| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Kechun Yang, Guozhang Jin, Jie W. The neuropharmacology of (-)-stepholidine and its potential applications. Current neuropharmacology. vol 5. issue 4. 2010-06-10. PMID:19305745. |
furthermore, spd exhibits neuroprotective effects through an antioxidative mechanism and slows down the progression of neuronal degeneration in the substantia nigra (sn) of pd patients and/or animal models. |
2010-06-10 |
2023-08-12 |
Not clear |
| Li-Fang Hu, Ming Lu, Chi Xin Tiong, Gavin S Dawe, Gang Hu, Jin-Song Bia. Neuroprotective effects of hydrogen sulfide on Parkinson's disease rat models. Aging cell. vol 9. issue 2. 2010-06-10. PMID:20041858. |
parkinson's disease (pd) is a neurodegenerative disorder characterized by a progressive loss of dopaminergic neurons in the substantia nigra (sn). |
2010-06-10 |
2023-08-12 |
rat |
| Yong-Sheng Wang, Jian-Ping Zhou, Zi-Feng Wei, Qing-You Tian, Hong-Xia Zhou, Yu-Xin Zhan. [Effect of phosphorylated c-Jun expression on COX-2 expression in the substantia nigra of MPTP mouse model of subacute Parkinson disease]. Nan fang yi ke da xue xue bao = Journal of Southern Medical University. vol 27. issue 8. 2010-06-09. PMID:17715026. |
to investigate the effect of phophorylated c-jun (p-c-jun) expression on the expression of cox-2 in the substantia nigra (sn) of the mptp mouse model of subacute parkinson disease (pd) and explore the possible mechanism of the dopaminergic (da) neuron death in pd. |
2010-06-09 |
2023-08-12 |
mouse |
| Ana Laura De Lella Ezcurra, Mariela Chertoff, Carina Ferrari, Mariana Graciarena, Fernando Pitoss. Chronic expression of low levels of tumor necrosis factor-alpha in the substantia nigra elicits progressive neurodegeneration, delayed motor symptoms and microglia/macrophage activation. Neurobiology of disease. vol 37. issue 3. 2010-06-08. PMID:19969084. |
microglial activation has been found in the substantia nigra (sn), one of the main brain regions affected in pd, for many years after the initiation of the disease. |
2010-06-08 |
2023-08-12 |
Not clear |
| Hong Jiang, Ning Song, Huamin Xu, Shuzhen Zhang, Jun Wang, Junxia Xi. Up-regulation of divalent metal transporter 1 in 6-hydroxydopamine intoxication is IRE/IRP dependent. Cell research. vol 20. issue 3. 2010-06-08. PMID:20125122. |
increased iron content of the substantia nigra (sn) has been found in pd patients, and divalent metal transporter 1 (dmt1) has been shown to be up-regulated in the sn of both mptp-induced pd models and pd patients. |
2010-06-08 |
2023-08-12 |
rat |
| Song Yu, Wei Zheng, Na Xin, Zhi-Hong Chi, Nai-Qian Wang, Ying-Xue Nie, Wan-Yu Feng, Zhan-You Wan. Curcumin prevents dopaminergic neuronal death through inhibition of the c-Jun N-terminal kinase pathway. Rejuvenation research. vol 13. issue 1. 2010-06-02. PMID:20230279. |
curcumin treatment significantly improved behavioral deficits, and enhanced the survival of tyrosine hydroxylase-positive neurons in the substantia nigra (sn) in the mptp-induced pd model mice. |
2010-06-02 |
2023-08-12 |
mouse |
| Fabio Coppedè, Roberto Ceravolo, Francesca Migheli, Francesca Fanucchi, Daniela Frosini, Gabriele Siciliano, Ubaldo Bonuccelli, Lucia Miglior. The hOGG1 Ser326Cys polymorphism is not associated with sporadic Parkinson's disease. Neuroscience letters. vol 473. issue 3. 2010-05-17. PMID:20193742. |
parkinson's disease (pd) is one of the most common neurodegenerative disorders characterized by progressive and profound loss of dopaminergic neurons in the substantia nigra (sn) resulting in resting tremor, rigidity, bradykinesia, and postural instability. |
2010-05-17 |
2023-08-12 |
mouse |
| Catherine R G Jones, Marjan Jahanshah. The substantia nigra, the basal ganglia, dopamine and temporal processing. Journal of neural transmission. Supplementum. issue 73. 2010-05-14. PMID:20411776. |
this review summarizes and discuses evidence from animal, pharmacological, clinical, and imaging research that supports this proposal, with particular reference to the role of the substantia nigra (sn). |
2010-05-14 |
2023-08-12 |
Not clear |
| Sabine Mehnert, Iris Reuter, Karsten Schepp, Peter Maaser, Erwin Stolz, Manfred Kap. Transcranial sonography for diagnosis of Parkinson's disease. BMC neurology. vol 10. 2010-05-05. PMID:20089201. |
although the phenomenon of an increased echogenicity of the substantia nigra (sn) is well known this method is still not widly used in the diagnostic workup. |
2010-05-05 |
2023-08-12 |
human |
| Chong Shi, Yu-xin Zhang, Zuo-feng Zhan. [Effect of phosphorylated-ERK1/2 on inducible nitric oxide synthase expression in the substantia nigra of mice with MPTP-induced Parkinson disease]. Nan fang yi ke da xue xue bao = Journal of Southern Medical University. vol 29. issue 1. 2010-04-29. PMID:19218114. |
to investigate the effect of phosphorylated-erk1/2 (p-erk1/2) on inducible nitric oxide synthase (inos) expression in the substantia nigra (sn) of a mouse model of parkinson's disease (pd), and explore the possible mechanism of dopaminergic (da) neuron loss in the sn of the midbrain in pd. |
2010-04-29 |
2023-08-12 |
mouse |
| Fleur L Warton, Fleur M Howells, Vivienne A Russel. Increased glutamate-stimulated release of dopamine in substantia nigra of a rat model for attention-deficit/hyperactivity disorder--lack of effect of methylphenidate. Metabolic brain disease. vol 24. issue 4. 2010-04-29. PMID:19821016. |
however, it is not known whether dysregulation occurs at the level of the cell bodies in the ventral tegmental area of the midbrain (vta) and substantia nigra (sn). |
2010-04-29 |
2023-08-12 |
rat |
| Esen Saka, M Akif Topcuoglu, Ahmet U Demir, Bulent Elibo. Transcranial sonography in Perry syndrome. Parkinsonism & related disorders. vol 16. issue 1. 2010-04-23. PMID:19505837. |
in both patients, transcranial sonography exhibited marked substantia nigra (sn) hyperechogenicity, which is characteristic of idiopathic parkinson's disease. |
2010-04-23 |
2023-08-12 |
human |
| Mislav Budisić, Zlatko Trkanjec, Arijana Lovrencić-Huzjan, Visnja Supanc, Vlasta Vuković, Vida Demari. [Transcranial sonography (TCS) in evaluation of patients with essential tremor]. Acta medica Croatica : casopis Hravatske akademije medicinskih znanosti. vol 63 Suppl 3. 2010-04-20. PMID:20232670. |
recent reports showed that substantia nigra (sn) hyperechogenicity detected by transcranial sonography (tcs) is a specific finding of parkinsons disease (pd). |
2010-04-20 |
2023-08-12 |
human |
| [Reactions of the somatosensory cortex neurons, activated by nociceptive afferents during stimulation of substantia nigra in experiment]. Georgian medical news. issue 175. 2010-04-15. PMID:19893130. |
in cats, we studied the influences of stimulation of the substantia nigra (sn) on postsynaptic processes evoked in neurons of the somatosensory cortex by stimulation of nociceptive (intensive stimulation of the tooth pulp) and non-nociceptive (moderate stimulation of the infra orbital nerve and ventroposteromedial (vpm) nucleus of the thalamus) afferent inputs. |
2010-04-15 |
2023-08-12 |
Not clear |
| Huamin Xu, Hong Jiang, Jun Wang, Junxia Xi. Rg1 protects the MPP+-treated MES23.5 cells via attenuating DMT1 up-regulation and cellular iron uptake. Neuropharmacology. vol 58. issue 2. 2010-04-13. PMID:19744503. |
our previous study observed the protective effect of rg1 on iron accumulation in the substantia nigra (sn) in 1-methyl-4-phenyl-1,2,3,6- tetrahydropyridine (mptp)-treated parkinson's disease (pd) mice. |
2010-04-13 |
2023-08-12 |
mouse |
| A V Droblenkov, N R Karelin. [Structural characteristics of neurons and macrogliocytes in the interconnected areas of the rat mesoaccumbocingulate dopaminergic system]. Morfologiia (Saint Petersburg, Russia). vol 136. issue 5. 2010-04-07. PMID:20210090. |
the density of neurons and gliocytes were determined in the middle part of the paranigral nucleus of ventral tegmental area (vta) and in substantia nigra (sn) compact part, as well as in the interconnected antero-medial parts of these midbrain nuclei, nucleus accumbens (na), v1 layer of a pregenual (cg3) and iii layer of a supragenual (cg2) cingulate fields. |
2010-04-07 |
2023-08-12 |
rat |
| A V Droblenkov, N R Karelin. [Structural characteristics of neurons and macrogliocytes in the interconnected areas of the rat mesoaccumbocingulate dopaminergic system]. Morfologiia (Saint Petersburg, Russia). vol 136. issue 5. 2010-04-07. PMID:20210090. |
the antero-medial parts of vta paranigral nucleus and of sn compact part, interconnected with specified cingulate structures and na, contain more neurons than the other areas, as they occupy greater volume, while there are no differences in the volume of neurons in the anterior and in the middle parts of these structures. |
2010-04-07 |
2023-08-12 |
rat |
| A V Droblenkov, N R Karelin. [Structural characteristics of neurons and macrogliocytes in the interconnected areas of the rat mesoaccumbocingulate dopaminergic system]. Morfologiia (Saint Petersburg, Russia). vol 136. issue 5. 2010-04-07. PMID:20210090. |
the anterior portion of sn compact part, besides, is remarkable for greater density of the neurons. |
2010-04-07 |
2023-08-12 |
rat |
| A V Droblenkov, N R Karelin. [Structural characteristics of neurons and macrogliocytes in the interconnected areas of the rat mesoaccumbocingulate dopaminergic system]. Morfologiia (Saint Petersburg, Russia). vol 136. issue 5. 2010-04-07. PMID:20210090. |
the anteromedial parts of vta paranigral nucleus and of sn compact part of (12.2 +/- 0.1 mm from the frontal pole) have the greatest diagnostic value for the morphological evaluation of addiction also because the lateral part of vta paranigral nucleus contains the greatest population of a nondopaminergic neurons, while the cell bodies of the neurons of the other vta nuclear groups are of small size. |
2010-04-07 |
2023-08-12 |
rat |
| Silvia A Mandel, Tali Fishman-Jacob, Moussa B H Youdi. Modeling sporadic Parkinson's disease by silencing the ubiquitin E3 ligase component, SKP1A. Parkinsonism & related disorders. vol 15 Suppl 3. 2010-03-31. PMID:20082978. |
large-scale transcriptomics analysis of gene expression profile of sporadic parkinson's disease (pd) substantia nigra (sn) has identified a number of differentially expressed genes participating in the neurotoxic cascade of da neurons death, in particular those related to handling of proteins, dopaminergic transmission and iron metabolism. |
2010-03-31 |
2023-08-12 |
human |