| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Wen-Wei Li, Ru Yang, Ding-Fang Ca. [Protective effects of Cistanche total glycosides on dopaminergic neuron in substantia nigra of model mice of Parkinson's disease]. Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine. vol 28. issue 3. 2009-01-05. PMID:18476428. |
to investigate the protective effects of cistanche total glycosides (ctg) on dopaminergic neuron in substantia nigra (sn) of model mice of parkinson's disease (pd). |
2009-01-05 |
2023-08-12 |
mouse |
| Christopher D Herzog, Biplob Dass, Mehdi Gasmi, Roy Bakay, James E Stansell, Mark Tuszynski, Krystof Bankiewicz, Er-Yun Chen, Yaping Chu, Kathie Bishop, Jeffrey H Kordower, Raymond T Bartu. Transgene expression, bioactivity, and safety of CERE-120 (AAV2-neurturin) following delivery to the monkey striatum. Molecular therapy : the journal of the American Society of Gene Therapy. vol 16. issue 10. 2008-12-12. PMID:18728639. |
we report here, for the first time, a dose-related: increase in ntn protein expression within the striatum and substantia nigra (sn) pars compacta of nonhuman primates; increase in nigrostriatal tyrosine hydroxylase (th), (the rate-limited enzyme for dopamine); and activation of phosphorylated signal-regulated kinase (a common neurotrophic signaling event). |
2008-12-12 |
2023-08-12 |
human |
| Lars M Ittner, Thomas Fath, Yazi D Ke, Mian Bi, Janet van Eersel, Kong M Li, Peter Gunning, Jürgen Göt. Parkinsonism and impaired axonal transport in a mouse model of frontotemporal dementia. Proceedings of the National Academy of Sciences of the United States of America. vol 105. issue 41. 2008-11-24. PMID:18832465. |
different from our previously generated tau transgenic strains, the k3 mice express the transgene in the substantia nigra (sn) and show an early-onset motor phenotype that reproduces parkinsonism with tremor, bradykinesia, abnormal gait, and postural instability. |
2008-11-24 |
2023-08-12 |
mouse |
| Takashi Matsuwaki, Keitaro Yamanouchi, Masugi Nishihar. The effect of glucocorticoids on bradykinesia induced by immobilization stress. Hormones and behavior. vol 54. issue 1. 2008-11-18. PMID:18342862. |
it was also recently reported that imo damages dopaminergic (da) neurons in the substantia nigra (sn), which is known to cause symptoms similar to parkinson's disease (pd). |
2008-11-18 |
2023-08-12 |
mouse |
| Tianhong Pan, Wen Zhu, Hongru Zhao, Hao Deng, Wenjie Xie, Joseph Jankovic, Weidong L. Nurr1 deficiency predisposes to lactacystin-induced dopaminergic neuron injury in vitro and in vivo. Brain research. vol 1222. 2008-11-12. PMID:18579122. |
at same time, we found that there was a severer loss of tyrosine hydroxylase (th)-positive neurons in substantia nigra (sn) and greater reduction of striatal dopamine (da) levels in nurr1 +/- mice as compared with that in nurr1 +/+ mice. |
2008-11-12 |
2023-08-12 |
mouse |
| Amjad Abuirmeileh, Alexander Harkavyi, Ann Kingsbury, Rebecca Lever, Peter S Whitto. The CRF-like peptide urocortin produces a long-lasting recovery in rats made hemiparkinsonian by 6-hydroxydopamine or lipopolysaccharide. Journal of the neurological sciences. vol 271. issue 1-2. 2008-11-05. PMID:18508084. |
the following day rats were dialysed to estimate extracellular striatal dopamine (da) and then sacrificed for estimation of striatal tissue da and subsequent immunohistochemistry of th(+) cells in the substantia nigra (sn). |
2008-11-05 |
2023-08-12 |
rat |
| Emilce Carrasco, Peter Werner, Diana Caspe. Prostaglandin receptor EP2 protects dopaminergic neurons against 6-OHDA-mediated low oxidative stress. Neuroscience letters. vol 441. issue 1. 2008-11-05. PMID:18597941. |
dopaminergic neurons in the substantia nigra (sn) selectively die in parkinson's disease (pd), but it is unclear how and why this occurs. |
2008-11-05 |
2023-08-12 |
human |
| Supriti Samantaray, Swapan K Ray, Naren L Bani. Calpain as a potential therapeutic target in Parkinson's disease. CNS & neurological disorders drug targets. vol 7. issue 3. 2008-11-05. PMID:18673214. |
pathophysiology of idiopathic parkinson's disease (pd) is associated with degeneration of dopaminergic neurons and inflammatory responses in the mid-brain substantia nigra (sn). |
2008-11-05 |
2023-08-12 |
Not clear |
| Jun Mo Kang, Jae-Chul Jung, Heejeong Kim, Heena Lim, Soyong Jang, Seikwan O. Neuroprotective effect of benzylideneacetophenone derivative on the MPTP model of neurodegeneration in mice. Archives of pharmacal research. vol 31. issue 9. 2008-10-28. PMID:18806951. |
immunohistochemistry and western blot were used to determine the expression levels of tyrosine hydroxylase (th), dopamine transporter (dat), ox-42 (a marker of microglial activation), and glial fibrillary acid protein (gfap, a marker of astrocyte activation) in the substantia nigra (sn) and striatum (st). |
2008-10-28 |
2023-08-12 |
mouse |
| María Clara Pott Godoy, Rodolfo Tarelli, Carina Cintia Ferrari, Maria Inés Sarchi, Fernando Juan Pitoss. Central and systemic IL-1 exacerbates neurodegeneration and motor symptoms in a model of Parkinson's disease. Brain : a journal of neurology. vol 131. issue Pt 7. 2008-10-22. PMID:18504291. |
activated microglial cells in the substantia nigra (sn) are found in all animal models of parkinson's disease and patients with the illness. |
2008-10-22 |
2023-08-12 |
Not clear |
| Jana Godau, Uwe Klose, Adriana Di Santo, Katherine Schweitzer, Daniela Ber. Multiregional brain iron deficiency in restless legs syndrome. Movement disorders : official journal of the Movement Disorder Society. vol 23. issue 8. 2008-10-20. PMID:18442125. |
evidence for tissue iron deficiency in restless legs syndrome (rls) is limited to the substantia nigra (sn). |
2008-10-20 |
2023-08-12 |
Not clear |
| Luigi Zecca, Henrik Wilms, Sebastian Geick, Jan-Hendrik Claasen, Lars-Ove Brandenburg, Christian Holzknecht, Michele L Panizza, Fabio A Zucca, Günther Deuschl, Jobst Sievers, Ralph Luciu. Human neuromelanin induces neuroinflammation and neurodegeneration in the rat substantia nigra: implications for Parkinson's disease. Acta neuropathologica. vol 116. issue 1. 2008-10-14. PMID:18343932. |
parkinson's disease (pd) is a common neurodegenerative disorder characterized by a selective loss of dopaminergic neurons in the substantia nigra (sn). |
2008-10-14 |
2023-08-12 |
human |
| Luigi Zecca, Henrik Wilms, Sebastian Geick, Jan-Hendrik Claasen, Lars-Ove Brandenburg, Christian Holzknecht, Michele L Panizza, Fabio A Zucca, Günther Deuschl, Jobst Sievers, Ralph Luciu. Human neuromelanin induces neuroinflammation and neurodegeneration in the rat substantia nigra: implications for Parkinson's disease. Acta neuropathologica. vol 116. issue 1. 2008-10-14. PMID:18343932. |
after different survival times (1, 8 or 12 weeks), brain slices from the cerebral cortex or substantia nigra (sn, 1 week) were stained with iba-1 and/or gfap antibody to monitor microglial and astrocytic reaction, and with tyrosine hydroxylase (th) to monitor dopaminergic cell survival (sn group only). |
2008-10-14 |
2023-08-12 |
human |
| Shankar J Chinta, Julie K Anderse. Redox imbalance in Parkinson's disease. Biochimica et biophysica acta. vol 1780. issue 11. 2008-10-08. PMID:18358848. |
parkinson's disease (pd) is an adult-onset neurodegenerative disorder characterized by preferential loss of dopaminergic neurons in an area of the midbrain called the substantia nigra (sn) along with occurrence of intraneuronal inclusions called lewy bodies. |
2008-10-08 |
2023-08-12 |
Not clear |
| b' Milija Mijajlovi\\xc4\\x87, Igor Petrovi\\xc4\\x87, Tanja Stojkovi\\xc4\\x87, Marina Svetel, Elka Stefanova, Vladimir S Kosti\\xc4\\x8. [Transcranial parenchymal sonography in the diagnosis of Parkinson\'s disease]. Vojnosanitetski pregled. vol 65. issue 8. 2008-09-25. PMID:18751340.' |
enlargement of the echogenic signal (hyperechogenicity) of the substantia nigra (sn) has been reported as a highly characteristic finding in idiopathic parkinson's disease (pd) and is thought to reflect increased amounts of iron, bound to proteins other than ferritin, in the sn in the course of neurodegeneration. |
2008-09-25 |
2023-08-12 |
Not clear |
| Steven R Danielson, Julie K Anderse. Oxidative and nitrative protein modifications in Parkinson's disease. Free radical biology & medicine. vol 44. issue 10. 2008-09-22. PMID:18395015. |
increased oxidative stress appears to be a common causative aspect involved in the preferential loss of dopaminergic neurons in a region of the brain prominently affected by the disorder, the substantia nigra (sn). |
2008-09-22 |
2023-08-12 |
Not clear |
| K Mukhida, M Hong, G B Miles, T Phillips, B A Baghbaderani, M McLeod, N Kobayashi, A Sen, L A Behie, R M Brownstone, I Mende. A multitarget basal ganglia dopaminergic and GABAergic transplantation strategy enhances behavioural recovery in parkinsonian rats. Brain : a journal of neurology. vol 131. issue Pt 8. 2008-09-15. PMID:18669492. |
the current transplantation paradigm for parkinson's disease that places foetal dopaminergic cells in the striatum neither normalizes neuronal activity in basal ganglia structures such as the substantia nigra (sn) and subthalamic nucleus (stn) nor leads to complete functional recovery. |
2008-09-15 |
2023-08-12 |
human |
| Jun-Ping Cao, Jing-Kao Yu, Chong Li, Yu Sun, Hong-Hua Yuan, Hong-Jun Wang, Dian-Shuai Ga. Integrin beta1 is involved in the signaling of glial cell line-derived neurotrophic factor. The Journal of comparative neurology. vol 509. issue 2. 2008-09-10. PMID:18465789. |
glial cell line-derived neurotrophic factor (gdnf) is a potent neurotrophic factor for the substantia nigra (sn) dopamine (da) neurons. |
2008-09-10 |
2023-08-12 |
Not clear |
| J M Hagenah, B Becker, N Brüggemann, A Djarmati, K Lohmann, A Sprenger, C Klein, G Seide. Transcranial sonography findings in a large family with homozygous and heterozygous PINK1 mutations. Journal of neurology, neurosurgery, and psychiatry. vol 79. issue 9. 2008-09-03. PMID:18469032. |
to investigate substantia nigra (sn) echogenicity in members of a family with homozygous and heterozygous pten induced kinase (pink1) mutations with or without signs of parkinson's disease (pd). |
2008-09-03 |
2023-08-12 |
Not clear |
| Xi Jun He, Hirofumi Yamauchi, Koji Uetsuka, Hiroyuki Nakayam. Neurotoxicity of MPTP to migrating neuroblasts: studies in acute and subacute mouse models of Parkinson's disease. Neurotoxicology. vol 29. issue 3. 2008-08-25. PMID:18387672. |
in recent years, the notion that the neurotoxicity of mptp is restricted to dopaminergic neurons in the substantia nigra (sn) has been challenged. |
2008-08-25 |
2023-08-12 |
mouse |