| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Chee Yeun Chung, James B Koprich, Hasan Siddiqi, Ole Isacso. Dynamic changes in presynaptic and axonal transport proteins combined with striatal neuroinflammation precede dopaminergic neuronal loss in a rat model of AAV alpha-synucleinopathy. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 29. issue 11. 2009-04-13. PMID:19295143. |
recombinant adeno-associated virus 2-mediated delivery of mutant (a53t) human alpha-synuclein into the substantia nigra (sn) under a neuron-specific synapsin promoter resulted in protracted neurodegeneration with significant dopaminergic (da) neuron loss by 17 weeks. |
2009-04-13 |
2023-08-12 |
human |
| Matthew T C Brown, Pablo Henny, J Paul Bolam, Peter J Magil. Activity of neurochemically heterogeneous dopaminergic neurons in the substantia nigra during spontaneous and driven changes in brain state. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 29. issue 9. 2009-04-10. PMID:19261887. |
dopaminergic neurons of the substantia nigra (sn) and ventral tegmental area (vta) are collectively implicated in motor- and reward-related behaviors. |
2009-04-10 |
2023-08-12 |
rat |
| Marianne Vázquez-Claverie, Pablo Garrido-Gil, Waldy San Sebastián, Silvia Belzunegui, Amaya Izal-Azcárate, Berta López, Irene Marcilla, María Rosario Luqui. 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) does not elicit long-lasting increases in cyclooxygenase-2 expression in dopaminergic neurons of monkeys. Journal of neuropathology and experimental neurology. vol 68. issue 1. 2009-04-09. PMID:19104449. |
chronically treated animals developed parkinsonian signs and were killed 6 months after the last treatment; tyrosine hydroxylase-expressing neurons decreased in all substantia nigra (sn) cell groups in both treatment groups. |
2009-04-09 |
2023-08-12 |
monkey |
| Shannon L Rhodes, Beate Rit. Genetics of iron regulation and the possible role of iron in Parkinson's disease. Neurobiology of disease. vol 32. issue 2. 2009-04-08. PMID:18675357. |
characteristic features of pd include dopaminergic neuron death in the substantia nigra (sn) pars compacta, accumulation of alpha-synuclein inclusions known as lewy bodies in the sn, and brain iron accumulation beyond that observed in non-pd brains of a similar age. |
2009-04-08 |
2023-08-12 |
human |
| Qian Wang, Huan Zheng, Zuo-feng Zhang, Yu-xin Zhan. [Ginsenoside Rg1 modulates COX-2 expression in the substantia nigra of mice with MPTP-induced Parkinson disease through the P38 signaling pathway]. Nan fang yi ke da xue xue bao = Journal of Southern Medical University. vol 28. issue 9. 2009-04-06. PMID:18819875. |
to investigate the role of p38 signaling pathway in modulating the expression of cyclooxygenase-2 (cox-2) in the substantia nigra (sn) of mice with 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (mptp)-induced parkinson disease (pd), and explore the possible mechanism of the dopaminergic (da) neuron death in pd and the effects of ginsenoside rg1 on the p38 signaling pathway and da neurons. |
2009-04-06 |
2023-08-12 |
mouse |
| Daniela Ber. Ultrasound in the (premotor) diagnosis of Parkinson's disease. Parkinsonism & related disorders. vol 13 Suppl 3. 2009-04-01. PMID:18267277. |
importantly, substantia nigra (sn) hyperechogenicity, the typical ultrasound marker of pd, can also be found in approximately 9% of healthy subjects. |
2009-04-01 |
2023-08-12 |
human |
| Kareem A Zaghloul, Justin A Blanco, Christoph T Weidemann, Kathryn McGill, Jurg L Jaggi, Gordon H Baltuch, Michael J Kahan. Human substantia nigra neurons encode unexpected financial rewards. Science (New York, N.Y.). vol 323. issue 5920. 2009-04-01. PMID:19286561. |
we used microelectrode recordings during deep brain stimulation surgery to study neuronal activity in the human substantia nigra (sn) while patients with parkinson's disease engaged in a probabilistic learning task motivated by virtual financial rewards. |
2009-04-01 |
2023-08-12 |
human |
| Begoña Sanchez, Jose L Relova, Rosalia Gallego, Isabel Ben-Batalla, Roman Perez-Fernande. 1,25-Dihydroxyvitamin D3 administration to 6-hydroxydopamine-lesioned rats increases glial cell line-derived neurotrophic factor and partially restores tyrosine hydroxylase expression in substantia nigra and striatum. Journal of neuroscience research. vol 87. issue 3. 2009-03-31. PMID:18816795. |
this study was carried out to explore the effects of 1,25(oh)(2)d(3) administration in a 6-ohda-lesioned rat model of parkinson's disease on gdnf and tyrosine hydroxylase (th) expression in substantia nigra (sn) and striatum. |
2009-03-31 |
2023-08-12 |
rat |
| Yeong-Gon Choi, Jae-Hyun Park, Sabina Li. Acupuncture inhibits ferric iron deposition and ferritin-heavy chain reduction in an MPTP-induced parkinsonism model. Neuroscience letters. vol 450. issue 2. 2009-03-24. PMID:19056464. |
the presence of ferric iron (fe(3+)), but not ferrous iron (fe(2+)), was strongly increased in the substantia nigra (sn) as a result of chronic loading of mptp, whereas the ferritin-heavy chain (f-h) was significantly decreased. |
2009-03-24 |
2023-08-12 |
mouse |
| Joanna Chwiej, Dariusz Adamek, Magdalena Szczerbowska-Boruchowska, Anna Krygowska-Wajs, Sylvain Bohic, Marek Lankos. Study of Cu chemical state inside single neurons from Parkinson's disease and control substantia nigra using the micro-XANES technique. Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS). vol 22. issue 3. 2009-02-23. PMID:18755393. |
however, a few processes such as oxidative stress, protein aggregation and mitochondrial dysfunction are suspected to lead to the atrophy and death of substantia nigra (sn) neurons in case of this neurodegenerative disorder. |
2009-02-23 |
2023-08-12 |
Not clear |
| Jiro Fukae, Shigeto Sato, Kahori Shiba, Ken-ichi Sato, Hideo Mori, Philip A Sharp, Yoshikuni Mizuno, Nobutaka Hattor. Programmed cell death-2 isoform1 is ubiquitinated by parkin and increased in the substantia nigra of patients with autosomal recessive Parkinson's disease. FEBS letters. vol 583. issue 3. 2009-02-16. PMID:19146857. |
accumulation of its substrate may induce dopaminergic neurodegeneration in the substantia nigra (sn) of arpd. |
2009-02-16 |
2023-08-12 |
Not clear |
| Zita Márkus, Gabriella Eördegh, Zsuzsanna Paróczy, G Benedek, A Nag. Modality distribution of sensory neurons in the feline caudate nucleus and the substantia nigra. Acta biologica Hungarica. vol 59. issue 3. 2009-02-11. PMID:18839694. |
despite extensive analysis of the motor functions of the basal ganglia and the fact that multisensory information processing appears critical for the execution of their behavioral action, little is known concerning the sensory functions of the caudate nucleus (cn) and the substantia nigra (sn). |
2009-02-11 |
2023-08-12 |
Not clear |
| Jana Godau, Anne-Kathrin Wevers, Alexandra Gaenslen, Adriana Di Santo, Inga Liepelt, Thomas Gasser, Daniela Ber. Sonographic abnormalities of brainstem structures in restless legs syndrome. Sleep medicine. vol 9. issue 7. 2009-02-02. PMID:18024170. |
using transcranial b-mode sonography (tcs), the first morphological marker for restless legs syndrome (rls), hypoechogenicity of the substantia nigra (sn) has been found. |
2009-02-02 |
2023-08-12 |
Not clear |
| Vandana Zaman, Heather A Boger, Ann-Charlotte Granholm, Baerbel Rohrer, Alfred Moore, Mona Buhusi, Greg A Gerhardt, Barry J Hoffer, Lawrence D Middaug. The nigrostriatal dopamine system of aging GFRalpha-1 heterozygous mice: neurochemistry, morphology and behavior. The European journal of neuroscience. vol 28. issue 8. 2009-01-26. PMID:18973577. |
monoamine concentrations and dopaminergic nerve terminals in the striatum and the number of dopaminergic neurons in the substantia nigra (sn) were assessed. |
2009-01-26 |
2023-08-12 |
mouse |
| Yuxin Liu, Liya Qin, Belinda Wilson, Xuefei Wu, Li Qian, Ann-Charlotte Granholm, Fulton T Crews, Jau-Shyong Hon. Endotoxin induces a delayed loss of TH-IR neurons in substantia nigra and motor behavioral deficits. Neurotoxicology. vol 29. issue 5. 2009-01-23. PMID:18471886. |
), causes a delayed and progressive loss of th-ir neurons in the substantia nigra (sn) in c57bl/six male mice. |
2009-01-23 |
2023-08-12 |
mouse |
| Noelia Granado, Esther O'Shea, Jordi Bove, Miquel Vila, Ma Isabel Colado, Rosario Moratall. Persistent MDMA-induced dopaminergic neurotoxicity in the striatum and substantia nigra of mice. Journal of neurochemistry. vol 107. issue 4. 2009-01-15. PMID:18823368. |
our results include the novel finding that mdma produces a significant decrease in the number of th-immunoreactive neurons in the substantia nigra (sn). |
2009-01-15 |
2023-08-12 |
mouse |
| Songhee Jeon, Youn Jung Kim, Seung-Tae Kim, Woongjoon Moon, Younbyoung Chae, Minjeong Kang, Mi-Young Chung, Hyangsook Lee, Mi-Sook Hong, Joo-Ho Chung, Tong H Joh, Hyejung Lee, Hi-Joon Par. Proteomic analysis of the neuroprotective mechanisms of acupuncture treatment in a Parkinson's disease mouse model. Proteomics. vol 8. issue 22. 2009-01-13. PMID:18942673. |
acupuncture is frequently used as an alternative therapy for parkinson's disease (pd), and it attenuates dopaminergic (da) neurodegeneration in the substantia nigra (sn) in pd animal models. |
2009-01-13 |
2023-08-12 |
mouse |
| Ilya D Iono. Self-amplification of nigral degeneration in Parkinson's disease: a hypothesis. The International journal of neuroscience. vol 118. issue 12. 2009-01-08. PMID:18937118. |
in normal brain, a specific interplay among the blood-brain barrier (bbb), substantia nigra (sn), and locus coeruleus (lc) creates the condition for a self-accelerating damage to the sn. |
2009-01-08 |
2023-08-12 |
Not clear |
| Julio Salazar, Natalia Mena, Stephane Hunot, Annick Prigent, Daniel Alvarez-Fischer, Miguel Arredondo, Charles Duyckaerts, Veronique Sazdovitch, Lin Zhao, Laura M Garrick, Marco T Nuñez, Michael D Garrick, Rita Raisman-Vozari, Etienne C Hirsc. Divalent metal transporter 1 (DMT1) contributes to neurodegeneration in animal models of Parkinson's disease. Proceedings of the National Academy of Sciences of the United States of America. vol 105. issue 47. 2009-01-07. PMID:19011085. |
dopaminergic cell death in the substantia nigra (sn) is central to parkinson's disease (pd), but the neurodegenerative mechanisms have not been completely elucidated. |
2009-01-07 |
2023-08-12 |
mouse |
| C A Frye, J J Paris, M E Rhode. Estrogen is necessary for 5alpha-pregnan-3alpha-ol-20-one (3alpha,5alpha-THP) infusion to the ventral tegmental area to facilitate social and sexual, but neither exploratory nor affective behavior of ovariectomized rats. Pharmacology, biochemistry, and behavior. vol 91. issue 2. 2009-01-06. PMID:18786558. |
ovx rats were primed with systemic 17beta-estradiol (10 microg) or oil vehicle and were infused 44 h later with 3alpha,5alpha-thp (100 ng) or beta-cyclodextrin vehicle to the vta, substantia nigra (sn), or central grey (cg). |
2009-01-06 |
2023-08-12 |
rat |