| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Erik K Kastman, Auriel A Willette, Christopher L Coe, Barbara B Bendlin, Kris J Kosmatka, Donald G McLaren, Guofan Xu, Elisa Canu, Aaron S Field, Andrew L Alexander, Mary Lou Voytko, T Mark Beasley, Ricki J Colman, Richard H Weindruch, Sterling C Johnso. A calorie-restricted diet decreases brain iron accumulation and preserves motor performance in old rhesus monkeys. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 30. issue 23. 2010-08-24. PMID:20534842. |
both the cr and control monkeys showed age-related increases in iron concentrations in globus pallidus (gp) and substantia nigra (sn), although the cr group had significantly less iron deposition in the gp, sn, red nucleus, and temporal cortex. |
2010-08-24 |
2023-08-12 |
monkey |
| Shirong Wang, Eric E Turne. Expression of dopamine pathway genes in the midbrain is independent of known ETS transcription factor activity. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 30. issue 27. 2010-08-16. PMID:20610757. |
ets transcription factors are hypothesized to play a similar role in vertebrates, and based on its expression in the adult mouse midbrain, etv5/erm has been proposed as a regulator of da gene expression in the substantia nigra (sn) and ventral tegmental area (vta). |
2010-08-16 |
2023-08-12 |
mouse |
| Masaoki Iwanami, Tomoyuki Miyamoto, Masayuki Miyamoto, Koichi Hirata, Etsuo Takad. Relevance of substantia nigra hyperechogenicity and reduced odor identification in idiopathic REM sleep behavior disorder. Sleep medicine. vol 11. issue 4. 2010-08-03. PMID:20223708. |
substantia nigra (sn) hyperechogenicity determined by transcranial sonography (tcs) and olfactory dysfunction are common findings in parkinson disease (pd), which may reveal a prodromal synucleinopathy in idiopathic rem sleep behavior disorder (irbd). |
2010-08-03 |
2023-08-12 |
Not clear |
| Jiuquan Zhang, Yanling Zhang, Jian Wang, Ping Cai, Chunxia Luo, Zhongming Qian, Yongming Dai, Hua Fen. Characterizing iron deposition in Parkinson's disease using susceptibility-weighted imaging: an in vivo MR study. Brain research. vol 1330. 2010-08-02. PMID:20303339. |
the phase shift values of the bilateral red nucleus (rn), substantia nigra (sn), caudate nucleus (ca), globus pallidus (gp), putamen (pu), thalamus (th) and frontal white matter (fwm) were examined for their relationship with the clinical status. |
2010-08-02 |
2023-08-12 |
Not clear |
| Su-Feng Fan, Pei-Ling Chao, Anya Maan-Yuh Li. Arsenite induces oxidative injury in rat brain: synergistic effect of iron. Annals of the New York Academy of Sciences. vol 1199. 2010-07-29. PMID:20633106. |
our in vivo study employed intranigral infusion of arsenite (5 nmol) in the substantia nigra (sn) of anesthetized rats. |
2010-07-29 |
2023-08-12 |
rat |
| Jens Ebentheuer, Monica Canelo, Ellen Trautmann, Claudia Trenkwalde. Substantia nigra echogenicity in progressive supranuclear palsy. Movement disorders : official journal of the Movement Disorder Society. vol 25. issue 6. 2010-07-28. PMID:20198715. |
a normoechogenic substantia nigra (sn) is a typical finding in transcranial sonography in patients with progressive supranuclear palsy (psp), whereas in patients with parkinson's disease a hyperechogenic sn is characteristic. |
2010-07-28 |
2023-08-12 |
Not clear |
| Tali Fishman-Jacob, Moussa B H Youdim, Silvia A Mande. Silencing/overexpressing selected genes as a model of sporadic Parkinson's disease. Neuro-degenerative diseases. vol 7. issue 1-3. 2010-07-21. PMID:20173338. |
high-throughput gene-based platform studies in human postmortem substantia nigra (sn) from sporadic parkinson's disease (pd) cases have revealed significant dysregulation of genes involved in biological processes linked to previously established neurodegenerative mechanisms in both sporadic and hereditary pd. |
2010-07-21 |
2023-08-12 |
human |
| Li Lu, Fengqiao Li, Xiaomin Wan. Novel anti-inflammatory and neuroprotective agents for Parkinson's disease. CNS & neurological disorders drug targets. vol 9. issue 2. 2010-07-12. PMID:20015029. |
parkinson's disease (pd) is a type of motor system disorder that results from the progressive loss of dopaminergic (daergic) neurons in the substantia nigra (sn) of the midbrain. |
2010-07-12 |
2023-08-12 |
Not clear |
| Johann Hagenah, Inke R König, Jürgen Sperner, Lucas Wessel, Günter Seidel, Kelly Condefer, Rachel Saunders-Pullman, Christine Klein, Norbert Brüggeman. Life-long increase of substantia nigra hyperechogenicity in transcranial sonography. NeuroImage. vol 51. issue 1. 2010-07-08. PMID:20152909. |
transcranial ultrasound of the substantia nigra (sn) shows a distinct hyperechogenicity in the majority of patients with parkinson's disease. |
2010-07-08 |
2023-08-12 |
human |
| Jiaming Mei, Chaoshi Ni. Alterations of Hrd1 expression in various encephalic regional neurons in 6-OHDA model of Parkinson's disease. Neuroscience letters. vol 474. issue 2. 2010-07-08. PMID:20227462. |
the results showed that hrd1 was up-regulated in 6-ohda-treated mice in various encephalic regional neurons, especially those in hippocampus, substantia nigra (sn), subthalamic nucleus (stn), striatum and frontal lobe. |
2010-07-08 |
2023-08-12 |
mouse |
| Hong-Ning Zhang, Chun-Na An, Hui-Nan Zhang, Xiao-Ping P. Protocatechuic acid inhibits neurotoxicity induced by MPTP in vivo. Neuroscience letters. vol 474. issue 2. 2010-07-08. PMID:20227465. |
parkinson's disease (pd) is characterized by the progressive degeneration of dopaminergic neurons in substantia nigra (sn) with the presence of alpha-synuclein inclusions termed lewy bodies. |
2010-07-08 |
2023-08-12 |
mouse |
| Joanna Chwie. The use of cluster and discriminant analysis in the investigations of the role of trace metals in the pathogenesis of Parkinson's disease. Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS). vol 24. issue 2. 2010-07-06. PMID:20413064. |
x-ray fluorescence microscopy was applied for two-dimensional elemental analysis of substantia nigra (sn) tissue. |
2010-07-06 |
2023-08-12 |
Not clear |
| Sang Ryong Kim, Eun Sook Chung, Eugene Bok, Hyung Hwan Baik, Young Cheul Chung, So Yoon Won, Eunhye Joe, Tae Hyong Kim, Soung Soo Kim, Min Young Jin, Sang Ho Choi, Byung Kwan Ji. Prothrombin kringle-2 induces death of mesencephalic dopaminergic neurons in vivo and in vitro via microglial activation. Journal of neuroscience research. vol 88. issue 7. 2010-06-30. PMID:20025058. |
to address this question, pkr-2 was injected into the rat substantia nigra (sn). |
2010-06-30 |
2023-08-12 |
human |
| Thyagarajan Subramanian, Christopher A Lieu, Kumaraswamy Guttalu, Daniela Ber. Detection of MPTP-induced substantia nigra hyperechogenicity in Rhesus monkeys by transcranial ultrasound. Ultrasound in medicine & biology. vol 36. issue 4. 2010-06-30. PMID:20211515. |
detection of substantia nigra (sn) hyperechogenicity by transcranial ultrasound has been proposed as a putative biomarker to differentiate between idiopathic parkinson's disease (pd) and other forms of parkinsonism. |
2010-06-30 |
2023-08-12 |
monkey |
| G Todd, J L Taylor, D Baumann, J E Butler, S R Duma, M Hayes, F Carew-Jones, O Piguet, S Behnke, M C Ridding, D Berg, K L Doubl. Substantia nigra echomorphology and motor cortex excitability. NeuroImage. vol 50. issue 4. 2010-06-23. PMID:20117219. |
the aim of our study was to investigate the relation between substantia nigra (sn) echomorphology and indices of motor cortex excitability. |
2010-06-23 |
2023-08-12 |
human |
| J L George, S Mok, D Moses, S Wilkins, A I Bush, R A Cherny, D I Finkelstei. Targeting the progression of Parkinson's disease. Current neuropharmacology. vol 7. issue 1. 2010-06-18. PMID:19721815. |
by the time a patient first presents with symptoms of parkinson's disease at the clinic, a significant proportion (50-70%) of the cells in the substantia nigra (sn) has already been destroyed. |
2010-06-18 |
2023-08-12 |
Not clear |
| Wen Zhu, Xuping Li, Wenjie Xie, Feifei Luo, Deepinder Kaur, Julie K Andersen, Joseph Jankovic, Weidong L. Genetic iron chelation protects against proteasome inhibition-induced dopamine neuron degeneration. Neurobiology of disease. vol 37. issue 2. 2010-06-15. PMID:19818853. |
impairment of the ubiquitin proteasome system (ups) and iron accumulation in the substantia nigra (sn) have both been implicated in the pathogenesis of parkinson's disease (pd). |
2010-06-15 |
2023-08-12 |
human |
| L Hunter Randy, Bing Guoyin. Agonism of Peroxisome Proliferator Receptor-Gamma may have Therapeutic Potential for Neuroinflammation and Parkinson's Disease. Current neuropharmacology. vol 5. issue 1. 2010-06-11. PMID:18615152. |
evidence suggests inflammation, mitochondria dysfunction, and oxidative stress play major roles in parkinson's disease (pd), where the primary pathology is the significant loss of dopaminergic neurons in the substantia nigra (sn). |
2010-06-11 |
2023-08-12 |
Not clear |
| Feng Zhang, Li Qian, Patrick M Flood, Jing-Shan Shi, Jau-Shyong Hong, Hui-Ming Ga. Inhibition of IkappaB kinase-beta protects dopamine neurons against lipopolysaccharide-induced neurotoxicity. The Journal of pharmacology and experimental therapeutics. vol 333. issue 3. 2010-06-11. PMID:20190013. |
parkinson's disease (pd) is a progressive neurological disorder characterized by a selective loss of dopamine (da) neurons in the substantia nigra (sn). |
2010-06-11 |
2023-08-12 |
Not clear |
| J E Olijslagers, T R Werkman, A C McCreary, C G Kruse, W J Wadma. Modulation of midbrain dopamine neurotransmission by serotonin, a versatile interaction between neurotransmitters and significance for antipsychotic drug action. Current neuropharmacology. vol 4. issue 1. 2010-06-10. PMID:18615139. |
we will discuss da/5-ht interactions at the level of receptors and g protein-coupled potassium channels and consequences for induction of depolarization blockade with specific attention to da neurons in the ventral tegmental area (vta) and the substantia nigra zona compacta (sn), neurons implicated in treatment efficacy and the side-effects of schizophrenia, respectively. |
2010-06-10 |
2023-08-12 |
Not clear |