| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Francesca Vaglini, Cristina Viaggi, Valentina Piro, Carla Pardini, Claudio Gerace, Marco Scarselli, Giovanni Umberto Corsin. Acetaldehyde and parkinsonism: role of CYP450 2E1. Frontiers in behavioral neuroscience. vol 7. 2013-06-27. PMID:23801948. |
the presence of cyp 2e1 has been detected in the dopamine (da) neurons of rodent substantia nigra (sn), but a precise function of the enzyme has not been elucidated yet. |
2013-06-27 |
2023-08-12 |
mouse |
| Raymond T Bartus, Tiffany L Baumann, Joao Siffert, Christopher D Herzog, Ron Alterman, Nicholas Boulis, Dennis A Turner, Mark Stacy, Anthony E Lang, Andres M Lozano, C Warren Olano. Safety/feasibility of targeting the substantia nigra with AAV2-neurturin in Parkinson patients. Neurology. vol 80. issue 18. 2013-06-26. PMID:23576625. |
in an effort to account for deficiencies in axonal transport that limit the effectiveness of neurotrophic factors, this study tested the safety and feasibility, in moderately advanced parkinson disease (pd), of bilaterally administering the gene therapy vector aav2-neurturin (cere-120) to the putamen plus substantia nigra (sn, a relatively small structure deep within the midbrain, in proximity to critical neuronal and vascular structures). |
2013-06-26 |
2023-08-12 |
Not clear |
| Sagar Kansara, Akash Trivedi, Sheng Chen, Joseph Jankovic, Weidong L. Early diagnosis and therapy of Parkinson's disease: can disease progression be curbed? Journal of neural transmission (Vienna, Austria : 1996). vol 120. issue 1. 2013-06-14. PMID:22733089. |
parkinson's disease (pd), the second most common neurodegenerative disorder, is characterized by the loss of dopamine (da) neurons in the substantia nigra (sn). |
2013-06-14 |
2023-08-12 |
Not clear |
| Alison I Bernstein, Karen L O'Malle. MPP+-induces PUMA- and p53-dependent, but ATF3-independent cell death. Toxicology letters. vol 219. issue 2. 2013-06-14. PMID:23500530. |
parkinson's disease (pd) is characterized by the progressive loss of dopaminergic neurons in the substantia nigra (sn) and depletion of striatal dopamine (da), leading to a range of motor symptoms, including resting tremor, rigidity, bradykinesia and postural abnormalities. |
2013-06-14 |
2023-08-12 |
mouse |
| Francisco Pan-Montojo, Richard H W Fun. Implications of Parkinson's disease pathophysiology for the development of cell replacement strategies and drug discovery in neurodegenerative diseases. CNS & neurological disorders drug targets. vol 11. issue 7. 2013-06-13. PMID:23131153. |
parkinson's disease (pd) is a progressive neurodegenerative disorder traditionally characterized by the loss of dopaminergic neurons in the substantia nigra (sn) at the midbrain. |
2013-06-13 |
2023-08-12 |
Not clear |
| Arjen J Boender, Andrea J van Rozen, Roger A H Ada. Nutritional state affects the expression of the obesity-associated genes Etv5, Faim2, Fto, and Negr1. Obesity (Silver Spring, Md.). vol 20. issue 12. 2013-06-11. PMID:22627920. |
to gain more insight into the neurobiological mechanisms involved, we set out to investigate the effect of dietary exposure on the expression levels of obesity-associated genes in the ventro-medial hypothalamus (vmh)/arcuate nucleus (arc) and the substantia nigra (sn)/ventral tegmental area (vta), two brain regions that are implicated in feeding behavior. |
2013-06-11 |
2023-08-12 |
Not clear |
| G Harish, Anita Mahadevan, M M Srinivas Bharath, S K Shanka. Alteration in glutathione content and associated enzyme activities in the synaptic terminals but not in the non-synaptic mitochondria from the frontal cortex of Parkinson's disease brains. Neurochemical research. vol 38. issue 1. 2013-05-29. PMID:23070472. |
this is reflected in the substantia nigra (sn) of pd patients as lowered antioxidant levels and elevated oxidative damage. |
2013-05-29 |
2023-08-12 |
human |
| Shelby K Suckow, Emily L Deichsel, Susan L Ingram, Michael M Morgan, Sue A Aiche. Columnar distribution of catecholaminergic neurons in the ventrolateral periaqueductal gray and their relationship to efferent pathways. Synapse (New York, N.Y.). vol 67. issue 2. 2013-05-29. PMID:23152302. |
in addition, the pag contains ascending pathways to regions involved in the regulation of reward, including the substantia nigra (sn) and the ventral tegmental area (vta). |
2013-05-29 |
2023-08-12 |
Not clear |
| Ling Shan, Koen Bossers, Sabina Luchetti, Rawien Balesar, Natasha Lethbridge, Paul L Chazot, Ai-Min Bao, Dick F Swaa. Alterations in the histaminergic system in the substantia nigra and striatum of Parkinson's patients: a postmortem study. Neurobiology of aging. vol 33. issue 7. 2013-05-27. PMID:22118942. |
earlier studies showed neuronal histamine production in the hypothalamic tuberomamillary nucleus to be unchanged in parkinson's disease (pd), whereas the histamine levels and innervation in the substantia nigra (sn) increased. |
2013-05-27 |
2023-08-12 |
Not clear |
| Yunjing Bai, Yonghua Peng, Jing Liang, Xigeng Zhen. Differential patterns of neuronal activation in rostral versus caudal ventral tegmental area involved in behavioral sensitization induced by an escalating-dose morphine administration paradigm. European journal of pharmacology. vol 689. issue 1-3. 2013-05-23. PMID:22659588. |
the purpose of the present study was to characterize neuronal activation in the ventral tegmental area (vta) and substantia nigra (sn) following chronic escalating-dose morphine exposure (days 1-7, 2 mg/kg/d; days 8-21, beginning at 10 mg/kg/d, increasing by 2 mg/kg/d), with steady-dose morphine (2 mg/kg/d, i.p., for 21 days) as the comparison. |
2013-05-23 |
2023-08-12 |
rat |
| Yoichi Imaizumi, Yohei Okada, Wado Akamatsu, Masato Koike, Naoko Kuzumaki, Hideki Hayakawa, Tomoko Nihira, Tetsuro Kobayashi, Manabu Ohyama, Shigeto Sato, Masashi Takanashi, Manabu Funayama, Akiyoshi Hirayama, Tomoyoshi Soga, Takako Hishiki, Makoto Suematsu, Takuya Yagi, Daisuke Ito, Arifumi Kosakai, Kozo Hayashi, Masanobu Shouji, Atsushi Nakanishi, Norihiro Suzuki, Yoshikuni Mizuno, Noboru Mizushima, Masayuki Amagai, Yasuo Uchiyama, Hideki Mochizuki, Nobutaka Hattori, Hideyuki Okan. Mitochondrial dysfunction associated with increased oxidative stress and α-synuclein accumulation in PARK2 iPSC-derived neurons and postmortem brain tissue. Molecular brain. vol 5. 2013-05-15. PMID:23039195. |
parkinson's disease (pd) is a neurodegenerative disease characterized by selective degeneration of dopaminergic neurons in the substantia nigra (sn). |
2013-05-15 |
2023-08-12 |
mouse |
| Guangwei Du, Mechelle M Lewis, Suman Sen, Jianli Wang, Michele L Shaffer, Martin Styner, Qing X Yang, Xuemei Huan. Imaging nigral pathology and clinical progression in Parkinson's disease. Movement disorders : official journal of the Movement Disorder Society. vol 27. issue 13. 2013-05-13. PMID:23008179. |
the pattern of dopamine cell loss in parkinson's disease (pd) is known to be prominent in the ventrolateral and caudal substantia nigra (sn), but less severe in the dorsal and rostral region. |
2013-05-13 |
2023-08-12 |
human |
| Bhaskaran David Prakash, Yih-Yian Sitoh, Louis C S Tan, Wing Lok A. Asymmetrical diffusion tensor imaging indices of the rostral substantia nigra in Parkinson's disease. Parkinsonism & related disorders. vol 18. issue 9. 2013-05-03. PMID:22705126. |
we aim to determine if asymmetry in fractional anisotropy (fa) and apparent diffusion coefficient (adc) can be detected in the substantia nigra (sn) of pd subjects. |
2013-05-03 |
2023-08-12 |
human |
| Andreas Schäfer, Birte U Forstmann, Jane Neumann, Sam Wharton, Alexander Mietke, Richard Bowtell, Robert Turne. Direct visualization of the subthalamic nucleus and its iron distribution using high-resolution susceptibility mapping. Human brain mapping. vol 33. issue 12. 2013-04-30. PMID:21932259. |
the susceptibility maps clearly distinguish the stn from the adjacent substantia nigra (sn). |
2013-04-30 |
2023-08-12 |
human |
| Wenjuan Shen, Renbin Qi, Jing Zhang, Zhigang Wang, Huadong Wang, Chaofeng Hu, Yanru Zhao, Man Bie, Yanping Wang, Yongmei Fu, Mengfei Chen, Daxiang L. Chlorogenic acid inhibits LPS-induced microglial activation and improves survival of dopaminergic neurons. Brain research bulletin. vol 88. issue 5. 2013-04-25. PMID:22580132. |
finally, in vivo data showed that cga pretreatment attenuated lps-induced il-1β and tnf-α release in substantia nigra (sn). |
2013-04-25 |
2023-08-12 |
Not clear |
| Carolien M Toxopeus, Natasha M Maurits, Gopal Valsan, Bernard A Conway, Klaus L Leenders, Bauke M de Jon. Cerebral activations related to ballistic, stepwise interrupted and gradually modulated movements in Parkinson patients. PloS one. vol 7. issue 7. 2013-04-19. PMID:22911738. |
in healthy subjects, movement initiation was characterized by antero-ventral striatum, substantia nigra (sn) and premotor activations while inhibition was dominated by subthalamic nucleus (stn) and pallidal activations, in line with the known role of these areas in simple movement. |
2013-04-19 |
2023-08-12 |
human |
| Shuwen Cao, David G Standaert, Ashley S Harm. The gamma chain subunit of Fc receptors is required for alpha-synuclein-induced pro-inflammatory signaling in microglia. Journal of neuroinflammation. vol 9. 2013-04-19. PMID:23186369. |
the protein alpha-synuclein (α-syn), which is found in the lewy bodies of dopamine-producing (da) neurons in the substantia nigra (sn), has an important role in the pathogenesis of parkinson's disease (pd). |
2013-04-19 |
2023-08-12 |
mouse |
| Wei-Feng Luo, Ying-Chun Zhang, Yu-Jing Sheng, Jun-Chu Fang, Chun-Feng Li. Transcranial sonography on Parkinson's disease and essential tremor in a Chinese population. Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology. vol 33. issue 5. 2013-04-18. PMID:22160731. |
the echo signal intensity of midbrain substantia nigra (sn) was measured and divided into grade i-v. |
2013-04-18 |
2023-08-12 |
Not clear |
| Lanying Song, Yuxi Shan, K C Kent Lloyd, Gino A Cortopass. Mutant Twinkle increases dopaminergic neurodegeneration, mtDNA deletions and modulates Parkin expression. Human molecular genetics. vol 21. issue 23. 2013-04-12. PMID:22949510. |
parkinson's disease (pd) is the second most common neurodegenerative disorder in the developed world, and is characterized by the loss of dopaminergic (da) neurons in the substantia nigra (sn). |
2013-04-12 |
2023-08-12 |
mouse |
| Terina N Martinez, Xi Chen, Sibali Bandyopadhyay, Alfred H Merrill, Malú G Tanse. Ceramide sphingolipid signaling mediates Tumor Necrosis Factor (TNF)-dependent toxicity via caspase signaling in dopaminergic neurons. Molecular neurodegeneration. vol 7. 2013-04-09. PMID:22973882. |
dopaminergic (da) neurons in the ventral midbrain selectively degenerate in parkinson's disease (pd) in part because their oxidative environment in the substantia nigra (sn) may render them vulnerable to neuroinflammatory stimuli. |
2013-04-09 |
2023-08-12 |
rat |