| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Giuseppe Di Giovanni, Wei-Xing Sh. Effects of scopolamine on dopamine neurons in the substantia nigra: role of the pedunculopontine tegmental nucleus. Synapse (New York, N.Y.). vol 63. issue 8. 2009-08-19. PMID:19360852. |
using in vivo extracellular single unit recording, this study examined whether blockade of the muscarinic receptor by scopolamine alters the firing properties of da neurons in the substantia nigra (sn). |
2009-08-19 |
2023-08-12 |
Not clear |
| Uwe Walte. Transcranial brain sonography findings in Parkinson's disease: implications for pathogenesis, early diagnosis and therapy. Expert review of neurotherapeutics. vol 9. issue 6. 2009-08-19. PMID:19496687. |
approximately 90% of pd patients exhibit substantia nigra (sn) hyperechogenicity, which is stable over time and discriminates pd from atypical parkinsonian disorders. |
2009-08-19 |
2023-08-12 |
Not clear |
| Merja H Voutilainen, Susanne Bäck, Eeva Pörsti, Liisa Toppinen, Lauri Lindgren, Päivi Lindholm, Johan Peränen, Mart Saarma, Raimo K Tuomine. Mesencephalic astrocyte-derived neurotrophic factor is neurorestorative in rat model of Parkinson's disease. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 29. issue 30. 2009-08-19. PMID:19641128. |
intrastriatally injected manf protected nigrostriatal dopaminergic nerves from 6-ohda-induced degeneration as evaluated by counting tyrosine hydroxylase (th)-positive cell bodies in the substantia nigra (sn) and th-positive fibers in the striatum. |
2009-08-19 |
2023-08-12 |
rat |
| Pier Giorgio Mastroberardino, Eric K Hoffman, Maxx P Horowitz, Ranjita Betarbet, Georgia Taylor, Dongmei Cheng, Hye Mee Na, Claire-Anne Gutekunst, Marla Gearing, John Q Trojanowski, Marjorie Anderson, Charleen T Chu, Junmin Peng, J Timothy Greenamyr. A novel transferrin/TfR2-mediated mitochondrial iron transport system is disrupted in Parkinson's disease. Neurobiology of disease. vol 34. issue 3. 2009-08-17. PMID:19250966. |
more than 80 years after iron accumulation was initially described in the substantia nigra (sn) of parkinson's disease (pd) patients, the mechanisms responsible for this phenomenon are still unknown. |
2009-08-17 |
2023-08-12 |
human |
| Jean-Pierre Louboutin, Lokesh Agrawal, Beverly A S Reyes, Elisabeth J Van Bockstaele, David S Straye. HIV-1 gp120 neurotoxicity proximally and at a distance from the point of exposure: protection by rSV40 delivery of antioxidant enzymes. Neurobiology of disease. vol 34. issue 3. 2009-08-17. PMID:19327399. |
toxicity of hiv-1 envelope glycoprotein (gp120) for substantia nigra (sn) neurons may contribute to the parkinsonian manifestations often seen in hiv-1-associated dementia (had). |
2009-08-17 |
2023-08-12 |
rat |
| Jean-Pierre Louboutin, Lokesh Agrawal, Beverly A S Reyes, Elisabeth J Van Bockstaele, David S Straye. HIV-1 gp120 neurotoxicity proximally and at a distance from the point of exposure: protection by rSV40 delivery of antioxidant enzymes. Neurobiology of disease. vol 34. issue 3. 2009-08-17. PMID:19327399. |
rats were injected stereotaxically into their caudate-putamen (cp); cp and (substantia nigra) sn neuron loss was quantified. |
2009-08-17 |
2023-08-12 |
rat |
| Thorsten Kahnt, Soyoung Q Park, Michael X Cohen, Anne Beck, Andreas Heinz, Jana Wras. Dorsal striatal-midbrain connectivity in humans predicts how reinforcements are used to guide decisions. Journal of cognitive neuroscience. vol 21. issue 7. 2009-08-12. PMID:18752410. |
using functional connectivity, we show that the ds and the vs are differentially connected to different midbrain regions (possibly corresponding to the substantia nigra [sn] and the ventral tegmental area [vta], respectively). |
2009-08-12 |
2023-08-12 |
human |
| Yoshinori Kajimoto, Hideto Miwa, Masae Okawa-Izawa, Masaya Hironishi, Tomoyoshi Kond. Transcranial sonography of the substantia nigra and MIBG myocardial scintigraphy: complementary role in the diagnosis of Parkinson's disease. Parkinsonism & related disorders. vol 15. issue 4. 2009-08-10. PMID:18691928. |
both transcranial sonography (tcs) of the substantia nigra (sn) and metaiodobenzylguanidine (mibg) myocardial scintigraphy have been determined to be useful for the diagnosis of parkinson's disease (pd). |
2009-08-10 |
2023-08-12 |
Not clear |
| Fang Zhao, Tongjian Cai, Mingchao Liu, Gang Zheng, Wenjing Luo, Jingyuan Che. Manganese induces dopaminergic neurodegeneration via microglial activation in a rat model of manganism. Toxicological sciences : an official journal of the Society of Toxicology. vol 107. issue 1. 2009-08-07. PMID:18836210. |
one day after administration of manganese, a few microglial cells in the substantia nigra (sn) were activated, although the number of tyrosine hydroxylase (th)-immunoreactive neurons in the sn was unaffected. |
2009-08-07 |
2023-08-12 |
rat |
| Fredric P Manfredsson, Nihal Tumer, Benedek Erdos, Tessa Landa, Christopher S Broxson, Layla F Sullivan, Aaron C Rising, Kevin D Foust, Yi Zhang, Nicholas Muzyczka, Oleg S Gorbatyuk, Philip J Scarpace, Ronald J Mande. Nigrostriatal rAAV-mediated GDNF overexpression induces robust weight loss in a rat model of age-related obesity. Molecular therapy : the journal of the American Society of Gene Therapy. vol 17. issue 6. 2009-08-07. PMID:19277011. |
in this study, we compared bilateral injections of raav2/5-gdnf in hypothalamus versus substantia nigra (sn) in aged brown-norway x fisher 344 rats. |
2009-08-07 |
2023-08-12 |
rat |
| Jason B Tatom, David B Wang, Robert D Dayton, Omar Skalli, Michael L Hutton, Dennis W Dickson, Ronald L Klei. Mimicking aspects of frontotemporal lobar degeneration and Lou Gehrig's disease in rats via TDP-43 overexpression. Molecular therapy : the journal of the American Society of Gene Therapy. vol 17. issue 4. 2009-08-05. PMID:19223871. |
we used an adeno-associated virus (aav) vector for human tdp-43 expression targeted to the substantia nigra (sn) of rats. |
2009-08-05 |
2023-08-12 |
human |
| Katayoun Sedaghat, David I Finkelstein, Andrew L Gundlac. Effect of unilateral lesion of the nigrostriatal dopamine pathway on survival and neurochemistry of parafascicular nucleus neurons in the rat--evaluation of time-course and LGR8 expression. Brain research. vol 1271. 2009-07-28. PMID:19328193. |
this study examined time-related effects of unilateral 6-hydroxydopamine (6-ohda) lesions of substantia nigra (sn) on the loss/survival of pf neurons and possible alterations in their lgr8 and vglut2 mrna expression. |
2009-07-28 |
2023-08-12 |
mouse |
| D E Redmond, J D Elsworth, R H Roth, C Leranth, T J Collier, B Blanchard, K B Bjugstad, R J Samulski, P Aebischer, J R Slade. Embryonic substantia nigra grafts in the mesencephalon send neurites to the host striatum in non-human primate after overexpression of GDNF. The Journal of comparative neurology. vol 515. issue 1. 2009-07-28. PMID:19399891. |
previous evidence of normal anatomic projections from ventral mesencephalic (vm) grafts placed in the substantia nigra (sn) has been limited to neonatal rodents and double grafting or bridging procedures. |
2009-07-28 |
2023-08-12 |
monkey |
| Helen Petrovitch, Robert D Abbott, G Webster Ross, James Nelson, Kamal H Masaki, Caroline M Tanner, Lenore J Launer, Lon R Whit. Bowel movement frequency in late-life and substantia nigra neuron density at death. Movement disorders : official journal of the Movement Disorder Society. vol 24. issue 3. 2009-07-27. PMID:19006191. |
constipation is associated with future risk of parkinson's disease (pd) and with incidental lewy bodies (lb) in the locus ceruleus or substantia nigra (sn). |
2009-07-27 |
2023-08-12 |
Not clear |
| Zhen-Yun Yuan, Ping Gu, Li Liu, Yan-Yong Wang, Jing Liu, Dong-Sheng Cui, Yuan Geng, Zhong-Xia Zhang, Ai-Ping Zhu, Lin Ma, Ming-Wei Wan. Neuroprotective effects of enriched environment in MPTP-treated SAMP8 mice. Neuroscience letters. vol 454. issue 1. 2009-07-15. PMID:19429044. |
furthermore, ee mice demonstrated reduced neurotoxicity, with less decreased th mrna and protein expression in substantia nigra (sn) after mptp administration compared with se mice. |
2009-07-15 |
2023-08-12 |
mouse |
| J Coste, L Ouchchane, L Sarry, P Derost, F Durif, J Gabrillargues, S Hemm, J J Lemair. New electrophysiological mapping combined with MRI in parkinsonian's subthalamic region. The European journal of neuroscience. vol 29. issue 8. 2009-07-13. PMID:19419425. |
ten bilateral surgeries were performed after 1.5-t (t2-weighted) anatomical mri identification of the stn, zona incerta (zi), forel's field h2 (h2) and substantia nigra (sn). |
2009-07-13 |
2023-08-12 |
Not clear |
| Min Jeong Kang, Suk Ju Gil, Hyun Chul Ko. Paraquat induces alternation of the dopamine catabolic pathways and glutathione levels in the substantia nigra of mice. Toxicology letters. vol 188. issue 2. 2009-07-13. PMID:19446248. |
in this study, we investigated the effect of pq on dopamine (da) and glutathione levels in the substantia nigra (sn) of mice. |
2009-07-13 |
2023-08-12 |
mouse |
| H Jourdi, L Hamo, T Oka, A Seegan, M Baudr. BDNF mediates the neuroprotective effects of positive AMPA receptor modulators against MPP+-induced toxicity in cultured hippocampal and mesencephalic slices. Neuropharmacology. vol 56. issue 5. 2009-07-02. PMID:19371576. |
neurotoxicity is involved in various neurodegenerative diseases including parkinson's disease (pd), which affects mesencephalic dopaminergic neurons of the substantia nigra (sn). |
2009-07-02 |
2023-08-12 |
Not clear |
| Fumino Fujiyam. [Anatomical connections of the basal ganglia]. Brain and nerve = Shinkei kenkyu no shinpo. vol 61. issue 4. 2009-07-01. PMID:19378803. |
the basal ganglia consist of the striatum, which includes the caudate-putamen and the core of the nucleus accumbens, the external segment of the globus pallidus (gpe), the subthalamic nucleus, the internal segment of the globus pallidus (gpi), and the substantia nigra (sn). |
2009-07-01 |
2023-08-12 |
Not clear |
| H L Sanchez, L B Silva, E L Portiansky, C B Herenu, R G Goya, G O Zuccolill. Dopaminergic mesencephalic systems and behavioral performance in very old rats. Neuroscience. vol 154. issue 4. 2009-06-29. PMID:18554807. |
morphometric analysis of the th-ir neurons of the substantia nigra (sn) and ventral tegmental area (vta) was performed using an appropriate image analysis system. |
2009-06-29 |
2023-08-12 |
rat |