| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Esperanza García, Ricardo Santana-Martínez, Carlos A Silva-Islas, Ana Laura Colín-González, Sonia Galván-Arzate, Yessica Heras, Perla D Maldonado, Julio Sotelo, Abel Santamarí. S-allyl cysteine protects against MPTP-induced striatal and nigral oxidative neurotoxicity in mice: participation of Nrf2. Free radical research. vol 48. issue 2. 2014-07-24. PMID:24147739. |
our findings suggest that sac can exert neuroprotection since the origin of the dopaminergic lesion-at the substantia nigra (sn)-not only by means of direct antioxidant actions, but also through nrf2 nuclear transactivation and phase 2 enzymes upregulation. |
2014-07-24 |
2023-08-12 |
mouse |
| Elżbieta Lorenc-Koci, Anna Czarnecka, Tomasz Lenda, Kinga Kamińska, Jolanta Konieczn. Molsidomine, a nitric oxide donor, modulates rotational behavior and monoamine metabolism in 6-OHDA lesioned rats treated chronically with L-DOPA. Neurochemistry international. vol 63. issue 8. 2014-07-22. PMID:24090640. |
the aim of our study was to examine the impact of chronic combined treatment with low doses of the no donor molsidomine (2 and 4mg/kg) and l-dopa (12.5 and 25mg/kg) on rotational behavior and monoamine metabolism in the striatum (str) and substantia nigra (sn) of unilaterally 6-ohda-lesioned rats. |
2014-07-22 |
2023-08-12 |
rat |
| Hye-Jin Moon, Yongmin Chang, Yeong Seon Lee, Hee Jin Song, Hyuk Won Chang, Jeonghun Ku, Yong Won Ch. T2 relaxometry using 3.0-tesla magnetic resonance imaging of the brain in early- and late-onset restless legs syndrome. Journal of clinical neurology (Seoul, Korea). vol 10. issue 3. 2014-07-21. PMID:25045371. |
measurement of the iron content in several brain regions, and in particular the substantia nigra (sn), in early- and late-onset rls patients using t2 relaxometry have yielded inconsistent results. |
2014-07-21 |
2023-08-13 |
Not clear |
| Alex A MacDonald, Ken N Seergobin, Adrian M Owen, Ruzbeh Tamjeedi, Oury Monchi, Hooman Ganjavi, Penny A MacDonal. Differential effects of Parkinson's disease and dopamine replacement on memory encoding and retrieval. PloS one. vol 8. issue 9. 2014-07-18. PMID:24086309. |
in pd, the dopamine-producing cells of the substantia nigra (sn) are significantly degenerated whereas those in the ventral tegmental area (vta) are relatively spared. |
2014-07-18 |
2023-08-12 |
Not clear |
| Marina S Hernandes, Graziella D R Santos, Cecília C Café-Mendes, Larissa S Lima, Cristoforo Scavone, Carolina D Munhoz, Luiz R G Britt. Microglial cells are involved in the susceptibility of NADPH oxidase knockout mice to 6-hydroxy-dopamine-induced neurodegeneration. PloS one. vol 8. issue 9. 2014-07-14. PMID:24086556. |
nox1 and nox2 gene expression were found to increase in striatum, whereas a marked increase of nox2 expression was observed in substantia nigra (sn) of wild-type (wt) mice after pd induction. |
2014-07-14 |
2023-08-12 |
mouse |
| Ji-Hi Pyo, You-Kyung Jeong, Sujung Yeo, Je-Hyun Lee, Mi-Young Jeong, Sung-Hoon Kim, Yeong-Gon Choi, Sabina Li. Neuroprotective effect of trans-cinnamaldehyde on the 6-hydroxydopamine-induced dopaminergic injury. Biological & pharmaceutical bulletin. vol 36. issue 12. 2014-07-14. PMID:24292051. |
at 7 d after the 6-ohda injection, 6-ohda led to a severe loss of tyrosine hydroxylase (th)-positive dopaminergic neurons in the striatum and substantia nigra (sn). |
2014-07-14 |
2023-08-12 |
mouse |
| Weidong L. Role of iron in UPS impairment model of Parkinson's disease. Parkinsonism & related disorders. vol 20 Suppl 1. 2014-07-11. PMID:24262171. |
our studies have shown that injection of the proteasome inhibitor lactacystin in the substantia nigra (sn) of rodents causes significant loss of dopamine (da) neurons and induces intracellular inclusion body formation, which is accompanied by excessive iron accumulation in the midbrain. |
2014-07-11 |
2023-08-12 |
Not clear |
| Mirco Cosottini, Daniela Frosini, Ilaria Pesaresi, Mauro Costagli, Laura Biagi, Roberto Ceravolo, Ubaldo Bonuccelli, Michela Tosett. MR imaging of the substantia nigra at 7 T enables diagnosis of Parkinson disease. Radiology. vol 271. issue 3. 2014-07-10. PMID:24601752. |
to evaluate the anatomy of the substantia nigra (sn) in healthy subjects by performing 7-t magnetic resonance (mr) imaging of the sn, and to prospectively define the accuracy of 7-t mr imaging in distinguishing parkinson disease (pd) patients from healthy subjects on an individual basis. |
2014-07-10 |
2023-08-12 |
human |
| Ashwin G Ramayya, Amrit Misra, Gordon H Baltuch, Michael J Kahan. Microstimulation of the human substantia nigra alters reinforcement learning. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 34. issue 20. 2014-07-10. PMID:24828643. |
animal studies have shown that substantia nigra (sn) dopaminergic (da) neurons strengthen action-reward associations during reinforcement learning, but their role in human learning is not known. |
2014-07-10 |
2023-08-13 |
human |
| Laura Parkkinen, Sean S O'Sullivan, Catherine Collins, Aviva Petrie, Janice L Holton, Tamas Revesz, Andrew J Lee. Disentangling the relationship between lewy bodies and nigral neuronal loss in Parkinson's disease. Journal of Parkinson's disease. vol 1. issue 3. 2014-07-07. PMID:23939308. |
density of pigmented neurons was measured in a single section of one half of the substantia nigra (sn) with delineation of the dorsal and ventral tiers whereas the cortical and nigral lb densities were determined using a morphometric approach. |
2014-07-07 |
2023-08-12 |
Not clear |
| Henriqueta Dias Cardoso, Eraldo Fonseca dos Santos Junior, David Filipe de Santana, Catarina Gonçalves-Pimentel, Monara Kaélle Angelim, Alinny R Isaac, Cláudia Jacques Lagranha, Rubem Carlos Araújo Guedes, Eduardo Isidoro Beltrão, Edgar Morya, Marcelo Cairrão Araújo Rodrigues, Belmira Lara da Silveira Andrade-da-Cost. Omega-3 deficiency and neurodegeneration in the substantia nigra: involvement of increased nitric oxide production and reduced BDNF expression. Biochimica et biophysica acta. vol 1840. issue 6. 2014-07-03. PMID:24361617. |
our previous study demonstrated that essential fatty acid (efa) dietary restriction over two generations induced midbrain dopaminergic cell loss and oxidative stress in the substantia nigra (sn) but not in the striatum of young rats. |
2014-07-03 |
2023-08-12 |
rat |
| M Jaber, M Benoit-Marand, L Prestoz, A Gaillar. Cell transplantation in the damaged adult brain. Revue neurologique. vol 169. issue 11. 2014-07-01. PMID:24112517. |
to date, cell replacement trials in pd aiming at replacing lost dopamine neurons were mainly focused on placing the transplanted cells within the target site, the striatum, and not within the lesioned site, the substantia nigra (sn). |
2014-07-01 |
2023-08-12 |
Not clear |
| Stefanie Behnke, Dirk Hellwig, Jan Bürmann, Anne Runkel, Georgios Farmakis, Carl M Kirsch, Klaus Fassbender, Georg Becker, Ulrich Dillmann, Jörg Spiege. Evaluation of transcranial sonographic findings and MIBG cardiac scintigraphy in the diagnosis of idiopathic Parkinson's disease. Parkinsonism & related disorders. vol 19. issue 11. 2014-06-27. PMID:23880025. |
the extent of substantia nigra hyperechogenicity (sn+) contralateral to the clinically more affected body side (sn(contra)) was compared to myocardial (123)i-mibg uptake. |
2014-06-27 |
2023-08-12 |
Not clear |
| Vanessa Stuckenholz, Michael Bacher, Monika Balzer-Geldsetzer, Daniel Alvarez-Fischer, Wolfgang H Oertel, Richard C Dodel, Carmen Noelke. The α7 nAChR agonist PNU-282987 reduces inflammation and MPTP-induced nigral dopaminergic cell loss in mice. Journal of Parkinson's disease. vol 3. issue 2. 2014-06-25. PMID:23938346. |
parkinson's disease (pd) is associated with neurodegeneration of dopaminergic neurons and an accompanying neuroinflammatory process in the substantia nigra (sn). |
2014-06-25 |
2023-08-12 |
mouse |
| Sachiko Tanaka, Atsuko Ishii, Hirokazu Ohtaki, Seiji Shioda, Takemi Yoshida, Satoshi Numazaw. Activation of microglia induces symptoms of Parkinson's disease in wild-type, but not in IL-1 knockout mice. Journal of neuroinflammation. vol 10. 2014-06-25. PMID:24289537. |
parkinson's disease (pd) is an age-related progressive neurodegenerative disorder caused by selective loss of dopaminergic neurons from the substantia nigra (sn) to the striatum. |
2014-06-25 |
2023-08-12 |
mouse |
| Jonas A Hosp, Andreas R Luf. Dopaminergic meso-cortical projections to m1: role in motor learning and motor cortex plasticity. Frontiers in neurology. vol 4. 2014-06-24. PMID:24109472. |
da fibers innervating m1 originate within the midbrain, precisely the ventral tegmental area (vta) and the medial portion of substantia nigra (sn). |
2014-06-24 |
2023-08-12 |
rat |
| Roger Cachope, Joseph F Chee. Local control of striatal dopamine release. Frontiers in behavioral neuroscience. vol 8. 2014-06-24. PMID:24904339. |
control of da release in the striatum is tightly linked to firing of da neurons in the ventral tegmental area (vta) and the substantia nigra (sn). |
2014-06-24 |
2023-08-13 |
Not clear |
| Frederick P Bellinger, Arjun V Raman, Rachel H Rueli, Miyoko T Bellinger, Andrea S Dewing, Lucia A Seale, Marilou A Andres, Jane H Uyehara-Lock, Lon R White, G Webster Ross, Marla J Berr. Changes in selenoprotein P in substantia nigra and putamen in Parkinson's disease. Journal of Parkinson's disease. vol 2. issue 2. 2014-06-20. PMID:23268326. |
sepp1 in midbrain was expressed in neurons of the substantia nigra (sn), and expression was concentrated within the centers of lewy bodies, the pathological hallmark of pd. |
2014-06-20 |
2023-08-12 |
human |
| Mikael Skorpil, Veli Söderlund, Anders Sundin, Per Svenningsso. MRI diffusion in Parkinson's disease: using the technique's inherent directional information to study the olfactory bulb and substantia nigra. Journal of Parkinson's disease. vol 2. issue 2. 2014-06-20. PMID:23939442. |
pathological studies have shown that parkinson's disease (pd) at early stages affects the olfactory bulb (ob) followed by an involvement of substantia nigra (sn) and other brain regions. |
2014-06-20 |
2023-08-12 |
Not clear |
| Anne L Spieles-Engemann, Kathy Steece-Collier, Michael M Behbehani, Timothy J Collier, Susan L Wohlgenant, Christopher J Kemp, Allyson Cole-Strauss, Nathan D Levine, Sara E Gombash, Valerie B Thompson, Jack W Lipton, Caryl E Sortwel. Subthalamic nucleus stimulation increases brain derived neurotrophic factor in the nigrostriatal system and primary motor cortex. Journal of Parkinson's disease. vol 1. issue 1. 2014-06-18. PMID:22328911. |
stn dbs also was associated with bilateral increases in bdnf mrna in the substantia nigra (sn) and internal globus pallidus (gpi). |
2014-06-18 |
2023-08-12 |
rat |