| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Mario Riverol, Cristina Ordóñez, María Collantes, Carla DiCaudo, Iván Peñuelas, Javier Arbizu, Irene Marcilla, María R Luqui. Levodopa induces long-lasting modification in the functional activity of the nigrostriatal pathway. Neurobiology of disease. vol 62. 2014-09-03. PMID:24076099. |
the levels of several striatal dopaminergic markers and the number of surviving dopaminergic neurons in the substantia nigra (sn) were also assessed. |
2014-09-03 |
2023-08-12 |
monkey |
| Akiyo Natsubori, Ken-ichi Honma, Sato Honm. Dual regulation of clock gene Per2 expression in discrete brain areas by the circadian pacemaker and methamphetamine-induced oscillator in rats. The European journal of neuroscience. vol 39. issue 2. 2014-09-03. PMID:24438490. |
circadian per2 rhythms in r-map rats were not affected in the scn but were slightly phase-advanced in the olfactory bulb (ob), caudate-putamen (cpu) and substantia nigra (sn) as compared with r-water rats. |
2014-09-03 |
2023-08-12 |
rat |
| J A Teske, C J Billington, C M Kot. Mechanisms underlying obesity resistance associated with high spontaneous physical activity. Neuroscience. vol 256. 2014-08-27. PMID:24161277. |
we further tested whether orexin action on dopamine one receptors (da1r) in the substantia nigra (sn) plays an important role in the generation of spa. |
2014-08-27 |
2023-08-12 |
rat |
| Jun Ming Wan. Allopregnanolone and neurogenesis in the nigrostriatal tract. Frontiers in cellular neuroscience. vol 8. 2014-08-27. PMID:25161608. |
loss of dopamine neurons in the substantia nigra (sn) is one of the main pathological features of parkinson's and also in, at least, a subset of alzheimer's patients. |
2014-08-27 |
2023-08-13 |
mouse |
| Z Zhang, L Hou, J-L Song, N Song, Y-J Sun, X Lin, X-L Wang, F-Z Zhang, Y-L G. Pro-inflammatory cytokine-mediated ferroportin down-regulation contributes to the nigral iron accumulation in lipopolysaccharide-induced Parkinsonian models. Neuroscience. vol 257. 2014-08-26. PMID:24183966. |
pro-inflammatory cytokines induced by inflammation and iron accumulation in the substantia nigra (sn) have been implicated in the pathogenesis of parkinson's disease (pd). |
2014-08-26 |
2023-08-12 |
rat |
| Timothy M Ellmore, Richard J Castriotta, Katie L Hendley, Brian M Aalbers, Erin Furr-Stimming, Ashley J Hood, Jessika Suescun, Michelle R Beurlot, Roy T Hendley, Mya C Schies. Altered nigrostriatal and nigrocortical functional connectivity in rapid eye movement sleep behavior disorder. Sleep. vol 36. issue 12. 2014-08-25. PMID:24293763. |
in the current study, we tested the hypothesis of altered functional connections of the substantia nigra (sn) in patients in whom rbd was diagnosed. |
2014-08-25 |
2023-08-12 |
Not clear |
| Eun Hee Ahn, Dae Won Kim, Min Jea Shin, Young Nam Kim, Hye Ri Kim, Su Jung Woo, So Mi Kim, Duk-Soo Kim, Joon Kim, Jinseu Park, Won Sik Eum, Hyun Sook Hwang, Soo Young Cho. PEP-1-ribosomal protein S3 protects dopaminergic neurons in an MPTP-induced Parkinson's disease mouse model. Free radical biology & medicine. vol 55. 2014-08-20. PMID:23178948. |
parkinson's disease (pd) is a neurodegenerative disease characterized by a gradual loss of dopaminergic (da) neurons in the substantia nigra (sn) of the brain. |
2014-08-20 |
2023-08-12 |
mouse |
| Wenjiao Tai, Xuan Ye, Xiuqi Bao, Baozhong Zhao, Xiaoliang Wang, Dan Zhan. Inhibition of Src tyrosine kinase activity by squamosamide derivative FLZ attenuates neuroinflammation in both in vivo and in vitro Parkinson's disease models. Neuropharmacology. vol 75. 2014-08-19. PMID:23916477. |
flz treatment significantly improved the motor dysfunction of pd model rats induced by intra-nigral injection of lps and this beneficial effect of flz attributed to the inhibition of microglial over-activation and the protection on dopaminergic neurons in the substantia nigra (sn). |
2014-08-19 |
2023-08-12 |
rat |
| Michaeline L Hebron, Irina Lonskaya, Charbel E-H Mouss. Tyrosine kinase inhibition facilitates autophagic SNCA/α-synuclein clearance. Autophagy. vol 9. issue 8. 2014-08-13. PMID:23787811. |
parkinson disease (pd) is a movement disorder characterized by death of dopaminergic substantia nigra (sn) neurons and brain accumulation of snca. |
2014-08-13 |
2023-08-12 |
mouse |
| Kimberlee D'Ardenne, Terry Lohrenz, Krystle A Bartley, P Read Montagu. Computational heterogeneity in the human mesencephalic dopamine system. Cognitive, affective & behavioral neuroscience. vol 13. issue 4. 2014-08-11. PMID:23943512. |
blood oxygenation level dependent responses in regions of substantia nigra (sn) and ventral tegmental area (vta), where dopamine neurons are located, coded for td and fictive errors, and additionally were related to the motivational salience signal. |
2014-08-11 |
2023-08-12 |
human |
| Christopher A Bates, Wei Zhen. Brain disposition of α-Synuclein: roles of brain barrier systems and implications for Parkinson's disease. Fluids and barriers of the CNS. vol 11. 2014-08-05. PMID:25093076. |
parkinson's disease (pd) is a neurodegenerative disorder characterized by the accumulation of α-synuclein (a-syn) into lewy body inclusions and the loss of dopaminergic neurons in the substantia nigra (sn). |
2014-08-05 |
2023-08-13 |
Not clear |
| Eung Seok Oh, Chaejeong Heo, Ji Seon Kim, Minah Suh, Young Hee Lee, Jong-Min Ki. Hyperspectral fluorescence imaging for cellular iron mapping in the in vitro model of Parkinson's disease. Journal of biomedical optics. vol 19. issue 5. 2014-08-04. PMID:24297062. |
parkinson's disease (pd) is characterized by progressive dopaminergic cell loss in the substantia nigra (sn) and elevated iron levels demonstrated by autopsy. |
2014-08-04 |
2023-08-12 |
Not clear |
| Anna Czarnecka, Tomasz Lenda, Helena Domin, Jolanta Konieczny, Maria Smiałowska, Elżbieta Lorenc-Koc. Alterations in the expression of nNOS in the substantia nigra and subthalamic nucleus of 6-OHDA-lesioned rats: the effects of chronic treatment with l-DOPA and the nitric oxide donor, molsidomine. Brain research. vol 1541. 2014-07-28. PMID:24129225. |
degeneration of dopaminergic neurons in the substantia nigra (sn) in parkinson's disease leads to disturbances in the nitrergic transmission in the basal ganglia. |
2014-07-28 |
2023-08-12 |
rat |
| Miklos Antal, Brandon M Beneduce, Wade G Regeh. The substantia nigra conveys target-dependent excitatory and inhibitory outputs from the basal ganglia to the thalamus. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 34. issue 23. 2014-07-25. PMID:24899724. |
the substantia nigra (sn) consists of gabaergic neurons of the pars reticulata that inhibit thalamic neurons and provide the primary output of the bg, and dopaminergic neurons of the pars compacta that modulate thalamic excitability. |
2014-07-25 |
2023-08-13 |
mouse |
| Esperanza García, Ricardo Santana-Martínez, Carlos A Silva-Islas, Ana Laura Colín-González, Sonia Galván-Arzate, Yessica Heras, Perla D Maldonado, Julio Sotelo, Abel Santamarí. S-allyl cysteine protects against MPTP-induced striatal and nigral oxidative neurotoxicity in mice: participation of Nrf2. Free radical research. vol 48. issue 2. 2014-07-24. PMID:24147739. |
our findings suggest that sac can exert neuroprotection since the origin of the dopaminergic lesion-at the substantia nigra (sn)-not only by means of direct antioxidant actions, but also through nrf2 nuclear transactivation and phase 2 enzymes upregulation. |
2014-07-24 |
2023-08-12 |
mouse |
| Elżbieta Lorenc-Koci, Anna Czarnecka, Tomasz Lenda, Kinga Kamińska, Jolanta Konieczn. Molsidomine, a nitric oxide donor, modulates rotational behavior and monoamine metabolism in 6-OHDA lesioned rats treated chronically with L-DOPA. Neurochemistry international. vol 63. issue 8. 2014-07-22. PMID:24090640. |
the aim of our study was to examine the impact of chronic combined treatment with low doses of the no donor molsidomine (2 and 4mg/kg) and l-dopa (12.5 and 25mg/kg) on rotational behavior and monoamine metabolism in the striatum (str) and substantia nigra (sn) of unilaterally 6-ohda-lesioned rats. |
2014-07-22 |
2023-08-12 |
rat |
| Hye-Jin Moon, Yongmin Chang, Yeong Seon Lee, Hee Jin Song, Hyuk Won Chang, Jeonghun Ku, Yong Won Ch. T2 relaxometry using 3.0-tesla magnetic resonance imaging of the brain in early- and late-onset restless legs syndrome. Journal of clinical neurology (Seoul, Korea). vol 10. issue 3. 2014-07-21. PMID:25045371. |
measurement of the iron content in several brain regions, and in particular the substantia nigra (sn), in early- and late-onset rls patients using t2 relaxometry have yielded inconsistent results. |
2014-07-21 |
2023-08-13 |
Not clear |
| Alex A MacDonald, Ken N Seergobin, Adrian M Owen, Ruzbeh Tamjeedi, Oury Monchi, Hooman Ganjavi, Penny A MacDonal. Differential effects of Parkinson's disease and dopamine replacement on memory encoding and retrieval. PloS one. vol 8. issue 9. 2014-07-18. PMID:24086309. |
in pd, the dopamine-producing cells of the substantia nigra (sn) are significantly degenerated whereas those in the ventral tegmental area (vta) are relatively spared. |
2014-07-18 |
2023-08-12 |
Not clear |
| Marina S Hernandes, Graziella D R Santos, Cecília C Café-Mendes, Larissa S Lima, Cristoforo Scavone, Carolina D Munhoz, Luiz R G Britt. Microglial cells are involved in the susceptibility of NADPH oxidase knockout mice to 6-hydroxy-dopamine-induced neurodegeneration. PloS one. vol 8. issue 9. 2014-07-14. PMID:24086556. |
nox1 and nox2 gene expression were found to increase in striatum, whereas a marked increase of nox2 expression was observed in substantia nigra (sn) of wild-type (wt) mice after pd induction. |
2014-07-14 |
2023-08-12 |
mouse |
| Ji-Hi Pyo, You-Kyung Jeong, Sujung Yeo, Je-Hyun Lee, Mi-Young Jeong, Sung-Hoon Kim, Yeong-Gon Choi, Sabina Li. Neuroprotective effect of trans-cinnamaldehyde on the 6-hydroxydopamine-induced dopaminergic injury. Biological & pharmaceutical bulletin. vol 36. issue 12. 2014-07-14. PMID:24292051. |
at 7 d after the 6-ohda injection, 6-ohda led to a severe loss of tyrosine hydroxylase (th)-positive dopaminergic neurons in the striatum and substantia nigra (sn). |
2014-07-14 |
2023-08-12 |
mouse |