| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Young Cheul Chung, Yoon-Seong Kim, Eugene Bok, Tae Young Yune, Sungho Maeng, Byung Kwan Ji. MMP-3 contributes to nigrostriatal dopaminergic neuronal loss, BBB damage, and neuroinflammation in an MPTP mouse model of Parkinson's disease. Mediators of inflammation. vol 2013. 2014-02-26. PMID:23853428. |
moreover, fitc-labeled albumin detection and immunostaining revealed that mptp caused damage to the bbb and increased the number of ed-1- and cd-3-immunopositive cells in the substantia nigra (sn). |
2014-02-26 |
2023-08-12 |
mouse |
| Hyeok Gyu Kwon, Sung Ho Jan. Differences in neural connectivity between the substantia nigra and ventral tegmental area in the human brain. Frontiers in human neuroscience. vol 8. 2014-02-25. PMID:24567711. |
many animal and a few human studies have reported on the neural connectivity of the substantia nigra (sn) and the ventral tegmental area (vta). |
2014-02-25 |
2023-08-12 |
human |
| Ci Wang, Guoguang Fan, Ke Xu, Shanshan Wan. Quantitative assessment of iron deposition in the midbrain using 3D-enhanced T2 star weighted angiography (ESWAN): a preliminary cross-sectional study of 20 Parkinson's disease patients. Magnetic resonance imaging. vol 31. issue 7. 2014-02-21. PMID:23746648. |
conventional magnetic resonance imaging (mri) assesses neurodegenerative structural changes in the cerebral anatomy of parkinson's disease (pd) patients but cannot detect non-structural abnormalities; however, enhanced t2 star weighted angiography (eswan) can precisely indicate pd-related substantia nigra (sn) iron deposition. |
2014-02-21 |
2023-08-12 |
human |
| Sara Ailane, Philip Long, Peter Jenner, Sarah Ros. Expression of integrin and CD44 receptors recognising osteopontin in the normal and LPS-lesioned rat substantia nigra. The European journal of neuroscience. vol 38. issue 3. 2014-02-19. PMID:23692556. |
the multifunctional protein osteopontin (opn) is expressed in the substantia nigra (sn) and protects nigral dopaminergic neurones against toxic insult in animal models of parkinson's disease, although the mechanisms involved are uncertain. |
2014-02-19 |
2023-08-12 |
rat |
| José Luiz Pedroso, Edson Bor-Seng-Shu, André C Felício, Pedro Braga-Neto, Marcelo Q Hoexter, Manoel Jacobsen Teixeira, Rodrigo A Bressan, Orlando Graziani Povoas Barsottin. Substantia nigra echogenicity is correlated with nigrostriatal impairment in Machado-Joseph disease. Parkinsonism & related disorders. vol 19. issue 8. 2014-02-17. PMID:23680416. |
several studies have demonstrated increased substantia nigra (sn) echogenicity in parkinson's disease (pd) and machado-joseph disease (mjd). |
2014-02-17 |
2023-08-12 |
Not clear |
| Andreia Neves Carvalho, Carla Marques, Elsa Rodrigues, Colin J Henderson, C Roland Wolf, Paulo Pereira, Maria João Gam. Ubiquitin-proteasome system impairment and MPTP-induced oxidative stress in the brain of C57BL/6 wild-type and GSTP knockout mice. Molecular neurobiology. vol 47. issue 2. 2014-02-13. PMID:23129554. |
parkinson's disease (pd) is neuropathologically characterized by selective death of dopaminergic neurons in the substantia nigra (sn) and accumulation of intracytoplasmic inclusions of aggregated proteins. |
2014-02-13 |
2023-08-12 |
mouse |
| Elzbieta Janda, Maddalena Parafati, Serafina Aprigliano, Cristina Carresi, Valeria Visalli, Iolanda Sacco, Domenica Ventrice, Tiziana Mega, Nuria Vadalá, Stefano Rinaldi, Vincenzo Musolino, Ernesto Palma, Santo Gratteri, Domenicantonio Rotiroti, Vincenzo Mollac. The antidote effect of quinone oxidoreductase 2 inhibitor against paraquat-induced toxicity in vitro and in vivo. British journal of pharmacology. vol 168. issue 1. 2014-02-10. PMID:22289031. |
pq toxicity in the substantia nigra (sn) was tested by a localized microinfusion and electrocorticography. |
2014-02-10 |
2023-08-12 |
rat |
| E Hensleigh, L M Pritchar. Glucocorticoid receptor expression and sub-cellular localization in dopamine neurons of the rat midbrain. Neuroscience letters. vol 556. 2014-02-10. PMID:24121048. |
glucocorticoid receptors were observed in dopaminergic neurons in both the substantia nigra (sn) and ventral tegmental area (vta). |
2014-02-10 |
2023-08-12 |
rat |
| Michaeline L Hebron, Irina Lonskaya, Charbel E-H Mouss. Nilotinib reverses loss of dopamine neurons and improves motor behavior via autophagic degradation of α-synuclein in Parkinson's disease models. Human molecular genetics. vol 22. issue 16. 2014-02-06. PMID:23666528. |
parkinson's disease is a movement disorder characterized by death of dopaminergic substantia nigra (sn) neurons and brain accumulation of α-synuclein. |
2014-02-06 |
2023-08-12 |
mouse |
| Matthew Benskey, Ki Yong Lee, Kevin Parikh, Keith J Lookingland, John L Goudrea. Sustained resistance to acute MPTP toxicity by hypothalamic dopamine neurons following chronic neurotoxicant exposure is associated with sustained up-regulation of parkin protein. Neurotoxicology. vol 37. 2014-02-05. PMID:23643664. |
nsda neurons displayed significant axon terminal degeneration (as reflected by decreases in da, tyrosine hydroxylase (th) and da transporter concentrations in the striatum) as well as loss of th-immunoreactive (ir) neurons in the substantia nigra (sn) following mptp, whereas tida neurons revealed no overt axon terminal pathology or loss of th-ir cell bodies. |
2014-02-05 |
2023-08-12 |
mouse |
| Xuekun Ding, Jing Liang, Xigeng Zheng, Yunjing Bai, Zhengkui Liu, Yingying Li, Xiaoli Xin. Altered phosphorylation of GluA1 in the striatum is associated with locomotor sensitization induced by exposure to increasing doses of morphine. European journal of pharmacology. vol 702. issue 1-3. 2014-02-04. PMID:23396226. |
our previous study demonstrated that neuronal activation in ventral tegmental area (vta) and substantia nigra (sn) was associated with behavioral sensitization induced by increasing doses of morphine. |
2014-02-04 |
2023-08-12 |
Not clear |
| Rong Li, Tao Liang, Lingyuan Xu, Ni Zheng, Kefeng Zhang, Xiaoqun Dua. Puerarin attenuates neuronal degeneration in the substantia nigra of 6-OHDA-lesioned rats through regulating BDNF expression and activating the Nrf2/ARE signaling pathway. Brain research. vol 1523. 2014-02-04. PMID:23747813. |
this study evaluated the potential neuroprotective role of puerarin (pr) on lesioned substantia nigra (sn) induced by 6-hydroxydopamine (6-ohda). |
2014-02-04 |
2023-08-12 |
rat |
| Hey-Kyeong Jeong, Ilo Jou, Eun-Hye Jo. Absence of Delayed Neuronal Death in ATP-Injected Brain: Possible Roles of Astrogliosis. Experimental neurobiology. vol 22. issue 4. 2014-01-27. PMID:24465146. |
in this study, we investigated possible mechanisms that prevent delayed neuronal death in the atp-injected substantia nigra (sn) and cortex, where delayed neuronal death does not occur. |
2014-01-27 |
2023-08-12 |
Not clear |
| Hueng-Chuen Fan, Shyi-Jou Chen, Horng-Jyh Harn, Shinn-Zong Li. Parkinson's disease: from genetics to treatments. Cell transplantation. vol 22. issue 4. 2014-01-23. PMID:23127617. |
the hallmark pathological features of pd are loss of dopaminergic neurons in the substantia nigra (sn) and the presence of neuronal intracellular lewy body (lb) inclusions. |
2014-01-23 |
2023-08-12 |
Not clear |
| Christopher A Brown, Morvarid K Karimi, LinLin Tian, Hugh Flores, Yi Su, Samer D Tabbal, Susan K Loftin, Stephen M Moerlein, Joel S Perlmutte. Validation of midbrain positron emission tomography measures for nigrostriatal neurons in macaques. Annals of neurology. vol 74. issue 4. 2014-01-21. PMID:23686841. |
in the present study, we compare presynaptic positron emission tomography (pet) tracer uptake in the substantia nigra (sn) to cell loss and motor impairment in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp)-treated nonhuman primates. |
2014-01-21 |
2023-08-12 |
Not clear |
| Hee Young Shin, Eun Youn Joo, Seong Tae Kim, Hun-Jong Dhong, Jin Whan Ch. Comparison study of olfactory function and substantia nigra hyperechogenicity in idiopathic REM sleep behavior disorder, Parkinson's disease and normal control. Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology. vol 34. issue 6. 2014-01-17. PMID:22843227. |
rapid eye movement (rem) sleep behavior disorder (rbd) is a preclinical feature of synucleinopathies, such as parkinson's disease (pd).this study aimed to investigate the presence of potential early manifestations of parkinsonism, such as olfactory dysfunction and substantia nigra (sn) hyperechogenicity, in idiopathic rbd (irbd) patients, pd patients and normal controls. |
2014-01-17 |
2023-08-12 |
Not clear |
| Rong Li, Ni Zheng, Tao Liang, Qiaoling He, Lingyuan X. Puerarin attenuates neuronal degeneration and blocks oxidative stress to elicit a neuroprotective effect on substantia nigra injury in 6-OHDA-lesioned rats. Brain research. vol 1517. 2014-01-17. PMID:23603411. |
in the present study, we aimed to investigate the protective effect of puerarin (pr) on the substantia nigra (sn) of 6-hydroxydopamine (6-ohda)-lesioned rats. |
2014-01-17 |
2023-08-12 |
rat |
| Tian-wei Liu, Ze-gang Ma, Yu Zhou, Jun-xia Xi. Transplantation of mouse CGR8 embryonic stem cells producing GDNF and TH protects against 6-hydroxydopamine neurotoxicity in the rat. The international journal of biochemistry & cell biology. vol 45. issue 7. 2014-01-14. PMID:23535049. |
in this study, we implanted engineered mouse embryonic stem (es) cgr8 cells, which stably co-express glial cell line-derived neurotrophic factor (gdnf) and tyrosine hydroxylase (th), into striatum (str) or both str and substantia nigra (sn) of parkinsonian rats lesioned by 6-hydroxydopamine (6-ohda). |
2014-01-14 |
2023-08-12 |
mouse |
| Jian Yu Wang, Jing Yu Yang, Fang Wang, Shi Yuan Fu, Yue Hou, Bo Jiang, Jie Ma, Cui Song, Chun Fu W. Neuroprotective effect of pseudoginsenoside-f11 on a rat model of Parkinson's disease induced by 6-hydroxydopamine. Evidence-based complementary and alternative medicine : eCAM. vol 2013. 2014-01-03. PMID:24386001. |
the expression of tyrosine hydroxylase (th) in substantia nigra (sn) and the content of extracellular dopamine (da) in striatum were also significantly increased after pf11 treatment. |
2014-01-03 |
2023-08-12 |
rat |
| Jochen Roepe. Dissecting the diversity of midbrain dopamine neurons. Trends in neurosciences. vol 36. issue 6. 2013-12-30. PMID:23582338. |
the largest populations of midbrain da neurons are localized in two neighboring nuclei, the substantia nigra (sn) and the ventral tegmental area (vta). |
2013-12-30 |
2023-08-12 |
Not clear |