| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xian-Ming Luo, Hai Lin, Wei Wang, Marilyn S Geaney, Lee Law, Shaun Wynyard, Shamim B Shaikh, Henry Waldvogel, Richard L M Faull, Robert B Elliott, Stephen J M Skinner, Jacqueline E Lee, Paul L-J Ta. Recovery of neurological functions in non-human primate model of Parkinson's disease by transplantation of encapsulated neonatal porcine choroid plexus cells. Journal of Parkinson's disease. vol 3. issue 3. 2014-06-17. PMID:24002224. |
parkinson's disease (pd) is a neurodegenerative disease that is primarily characterized by degeneration of dopaminergic (da) neurons in the substantia nigra (sn) and a loss of their fibre projections in the striatum. |
2014-06-17 |
2023-08-12 |
monkey |
| Michael F Salvator. ser31 Tyrosine hydroxylase phosphorylation parallels differences in dopamine recovery in nigrostriatal pathway following 6-OHDA lesion. Journal of neurochemistry. vol 129. issue 3. 2014-06-04. PMID:24410633. |
the tissue content of da was determined against th protein loss in the striatum and substantia nigra (sn) following 6-hydroxydopamine lesion in the medial forebrain bundle in young sprague-dawley male rats. |
2014-06-04 |
2023-08-12 |
rat |
| Hong-Mei Wang, Ting Zhang, Qiang Li, Jian-Kang Huang, Rong-Fu Chen, Xiao-Jiang Su. Inhibition of glycogen synthase kinase-3β by lithium chloride suppresses 6-hydroxydopamine-induced inflammatory response in primary cultured astrocytes. Neurochemistry international. vol 63. issue 5. 2014-06-02. PMID:23871716. |
activated microglia and astrocytes are found in the substantia nigra (sn) of parkinson's disease brains as well as in animal models of parkinson's disease. |
2014-06-02 |
2023-08-12 |
Not clear |
| Marianna A Pagida, Anastasia E Konstantinidou, Effrosini Tsekoura, Efstratios Patsouris, Maria T Panayotacopoulo. Immunohistochemical demonstration of urocortin 1 in Edinger-Westphal nucleus of the human neonate: colocalization with tyrosine hydroxylase under acute perinatal hypoxia. Neuroscience letters. vol 554. 2014-05-16. PMID:24012814. |
increased expression of tyrosine hydroxylase (th) was shown in the substantia nigra (sn) and ventral tegmental area (vta) of human neonates that suffered severe/acute perinatal hypoxic insults, but also in all neurons of the edinger-westphal nucleus (ew). |
2014-05-16 |
2023-08-12 |
human |
| Tobias Böttcher, Arndt Rolfs, Bianca Meyer, Annette Grossmann, Daniela Berg, Peter Kropp, Reiner Benecke, Uwe Walte. Clinical, genetic, and brain sonographic features related to Parkinson's disease in Gaucher disease. Journal of neurology. vol 260. issue 10. 2014-05-13. PMID:23811968. |
substantia nigra (sn) hyperechogenicity, a sonographic feature thought to reflect iron accumulation, has been described in both pd and gaucher disease patients. |
2014-05-13 |
2023-08-12 |
human |
| Andreas Hermann, Kai F Loewenbrück, Änne Boldt, Christiane Fiedler, Martina Maisel, Joanna Kalucka, Johannes Schwarz, Georg Breier, Alexander Storc. Lack of vascular endothelial growth factor receptor-2/Flk1 signaling does not affect substantia nigra development. Neuroscience letters. vol 553. 2014-05-08. PMID:23994060. |
in the substantia nigra (sn) of adult flk1 cko mice, nonbiased stereological cell counts revealed no reduction of th-positive neurons of flk1 cko mice compared with control cre/wt mice (in which the wild-type flk1 allele is expressed in parallel with the cre recombinase allele). |
2014-05-08 |
2023-08-12 |
mouse |
| Hyo Geun Kim, Tae-mi Kim, Gunhyuk Park, Tae Hee Lee, Myung Sook O. Repeated heat exposure impairs nigrostriatal dopaminergic neurons in mice. Biological & pharmaceutical bulletin. vol 36. issue 10. 2014-04-28. PMID:23842035. |
then, we conducted a histological analysis using tyrosine hydroxylase (th) immunoreactivity in the striatum and substantia nigra (sn). |
2014-04-28 |
2023-08-12 |
mouse |
| Christopher D Herzog, Lamar Brown, Brian R Kruegel, Alistair Wilson, Malú G Tansey, Fred H Gage, Eugene M Johnson, Raymond T Bartu. Enhanced neurotrophic distribution, cell signaling and neuroprotection following substantia nigral versus striatal delivery of AAV2-NRTN (CERE-120). Neurobiology of disease. vol 58. 2014-04-23. PMID:23631873. |
we tested whether a significantly greater neurotrophic response might be induced in sn neurons when the neurotrophic factor neurturin (nrtn) is also targeted to the substantia nigra (sn), compared to the more conventional, striatum-only target. |
2014-04-23 |
2023-08-12 |
Not clear |
| Philipp Mahlknecht, Klaus Seppi, Heike Stockner, Michael Nocker, Christoph Scherfler, Stefan Kiechl, Johann Willeit, Christoph Schmidauer, Arno Gasperi, Gregorio Rungger, Werner Poew. Substantia nigra hyperechogenicity as a marker for Parkinson's disease: a population-based study. Neuro-degenerative diseases. vol 12. issue 4. 2014-04-21. PMID:23689066. |
according to hospital-based studies, an enlarged echogenicity in the area of the substantia nigra (sn) assessed with transcranial sonography (tcs) may represent a useful biomarker in the diagnosis of pd. |
2014-04-21 |
2023-08-12 |
Not clear |
| Angélique Virgone-Carlotta, Josselin Uhlrich, Muhammad Numan Akram, Denis Ressnikoff, Fabrice Chrétien, Chantal Domenget, Romain Gherardi, Geneviève Despars, Pierre Jurdic, Jérôme Honnorat, Serge Nataf, Monique Toure. Mapping and kinetics of microglia/neuron cell-to-cell contacts in the 6-OHDA murine model of Parkinson's disease. Glia. vol 61. issue 10. 2014-03-27. PMID:23893349. |
indeed, we sought to map microglia/neuron appositions in substantia nigra (sn) of 6-ohda injected c57bl/6 mice and cx3cr1/(gfp/+) mice. |
2014-03-27 |
2023-08-12 |
mouse |
| Shu-Juan Fan, Frank Y Lee, Matthew M Cheung, Abby Y Ding, Jian Yang, Samantha J Ma, Pek-Lan Khong, Ed X W. Bilateral substantia nigra and pyramidal tract changes following experimental intracerebral hemorrhage: an MR diffusion tensor imaging study. NMR in biomedicine. vol 26. issue 9. 2014-03-25. PMID:23417762. |
secondary injury of the ipsilateral substantia nigra (sn) and pyramidal tract (py) is common after cerebral stroke. |
2014-03-25 |
2023-08-12 |
rat |
| Gabriela Oana Bodea, Jan-Hendrik Spille, Philipp Abe, Aycan Senturk Andersson, Amparo Acker-Palmer, Ralf Stumm, Ulrich Kubitscheck, Sandra Blaes. Reelin and CXCL12 regulate distinct migratory behaviors during the development of the dopaminergic system. Development (Cambridge, England). vol 141. issue 3. 2014-03-20. PMID:24449842. |
the proper functioning of the dopaminergic system requires the coordinated formation of projections extending from dopaminergic neurons in the substantia nigra (sn), ventral tegmental area (vta) and retrorubral field to a wide array of forebrain targets including the striatum, nucleus accumbens and prefrontal cortex. |
2014-03-20 |
2023-08-12 |
mouse |
| Eun-Ju Kang, Young-Hyurk Lee, Min-Jeong Kim, Yeon-Mi Lee, B Mohana Kumar, Byeong-Gyun Jeon, Sun-A Ock, Hyun-Joon Kim, Gyu-Jin Rh. Transplantation of porcine umbilical cord matrix mesenchymal stem cells in a mouse model of Parkinson's disease. Journal of tissue engineering and regenerative medicine. vol 7. issue 3. 2014-03-19. PMID:22081626. |
based on these findings, ucm-mscs were transplanted into the right substantia nigra (sn) of a mouse pd model. |
2014-03-19 |
2023-08-12 |
mouse |
| Zhixiang Wu, Yinghua Yu, Yizhen Wu, Craig Patch, Alexander Szabo, Xu-Feng Huan. Reduction of histamine H1 receptor binding induced by high-fat diet can be prevented by DHA and dietary fiber in specific brain areas of male rats. Brain research bulletin. vol 97. 2014-03-18. PMID:23817050. |
we found that hf diet significantly decreased h1r binding densities in the substantia nigra (sn), caudate putamen (cpu), hypothalamic arcuate nucleus (arc), ventral tegmental area (vta), piriform cortex (pir) and primary motor cortex (m1), compared with low-fat fed rats, and the suppression of receptor binding density ranged from 31% to 48%. |
2014-03-18 |
2023-08-12 |
rat |
| Rashika N Karunasinghe, Janusz Lipsk. Oxygen and glucose deprivation (OGD)-induced spreading depression in the Substantia Nigra. Brain research. vol 1527. 2014-03-14. PMID:23796781. |
although sd has been well characterized in the cerebral cortex and hippocampus, little is known of this event in the substantia nigra (sn), a brainstem nucleus engaged in motor control and reward-related behavior. |
2014-03-14 |
2023-08-12 |
human |
| N Emmanuel Díaz-Martínez, Elisa Tamariz, N Fabián Díaz, Claudia M García-Peña, Alfredo Varela-Echavarría, Iván Velasc. Recovery from experimental parkinsonism by semaphorin-guided axonal growth of grafted dopamine neurons. Molecular therapy : the journal of the American Society of Gene Therapy. vol 21. issue 8. 2014-03-06. PMID:23732989. |
one strategy to promote axonal growth of dopaminergic neurons from the substantia nigra (sn) to the striatum is degradation of inhibitory components such as chondroitin sulphate proteoglycans (cspg). |
2014-03-06 |
2023-08-12 |
rat |
| Zhengwei Cai, Lir-Wan Fan, Asuka Kaizaki, Lu-Tai Tien, Tangeng Ma, Yi Pang, Shuying Lin, Rick C S Lin, Kimberly L Simpso. Neonatal systemic exposure to lipopolysaccharide enhances susceptibility of nigrostriatal dopaminergic neurons to rotenone neurotoxicity in later life. Developmental neuroscience. vol 35. issue 2-3. 2014-03-05. PMID:23446007. |
systemically administered lps can penetrate into the neonatal rat brain and cause acute and chronic brain inflammation, as evidenced by persistent increases in il-1β levels, cyclooxygenase-2 expression and microglial activation in the substantia nigra (sn) of p70 rats. |
2014-03-05 |
2023-08-12 |
rat |
| María Sierra, Jon Infante, José Bercian. Substantia nigra echogenicity in Friedreich's ataxia patients. Cerebellum (London, England). vol 12. issue 4. 2014-03-03. PMID:23239281. |
the aim of this study is to assess the presence of substantia nigra (sn) hypoechogenicity in a cohort of friedreich's ataxia (frda) patients and its possible association with restless syndrome (rls). |
2014-03-03 |
2023-08-12 |
human |
| Kiyoka Kinugawa, Yann Monnet, Catherine Béchade, Daniel Alvarez-Fischer, Etienne C Hirsch, Alain Bessis, Stéphane Huno. DAP12 and CD11b contribute to the microglial-induced death of dopaminergic neurons in vitro but not in vivo in the MPTP mouse model of Parkinson's disease. Journal of neuroinflammation. vol 10. 2014-03-03. PMID:23844828. |
parkinson's disease (pd) is a neurodegenerative disorder characterized by a loss of dopaminergic neurons (dn) in the substantia nigra (sn). |
2014-03-03 |
2023-08-12 |
mouse |
| Maik M A Worlitzer, Thomas Viel, Andreas H Jacobs, Jens C Schwambor. The majority of newly generated cells in the adult mouse substantia nigra express low levels of Doublecortin, but their proliferation is unaffected by 6-OHDA-induced nigral lesion or Minocycline-mediated inhibition of neuroinflammation. The European journal of neuroscience. vol 38. issue 5. 2014-02-26. PMID:23734736. |
parkinson's disease is characterized by a selective loss of dopaminergic neurons in the substantia nigra (sn). |
2014-02-26 |
2023-08-12 |
mouse |