| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Simone van de Loo, Uwe Walter, Stefanie Behnke, Johann Hagenah, Matthias Lorenz, Matthias Sitzer, Rüdiger Hilker, Daniela Ber. Reproducibility and diagnostic accuracy of substantia nigra sonography for the diagnosis of Parkinson's disease. Journal of neurology, neurosurgery, and psychiatry. vol 81. issue 10. 2010-10-19. PMID:20543186. |
transcranial sonography (tcs) shows characteristic hyperechogenicity of the substantia nigra (sn) in patients with parkinson's disease (pd). |
2010-10-19 |
2023-08-12 |
Not clear |
| Joanna Iczkiewicz, Lauren Broom, Jonathan D Cooper, Andrew Ming Sham Wong, Sarah Rose, Peter Jenne. The RGD-containing peptide fragment of osteopontin protects tyrosine hydroxylase positive cells against toxic insult in primary ventral mesencephalic cultures and in the rat substantia nigra. Journal of neurochemistry. vol 114. issue 6. 2010-10-19. PMID:20626561. |
we have previously shown that the multi-functional phosphoprotein osteopontin (opn) is present in the substantia nigra (sn) and that its mrna and protein expression are up-regulated following toxic insult. |
2010-10-19 |
2023-08-12 |
rat |
| Danny Galleguillos, José A Fuentealba, Luis M Gómez, Mathias Saver, Andrea Gómez, Kevin Nash, Corinna Burger, Katia Gysling, María E André. Nurr1 regulates RET expression in dopamine neurons of adult rat midbrain. Journal of neurochemistry. vol 114. issue 4. 2010-10-06. PMID:20533997. |
using an adeno-associated vector-delivered anti-nurr1 ribozyme, we knocked-down nurr1 expression unilaterally in the substantia nigra (sn) of adult rats. |
2010-10-06 |
2023-08-12 |
human |
| I Nestrasil, S Michaeli, T Liimatainen, C E Rydeen, C M Kotz, J P Nixon, T Hanson, Paul J Tuit. T1rho and T2rho MRI in the evaluation of Parkinson's disease. Journal of neurology. vol 257. issue 6. 2010-09-29. PMID:20058018. |
using t(1rho) and t(2rho) on a 4t mri scanner, we assessed the substantia nigra (sn) of nine non-demented moderately affected pd and ten gender- and age-matched control participants. |
2010-09-29 |
2023-08-12 |
human |
| Vincent Seutin, Dominique Enge. Differences in Na+ conductance density and Na+ channel functional properties between dopamine and GABA neurons of the rat substantia nigra. Journal of neurophysiology. vol 103. issue 6. 2010-09-09. PMID:20357070. |
dopamine (da) neurons and gaba neurons of the substantia nigra (sn) promote distinct functions in the control of movement and have different firing properties and action potential (ap) waveforms. |
2010-09-09 |
2023-08-12 |
rat |
| Liviu Aron, Pontus Klein, Thu-Trang Pham, Edgar R Kramer, Wolfgang Wurst, Rüdiger Klei. Pro-survival role for Parkinson's associated gene DJ-1 revealed in trophically impaired dopaminergic neurons. PLoS biology. vol 8. issue 4. 2010-09-01. PMID:20386724. |
the mechanisms underlying the selective death of substantia nigra (sn) neurons in parkinson disease (pd) remain elusive. |
2010-09-01 |
2023-08-12 |
mouse |
| Michela Di Salvio, Luca G Di Giovannantonio, Daniela Omodei, Dario Acampora, Antonio Simeon. Otx2 expression is restricted to dopaminergic neurons of the ventral tegmental area in the adult brain. The International journal of developmental biology. vol 54. issue 5. 2010-08-30. PMID:19924631. |
despite great efforts, the molecular basis and the genetic factors differentially controlling identity, survival and vulnerability to neurodegeneration of mdda neurons of the substantia nigra (sn) and ventral tegmental area (vta) are poorly understood. |
2010-08-30 |
2023-08-12 |
mouse |
| Erik K Kastman, Auriel A Willette, Christopher L Coe, Barbara B Bendlin, Kris J Kosmatka, Donald G McLaren, Guofan Xu, Elisa Canu, Aaron S Field, Andrew L Alexander, Mary Lou Voytko, T Mark Beasley, Ricki J Colman, Richard H Weindruch, Sterling C Johnso. A calorie-restricted diet decreases brain iron accumulation and preserves motor performance in old rhesus monkeys. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 30. issue 23. 2010-08-24. PMID:20534842. |
both the cr and control monkeys showed age-related increases in iron concentrations in globus pallidus (gp) and substantia nigra (sn), although the cr group had significantly less iron deposition in the gp, sn, red nucleus, and temporal cortex. |
2010-08-24 |
2023-08-12 |
monkey |
| Shirong Wang, Eric E Turne. Expression of dopamine pathway genes in the midbrain is independent of known ETS transcription factor activity. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 30. issue 27. 2010-08-16. PMID:20610757. |
ets transcription factors are hypothesized to play a similar role in vertebrates, and based on its expression in the adult mouse midbrain, etv5/erm has been proposed as a regulator of da gene expression in the substantia nigra (sn) and ventral tegmental area (vta). |
2010-08-16 |
2023-08-12 |
mouse |
| Masaoki Iwanami, Tomoyuki Miyamoto, Masayuki Miyamoto, Koichi Hirata, Etsuo Takad. Relevance of substantia nigra hyperechogenicity and reduced odor identification in idiopathic REM sleep behavior disorder. Sleep medicine. vol 11. issue 4. 2010-08-03. PMID:20223708. |
substantia nigra (sn) hyperechogenicity determined by transcranial sonography (tcs) and olfactory dysfunction are common findings in parkinson disease (pd), which may reveal a prodromal synucleinopathy in idiopathic rem sleep behavior disorder (irbd). |
2010-08-03 |
2023-08-12 |
Not clear |
| Jiuquan Zhang, Yanling Zhang, Jian Wang, Ping Cai, Chunxia Luo, Zhongming Qian, Yongming Dai, Hua Fen. Characterizing iron deposition in Parkinson's disease using susceptibility-weighted imaging: an in vivo MR study. Brain research. vol 1330. 2010-08-02. PMID:20303339. |
the phase shift values of the bilateral red nucleus (rn), substantia nigra (sn), caudate nucleus (ca), globus pallidus (gp), putamen (pu), thalamus (th) and frontal white matter (fwm) were examined for their relationship with the clinical status. |
2010-08-02 |
2023-08-12 |
Not clear |
| Su-Feng Fan, Pei-Ling Chao, Anya Maan-Yuh Li. Arsenite induces oxidative injury in rat brain: synergistic effect of iron. Annals of the New York Academy of Sciences. vol 1199. 2010-07-29. PMID:20633106. |
our in vivo study employed intranigral infusion of arsenite (5 nmol) in the substantia nigra (sn) of anesthetized rats. |
2010-07-29 |
2023-08-12 |
rat |
| Jens Ebentheuer, Monica Canelo, Ellen Trautmann, Claudia Trenkwalde. Substantia nigra echogenicity in progressive supranuclear palsy. Movement disorders : official journal of the Movement Disorder Society. vol 25. issue 6. 2010-07-28. PMID:20198715. |
a normoechogenic substantia nigra (sn) is a typical finding in transcranial sonography in patients with progressive supranuclear palsy (psp), whereas in patients with parkinson's disease a hyperechogenic sn is characteristic. |
2010-07-28 |
2023-08-12 |
Not clear |
| Tali Fishman-Jacob, Moussa B H Youdim, Silvia A Mande. Silencing/overexpressing selected genes as a model of sporadic Parkinson's disease. Neuro-degenerative diseases. vol 7. issue 1-3. 2010-07-21. PMID:20173338. |
high-throughput gene-based platform studies in human postmortem substantia nigra (sn) from sporadic parkinson's disease (pd) cases have revealed significant dysregulation of genes involved in biological processes linked to previously established neurodegenerative mechanisms in both sporadic and hereditary pd. |
2010-07-21 |
2023-08-12 |
human |
| Li Lu, Fengqiao Li, Xiaomin Wan. Novel anti-inflammatory and neuroprotective agents for Parkinson's disease. CNS & neurological disorders drug targets. vol 9. issue 2. 2010-07-12. PMID:20015029. |
parkinson's disease (pd) is a type of motor system disorder that results from the progressive loss of dopaminergic (daergic) neurons in the substantia nigra (sn) of the midbrain. |
2010-07-12 |
2023-08-12 |
Not clear |
| Johann Hagenah, Inke R König, Jürgen Sperner, Lucas Wessel, Günter Seidel, Kelly Condefer, Rachel Saunders-Pullman, Christine Klein, Norbert Brüggeman. Life-long increase of substantia nigra hyperechogenicity in transcranial sonography. NeuroImage. vol 51. issue 1. 2010-07-08. PMID:20152909. |
transcranial ultrasound of the substantia nigra (sn) shows a distinct hyperechogenicity in the majority of patients with parkinson's disease. |
2010-07-08 |
2023-08-12 |
human |
| Jiaming Mei, Chaoshi Ni. Alterations of Hrd1 expression in various encephalic regional neurons in 6-OHDA model of Parkinson's disease. Neuroscience letters. vol 474. issue 2. 2010-07-08. PMID:20227462. |
the results showed that hrd1 was up-regulated in 6-ohda-treated mice in various encephalic regional neurons, especially those in hippocampus, substantia nigra (sn), subthalamic nucleus (stn), striatum and frontal lobe. |
2010-07-08 |
2023-08-12 |
mouse |
| Hong-Ning Zhang, Chun-Na An, Hui-Nan Zhang, Xiao-Ping P. Protocatechuic acid inhibits neurotoxicity induced by MPTP in vivo. Neuroscience letters. vol 474. issue 2. 2010-07-08. PMID:20227465. |
parkinson's disease (pd) is characterized by the progressive degeneration of dopaminergic neurons in substantia nigra (sn) with the presence of alpha-synuclein inclusions termed lewy bodies. |
2010-07-08 |
2023-08-12 |
mouse |
| Joanna Chwie. The use of cluster and discriminant analysis in the investigations of the role of trace metals in the pathogenesis of Parkinson's disease. Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS). vol 24. issue 2. 2010-07-06. PMID:20413064. |
x-ray fluorescence microscopy was applied for two-dimensional elemental analysis of substantia nigra (sn) tissue. |
2010-07-06 |
2023-08-12 |
Not clear |
| Sang Ryong Kim, Eun Sook Chung, Eugene Bok, Hyung Hwan Baik, Young Cheul Chung, So Yoon Won, Eunhye Joe, Tae Hyong Kim, Soung Soo Kim, Min Young Jin, Sang Ho Choi, Byung Kwan Ji. Prothrombin kringle-2 induces death of mesencephalic dopaminergic neurons in vivo and in vitro via microglial activation. Journal of neuroscience research. vol 88. issue 7. 2010-06-30. PMID:20025058. |
to address this question, pkr-2 was injected into the rat substantia nigra (sn). |
2010-06-30 |
2023-08-12 |
human |