| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| E C Hirsc. Iron transport in Parkinson's disease. Parkinsonism & related disorders. vol 15 Suppl 3. 2010-03-31. PMID:20082992. |
dopaminergic cell death in the substantia nigra (sn) is central to parkinson's disease (pd) but the neurodegenerative mechanisms have not been completely elucidated. |
2010-03-31 |
2023-08-12 |
mouse |
| M S Oh, S J Hong, Y Huh, K-S Ki. Expression of transgenes in midbrain dopamine neurons using the tyrosine hydroxylase promoter. Gene therapy. vol 16. issue 3. 2010-03-26. PMID:18800154. |
the midbrain dopamine (da) neuron system consists of the retrorubral area (a8), the substantia nigra (sn; a9) and the ventral tegmental area (vta; a10). |
2010-03-26 |
2023-08-12 |
rat |
| June-Hee Park, Grigori Enikolopo. Transient elevation of adult hippocampal neurogenesis after dopamine depletion. Experimental neurology. vol 222. issue 2. 2010-03-26. PMID:20079351. |
the dentate gyrus (dg), a site of continuous production of new neurons in the adult hippocampus, receives dopaminergic inputs from the neurons of the substantia nigra (sn). |
2010-03-26 |
2023-08-12 |
mouse |
| Irene Yaroslavsky, Shanaz M Tejani-But. Voluntary alcohol consumption alters stress-induced changes in dopamine-2 receptor binding in Wistar-Kyoto rat brain. Pharmacology, biochemistry, and behavior. vol 94. issue 3. 2010-03-23. PMID:19896970. |
quantitative autoradiography experiments showed that chronic stress increased d2 receptor binding in the caudate putamen (cpu), nucleus accumbens (nac), substantia nigra (sn) and ventral tegmental area (vta) of wky rats, and reduced receptor binding in the cpu and sn of wis rats. |
2010-03-23 |
2023-08-12 |
rat |
| Michael F Salvatore, Brandon S Pruett, Sandy L Spann, Charles Dempse. Aging reveals a role for nigral tyrosine hydroxylase ser31 phosphorylation in locomotor activity generation. PloS one. vol 4. issue 12. 2010-03-17. PMID:20037632. |
however, in the substantia nigra (sn), there is equivalent loss of da or th in aging and at the onset of pd symptoms. |
2010-03-17 |
2023-08-12 |
Not clear |
| Petra Bártová, David Skoloudík, Pavel Ressner, Katerina Langová, Roman Herzig, Petr Kanovsk. Correlation between substantia nigra features detected by sonography and Parkinson disease symptoms. Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine. vol 29. issue 1. 2010-03-10. PMID:20040773. |
the aim of this study was to assess the correlation between substantia nigra (sn) echogenic features and area and the clinical symptoms in patients with parkinson disease (pd). |
2010-03-10 |
2023-08-12 |
Not clear |
| Y-Q Xue, B-F Ma, L-R Zhao, J B Tatom, B Li, L-X Jiang, R L Klein, W-M Dua. AAV9-mediated erythropoietin gene delivery into the brain protects nigral dopaminergic neurons in a rat model of Parkinson's disease. Gene therapy. vol 17. issue 1. 2010-03-08. PMID:19727138. |
we have recently shown that intrastriatal injection of recombinant human erythropoietin (epo) protects dopaminergic (da) neurons in the substantia nigra (sn) from 6-hydroxydopamine (6-ohda) toxicity in a rat model of parkinson's disease. |
2010-03-08 |
2023-08-12 |
human |
| Joanne Clark, David K Simo. Transcribe to survive: transcriptional control of antioxidant defense programs for neuroprotection in Parkinson's disease. Antioxidants & redox signaling. vol 11. issue 3. 2010-03-01. PMID:18717631. |
parkinson's disease (pd) is a progressive, primarily motor disorder that is characterized by loss of dopaminergic (da) neurons within the substantia nigra (sn). |
2010-03-01 |
2023-08-12 |
mouse |
| Donna W Lee, Deepinder Kaur, Shankar J Chinta, Subramanian Rajagopalan, Julie K Anderse. A disruption in iron-sulfur center biogenesis via inhibition of mitochondrial dithiol glutaredoxin 2 may contribute to mitochondrial and cellular iron dysregulation in mammalian glutathione-depleted dopaminergic cells: implications for Parkinson's disease. Antioxidants & redox signaling. vol 11. issue 9. 2010-03-01. PMID:19290777. |
parkinson's disease (pd) is characterized by early glutathione depletion in the substantia nigra (sn). |
2010-03-01 |
2023-08-12 |
Not clear |
| Stephan Brecht, Vicki Waetzig, Ute Hidding, Uwe-Karsten Hanisch, Michael Walther, Thomas Herdegen, Wolfram F Neis. FK506 protects against various immune responses and secondary degeneration following cerebral ischemia. Anatomical record (Hoboken, N.J. : 2007). vol 292. issue 12. 2010-02-26. PMID:19728359. |
repetitive application of fk506 over 20 days attenuated the activation of microglia in the substantia nigra (sn), an area of secondary degeneration. |
2010-02-26 |
2023-08-12 |
rat |
| Yu Luo, Sara Arezou Sarabi, Cristina Backman, Lufei Shan, Barry Hoffer, Howard Federof. Expression pattern of NuIP gene in adult mouse brain. Brain research. vol 1302. 2010-02-23. PMID:19765553. |
interestingly, nuip is expressed in high levels in midbrain dopaminergic neurons including ventral tegmental area (vta) and substantia nigra (sn) dopaminergic neurons but is not expressed or expressed in low levels in other dopaminergic neurons such as olfactory bulb and hypothalamus. |
2010-02-23 |
2023-08-12 |
mouse |
| J J Hadda. Endotoxin-mediated regulation of nuclear factor-kappaB nuclear translocation and activation in the hippocampus of the central nervous system: modulation by intracerebroventricular treatment with thymulin and the immunomodulatory role of the IkappaB-alpha/pIkappaB-alpha pathway. Neuroscience. vol 164. issue 4. 2010-02-19. PMID:19782726. |
et did not induce the dna-binding activity of nf-kappab in the diencephalon (de) or substantia nigra (sn) at various time points, when compared with baseline levels of expression. |
2010-02-19 |
2023-08-12 |
Not clear |
| Hong-Ning Zhang, Chun-Na An, Man Xu, De-An Guo, Min Li, Xiao-Ping P. Protocatechuic acid inhibits rat pheochromocytoma cell damage induced by a dopaminergic neurotoxin. Biological & pharmaceutical bulletin. vol 32. issue 11. 2010-02-17. PMID:19881299. |
parkinson's disease (pd) is characterized by the progressive degeneration of dopaminergic neurons in the substantia nigra (sn) with the presence of alpha-synuclein inclusions termed lewy bodies. |
2010-02-17 |
2023-08-12 |
rat |
| Chee Yeun Chung, James B Koprich, Penelope J Hallett, Ole Isacso. Functional enhancement and protection of dopaminergic terminals by RAB3B overexpression. Proceedings of the National Academy of Sciences of the United States of America. vol 106. issue 52. 2010-02-17. PMID:20007772. |
in parkinson's disease (pd), dopaminergic (da) neurons in the substantia nigra (sn, a9) are particularly vulnerable, compared to adjacent da neurons within the ventral tegmental area (vta, a10). |
2010-02-17 |
2023-08-12 |
human |
| Lokesh Agrawal, Jean-Pierre Louboutin, Elena Marusich, Beverley A S Reyes, Elisabeth J Van Bockstaele, David S Straye. Dopaminergic neurotoxicity of HIV-1 gp120: reactive oxygen species as signaling intermediates. Brain research. vol 1306. 2010-02-03. PMID:19815008. |
we examined the role of reactive oxygen species (ros) in loss of dopaminergic neurons (dns) from the substantia nigra (sn) in neuroaids. |
2010-02-03 |
2023-08-12 |
rat |
| Xiaomin Su, Adrian P Kells, Eric J Huang, Han S Lee, Piotr Hadaczek, Janine Beyer, John Bringas, Philip Pivirotto, Janine Penticuff, Jamie Eberling, Howard J Federoff, John Forsayeth, Krystof S Bankiewic. Safety evaluation of AAV2-GDNF gene transfer into the dopaminergic nigrostriatal pathway in aged and parkinsonian rhesus monkeys. Human gene therapy. vol 20. issue 12. 2010-02-01. PMID:19671001. |
in the first study, a total of 17 animals received one of two doses of aav2-gdnf into either putamen or substantia nigra (sn). |
2010-02-01 |
2023-08-12 |
monkey |
| Rachel Hammond, Sandra Blaess, Asa Abeliovic. Sonic hedgehog is a chemoattractant for midbrain dopaminergic axons. PloS one. vol 4. issue 9. 2010-02-01. PMID:19774071. |
midbrain dopaminergic axons project from the substantia nigra (sn) and the ventral tegmental area (vta) to rostral target tissues, including the striatum, pallidum, and hypothalamus. |
2010-02-01 |
2023-08-12 |
mouse |
| Jin Ok Yang, Woo-Yeon Kim, So-Young Jeong, Jung-Hwa Oh, Sungwoong Jho, Jong Bhak, Nam-Soon Ki. PDbase: a database of Parkinson's disease-related genes and genetic variation using substantia nigra ESTs. BMC genomics. vol 10 Suppl 3. 2010-02-01. PMID:19958497. |
therefore, we have constructed a database of pd-related gene and genetic variations using the substantia nigra (sn) in pd and normal tissues. |
2010-02-01 |
2023-08-12 |
Not clear |
| Daniela Ber. Transcranial ultrasound as a risk marker for Parkinson's disease. Movement disorders : official journal of the Movement Disorder Society. vol 24 Suppl 2. 2010-01-26. PMID:19877199. |
substantia nigra (sn) hyperechogenicity, assessed by transcranial sonography, has been shown to be a typical marker for pd. |
2010-01-26 |
2023-08-12 |
human |
| Carles Gaig, Eduardo Tolos. When does Parkinson's disease begin? Movement disorders : official journal of the Movement Disorder Society. vol 24 Suppl 2. 2010-01-26. PMID:19877243. |
pathological and neuroimaging studies have shown that in parkinson's disease (pd) there is a "subclinical" or "premotor" period during which dopaminergic neurons in the substantia nigra (sn) degenerate but typical motor symptoms have not yet developed. |
2010-01-26 |
2023-08-12 |
Not clear |