| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| J A Priebe, P Rieckmann, S Lautenbache. [Central pain processing and Parkinson's disease. Epidemiology, physiology, and experimental results issuing pain processing]. Schmerz (Berlin, Germany). vol 26. issue 6. 2013-11-19. PMID:23052966. |
parkinson's disease (pd) is caused by degeneration of the dopaminergic neurons in the substantia nigra (sn) and a resulting dysfunction of the nigrostriatal pathways including the basal ganglia. |
2013-11-19 |
2023-08-12 |
Not clear |
| Yoshinori Koshimizu, Fumino Fujiyama, Kouichi C Nakamura, Takahiro Furuta, Takeshi Kanek. Quantitative analysis of axon bouton distribution of subthalamic nucleus neurons in the rat by single neuron visualization with a viral vector. The Journal of comparative neurology. vol 521. issue 9. 2013-11-12. PMID:23595816. |
the subthalamic nucleus (stn) of the basal ganglia plays a key role in motor control, and stn efferents are known to mainly target the external segment of the globus pallidus (gpe), entopeduncular nucleus (ep), and substantia nigra (sn) with some axon collaterals to the other regions. |
2013-11-12 |
2023-08-12 |
rat |
| Patrick P Michel, Damien Toulorge, Serge Guerreiro, Etienne C Hirsc. Specific needs of dopamine neurons for stimulation in order to survive: implication for Parkinson disease. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 27. issue 9. 2013-11-12. PMID:23699175. |
parkinson disease (pd) is a degenerative brain disorder characterized by motor symptoms that are unequivocally associated with the loss of dopaminergic (da) neurons in the substantia nigra (sn). |
2013-11-12 |
2023-08-12 |
Not clear |
| Brandon S Pruett, Michael F Salvator. Nigral GFRα1 infusion in aged rats increases locomotor activity, nigral tyrosine hydroxylase, and dopamine content in synchronicity. Molecular neurobiology. vol 47. issue 3. 2013-11-11. PMID:23321789. |
delivery of exogenous glial cell line-derived neurotrophic factor (gdnf) increases locomotor activity in rodent models of aging and parkinson's disease in conjunction with increased dopamine (da) tissue content in substantia nigra (sn). |
2013-11-11 |
2023-08-12 |
rat |
| Liya Qin, Yuxin Liu, Jau-Shyong Hong, Fulton T Crew. NADPH oxidase and aging drive microglial activation, oxidative stress, and dopaminergic neurodegeneration following systemic LPS administration. Glia. vol 61. issue 6. 2013-10-29. PMID:23536230. |
parkinson's disease is characterized by a progressive degeneration of substantia nigra (sn) dopaminergic neurons with age. |
2013-10-29 |
2023-08-12 |
mouse |
| Michael T Stefanik, Yonatan M Kupchik, Robyn M Brown, Peter W Kaliva. Optogenetic evidence that pallidal projections, not nigral projections, from the nucleus accumbens core are necessary for reinstating cocaine seeking. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 33. issue 34. 2013-10-28. PMID:23966687. |
projections from nacore that could carry information necessary to initiate reinstated cocaine seeking include outputs via the indirect pathway to the dorsolateral subcompartment of the ventral pallidum (dlvp) and through the direct pathway to the medial substantia nigra (sn). |
2013-10-28 |
2023-08-12 |
rat |
| J I Romero-Romo, C C C Bauer, E H Pasaye, R A Gutiérrez, R Favila, F A Barrio. Abnormal functioning of the thalamocortical system underlies the conscious awareness of the phantom limb phenomenon. The neuroradiology journal. vol 23. issue 6. 2013-10-24. PMID:24148720. |
while all subjects shared neural processing of distinctive regional cerebral activations during motor imagery of the intact toes (prefrontal (pf), supplementary motor area (sma), primary motor cortex (m1), superior temporal gyrus (stg)), it was only during motor imagery of the amputated toes in amputees that we observed an increased blood oxygen level-dependent (bold) signal in the contralateral basal ganglia at the medial globus pallidus (mgp), substantia nigra (sn), and thalamus. |
2013-10-24 |
2023-08-12 |
human |
| Joanna A Korecka, Ruben Eggers, Dick F Swaab, Koen Bossers, Joost Verhaage. Modeling early Parkinson's disease pathology with chronic low dose MPTP treatment. Restorative neurology and neuroscience. vol 31. issue 2. 2013-09-20. PMID:23271419. |
parkinson's disease (pd) is a movement disorder mainly characterized by progressive neurodegeneration of dopaminergic (daergic) neurons in the substantia nigra (sn). |
2013-09-20 |
2023-08-12 |
Not clear |
| Ofelia M Littrell, Ann-Charlotte Granholm, Greg A Gerhardt, Heather A Boge. Glial cell-line derived neurotrophic factor (GDNF) replacement attenuates motor impairments and nigrostriatal dopamine deficits in 12-month-old mice with a partial deletion of GDNF. Pharmacology, biochemistry, and behavior. vol 104. 2013-09-17. PMID:23290934. |
studies using gdnf heterozygous (gdnf(+/-)) mice have demonstrated that a partial reduction of gdnf leads to an age-related accelerated decline in nigrostriatal da system- and motor-function and increased neuro-inflammation and oxidative stress in the substantia nigra (sn). |
2013-09-17 |
2023-08-12 |
mouse |
| Lingling Lu, Chunyan Zhang, Qing Cai, Qiang Lu, Chunli Duan, Yuangang Zhu, Hui Yan. Voltage-dependent anion channel involved in the α-synuclein-induced dopaminergic neuron toxicity in rats. Acta biochimica et biophysica Sinica. vol 45. issue 3. 2013-09-12. PMID:23291291. |
furthermore, over-expression of α-syn in rat brain partly mimics the neuropathological and behavioral features of pd by triggering the degeneration of dopaminergic neurons in the substantia nigra (sn). |
2013-09-12 |
2023-08-12 |
rat |
| Bailin Wu, Bo Song, Haiqing Yang, Boyuan Huang, Bo Chi, Yansu Guo, Huaijun Li. Central nervous system damage due to acute paraquat poisoning: an experimental study with rat model. Neurotoxicology. vol 35. 2013-09-10. PMID:23261591. |
in substantia nigra (sn) and striatum we found obvious microglia (labeled by iba-1) activation within one week. |
2013-09-10 |
2023-08-12 |
rat |
| Judith Thomas Tayra, Masahiro Kameda, Takao Yasuhara, Takashi Agari, Tomohito Kadota, Feifei Wang, Yoichiro Kikuchi, Hanbai Liang, Aiko Shinko, Takaaki Wakamori, Brigitta Vcelar, Robert Weik, Isao Dat. The neuroprotective and neurorescue effects of carbamylated erythropoietin Fc fusion protein (CEPO-Fc) in a rat model of Parkinson's disease. Brain research. vol 1502. 2013-09-05. PMID:23380533. |
histologically, significantly more tyrosine hydroxylase (th)-positive neurons were recognized in the substantia nigra (sn) pars compacta in the cepo-fc group than in the pbs and epo-fc groups. |
2013-09-05 |
2023-08-12 |
rat |
| Amy Reeve, Martin Meagher, Nichola Lax, Eve Simcox, Philippa Hepplewhite, Evelyn Jaros, Doug Turnbul. The impact of pathogenic mitochondrial DNA mutations on substantia nigra neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 33. issue 26. 2013-09-05. PMID:23804100. |
mitochondrial defects within substantia nigra (sn) neurons are implicated in the pathogenesis of parkinson's disease. |
2013-09-05 |
2023-08-12 |
Not clear |
| Yasuko Ohe, Takeshi Hayashi, Akira Uchino, Norio Tanahash. [Secondary degeneration of the substantia nigra after cerebral infarctions including the striatum]. Brain and nerve = Shinkei kenkyu no shinpo. vol 65. issue 3. 2013-08-16. PMID:23475521. |
secondary degeneration of the substantia nigra (sn) after damage to the ipsilateral striatum has been widely reported in animal stroke models. |
2013-08-16 |
2023-08-12 |
Not clear |
| Sudarshan Phani, Michael Jablonski, Josh Pelta-Heller, Jingli Cai, Lorraine Iacovitt. Gremlin is a novel VTA derived neuroprotective factor for dopamine neurons. Brain research. vol 1500. 2013-08-15. PMID:23348379. |
in humans, da neurons of the substantia nigra (sn) and their projections to the striatum show selective vulnerability, while neighboring da neurons of the ventral tegmental area (vta) are relatively spared from degeneration. |
2013-08-15 |
2023-08-12 |
Not clear |
| Stefano Delli Pizzi, Cosmo Rossi, Vincenzo Di Matteo, Ennio Esposito, Simone Guarnieri, Maria Addolorata Mariggiò, Raffaella Franciotti, Massimo Caulo, Astrid Thomas, Marco Onofrj, Armando Tartaro, Laura Bonann. Morphological and metabolic changes in the nigro-striatal pathway of synthetic proteasome inhibitor (PSI)-treated rats: a MRI and MRS study. PloS one. vol 8. issue 2. 2013-08-15. PMID:23431380. |
systemic administration of a synthetic proteasome inhibitor (psi) in rats has been described as able to provide a model of parkinson's disease (pd), characterized by behavioral and biochemical modifications, including loss of dopaminergic neurons in the substantia nigra (sn), as assessed by post-mortem studies. |
2013-08-15 |
2023-08-12 |
rat |
| Mechelle M Lewis, Guangwei Du, Michal Kidacki, Nisargkumar Patel, Michele L Shaffer, Richard B Mailman, Xuemei Huan. Higher iron in the red nucleus marks Parkinson's dyskinesia. Neurobiology of aging. vol 34. issue 5. 2013-08-13. PMID:23177595. |
dopamine cell loss and increased iron in the substantia nigra (sn) characterize parkinson's disease (pd), with cerebellar involvement increasingly recognized, particularly in motor compensation and levodopa-induced dyskinesia (lid) development. |
2013-08-13 |
2023-08-12 |
human |
| Lu-Tai Tien, Asuka Kaizaki, Yi Pang, Zhengwei Cai, Abhay J Bhatt, Lir-Wan Fa. Neonatal exposure to lipopolysaccharide enhances accumulation of α-synuclein aggregation and dopamine transporter protein expression in the substantia nigra in responses to rotenone challenge in later life. Toxicology. vol 308. 2013-08-13. PMID:23567316. |
our previous studies show that perinatal lipopolysaccharide (lps) exposure enhances adult susceptibility to rotenone-induced injury to the dopaminergic system in the substantia nigra (sn) of the adult rat brain. |
2013-08-13 |
2023-08-12 |
rat |
| Ahmed Sharaf, Kerstin Krieglstein, Björn Spitta. Distribution of microglia in the postnatal murine nigrostriatal system. Cell and tissue research. vol 351. issue 3. 2013-08-07. PMID:23250575. |
parkinson's disease (pd) is characterized by the degeneration of dopaminergic neurons in the substantia nigra (sn) and the subsequent loss of striatal target innervation. |
2013-08-07 |
2023-08-12 |
mouse |
| Jost-Julian Rumpf, David Weise, Christopher Fricke, Tino Wetzig, Jan-Christoph Simon, Joseph Classe. Sonographic abnormality of the substantia nigra in melanoma patients. Movement disorders : official journal of the Movement Disorder Society. vol 28. issue 2. 2013-08-06. PMID:23114984. |
transcranial sonography of the midbrain reveals an extended echogenic substantia nigra (sn) area in a high proportion of patients with pd. |
2013-08-06 |
2023-08-12 |
Not clear |