| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Julia J Didonet, Judney C Cavalcante, Lisiane de S Souza, Miriam S M O Costa, Eunice André, Vanessa de P Soares-Rachetti, Remo Guerrini, Girolamo Calo', Elaine C Gaviol. Neuropeptide S counteracts 6-OHDA-induced motor deficits in mice. Behavioural brain research. vol 266. 2014-12-12. PMID:24613977. |
6-ohda injection evoked motor deficits and significantly reduced tyrosine hidroxylase (th)-positive cells in the substantia nigra (sn) and ventral tegmental area. |
2014-12-12 |
2023-08-12 |
mouse |
| Eun Jeong Sohn, Min Jea Shin, Dae Won Kim, Eun Hee Ahn, Hyo Sang Jo, Duk-Soo Kim, Sung-Woo Cho, Kyu Hyung Han, Jinseu Park, Won Sik Eum, Hyun Sook Hwang, Soo Young Cho. Tat-fused recombinant human SAG prevents dopaminergic neurodegeneration in a MPTP-induced Parkinson's disease model. Molecules and cells. vol 37. issue 3. 2014-12-12. PMID:24625574. |
in this study, we investigate whether tat-sag, fused with a tat domain, could protect sh-sy5y neuroblastoma cells against 1-methyl-4-phenylpyridinium (mpp(+)) and dopaminergic (da) neurons in the substantia nigra (sn) against 1-methyl-4-phenyl-1,2,3,6-tetra-hydropyridine (mptp) toxicity. |
2014-12-12 |
2023-08-12 |
mouse |
| Kaela R S Reinert, Claudia D Umphlet, Ariana Quattlebaum, Heather A Boge. Short-term effects of an endotoxin on substantia nigra dopamine neurons. Brain research. vol 1557. 2014-12-03. PMID:24513404. |
studies using the endotoxin lipopolysaccharide (lps), a potent inflammogen, show that systemic insults can trigger prolonged microglial activation and pro-inflammatory cytokine production leading to degeneration of substantia nigra (sn) dopamine (da) neurons, mimicking idiopathic pd. |
2014-12-03 |
2023-08-12 |
mouse |
| Carmen Noelker, Lydie Morel, Anke Osterloh, Daniel Alvarez-Fischer, Thomas Lescot, Minka Breloer, Maike Gold, Wolfgang H Oertel, Carmen Henze, Patrick P Michel, Richard C Dodel, Lixia Lu, Etienne C Hirsch, Stéphane Hunot, Andreas Hartman. Heat shock protein 60: an endogenous inducer of dopaminergic cell death in Parkinson disease. Journal of neuroinflammation. vol 11. 2014-12-01. PMID:24886419. |
increasing evidence suggests that inflammation associated with microglial cell activation in the substantia nigra (sn) of patients with parkinson disease (pd) is not only a consequence of neuronal degeneration, but may actively sustain dopaminergic (da) cell loss over time. |
2014-12-01 |
2023-08-13 |
Not clear |
| Ilona Klejbor, Beata Ludkiewicz, Sławomir Wojcik, Krzysztof Turlejsk. Correlation between dopaminergic phenotype and expression of calretinin in the midbrain nuclei of the opossum (Monodelphis domestica): an immunohistological study. Acta neurobiologiae experimentalis. vol 73. issue 4. 2014-11-21. PMID:24457643. |
we investigated distribution and morphology of neurons of the midbrain nuclei: the ventral tegmental area (vta), substantia nigra (sn) and periaqueductal gray (pag) of the adult grey short-tailed opossums that were double immunolabeled for the presence of calretinin (cr) and/or tyrosine hydroxylase (th). |
2014-11-21 |
2023-08-12 |
Not clear |
| Mrudang Shah, Subramanian Rajagopalan, Liping Xu, Chandrashekhar Voshavar, Yevgeniya Shurubor, Flint Beal, Julie K Andersen, Aloke K Dutt. The high-affinity D2/D3 agonist D512 protects PC12 cells from 6-OHDA-induced apoptotic cell death and rescues dopaminergic neurons in the MPTP mouse model of Parkinson's disease. Journal of neurochemistry. vol 131. issue 1. 2014-11-21. PMID:24848702. |
in vivo, pre-treatment with 0.5 mg/kg d-512 was protective against neurodegenerative phenotypes associated with systemic administration of mptp, including losses in striatal dopamine, reductions in numbers of daergic neurons in the substantia nigra (sn), and locomotor dysfunction. |
2014-11-21 |
2023-08-13 |
mouse |
| Maxime Assous, Laurence Had-Aissouni, Paolo Gubellini, Christophe Melon, Imane Nafia, Pascal Salin, Lydia Kerkerian-Le-Goff, Philippe Kachidia. Progressive Parkinsonism by acute dysfunction of excitatory amino acid transporters in the rat substantia nigra. Neurobiology of disease. vol 65. 2014-11-13. PMID:24480091. |
parkinson's disease (pd) is characterized by the progressive degeneration of substantia nigra (sn) dopamine neurons, involving a multifactorial cascade of pathogenic events. |
2014-11-13 |
2023-08-12 |
rat |
| Tiago Martins Rodrigues, André Jerónimo-Santos, Tiago Fleming Outeiro, Ana Maria Sebastião, Maria José Diógene. Challenges and promises in the development of neurotrophic factor-based therapies for Parkinson's disease. Drugs & aging. vol 31. issue 4. 2014-11-13. PMID:24610720. |
parkinson's disease (pd) is a chronic movement disorder typically coupled to progressive degeneration of dopaminergic neurons in the substantia nigra (sn). |
2014-11-13 |
2023-08-12 |
human |
| Lucía F Cardo, Eliecer Coto, Lorena de Mena, René Ribacoba, Ignacio F Mata, Manuel Menéndez, Germán Moris, Victoria Alvare. Alpha-synuclein transcript isoforms in three different brain regions from Parkinson's disease and healthy subjects in relation to the SNCA rs356165/rs11931074 polymorphisms. Neuroscience letters. vol 562. 2014-11-12. PMID:24418406. |
our aim was to measure the different snca transcripts in the substantia nigra (sn), cerebellum (cb), and occipital cortex (oc) from pd-patients (n=9) and healthy subjects (n=6). |
2014-11-12 |
2023-08-12 |
human |
| Christina E Khodr, Amanda Becerra, Ye Han, Martha C Boh. Targeting alpha-synuclein with a microRNA-embedded silencing vector in the rat substantia nigra: positive and negative effects. Brain research. vol 1550. 2014-11-03. PMID:24463035. |
previously we showed that human (h)snca gene silencing using a short hairpin (sh)rna in rat substantia nigra (sn) protects against a hsnca-induced forelimb deficit, but not dopamine (da) neuron loss. |
2014-11-03 |
2023-08-12 |
human |
| Dardo Tomasi, Nora D Volko. Functional connectivity of substantia nigra and ventral tegmental area: maturation during adolescence and effects of ADHD. Cerebral cortex (New York, N.Y. : 1991). vol 24. issue 4. 2014-10-29. PMID:23242198. |
this transition is characterized by age-related increases in the functional connectivity of the ventral tegmental area (vta) with limbic regions and with the default mode network and by decreases in the connectivity of the substantia nigra (sn) with motor and medial temporal cortices. |
2014-10-29 |
2023-08-12 |
Not clear |
| M J Tobia, R Guo, U Schwarze, W Boehmer, J Gläscher, B Finckh, A Marschner, C Büchel, K Obermayer, T Somme. Neural systems for choice and valuation with counterfactual learning signals. NeuroImage. vol 89. 2014-10-29. PMID:24321554. |
the depletion procedure revealed significantly different neural responses to expected value in the vmpfc, caudate, and dopaminergic midbrain in the vicinity of the substantia nigra (sn). |
2014-10-29 |
2023-08-12 |
human |
| Virginie Licker, Natacha Turck, Enikö Kövari, Karim Burkhardt, Mélanie Côte, Maria Surini-Demiri, Johannes A Lobrinus, Jean-Charles Sanchez, Pierre R Burkhar. Proteomic analysis of human substantia nigra identifies novel candidates involved in Parkinson's disease pathogenesis. Proteomics. vol 14. issue 6. 2014-10-27. PMID:24449343. |
parkinson's disease (pd) pathology spreads throughout the brain following a region-specific process predominantly affecting the substantia nigra (sn) pars compacta. |
2014-10-27 |
2023-08-12 |
human |
| Guangwei Du, Mechelle M Lewis, Nicholas W Sterling, Lan Kong, Honglei Chen, Richard B Mailman, Xuemei Huan. Microstructural changes in the substantia nigra of asymptomatic agricultural workers. Neurotoxicology and teratology. vol 41. 2014-10-22. PMID:24334261. |
parkinson's disease (pd) is marked by the loss of dopamine neurons in the substantia nigra (sn). |
2014-10-22 |
2023-08-12 |
human |
| Satyndra Kumar Yadav, Jay Prakash, Shikha Chouhan, Susan Westfall, Mradul Verma, Tryambak Deo Singh, Surya Pratap Sing. Comparison of the neuroprotective potential of Mucuna pruriens seed extract with estrogen in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced PD mice model. Neurochemistry international. vol 65. 2014-10-20. PMID:24333323. |
the recovery of dopamine neurons in the substantia nigra (sn) region was estimated by tyrosine hydroxylase (th), immunostaining. |
2014-10-20 |
2023-08-12 |
mouse |
| Victor Tapias, Jason R Cannon, J Timothy Greenamyr. Pomegranate juice exacerbates oxidative stress and nigrostriatal degeneration in Parkinson's disease. Neurobiology of aging. vol 35. issue 5. 2014-10-06. PMID:24315037. |
numerous factors contribute to the death of substantia nigra (sn) dopamine (da) neurons in parkinson's disease (pd). |
2014-10-06 |
2023-08-12 |
rat |
| Jolanta Konieczny, Anna Czarnecka, Tomasz Lenda, Kinga Kamińska, Elżbieta Lorenc-Koc. Chronic L-DOPA treatment attenuates behavioral and biochemical deficits induced by unilateral lactacystin administration into the rat substantia nigra. Behavioural brain research. vol 261. 2014-10-06. PMID:24361083. |
wistar rats were injected unilaterally with lactacystin (2.5 μg/2 μl) or 6-ohda (8 μg/2 μl) into the substantia nigra (sn) pars compacta. |
2014-10-06 |
2023-08-12 |
rat |
| Erik Hrabovszky, Csilla S Molnár, Beáta Á Borsay, Péter Gergely, László Herczeg, Zsolt Liposit. Orexinergic input to dopaminergic neurons of the human ventral tegmental area. PloS one. vol 8. issue 12. 2014-10-06. PMID:24376626. |
dual-label immunohistochemistry was used and orexinergic projections to the vta and to da neurons of the neighboring substantia nigra (sn) were analyzed comparatively in adult male humans and rats. |
2014-10-06 |
2023-08-12 |
human |
| Katherine M Davies, Sylvain Bohic, Asunción Carmona, Richard Ortega, Veronica Cottam, Dominic J Hare, John P M Finberg, Stefanie Reyes, Glenda M Halliday, Julian F B Mercer, Kay L Doubl. Copper pathology in vulnerable brain regions in Parkinson's disease. Neurobiology of aging. vol 35. issue 4. 2014-09-29. PMID:24176624. |
synchrotron-based x-ray fluorescence microscopy, immunofluorescence, and western blotting were used to investigate changes in copper (cu) and cu-associated pathways in the vulnerable substantia nigra (sn) and locus coeruleus (lc) and in nondegenerating brain regions in cases of parkinson's disease (pd) and appropriate healthy and disease controls. |
2014-09-29 |
2023-08-12 |
Not clear |
| X Yue, D J Hariri, B Caballero, S Zhang, M J Bartlett, O Kaut, D W Mount, U Wüllner, S J Sherman, T Fal. Comparative study of the neurotrophic effects elicited by VEGF-B and GDNF in preclinical in vivo models of Parkinson's disease. Neuroscience. vol 258. 2014-09-29. PMID:24291725. |
both doses of vegf-b caused an increase in tyrosine hydroxylase (th)-positive cell and fiber count in the substantia nigra (sn) and striatum in the neuroprotective experiment. |
2014-09-29 |
2023-08-12 |
human |