| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Amanda M Snyder, XinSheng Wang, Stephanie M Patton, Paolo Arosio, Sonia Levi, Christopher J Earley, Richard P Allen, James R Conno. Mitochondrial ferritin in the substantia nigra in restless legs syndrome. Journal of neuropathology and experimental neurology. vol 68. issue 11. 2009-11-24. PMID:19816198. |
human substantia nigra (sn) and putamen autopsy samples from 8 rls cases and 8 controls were analyzed. |
2009-11-24 |
2023-08-12 |
human |
| Nadja Van Camp, Ines Blockx, Marleen Verhoye, Cindy Casteels, Frea Coun, Alexander Leemans, Jan Sijbers, Veerle Baekelandt, Koen Van Laere, Annemie Van der Linde. Diffusion tensor imaging in a rat model of Parkinson's disease after lesioning of the nigrostriatal tract. NMR in biomedicine. vol 22. issue 7. 2009-11-05. PMID:19378292. |
despite a nearly complete lesion of the nigrostriatal tract, dti changes were limited to the ipsilateral substantia nigra (sn). |
2009-11-05 |
2023-08-12 |
rat |
| Amy K Reeve, Kim J Krishnan, Geoffrey Taylor, Joanna L Elson, Andreas Bender, Robert W Taylor, Christopher M Morris, Doug M Turnbul. The low abundance of clonally expanded mitochondrial DNA point mutations in aged substantia nigra neurons. Aging cell. vol 8. issue 4. 2009-10-26. PMID:19489744. |
clonally expanded mitochondrial dna (mtdna) deletions accumulate with age in human substantia nigra (sn) and high levels cause respiratory chain deficiency. |
2009-10-26 |
2023-08-12 |
human |
| U Walter, S Wagner, S Horowski, R Benecke, U K Zett. Transcranial brain sonography findings predict disease progression in multiple sclerosis. Neurology. vol 73. issue 13. 2009-10-21. PMID:19657105. |
transcranial sonography (tcs) shows hyperechogenic lesions of substantia nigra (sn) and basal ganglia, thought to reflect iron accumulation, in a number of primary neurodegenerative diseases. |
2009-10-21 |
2023-08-12 |
Not clear |
| Baohua Cheng, Xinxin Yang, Liangxiang An, Bo Gao, Xia Liu, Shuwei Li. Ketogenic diet protects dopaminergic neurons against 6-OHDA neurotoxicity via up-regulating glutathione in a rat model of Parkinson's disease. Brain research. vol 1286. 2009-10-20. PMID:19559687. |
in our present work, we examined whether kd protected dopaminergic neurons of substantia nigra (sn) against 6-hydroxydopamine (6-ohda) neurotoxicity in a rat model of parkinson's disease (pd) using nissl staining and tyrosine hydroxylase (th) immunohistochemistry. |
2009-10-20 |
2023-08-12 |
rat |
| S Behnke, U Schroeder, U Dillmann, H G Buchholz, M Schreckenberger, G Fuss, W Reith, D Berg, C M Kric. Hyperechogenicity of the substantia nigra in healthy controls is related to MRI changes and to neuronal loss as determined by F-Dopa PET. NeuroImage. vol 47. issue 4. 2009-10-15. PMID:19497378. |
transcranial ultrasound (tcs) has been shown to reveal hyperechogenicity of the substantia nigra (sn) in parkinsonian patients and in about 10% of healthy controls. |
2009-10-15 |
2023-08-12 |
human |
| Katharina Faust, Stephan Gehrke, Yufeng Yang, Lichuan Yang, M Flint Beal, Bingwei L. Neuroprotective effects of compounds with antioxidant and anti-inflammatory properties in a Drosophila model of Parkinson's disease. BMC neuroscience. vol 10. 2009-10-01. PMID:19723328. |
although the cause of pd remains unknown, several pathogenic factors have been identified, which cause dopaminergic neuron (dn) death in the substantia nigra (sn). |
2009-10-01 |
2023-08-12 |
drosophila_melanogaster |
| Michael F Salvatore, Greg A Gerhardt, Robert D Dayton, Ronald L Klein, John A Stanfor. Bilateral effects of unilateral GDNF administration on dopamine- and GABA-regulating proteins in the rat nigrostriatal system. Experimental neurology. vol 219. issue 1. 2009-09-25. PMID:19460370. |
therefore in these studies we assessed dopamine- and gaba-regulating proteins in the striatum and substantia nigra (sn) of 24 month old fischer 344 rats, 30 days after a single unilateral striatal delivery of gdnf. |
2009-09-25 |
2023-08-12 |
rat |
| Anna L Bartels, Klaus L Leender. Parkinson's disease: the syndrome, the pathogenesis and pathophysiology. Cortex; a journal devoted to the study of the nervous system and behavior. vol 45. issue 8. 2009-09-22. PMID:19095226. |
an important pathophysiological feature in pd is the loss of part of the dopaminergic neurons in the substantia nigra (sn) resulting in a specific dysorganisation of the complicated basal ganglia (bg) circuits. |
2009-09-22 |
2023-08-12 |
Not clear |
| Juan Liu, Dawei Zan. Response of neural precursor cells in the brain of Parkinson's disease mouse model after LIF administration. Neurological research. vol 31. issue 7. 2009-09-17. PMID:19108756. |
to access the response of endogenous neural precursor cells (npcs) in the area of substantia nigra (sn) in the mouse model of parkinson's disease (pd). |
2009-09-17 |
2023-08-12 |
mouse |
| Manuela Di Benedetto, Chiara Cavina, Claudio D'Addario, Giorgia Leoni, Sanzio Candeletti, Brian M Cox, Patrizia Romuald. Alterations of N/OFQ and NOP receptor gene expression in the substantia nigra and caudate putamen of MPP+ and 6-OHDA lesioned rats. Neuropharmacology. vol 56. issue 4. 2009-09-17. PMID:19162046. |
we injected the neurotoxins mpp+ or 6-ohda into the cerebral ventricles and 10 days later measured n/ofq and nopr gene expression in caudate putamen (cp) and substantia nigra (sn), by rt-pcr. |
2009-09-17 |
2023-08-12 |
rat |
| Claudia Funke, Juergen Tomiuk, Olaf Riess, Daniela Berg, Anne S Soeh. Genetic analysis of heme oxygenase-1 (HO-1) in German Parkinson's disease patients. Journal of neural transmission (Vienna, Austria : 1996). vol 116. issue 7. 2009-09-08. PMID:19475336. |
iron, which is elevated in the substantia nigra (sn) of pd patients, seems to be of pivotal importance, because of its capacity to enhance the amplification of reactive-oxygen species. |
2009-09-08 |
2023-08-12 |
Not clear |
| Ilse S Pienaar, Timothy Schallert, Suzél Hattingh, William M U Daniel. Behavioral and quantitative mitochondrial proteome analyses of the effects of simvastatin: implications for models of neural degeneration. Journal of neural transmission (Vienna, Austria : 1996). vol 116. issue 7. 2009-09-08. PMID:19504041. |
rats were pre-treated with simvastatin for 14 days, followed by a single unihemispheric (substantia nigra; sn) injection of rotenone, a mitochondrial complex i (co-i) inhibitor. |
2009-09-08 |
2023-08-12 |
rat |
| Tinmarla F Oo, Deanna M Marchionini, Olga Yarygina, Paul D O'Leary, Richard A Hughes, Nikolai Kholodilov, Robert E Burk. Brain-derived neurotrophic factor regulates early postnatal developmental cell death of dopamine neurons of the substantia nigra in vivo. Molecular and cellular neurosciences. vol 41. issue 4. 2009-09-07. PMID:19409492. |
to assess a possible local role, we blocked bdnf signaling in the substantia nigra (sn) of postnatal rats by injection of either neutralizing antibodies or a peptide antagonist. |
2009-09-07 |
2023-08-12 |
mouse |
| Mark Obermann, M Küper, O Kastrup, O Yaldizli, S Esser, J Thiermann, E Koutsilieri, G Arendt, H-C Diener, M Maschk. Substantia nigra hyperechogenicity and CSF dopamine depletion in HIV. Journal of neurology. vol 256. issue 6. 2009-09-02. PMID:19240951. |
decreased dopamine (da) levels in the cerebrospinal fluid (csf) and neuronal loss in the substantia nigra (sn) have been reported in hiv-infected patients, suggesting nigrostriatal damage. |
2009-09-02 |
2023-08-12 |
human |
| Marcus M Unger, Jens C Möller, Tim Ohletz, Karin Stiasny-Kolster, Wolfgang H Oertel, Geert Maye. Transcranial midbrain sonography in narcoleptic subjects with and without concomitant REM sleep behaviour disorder. Journal of neurology. vol 256. issue 6. 2009-09-02. PMID:19252799. |
substantia nigra (sn) hyperechogenicity--a sonographic vulnerability marker for parkinson's disease (pd)--has been recently described in patients with idiopathic rem sleep behaviour disorder (rbd). |
2009-09-02 |
2023-08-12 |
human |
| Gonzalo Bustos, Jorge Abarca, Victor Bustos, Eduardo Riquelme, Viviana Noriega, Catherine Moya, Jorge Campusan. NMDA receptors mediate an early up-regulation of brain-derived neurotrophic factor expression in substantia nigra in a rat model of presymptomatic Parkinson's disease. Journal of neuroscience research. vol 87. issue 10. 2009-08-31. PMID:19326433. |
in the present study, we used in vivo microdialysis, semiquantitative reverse transcriptase-polymerase chain reaction, and immunohistochemistry to study n-methyl-d-aspartic acid (nmda) receptor regulation of bdnf expression in substantia nigra (sn) of adult rats after partial lesioning of the nigrostriatal da pathway with unilateral striatal injections of 6-hydroxydopamine (6-ohda). |
2009-08-31 |
2023-08-12 |
rat |
| Catherine M Cahill, Debomoy K Lahiri, Xudong Huang, Jack T Roger. Amyloid precursor protein and alpha synuclein translation, implications for iron and inflammation in neurodegenerative diseases. Biochimica et biophysica acta. vol 1790. issue 7. 2009-08-27. PMID:19166904. |
together with the demonstration of metal dependent translation of app mrna, the involvement of metals in the plaque of ad patients and of increased iron in striatal neurons in the substantia nigra (sn) of parkinson's disease patients have stimulated the development of metal attenuating agents and iron chelators as a major new therapeutic strategy for the treatment of these neurodegenerative diseases. |
2009-08-27 |
2023-08-12 |
Not clear |
| Vitaly Napadow, Rupali Dhond, Kyungmo Park, Jieun Kim, Nikos Makris, Kenneth K Kwong, Richard E Harris, Patrick L Purdon, Norman Kettner, Kathleen K S Hu. Time-variant fMRI activity in the brainstem and higher structures in response to acupuncture. NeuroImage. vol 47. issue 1. 2009-08-24. PMID:19345268. |
specifically, va modulated activity in the substantia nigra (sn), nucleus raphe magnus, locus ceruleus, nucleus cuneiformis, and periaqueductal gray (pag). |
2009-08-24 |
2023-08-12 |
human |
| Annemarie M M Vlaar, Angela Bouwmans, Werner H Mess, Selma C Tromp, Wim E J Webe. Transcranial duplex in the differential diagnosis of parkinsonian syndromes: a systematic review. Journal of neurology. vol 256. issue 4. 2009-08-20. PMID:19224315. |
transcranial duplex scanning (tcd) of the substantia nigra (sn) is increasingly used to diagnose idiopathic parkinson's disease (ipd). |
2009-08-20 |
2023-08-12 |
Not clear |