| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Fabio Coppedè, Roberto Ceravolo, Francesca Migheli, Francesca Fanucchi, Daniela Frosini, Gabriele Siciliano, Ubaldo Bonuccelli, Lucia Miglior. The hOGG1 Ser326Cys polymorphism is not associated with sporadic Parkinson's disease. Neuroscience letters. vol 473. issue 3. 2010-05-17. PMID:20193742. |
parkinson's disease (pd) is one of the most common neurodegenerative disorders characterized by progressive and profound loss of dopaminergic neurons in the substantia nigra (sn) resulting in resting tremor, rigidity, bradykinesia, and postural instability. |
2010-05-17 |
2023-08-12 |
mouse |
| Catherine R G Jones, Marjan Jahanshah. The substantia nigra, the basal ganglia, dopamine and temporal processing. Journal of neural transmission. Supplementum. issue 73. 2010-05-14. PMID:20411776. |
this review summarizes and discuses evidence from animal, pharmacological, clinical, and imaging research that supports this proposal, with particular reference to the role of the substantia nigra (sn). |
2010-05-14 |
2023-08-12 |
Not clear |
| Sabine Mehnert, Iris Reuter, Karsten Schepp, Peter Maaser, Erwin Stolz, Manfred Kap. Transcranial sonography for diagnosis of Parkinson's disease. BMC neurology. vol 10. 2010-05-05. PMID:20089201. |
although the phenomenon of an increased echogenicity of the substantia nigra (sn) is well known this method is still not widly used in the diagnostic workup. |
2010-05-05 |
2023-08-12 |
human |
| Chong Shi, Yu-xin Zhang, Zuo-feng Zhan. [Effect of phosphorylated-ERK1/2 on inducible nitric oxide synthase expression in the substantia nigra of mice with MPTP-induced Parkinson disease]. Nan fang yi ke da xue xue bao = Journal of Southern Medical University. vol 29. issue 1. 2010-04-29. PMID:19218114. |
to investigate the effect of phosphorylated-erk1/2 (p-erk1/2) on inducible nitric oxide synthase (inos) expression in the substantia nigra (sn) of a mouse model of parkinson's disease (pd), and explore the possible mechanism of dopaminergic (da) neuron loss in the sn of the midbrain in pd. |
2010-04-29 |
2023-08-12 |
mouse |
| Fleur L Warton, Fleur M Howells, Vivienne A Russel. Increased glutamate-stimulated release of dopamine in substantia nigra of a rat model for attention-deficit/hyperactivity disorder--lack of effect of methylphenidate. Metabolic brain disease. vol 24. issue 4. 2010-04-29. PMID:19821016. |
however, it is not known whether dysregulation occurs at the level of the cell bodies in the ventral tegmental area of the midbrain (vta) and substantia nigra (sn). |
2010-04-29 |
2023-08-12 |
rat |
| Esen Saka, M Akif Topcuoglu, Ahmet U Demir, Bulent Elibo. Transcranial sonography in Perry syndrome. Parkinsonism & related disorders. vol 16. issue 1. 2010-04-23. PMID:19505837. |
in both patients, transcranial sonography exhibited marked substantia nigra (sn) hyperechogenicity, which is characteristic of idiopathic parkinson's disease. |
2010-04-23 |
2023-08-12 |
human |
| Mislav Budisić, Zlatko Trkanjec, Arijana Lovrencić-Huzjan, Visnja Supanc, Vlasta Vuković, Vida Demari. [Transcranial sonography (TCS) in evaluation of patients with essential tremor]. Acta medica Croatica : casopis Hravatske akademije medicinskih znanosti. vol 63 Suppl 3. 2010-04-20. PMID:20232670. |
recent reports showed that substantia nigra (sn) hyperechogenicity detected by transcranial sonography (tcs) is a specific finding of parkinsons disease (pd). |
2010-04-20 |
2023-08-12 |
human |
| [Reactions of the somatosensory cortex neurons, activated by nociceptive afferents during stimulation of substantia nigra in experiment]. Georgian medical news. issue 175. 2010-04-15. PMID:19893130. |
in cats, we studied the influences of stimulation of the substantia nigra (sn) on postsynaptic processes evoked in neurons of the somatosensory cortex by stimulation of nociceptive (intensive stimulation of the tooth pulp) and non-nociceptive (moderate stimulation of the infra orbital nerve and ventroposteromedial (vpm) nucleus of the thalamus) afferent inputs. |
2010-04-15 |
2023-08-12 |
Not clear |
| Huamin Xu, Hong Jiang, Jun Wang, Junxia Xi. Rg1 protects the MPP+-treated MES23.5 cells via attenuating DMT1 up-regulation and cellular iron uptake. Neuropharmacology. vol 58. issue 2. 2010-04-13. PMID:19744503. |
our previous study observed the protective effect of rg1 on iron accumulation in the substantia nigra (sn) in 1-methyl-4-phenyl-1,2,3,6- tetrahydropyridine (mptp)-treated parkinson's disease (pd) mice. |
2010-04-13 |
2023-08-12 |
mouse |
| A V Droblenkov, N R Karelin. [Structural characteristics of neurons and macrogliocytes in the interconnected areas of the rat mesoaccumbocingulate dopaminergic system]. Morfologiia (Saint Petersburg, Russia). vol 136. issue 5. 2010-04-07. PMID:20210090. |
the density of neurons and gliocytes were determined in the middle part of the paranigral nucleus of ventral tegmental area (vta) and in substantia nigra (sn) compact part, as well as in the interconnected antero-medial parts of these midbrain nuclei, nucleus accumbens (na), v1 layer of a pregenual (cg3) and iii layer of a supragenual (cg2) cingulate fields. |
2010-04-07 |
2023-08-12 |
rat |
| A V Droblenkov, N R Karelin. [Structural characteristics of neurons and macrogliocytes in the interconnected areas of the rat mesoaccumbocingulate dopaminergic system]. Morfologiia (Saint Petersburg, Russia). vol 136. issue 5. 2010-04-07. PMID:20210090. |
the antero-medial parts of vta paranigral nucleus and of sn compact part, interconnected with specified cingulate structures and na, contain more neurons than the other areas, as they occupy greater volume, while there are no differences in the volume of neurons in the anterior and in the middle parts of these structures. |
2010-04-07 |
2023-08-12 |
rat |
| A V Droblenkov, N R Karelin. [Structural characteristics of neurons and macrogliocytes in the interconnected areas of the rat mesoaccumbocingulate dopaminergic system]. Morfologiia (Saint Petersburg, Russia). vol 136. issue 5. 2010-04-07. PMID:20210090. |
the anterior portion of sn compact part, besides, is remarkable for greater density of the neurons. |
2010-04-07 |
2023-08-12 |
rat |
| A V Droblenkov, N R Karelin. [Structural characteristics of neurons and macrogliocytes in the interconnected areas of the rat mesoaccumbocingulate dopaminergic system]. Morfologiia (Saint Petersburg, Russia). vol 136. issue 5. 2010-04-07. PMID:20210090. |
the anteromedial parts of vta paranigral nucleus and of sn compact part of (12.2 +/- 0.1 mm from the frontal pole) have the greatest diagnostic value for the morphological evaluation of addiction also because the lateral part of vta paranigral nucleus contains the greatest population of a nondopaminergic neurons, while the cell bodies of the neurons of the other vta nuclear groups are of small size. |
2010-04-07 |
2023-08-12 |
rat |
| Silvia A Mandel, Tali Fishman-Jacob, Moussa B H Youdi. Modeling sporadic Parkinson's disease by silencing the ubiquitin E3 ligase component, SKP1A. Parkinsonism & related disorders. vol 15 Suppl 3. 2010-03-31. PMID:20082978. |
large-scale transcriptomics analysis of gene expression profile of sporadic parkinson's disease (pd) substantia nigra (sn) has identified a number of differentially expressed genes participating in the neurotoxic cascade of da neurons death, in particular those related to handling of proteins, dopaminergic transmission and iron metabolism. |
2010-03-31 |
2023-08-12 |
human |
| E C Hirsc. Iron transport in Parkinson's disease. Parkinsonism & related disorders. vol 15 Suppl 3. 2010-03-31. PMID:20082992. |
dopaminergic cell death in the substantia nigra (sn) is central to parkinson's disease (pd) but the neurodegenerative mechanisms have not been completely elucidated. |
2010-03-31 |
2023-08-12 |
mouse |
| M S Oh, S J Hong, Y Huh, K-S Ki. Expression of transgenes in midbrain dopamine neurons using the tyrosine hydroxylase promoter. Gene therapy. vol 16. issue 3. 2010-03-26. PMID:18800154. |
the midbrain dopamine (da) neuron system consists of the retrorubral area (a8), the substantia nigra (sn; a9) and the ventral tegmental area (vta; a10). |
2010-03-26 |
2023-08-12 |
rat |
| June-Hee Park, Grigori Enikolopo. Transient elevation of adult hippocampal neurogenesis after dopamine depletion. Experimental neurology. vol 222. issue 2. 2010-03-26. PMID:20079351. |
the dentate gyrus (dg), a site of continuous production of new neurons in the adult hippocampus, receives dopaminergic inputs from the neurons of the substantia nigra (sn). |
2010-03-26 |
2023-08-12 |
mouse |
| Irene Yaroslavsky, Shanaz M Tejani-But. Voluntary alcohol consumption alters stress-induced changes in dopamine-2 receptor binding in Wistar-Kyoto rat brain. Pharmacology, biochemistry, and behavior. vol 94. issue 3. 2010-03-23. PMID:19896970. |
quantitative autoradiography experiments showed that chronic stress increased d2 receptor binding in the caudate putamen (cpu), nucleus accumbens (nac), substantia nigra (sn) and ventral tegmental area (vta) of wky rats, and reduced receptor binding in the cpu and sn of wis rats. |
2010-03-23 |
2023-08-12 |
rat |
| Michael F Salvatore, Brandon S Pruett, Sandy L Spann, Charles Dempse. Aging reveals a role for nigral tyrosine hydroxylase ser31 phosphorylation in locomotor activity generation. PloS one. vol 4. issue 12. 2010-03-17. PMID:20037632. |
however, in the substantia nigra (sn), there is equivalent loss of da or th in aging and at the onset of pd symptoms. |
2010-03-17 |
2023-08-12 |
Not clear |
| Petra Bártová, David Skoloudík, Pavel Ressner, Katerina Langová, Roman Herzig, Petr Kanovsk. Correlation between substantia nigra features detected by sonography and Parkinson disease symptoms. Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine. vol 29. issue 1. 2010-03-10. PMID:20040773. |
the aim of this study was to assess the correlation between substantia nigra (sn) echogenic features and area and the clinical symptoms in patients with parkinson disease (pd). |
2010-03-10 |
2023-08-12 |
Not clear |