| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Constantin Mänz, Jana Godau, Daniela Berg, Benjamin Bender, Ulrike Ernemann, Uwe Klos. The regional distribution of T2-relaxation times in MR images of the substantia nigra and crus cerebri. Neuroradiology. vol 52. issue 8. 2010-11-22. PMID:19859701. |
when scanning the size of the substantia nigra (sn), for example in parkinson's disease, it is important to precisely locate its true anatomic location. |
2010-11-22 |
2023-08-12 |
Not clear |
| Kerstin Krauel, Hendrik C Feldhaus, Andrea Simon, Claudia Rehe, Martin Glaser, Hans-Henning Flechtner, Hans-Jochen Heinze, Ludwig Niehau. Increased echogenicity of the substantia nigra in children and adolescents with attention-deficit/hyperactivity disorder. Biological psychiatry. vol 68. issue 4. 2010-11-22. PMID:20227683. |
recent neurobiological models on attention-deficit/hyperactivity disorder (adhd) as well as findings from imaging studies suggest a crucial involvement of dopaminergic midbrain nuclei, especially the substantia nigra (sn), in the pathogenesis of adhd symptoms. |
2010-11-22 |
2023-08-12 |
Not clear |
| Ning Song, Jun Wang, Hong Jiang, Junxia Xi. Ferroportin1 and hephaestin overexpression attenuate iron-induced oxidative stress in MES23.5 dopaminergic cells. Journal of cellular biochemistry. vol 110. issue 5. 2010-11-15. PMID:20564203. |
elevated iron was found in the substantia nigra (sn) of patients with parkinson's disease (pd). |
2010-11-15 |
2023-08-12 |
Not clear |
| Daniela Berg, Alexandra Gaensle. Place value of transcranial sonography in early diagnosis of Parkinson's disease. Neuro-degenerative diseases. vol 7. issue 5. 2010-11-04. PMID:20616564. |
substantia nigra (sn) hyperechogenicity is the characteristic feature of idiopathic pd, which can help in the differentiation of atypical parkinsonian syndromes like multiple system atrophy or progressive supranuclear palsy. |
2010-11-04 |
2023-08-12 |
Not clear |
| Joanne Clark, Elizabeth L Clore, Kangni Zheng, Anthony Adame, Eliezer Masliah, David K Simo. Oral N-acetyl-cysteine attenuates loss of dopaminergic terminals in alpha-synuclein overexpressing mice. PloS one. vol 5. issue 8. 2010-11-04. PMID:20808797. |
levels of glutathione are lower in the substantia nigra (sn) early in parkinson's disease (pd) and this may contribute to mitochondrial dysfunction and oxidative stress. |
2010-11-04 |
2023-08-12 |
mouse |
| Eleni A Markakis, Kenneth P Vives, Jeremy Bober, Stefan Leichtle, Csaba Leranth, Jeff Beecham, John D Elsworth, Robert H Roth, R Jude Samulski, D Eugene Redmon. Comparative transduction efficiency of AAV vector serotypes 1-6 in the substantia nigra and striatum of the primate brain. Molecular therapy : the journal of the American Society of Gene Therapy. vol 18. issue 3. 2010-10-29. PMID:20010918. |
vector injections were placed in the substantia nigra (sn) and the caudate nucleus (cd). |
2010-10-29 |
2023-08-12 |
Not clear |
| Chao Li, S Biswas, Xingang Li, A K Dutta, Weidong L. Novel D3 dopamine receptor-preferring agonist D-264: Evidence of neuroprotective property in Parkinson's disease animal models induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine and lactacystin. Journal of neuroscience research. vol 88. issue 11. 2010-10-20. PMID:20623619. |
we found that d-264 significantly improved behavioral performance, attenuated both mptp- and lactacystin-induced da neuron loss, and blocked proteasomal inhibition and microglial activation in the substantia nigra (sn). |
2010-10-20 |
2023-08-12 |
mouse |
| Simone van de Loo, Uwe Walter, Stefanie Behnke, Johann Hagenah, Matthias Lorenz, Matthias Sitzer, Rüdiger Hilker, Daniela Ber. Reproducibility and diagnostic accuracy of substantia nigra sonography for the diagnosis of Parkinson's disease. Journal of neurology, neurosurgery, and psychiatry. vol 81. issue 10. 2010-10-19. PMID:20543186. |
transcranial sonography (tcs) shows characteristic hyperechogenicity of the substantia nigra (sn) in patients with parkinson's disease (pd). |
2010-10-19 |
2023-08-12 |
Not clear |
| Joanna Iczkiewicz, Lauren Broom, Jonathan D Cooper, Andrew Ming Sham Wong, Sarah Rose, Peter Jenne. The RGD-containing peptide fragment of osteopontin protects tyrosine hydroxylase positive cells against toxic insult in primary ventral mesencephalic cultures and in the rat substantia nigra. Journal of neurochemistry. vol 114. issue 6. 2010-10-19. PMID:20626561. |
we have previously shown that the multi-functional phosphoprotein osteopontin (opn) is present in the substantia nigra (sn) and that its mrna and protein expression are up-regulated following toxic insult. |
2010-10-19 |
2023-08-12 |
rat |
| Danny Galleguillos, José A Fuentealba, Luis M Gómez, Mathias Saver, Andrea Gómez, Kevin Nash, Corinna Burger, Katia Gysling, María E André. Nurr1 regulates RET expression in dopamine neurons of adult rat midbrain. Journal of neurochemistry. vol 114. issue 4. 2010-10-06. PMID:20533997. |
using an adeno-associated vector-delivered anti-nurr1 ribozyme, we knocked-down nurr1 expression unilaterally in the substantia nigra (sn) of adult rats. |
2010-10-06 |
2023-08-12 |
human |
| I Nestrasil, S Michaeli, T Liimatainen, C E Rydeen, C M Kotz, J P Nixon, T Hanson, Paul J Tuit. T1rho and T2rho MRI in the evaluation of Parkinson's disease. Journal of neurology. vol 257. issue 6. 2010-09-29. PMID:20058018. |
using t(1rho) and t(2rho) on a 4t mri scanner, we assessed the substantia nigra (sn) of nine non-demented moderately affected pd and ten gender- and age-matched control participants. |
2010-09-29 |
2023-08-12 |
human |
| Vincent Seutin, Dominique Enge. Differences in Na+ conductance density and Na+ channel functional properties between dopamine and GABA neurons of the rat substantia nigra. Journal of neurophysiology. vol 103. issue 6. 2010-09-09. PMID:20357070. |
dopamine (da) neurons and gaba neurons of the substantia nigra (sn) promote distinct functions in the control of movement and have different firing properties and action potential (ap) waveforms. |
2010-09-09 |
2023-08-12 |
rat |
| Liviu Aron, Pontus Klein, Thu-Trang Pham, Edgar R Kramer, Wolfgang Wurst, Rüdiger Klei. Pro-survival role for Parkinson's associated gene DJ-1 revealed in trophically impaired dopaminergic neurons. PLoS biology. vol 8. issue 4. 2010-09-01. PMID:20386724. |
the mechanisms underlying the selective death of substantia nigra (sn) neurons in parkinson disease (pd) remain elusive. |
2010-09-01 |
2023-08-12 |
mouse |
| Michela Di Salvio, Luca G Di Giovannantonio, Daniela Omodei, Dario Acampora, Antonio Simeon. Otx2 expression is restricted to dopaminergic neurons of the ventral tegmental area in the adult brain. The International journal of developmental biology. vol 54. issue 5. 2010-08-30. PMID:19924631. |
despite great efforts, the molecular basis and the genetic factors differentially controlling identity, survival and vulnerability to neurodegeneration of mdda neurons of the substantia nigra (sn) and ventral tegmental area (vta) are poorly understood. |
2010-08-30 |
2023-08-12 |
mouse |
| Erik K Kastman, Auriel A Willette, Christopher L Coe, Barbara B Bendlin, Kris J Kosmatka, Donald G McLaren, Guofan Xu, Elisa Canu, Aaron S Field, Andrew L Alexander, Mary Lou Voytko, T Mark Beasley, Ricki J Colman, Richard H Weindruch, Sterling C Johnso. A calorie-restricted diet decreases brain iron accumulation and preserves motor performance in old rhesus monkeys. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 30. issue 23. 2010-08-24. PMID:20534842. |
both the cr and control monkeys showed age-related increases in iron concentrations in globus pallidus (gp) and substantia nigra (sn), although the cr group had significantly less iron deposition in the gp, sn, red nucleus, and temporal cortex. |
2010-08-24 |
2023-08-12 |
monkey |
| Shirong Wang, Eric E Turne. Expression of dopamine pathway genes in the midbrain is independent of known ETS transcription factor activity. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 30. issue 27. 2010-08-16. PMID:20610757. |
ets transcription factors are hypothesized to play a similar role in vertebrates, and based on its expression in the adult mouse midbrain, etv5/erm has been proposed as a regulator of da gene expression in the substantia nigra (sn) and ventral tegmental area (vta). |
2010-08-16 |
2023-08-12 |
mouse |
| Masaoki Iwanami, Tomoyuki Miyamoto, Masayuki Miyamoto, Koichi Hirata, Etsuo Takad. Relevance of substantia nigra hyperechogenicity and reduced odor identification in idiopathic REM sleep behavior disorder. Sleep medicine. vol 11. issue 4. 2010-08-03. PMID:20223708. |
substantia nigra (sn) hyperechogenicity determined by transcranial sonography (tcs) and olfactory dysfunction are common findings in parkinson disease (pd), which may reveal a prodromal synucleinopathy in idiopathic rem sleep behavior disorder (irbd). |
2010-08-03 |
2023-08-12 |
Not clear |
| Jiuquan Zhang, Yanling Zhang, Jian Wang, Ping Cai, Chunxia Luo, Zhongming Qian, Yongming Dai, Hua Fen. Characterizing iron deposition in Parkinson's disease using susceptibility-weighted imaging: an in vivo MR study. Brain research. vol 1330. 2010-08-02. PMID:20303339. |
the phase shift values of the bilateral red nucleus (rn), substantia nigra (sn), caudate nucleus (ca), globus pallidus (gp), putamen (pu), thalamus (th) and frontal white matter (fwm) were examined for their relationship with the clinical status. |
2010-08-02 |
2023-08-12 |
Not clear |
| Su-Feng Fan, Pei-Ling Chao, Anya Maan-Yuh Li. Arsenite induces oxidative injury in rat brain: synergistic effect of iron. Annals of the New York Academy of Sciences. vol 1199. 2010-07-29. PMID:20633106. |
our in vivo study employed intranigral infusion of arsenite (5 nmol) in the substantia nigra (sn) of anesthetized rats. |
2010-07-29 |
2023-08-12 |
rat |
| Jens Ebentheuer, Monica Canelo, Ellen Trautmann, Claudia Trenkwalde. Substantia nigra echogenicity in progressive supranuclear palsy. Movement disorders : official journal of the Movement Disorder Society. vol 25. issue 6. 2010-07-28. PMID:20198715. |
a normoechogenic substantia nigra (sn) is a typical finding in transcranial sonography in patients with progressive supranuclear palsy (psp), whereas in patients with parkinson's disease a hyperechogenic sn is characteristic. |
2010-07-28 |
2023-08-12 |
Not clear |