| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Satyndra Kumar Yadav, Jay Prakash, Shikha Chouhan, Surya Pratap Sing. Mucuna pruriens seed extract reduces oxidative stress in nigrostriatal tissue and improves neurobehavioral activity in paraquat-induced Parkinsonian mouse model. Neurochemistry international. vol 62. issue 8. 2013-12-26. PMID:23562769. |
furthermore, we observed a significant reduction in tyrosine hydroxylase (th) immunoreactivity in the substantia nigra (sn) and striatum region of the brain, after treatment with pq which was considerably restored by the use of mp seed extract. |
2013-12-26 |
2023-08-12 |
mouse |
| Baowan Li. Encephalopathy: a vicious cascade following forebrain ischemia and hypoxia. Central nervous system agents in medicinal chemistry. vol 13. issue 1. 2013-12-23. PMID:23369190. |
death of neurons in the cortex, limbic system, globus pallidus (gp) and substantia nigra (sn) and damage to white matter are responsible. |
2013-12-23 |
2023-08-12 |
human |
| Sridhar Narla, Ilona Klejbor, Barbara Birkaya, Yu-Wei Lee, Janusz Morys, Ewa K Stachowiak, Christopher Terranova, Merouane Bencherif, Michal K Stachowia. α7 nicotinic receptor agonist reactivates neurogenesis in adult brain. Biochemical pharmacology. vol 86. issue 8. 2013-12-17. PMID:23933384. |
tc-7020-induced neuronogenesis is observed in different brain regions, including: (1) βiii tubulin-expressing cortical neurons, (2) calretinin expressing hippocampal neurons and (3) cells in substantia nigra (sn) expressing predopaminergic nurr1+phenotype. |
2013-12-17 |
2023-08-12 |
mouse |
| Yubo Liu, Guangbin Wang, Lianxin Zhao, Mingbin Geng, Lijuan Wang, Xue Bai, Jianbin Hu, Xiaoni Ma. SWI phase asymmetries in deep gray matter of healthy adults: is there an association with handedness? Brain imaging and behavior. vol 7. issue 2. 2013-12-12. PMID:23329356. |
for each subject, phase values were detected in bilateral frontal white matters (fwm), caudate nucleus (ca), putamen (pu), globus pallidus (gp), thalamus (th), red nucleus (rn) and substantia nigra (sn) on phase images. |
2013-12-12 |
2023-08-12 |
human |
| Darren Opland, Amy Sutton, Hillary Woodworth, Juliette Brown, Raluca Bugescu, Adriana Garcia, Lyndsay Christensen, Christopher Rhodes, Martin Myers, Gina Leinninge. Loss of neurotensin receptor-1 disrupts the control of the mesolimbic dopamine system by leptin and promotes hedonic feeding and obesity. Molecular metabolism. vol 2. issue 4. 2013-12-11. PMID:24327958. |
lha nts cells project to da-containing midbrain areas, including the ventral tegmental area (vta) and the substantia nigra (sn), where many da neurons express ntsr1. |
2013-12-11 |
2023-08-12 |
mouse |
| Stefan T Schwarz, Maryam Abaei, Vamsi Gontu, Paul S Morgan, Nin Bajaj, Dorothee P Aue. Diffusion tensor imaging of nigral degeneration in Parkinson's disease: A region-of-interest and voxel-based study at 3 T and systematic review with meta-analysis. NeuroImage. Clinical. vol 3. 2013-11-25. PMID:24273730. |
these parameters, when measured in the substantia nigra (sn), have not only shown promising but also varying and controversial results. |
2013-11-25 |
2023-08-12 |
human |
| J A Priebe, P Rieckmann, S Lautenbache. [Central pain processing and Parkinson's disease. Epidemiology, physiology, and experimental results issuing pain processing]. Schmerz (Berlin, Germany). vol 26. issue 6. 2013-11-19. PMID:23052966. |
parkinson's disease (pd) is caused by degeneration of the dopaminergic neurons in the substantia nigra (sn) and a resulting dysfunction of the nigrostriatal pathways including the basal ganglia. |
2013-11-19 |
2023-08-12 |
Not clear |
| Yoshinori Koshimizu, Fumino Fujiyama, Kouichi C Nakamura, Takahiro Furuta, Takeshi Kanek. Quantitative analysis of axon bouton distribution of subthalamic nucleus neurons in the rat by single neuron visualization with a viral vector. The Journal of comparative neurology. vol 521. issue 9. 2013-11-12. PMID:23595816. |
the subthalamic nucleus (stn) of the basal ganglia plays a key role in motor control, and stn efferents are known to mainly target the external segment of the globus pallidus (gpe), entopeduncular nucleus (ep), and substantia nigra (sn) with some axon collaterals to the other regions. |
2013-11-12 |
2023-08-12 |
rat |
| Patrick P Michel, Damien Toulorge, Serge Guerreiro, Etienne C Hirsc. Specific needs of dopamine neurons for stimulation in order to survive: implication for Parkinson disease. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 27. issue 9. 2013-11-12. PMID:23699175. |
parkinson disease (pd) is a degenerative brain disorder characterized by motor symptoms that are unequivocally associated with the loss of dopaminergic (da) neurons in the substantia nigra (sn). |
2013-11-12 |
2023-08-12 |
Not clear |
| Brandon S Pruett, Michael F Salvator. Nigral GFRα1 infusion in aged rats increases locomotor activity, nigral tyrosine hydroxylase, and dopamine content in synchronicity. Molecular neurobiology. vol 47. issue 3. 2013-11-11. PMID:23321789. |
delivery of exogenous glial cell line-derived neurotrophic factor (gdnf) increases locomotor activity in rodent models of aging and parkinson's disease in conjunction with increased dopamine (da) tissue content in substantia nigra (sn). |
2013-11-11 |
2023-08-12 |
rat |
| Liya Qin, Yuxin Liu, Jau-Shyong Hong, Fulton T Crew. NADPH oxidase and aging drive microglial activation, oxidative stress, and dopaminergic neurodegeneration following systemic LPS administration. Glia. vol 61. issue 6. 2013-10-29. PMID:23536230. |
parkinson's disease is characterized by a progressive degeneration of substantia nigra (sn) dopaminergic neurons with age. |
2013-10-29 |
2023-08-12 |
mouse |
| Michael T Stefanik, Yonatan M Kupchik, Robyn M Brown, Peter W Kaliva. Optogenetic evidence that pallidal projections, not nigral projections, from the nucleus accumbens core are necessary for reinstating cocaine seeking. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 33. issue 34. 2013-10-28. PMID:23966687. |
projections from nacore that could carry information necessary to initiate reinstated cocaine seeking include outputs via the indirect pathway to the dorsolateral subcompartment of the ventral pallidum (dlvp) and through the direct pathway to the medial substantia nigra (sn). |
2013-10-28 |
2023-08-12 |
rat |
| J I Romero-Romo, C C C Bauer, E H Pasaye, R A Gutiérrez, R Favila, F A Barrio. Abnormal functioning of the thalamocortical system underlies the conscious awareness of the phantom limb phenomenon. The neuroradiology journal. vol 23. issue 6. 2013-10-24. PMID:24148720. |
while all subjects shared neural processing of distinctive regional cerebral activations during motor imagery of the intact toes (prefrontal (pf), supplementary motor area (sma), primary motor cortex (m1), superior temporal gyrus (stg)), it was only during motor imagery of the amputated toes in amputees that we observed an increased blood oxygen level-dependent (bold) signal in the contralateral basal ganglia at the medial globus pallidus (mgp), substantia nigra (sn), and thalamus. |
2013-10-24 |
2023-08-12 |
human |
| Joanna A Korecka, Ruben Eggers, Dick F Swaab, Koen Bossers, Joost Verhaage. Modeling early Parkinson's disease pathology with chronic low dose MPTP treatment. Restorative neurology and neuroscience. vol 31. issue 2. 2013-09-20. PMID:23271419. |
parkinson's disease (pd) is a movement disorder mainly characterized by progressive neurodegeneration of dopaminergic (daergic) neurons in the substantia nigra (sn). |
2013-09-20 |
2023-08-12 |
Not clear |
| Ofelia M Littrell, Ann-Charlotte Granholm, Greg A Gerhardt, Heather A Boge. Glial cell-line derived neurotrophic factor (GDNF) replacement attenuates motor impairments and nigrostriatal dopamine deficits in 12-month-old mice with a partial deletion of GDNF. Pharmacology, biochemistry, and behavior. vol 104. 2013-09-17. PMID:23290934. |
studies using gdnf heterozygous (gdnf(+/-)) mice have demonstrated that a partial reduction of gdnf leads to an age-related accelerated decline in nigrostriatal da system- and motor-function and increased neuro-inflammation and oxidative stress in the substantia nigra (sn). |
2013-09-17 |
2023-08-12 |
mouse |
| Lingling Lu, Chunyan Zhang, Qing Cai, Qiang Lu, Chunli Duan, Yuangang Zhu, Hui Yan. Voltage-dependent anion channel involved in the α-synuclein-induced dopaminergic neuron toxicity in rats. Acta biochimica et biophysica Sinica. vol 45. issue 3. 2013-09-12. PMID:23291291. |
furthermore, over-expression of α-syn in rat brain partly mimics the neuropathological and behavioral features of pd by triggering the degeneration of dopaminergic neurons in the substantia nigra (sn). |
2013-09-12 |
2023-08-12 |
rat |
| Bailin Wu, Bo Song, Haiqing Yang, Boyuan Huang, Bo Chi, Yansu Guo, Huaijun Li. Central nervous system damage due to acute paraquat poisoning: an experimental study with rat model. Neurotoxicology. vol 35. 2013-09-10. PMID:23261591. |
in substantia nigra (sn) and striatum we found obvious microglia (labeled by iba-1) activation within one week. |
2013-09-10 |
2023-08-12 |
rat |
| Judith Thomas Tayra, Masahiro Kameda, Takao Yasuhara, Takashi Agari, Tomohito Kadota, Feifei Wang, Yoichiro Kikuchi, Hanbai Liang, Aiko Shinko, Takaaki Wakamori, Brigitta Vcelar, Robert Weik, Isao Dat. The neuroprotective and neurorescue effects of carbamylated erythropoietin Fc fusion protein (CEPO-Fc) in a rat model of Parkinson's disease. Brain research. vol 1502. 2013-09-05. PMID:23380533. |
histologically, significantly more tyrosine hydroxylase (th)-positive neurons were recognized in the substantia nigra (sn) pars compacta in the cepo-fc group than in the pbs and epo-fc groups. |
2013-09-05 |
2023-08-12 |
rat |
| Amy Reeve, Martin Meagher, Nichola Lax, Eve Simcox, Philippa Hepplewhite, Evelyn Jaros, Doug Turnbul. The impact of pathogenic mitochondrial DNA mutations on substantia nigra neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 33. issue 26. 2013-09-05. PMID:23804100. |
mitochondrial defects within substantia nigra (sn) neurons are implicated in the pathogenesis of parkinson's disease. |
2013-09-05 |
2023-08-12 |
Not clear |
| Yasuko Ohe, Takeshi Hayashi, Akira Uchino, Norio Tanahash. [Secondary degeneration of the substantia nigra after cerebral infarctions including the striatum]. Brain and nerve = Shinkei kenkyu no shinpo. vol 65. issue 3. 2013-08-16. PMID:23475521. |
secondary degeneration of the substantia nigra (sn) after damage to the ipsilateral striatum has been widely reported in animal stroke models. |
2013-08-16 |
2023-08-12 |
Not clear |