipine and verapamil had no effect. |
2015-05-21 |
2023-08-13 |
rat |
Hashem Haghdoost-Yazdi, Mohammad Sarookhani, Ayda Faraj, Negin Fraidouni, Tahereh Dargahi, Mohammad Hosein Yaghoubidoust, Hassan Azhdari-Zarmehr. Evaluation of the association between blood homocysteine concentration and the degree of behavioral symptoms in the 6-hydroxydopamine-induced Parkinsonism in rat. Pharmacology, biochemistry, and behavior. vol 124. 2015-05-19. PMID:24992727. |
considering the direct correlation between the severity of rotational behavior and the degree of lesion in the substantia nigra (sn), our data indicate that higher thcy values can predict higher sn dopaminergic neurodegeneration. |
2015-05-19 |
2023-08-13 |
rat |
Sujung Yeo, Keon Sang An, Yeon-Mi Hong, Yeong-Gon Choi, Bruce Rosen, Sung-Hoon Kim, Sabina Li. Neuroprotective changes in degeneration-related gene expression in the substantia nigra following acupuncture in an MPTP mouse model of Parkinsonism: Microarray analysis. Genetics and molecular biology. vol 38. issue 1. 2015-05-18. PMID:25983633. |
parkinson's disease (pd) is a neurodegenerative disorder characterized by the death of dopamine-generating cells in the substantia nigra (sn). |
2015-05-18 |
2023-08-13 |
mouse |
Jin-Lan Meng, Yuan-Yi Ma, Hai-Yun Luo, Shu-Zhen Kong, Yong-Wen He, Bao-Cai Dong, Shi-Hao Wu, Min H. [Estrogen protects the dopaminergic neurons in substantia nigra against damage induced by 6-hydroxydopamine]. Sheng li xue bao : [Acta physiologica Sinica]. vol 60. issue 3. 2015-05-16. PMID:18560728. |
until now there is lack of animal experimental data on the supportive effect of estrogen on function of dopaminergic neurons in substantia nigra (sn) in physiological state. |
2015-05-16 |
2023-08-12 |
human |
Vishnu P Murty, Maheen Shermohammed, David V Smith, R McKell Carter, Scott A Huettel, R Alison Adcoc. Resting state networks distinguish human ventral tegmental area from substantia nigra. NeuroImage. vol 100. 2015-05-12. PMID:24979343. |
one schema originating in rodent models delineated ventral tegmental area (vta), implicated in complex behaviors like addiction, from more lateral substantia nigra (sn), preferentially implicated in movement. |
2015-05-12 |
2023-08-13 |
human |
Kuldip D Dave, Shehan De Silva, Niketa P Sheth, Sylvie Ramboz, Melissa J Beck, Changyu Quang, Robert C Switzer, Syed O Ahmad, Susan M Sunkin, Dan Walker, Xiaoxia Cui, Daniel A Fisher, Aaron M McCoy, Kevin Gamber, Xiaodong Ding, Matthew S Goldberg, Stanley A Benkovic, Meredith Haupt, Marco A S Baptista, Brian K Fiske, Todd B Sherer, Mark A Frasie. Phenotypic characterization of recessive gene knockout rat models of Parkinson's disease. Neurobiology of disease. vol 70. 2015-04-21. PMID:24969022. |
these results demonstrate that inactivation of the pink1 or dj-1 genes in the rat produces progressive neurodegeneration and early behavioral deficits, suggesting that these recessive genes may be essential for the survival of dopaminergic neurons in the substantia nigra (sn). |
2015-04-21 |
2023-08-13 |
rat |