| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Fan Yang, Yunhui Liu, Jie Tu, Jun Wan, Jie Zhang, Bifeng Wu, Shanping Chen, Jiawei Zhou, Yangling Mu, Liping Wan. Activated astrocytes enhance the dopaminergic differentiation of stem cells and promote brain repair through bFGF. Nature communications. vol 5. 2015-10-02. PMID:25517983. |
light activation of transplanted astrocytes in the substantia nigra (sn) also upregulates bfgf levels in vivo and promotes the regenerative effects of co-transplanted stem cells. |
2015-10-02 |
2023-08-13 |
mouse |
| Julia Kraemmer, Gabor G Kovacs, Laura Perju-Dumbrava, Susanne Pirker, Tatiana Traub-Weidinger, Walter Pirke. Correlation of striatal dopamine transporter imaging with post mortem substantia nigra cell counts. Movement disorders : official journal of the Movement Disorder Society. vol 29. issue 14. 2015-09-21. PMID:25048738. |
only limited data are available on the relationship between striatal dopamine transporter binding and dopaminergic cell loss in the substantia nigra (sn). |
2015-09-21 |
2023-08-13 |
human |
| b' Selva Moheb Saadat, \\xc4\\xb0rfan De\\xc4\\x9firmenci, Serhat \\xc3\\x96zkan, Faruk Saydam, Zeynep \\xc3\\x96zdemir K\\xc3\\xb6ro\\xc4\\x9flu, Ertu\\xc4\\x9frul \\xc3\\x87olak, Hasan Veysi G\\xc3\\xbcne\\xc5\\x9. Is the 1254T>C polymorphism in the DMT1 gene associated with Parkinson\'s disease? Neuroscience letters. vol 594. 2015-09-14. PMID:25817364.' |
the main pathological characteristic of pd is the death of dopaminergic neurons in the substantia nigra (sn) pars compacta. |
2015-09-14 |
2023-08-13 |
Not clear |
| Qian Wang, Hui Zhang, Ming Liu, Zuofeng Zhang, Zifeng Wei, Na Sun, Tongyao Mao, Yuxin Zhan. [P38 MAPK signaling pathway regulates nuclear factor-κB and inducible nitric oxide synthase expressions in the substantia nigra in a mouse model of Parkinson's disease]. Nan fang yi ke da xue xue bao = Journal of Southern Medical University. vol 34. issue 8. 2015-09-01. PMID:25176090. |
to investigate the role of p38 mitogen-activated protein kinase (p38 mapk) signaling pathway in regulating the expression of nuclear factor-κb (nf-κb) and inducible nitric oxide synthase (inos) in the substantia nigra (sn) of a mouse model of parkinson's disease (pd). |
2015-09-01 |
2023-08-13 |
mouse |
| Max C Keuken, Birte U Forstman. A probabilistic atlas of the basal ganglia using 7 T MRI. Data in brief. vol 4. 2015-08-31. PMID:26322322. |
the atlas includes six subcortical nuclei: the striatum (str), the globus pallidus internal and external segment (gpi/e), the subthalamic nucleus (stn), the substantia nigra (sn), and the red nucleus (rn). |
2015-08-31 |
2023-08-13 |
Not clear |
| A Harkavyi, N Rampersaud, P S Whitto. Neuroprotection by Exendin-4 Is GLP-1 Receptor Specific but DA D3 Receptor Dependent, Causing Altered BrdU Incorporation in Subventricular Zone and Substantia Nigra. Journal of neurodegenerative diseases. vol 2013. 2015-08-28. PMID:26316987. |
in the present study, we determined the effects of ex-4 on cellular brdu incorporation in the rat subventricular zone (svz) and substantia nigra (sn). |
2015-08-28 |
2023-08-13 |
rat |
| Rita Kumari, J B Senthil Kumar, Pratibha Mehta Luthr. Post-lesion administration of 7-NI attenuated motor and non-motor deficits in 6-OHDA induced bilaterally lesioned female rat model of Parkinson's disease. Neuroscience letters. vol 589. 2015-08-27. PMID:25528406. |
sprague-dawley female rats with bilateral intraventricular injection of either 6-ohda (10.5μg) (n=8-11/group) or saline (sham; n=8/group) at substantia nigra (sn) were provided with 7-ni (30mg/kg/day) intraperitoneal, once a day during the 3 consecutive days of short term treatment. |
2015-08-27 |
2023-08-13 |
rat |
| YuYing Huang, JunFang Chen, Ying Chen, YingHan Zhuang, Mu Sun, Thomas Behnisc. The neurotoxin 1-methyl-4-phenylpyridinium (MPP(+)) alters hippocampal excitatory synaptic transmission by modulation of the GABAergic system. Frontiers in cellular neuroscience. vol 9. 2015-08-24. PMID:26300734. |
a common view is that mptp is metabolized to 1-methyl-4-phenylpyridinium ion (mpp(+)) to induce its neurodegenerative effects on dopaminergic neurons in the substantia nigra (sn). |
2015-08-24 |
2023-08-13 |
mouse |
| Marina A Gruden, Tatiana V Davydova, Victor B Narkevich, Valentina G Fomina, Chao Wang, Vladimir S Kudrin, Ludmilla A Morozova-Roche, Robert D E Sewel. Noradrenergic and serotonergic neurochemistry arising from intranasal inoculation with α-synuclein aggregates which incite parkinsonian-like symptoms. Behavioural brain research. vol 279. 2015-08-20. PMID:25446742. |
levels of noradrenaline (na), serotonin (5-ht) and 5-hydroxyindoleacetic acid (5-hiaa) were detected using hplc with electrochemical detection in the substantia nigra (sn) and striatum. |
2015-08-20 |
2023-08-13 |
mouse |
| Liang Tan, Hongfei Ge, Jun Tang, Chuhua Fu, Wangsheng Duanmu, Yujie Chen, Rong Hu, Jianfeng Sui, Xin Liu, Hua Fen. Amantadine preserves dopamine level and attenuates depression-like behavior induced by traumatic brain injury in rats. Behavioural brain research. vol 279. 2015-08-20. PMID:25447294. |
the da concentration in the striatum of the injured rats, as well as the degeneration and apoptosis of dopaminergic neurons in the substantia nigra (sn), were checked along with the depression-like behavior. |
2015-08-20 |
2023-08-13 |
rat |
| Lucía F Cardo, Eliecer Coto, René Ribacoba, Manuel Menéndez, Germán Moris, Esther Suárez, Victoria Alvare. MiRNA profile in the substantia nigra of Parkinson's disease and healthy subjects. Journal of molecular neuroscience : MN. vol 54. issue 4. 2015-08-14. PMID:25284245. |
our aim was to characterize the level of mirnas in the substantia nigra (sn) of pd patients and healthy donors. |
2015-08-14 |
2023-08-13 |
human |
| Beatriz Raposo Corradini, Priscila Iamashita, Edilaine Tampellini, José Marcelo Farfel, Lea Tenenholz Grinberg, Carlos Alberto Moreira-Filh. Complex network-driven view of genomic mechanisms underlying Parkinson's disease: analyses in dorsal motor vagal nucleus, locus coeruleus, and substantia nigra. BioMed research international. vol 2014. 2015-08-12. PMID:25525598. |
to study the molecular mechanisms involved in idiopathic pd we conducted a comparative study of transcriptional interaction networks in the dorsal motor vagal nucleus (va), locus coeruleus (lc), and substantia nigra (sn) of idiopathic pd in braak stages 4-5 (pd) and disease-free controls (ct) using postmortem samples. |
2015-08-12 |
2023-08-13 |
Not clear |
| Yuka Hama, Ichiro Yabe, Koichi Wakabayashi, Takahiro Kano, Makoto Hirotani, Yuriko Iwakura, Jun Utsumi, Hidenao Sasak. Level of plasma neuregulin-1 SMDF is reduced in patients with idiopathic Parkinson's disease. Neuroscience letters. vol 587. 2015-08-10. PMID:25524406. |
parkinson's disease (pd) is characterised by the progressive loss of dopaminergic neurons, neurons that are regulated by the development, protection and function of neuregulin-1 (nrg1)-erbb4 signals, in the substantia nigra (sn). |
2015-08-10 |
2023-08-13 |
Not clear |
| Lanying Song, Gino Cortopass. Mitochondrial complex I defects increase ubiquitin in substantia nigra. Brain research. vol 1594. 2015-08-04. PMID:25446449. |
parkinson׳s disease (pd) is the second most common neurodegenerative disorder in the developed world, and is characterized by the loss of dopaminergic (da) neurons in the substantia nigra (sn) of midbrain. |
2015-08-04 |
2023-08-13 |
mouse |
| J A D Dela Cruz, R Schmidt-Kastner, J A A Stevens, H W M Steinbusch, B P F Rutte. Differential distribution of hypoxia-inducible factor 1-beta (ARNT or ARNT2) in mouse substantia nigra and ventral tegmental area. Journal of chemical neuroanatomy. vol 61-62. 2015-07-31. PMID:25017895. |
in the current study, we analyzed the hif-1 beta subunit, as formed by aryl hydrocarbon receptor nuclear translocator (arnt) or arnt2, in the mouse substantia nigra (sn) and the ventral tegmental area (vta). |
2015-07-31 |
2023-08-13 |
mouse |
| Xiangchuan Chen, Daniel E Huddleston, Jason Langley, Sinyeob Ahn, Christopher J Barnum, Stewart A Factor, Allan I Levey, Xiaoping H. Simultaneous imaging of locus coeruleus and substantia nigra with a quantitative neuromelanin MRI approach. Magnetic resonance imaging. vol 32. issue 10. 2015-07-30. PMID:25086330. |
quantitative mri of neuromelanin (nm) containing structures (referred to as nm-mri) in the brainstem, namely the locus coeruleus (lc) and substantia nigra (sn), may assist with the early detection of parkinson's disease (pd) and alzheimer's disease (ad) as well as differential diagnosis in the early disease stages. |
2015-07-30 |
2023-08-13 |
Not clear |
| Kim-Ann Saal, Jan C Koch, Lars Tatenhorst, Eva M Szegő, Vinicius Toledo Ribas, Uwe Michel, Mathias Bähr, Lars Tönges, Paul Lingo. AAV.shRNA-mediated downregulation of ROCK2 attenuates degeneration of dopaminergic neurons in toxin-induced models of Parkinson's disease in vitro and in vivo. Neurobiology of disease. vol 73. 2015-07-29. PMID:25283984. |
parkinson's disease (pd) is a neurodegenerative disorder with prominent neuronal cell death in the substantia nigra (sn) and other parts of the brain. |
2015-07-29 |
2023-08-13 |
rat |
| Wataru Sako, Nagahisa Murakami, Yuishin Izumi, Ryuji Kaj. MRI can detect nigral volume loss in patients with Parkinson's disease: evidence from a meta-analysis. Journal of Parkinson's disease. vol 4. issue 3. 2015-07-27. PMID:24577503. |
parkinson's disease (pd) involves the degeneration of dopaminergic neurons in substantia nigra (sn) compacta. |
2015-07-27 |
2023-08-12 |
Not clear |
| Zhi-Yong Wang, Hui Lian, Qing-Qing Cai, Hai-Yan Song, Xiao-Li Zhang, Li Zhou, Yi-Min Zhang, Li-Fei Zheng, Jin-Xia Zh. No direct projection is observed from the substantia nigra to the dorsal vagus complex in the rat. Journal of Parkinson's disease. vol 4. issue 3. 2015-07-27. PMID:24613863. |
parkinson's disease (pd) is a neurodegenerative disorder that is characterized by degeneration of dopaminergic neurons in the substantia nigra (sn). |
2015-07-27 |
2023-08-12 |
rat |
| Patrik Fazio, Per Svenningsson, Anton Forsberg, Erik G Jönsson, Nahid Amini, Ryuji Nakao, Sangram Nag, Christer Halldin, Lars Farde, Andrea Varron. Quantitative Analysis of ¹⁸F-(E)-N-(3-Iodoprop-2-Enyl)-2β-Carbofluoroethoxy-3β-(4'-Methyl-Phenyl) Nortropane Binding to the Dopamine Transporter in Parkinson Disease. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. vol 56. issue 5. 2015-07-24. PMID:25791993. |
(18)f-(e)-n-(3-iodoprop-2-enyl)-2β-carbofluoroethoxy-3β-(4'-methyl-phenyl) nortropane ((18)f-fe-pe2i) is a recently developed radioligand for the in vivo quantification of the dopamine transporter (dat) in the striatum and substantia nigra (sn). |
2015-07-24 |
2023-08-13 |
Not clear |