| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jana Godau, Almut Manz, Anne-Kathrin Wevers, Alexandra Gaenslen, Daniela Ber. Sonographic substantia nigra hypoechogenicity in polyneuropathy and restless legs syndrome. Movement disorders : official journal of the Movement Disorder Society. vol 24. issue 1. 2009-06-04. PMID:19170194. |
substantia nigra (sn) hypoechogenicity assessed by transcranial b-mode sonography (tcs) is typical for idiopathic restless legs syndrome (rls). |
2009-06-04 |
2023-08-12 |
Not clear |
| You-Joung Kim, Hyun-Jung Park, Gwang Lee, Oh Young Bang, Young Hwan Ahn, Eunhye Joe, Hyun Ok Kim, Phil Hyu Le. Neuroprotective effects of human mesenchymal stem cells on dopaminergic neurons through anti-inflammatory action. Glia. vol 57. issue 1. 2009-05-26. PMID:18661552. |
parkinson's disease (pd) is a common, progressive neurodegenerative disorder caused by the loss of dopaminergic neurons in the substantia nigra (sn). |
2009-05-26 |
2023-08-12 |
human |
| Eugene V Mosharov, Kristin E Larsen, Ellen Kanter, Kester A Phillips, Krystal Wilson, Yvonne Schmitz, David E Krantz, Kazuto Kobayashi, Robert H Edwards, David Sulze. Interplay between cytosolic dopamine, calcium, and alpha-synuclein causes selective death of substantia nigra neurons. Neuron. vol 62. issue 2. 2009-05-20. PMID:19409267. |
parkinson's disease (pd) is a synucleinopathy characterized by a preferential loss of dopaminergic neurons in the substantia nigra (sn), whereas neurons of the ventral tegmental area (vta) are spared. |
2009-05-20 |
2023-08-12 |
Not clear |
| Sabrina Wang, Jia-Ying Yan, Yu-Kang Lo, Paul M Carvey, Zaodung Lin. Dopaminergic and serotoninergic deficiencies in young adult rats prenatally exposed to the bacterial lipopolysaccharide. Brain research. vol 1265. 2009-05-13. PMID:19236855. |
we have reported previously that prenatal bacterial lipopolysaccharide (lps) exposure at the gestation window of vulnerability could consistently lead to dopamine (da) neuron loss in the substantia nigra (sn). |
2009-05-13 |
2023-08-12 |
rat |
| Thomas C Jhou, Stefanie Geisler, Michela Marinelli, Beth A Degarmo, Daniel S Zah. The mesopontine rostromedial tegmental nucleus: A structure targeted by the lateral habenula that projects to the ventral tegmental area of Tsai and substantia nigra compacta. The Journal of comparative neurology. vol 513. issue 6. 2009-04-27. PMID:19235216. |
prior studies revealed that aversive stimuli and psychostimulant drugs elicit fos expression in neurons clustered above and behind the interpeduncular nucleus that project strongly to the ventral tegmental area (vta) and substantia nigra (sn) compacta (c). |
2009-04-27 |
2023-08-12 |
Not clear |
| Jun Wang, Hua-Min Xu, Hai-Dong Yang, Xi-Xun Du, Hong Jiang, Jun-Xia Xi. Rg1 reduces nigral iron levels of MPTP-treated C57BL6 mice by regulating certain iron transport proteins. Neurochemistry international. vol 54. issue 1. 2009-04-24. PMID:19000728. |
elevated iron levels in the substantia nigra (sn) participate in neuronal death in parkinson's disease, in which the misregulation of iron transporters such as divalent metal transporter (dmt1) and ferroportin1 (fp1) are involved. |
2009-04-24 |
2023-08-12 |
mouse |
| Shuei Sugama, Takato Takenouchi, Hiroshi Kitani, Masayo Fujita, Makoto Hashimot. Microglial activation is inhibited by corticosterone in dopaminergic neurodegeneration. Journal of neuroimmunology. vol 208. issue 1-2. 2009-04-24. PMID:19201037. |
acute mptp treatment induced moderate tyrosine hydroxylase (th)-immunoreactive neuronal loss in the substantia nigra (sn) of shm mice; this neuronal loss was significantly enhanced in adx mice, but eventually recovered following the administration of corticosterone. |
2009-04-24 |
2023-08-12 |
mouse |
| Greg T Sutherland, Nicholas A Matigian, Alistair M Chalk, Matthew J Anderson, Peter A Silburn, Alan Mackay-Sim, Christine A Wells, George D Mellic. A cross-study transcriptional analysis of Parkinson's disease. PloS one. vol 4. issue 3. 2009-04-24. PMID:19305504. |
moreover data convergence increased when the analysis was limited to the five substantia nigra (sn) data sets; this highlighted the down regulation of dopamine receptor signaling and insulin-like growth factor 1 (igf1) signaling pathways. |
2009-04-24 |
2023-08-12 |
Not clear |
| C Nioche, E A Cabanis, C Haba. Functional connectivity of the human red nucleus in the brain resting state at 3T. AJNR. American journal of neuroradiology. vol 30. issue 2. 2009-04-23. PMID:19022864. |
because the rn is located very close to the substantia nigra (sn), the nigral network was also studied to ensure that these 2 circuits were correctly dissociated. |
2009-04-23 |
2023-08-12 |
human |
| Shin-Ichi Kyuho. Preventive effects of genistein on motor dysfunction following 6-hydroxydopamine injection in ovariectomized rats. Neuroscience letters. vol 448. issue 1. 2009-04-16. PMID:18952148. |
because they have been reported to possess neuroprotective effects on dopaminergic neurons in the substantia nigra (sn), isoflavones appear particularly promising for post-menopausal women at risk for pd. |
2009-04-16 |
2023-08-12 |
rat |
| b' Milija Mijajlovi\\xc4\\x87, Natasa Dragasevi\\xc4\\x87, Elka Stefanova, Igor Petrovi\\xc4\\x87, Marina Svetel, Vladimir S Kosti\\xc4\\x8. Transcranial sonography in spinocerebellar ataxia type 2. Journal of neurology. vol 255. issue 8. 2009-04-14. PMID:18458857.' |
to study the use of transcranial brain parenchyma sonography (tcs), in particular the echogenic signal in the substantia nigra (sn), in patients with spinocerebellar ataxia type 2 (sca2), recently recognized as an uncommon cause of parkinsonism. |
2009-04-14 |
2023-08-12 |
Not clear |
| Andreas Bender, Rachel-Maria Schwarzkopf, Anja McMillan, Kim J Krishnan, Gabriele Rieder, Manuela Neumann, Matthias Elstner, Douglas M Turnbull, Thomas Klopstoc. Dopaminergic midbrain neurons are the prime target for mitochondrial DNA deletions. Journal of neurology. vol 255. issue 8. 2009-04-14. PMID:18604467. |
by employing quantitative single cell techniques, we were recently able to show significantly high levels of mtdna deletions in dopaminergic substantia nigra (sn) neurons from pd patients and age-matched controls. |
2009-04-14 |
2023-08-12 |
human |
| E Lorenc-Koci, L Antkiewicz-Michaluk, A Kamińska, T Lenda, B Zieba, J Wierońska, M Smiałowska, G Schulze, H Rommelspache. The influence of acute and chronic administration of 1,2-dimethyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline on the function of the nigrostriatal dopaminergic system in rats. Neuroscience. vol 156. issue 4. 2009-04-14. PMID:18809471. |
in the substantia nigra (sn), only the higher dose of nmsal produced such effect. |
2009-04-14 |
2023-08-12 |
rat |
| Salma Bukhatwa, Mahmoud M Iravani, Bai-Yun Zeng, Jonathan D Cooper, Sarah Rose, Peter Jenne. An immunohistochemical and stereological analysis of PSI-induced nigral neuronal degeneration in the rat. Journal of neurochemistry. vol 109. issue 1. 2009-04-13. PMID:19187437. |
a major controversy centres over the use of manual counting of tyrosine hydroxylase (th) positive neurons at the level of third cranial nerve as opposed to employing systematic stereological analysis of cell loss in the entire substantia nigra (sn). |
2009-04-13 |
2023-08-12 |
rat |
| Chee Yeun Chung, James B Koprich, Hasan Siddiqi, Ole Isacso. Dynamic changes in presynaptic and axonal transport proteins combined with striatal neuroinflammation precede dopaminergic neuronal loss in a rat model of AAV alpha-synucleinopathy. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 29. issue 11. 2009-04-13. PMID:19295143. |
recombinant adeno-associated virus 2-mediated delivery of mutant (a53t) human alpha-synuclein into the substantia nigra (sn) under a neuron-specific synapsin promoter resulted in protracted neurodegeneration with significant dopaminergic (da) neuron loss by 17 weeks. |
2009-04-13 |
2023-08-12 |
human |
| Matthew T C Brown, Pablo Henny, J Paul Bolam, Peter J Magil. Activity of neurochemically heterogeneous dopaminergic neurons in the substantia nigra during spontaneous and driven changes in brain state. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 29. issue 9. 2009-04-10. PMID:19261887. |
dopaminergic neurons of the substantia nigra (sn) and ventral tegmental area (vta) are collectively implicated in motor- and reward-related behaviors. |
2009-04-10 |
2023-08-12 |
rat |
| Marianne Vázquez-Claverie, Pablo Garrido-Gil, Waldy San Sebastián, Silvia Belzunegui, Amaya Izal-Azcárate, Berta López, Irene Marcilla, María Rosario Luqui. 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) does not elicit long-lasting increases in cyclooxygenase-2 expression in dopaminergic neurons of monkeys. Journal of neuropathology and experimental neurology. vol 68. issue 1. 2009-04-09. PMID:19104449. |
chronically treated animals developed parkinsonian signs and were killed 6 months after the last treatment; tyrosine hydroxylase-expressing neurons decreased in all substantia nigra (sn) cell groups in both treatment groups. |
2009-04-09 |
2023-08-12 |
monkey |
| Shannon L Rhodes, Beate Rit. Genetics of iron regulation and the possible role of iron in Parkinson's disease. Neurobiology of disease. vol 32. issue 2. 2009-04-08. PMID:18675357. |
characteristic features of pd include dopaminergic neuron death in the substantia nigra (sn) pars compacta, accumulation of alpha-synuclein inclusions known as lewy bodies in the sn, and brain iron accumulation beyond that observed in non-pd brains of a similar age. |
2009-04-08 |
2023-08-12 |
human |
| Qian Wang, Huan Zheng, Zuo-feng Zhang, Yu-xin Zhan. [Ginsenoside Rg1 modulates COX-2 expression in the substantia nigra of mice with MPTP-induced Parkinson disease through the P38 signaling pathway]. Nan fang yi ke da xue xue bao = Journal of Southern Medical University. vol 28. issue 9. 2009-04-06. PMID:18819875. |
to investigate the role of p38 signaling pathway in modulating the expression of cyclooxygenase-2 (cox-2) in the substantia nigra (sn) of mice with 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (mptp)-induced parkinson disease (pd), and explore the possible mechanism of the dopaminergic (da) neuron death in pd and the effects of ginsenoside rg1 on the p38 signaling pathway and da neurons. |
2009-04-06 |
2023-08-12 |
mouse |
| Daniela Ber. Ultrasound in the (premotor) diagnosis of Parkinson's disease. Parkinsonism & related disorders. vol 13 Suppl 3. 2009-04-01. PMID:18267277. |
importantly, substantia nigra (sn) hyperechogenicity, the typical ultrasound marker of pd, can also be found in approximately 9% of healthy subjects. |
2009-04-01 |
2023-08-12 |
human |