| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Vandana Zaman, Heather A Boger, Ann-Charlotte Granholm, Baerbel Rohrer, Alfred Moore, Mona Buhusi, Greg A Gerhardt, Barry J Hoffer, Lawrence D Middaug. The nigrostriatal dopamine system of aging GFRalpha-1 heterozygous mice: neurochemistry, morphology and behavior. The European journal of neuroscience. vol 28. issue 8. 2009-01-26. PMID:18973577. |
monoamine concentrations and dopaminergic nerve terminals in the striatum and the number of dopaminergic neurons in the substantia nigra (sn) were assessed. |
2009-01-26 |
2023-08-12 |
mouse |
| Yuxin Liu, Liya Qin, Belinda Wilson, Xuefei Wu, Li Qian, Ann-Charlotte Granholm, Fulton T Crews, Jau-Shyong Hon. Endotoxin induces a delayed loss of TH-IR neurons in substantia nigra and motor behavioral deficits. Neurotoxicology. vol 29. issue 5. 2009-01-23. PMID:18471886. |
), causes a delayed and progressive loss of th-ir neurons in the substantia nigra (sn) in c57bl/six male mice. |
2009-01-23 |
2023-08-12 |
mouse |
| Noelia Granado, Esther O'Shea, Jordi Bove, Miquel Vila, Ma Isabel Colado, Rosario Moratall. Persistent MDMA-induced dopaminergic neurotoxicity in the striatum and substantia nigra of mice. Journal of neurochemistry. vol 107. issue 4. 2009-01-15. PMID:18823368. |
our results include the novel finding that mdma produces a significant decrease in the number of th-immunoreactive neurons in the substantia nigra (sn). |
2009-01-15 |
2023-08-12 |
mouse |
| Songhee Jeon, Youn Jung Kim, Seung-Tae Kim, Woongjoon Moon, Younbyoung Chae, Minjeong Kang, Mi-Young Chung, Hyangsook Lee, Mi-Sook Hong, Joo-Ho Chung, Tong H Joh, Hyejung Lee, Hi-Joon Par. Proteomic analysis of the neuroprotective mechanisms of acupuncture treatment in a Parkinson's disease mouse model. Proteomics. vol 8. issue 22. 2009-01-13. PMID:18942673. |
acupuncture is frequently used as an alternative therapy for parkinson's disease (pd), and it attenuates dopaminergic (da) neurodegeneration in the substantia nigra (sn) in pd animal models. |
2009-01-13 |
2023-08-12 |
mouse |
| Ilya D Iono. Self-amplification of nigral degeneration in Parkinson's disease: a hypothesis. The International journal of neuroscience. vol 118. issue 12. 2009-01-08. PMID:18937118. |
in normal brain, a specific interplay among the blood-brain barrier (bbb), substantia nigra (sn), and locus coeruleus (lc) creates the condition for a self-accelerating damage to the sn. |
2009-01-08 |
2023-08-12 |
Not clear |
| Julio Salazar, Natalia Mena, Stephane Hunot, Annick Prigent, Daniel Alvarez-Fischer, Miguel Arredondo, Charles Duyckaerts, Veronique Sazdovitch, Lin Zhao, Laura M Garrick, Marco T Nuñez, Michael D Garrick, Rita Raisman-Vozari, Etienne C Hirsc. Divalent metal transporter 1 (DMT1) contributes to neurodegeneration in animal models of Parkinson's disease. Proceedings of the National Academy of Sciences of the United States of America. vol 105. issue 47. 2009-01-07. PMID:19011085. |
dopaminergic cell death in the substantia nigra (sn) is central to parkinson's disease (pd), but the neurodegenerative mechanisms have not been completely elucidated. |
2009-01-07 |
2023-08-12 |
mouse |
| C A Frye, J J Paris, M E Rhode. Estrogen is necessary for 5alpha-pregnan-3alpha-ol-20-one (3alpha,5alpha-THP) infusion to the ventral tegmental area to facilitate social and sexual, but neither exploratory nor affective behavior of ovariectomized rats. Pharmacology, biochemistry, and behavior. vol 91. issue 2. 2009-01-06. PMID:18786558. |
ovx rats were primed with systemic 17beta-estradiol (10 microg) or oil vehicle and were infused 44 h later with 3alpha,5alpha-thp (100 ng) or beta-cyclodextrin vehicle to the vta, substantia nigra (sn), or central grey (cg). |
2009-01-06 |
2023-08-12 |
rat |
| Wen-Wei Li, Ru Yang, Ding-Fang Ca. [Protective effects of Cistanche total glycosides on dopaminergic neuron in substantia nigra of model mice of Parkinson's disease]. Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine. vol 28. issue 3. 2009-01-05. PMID:18476428. |
to investigate the protective effects of cistanche total glycosides (ctg) on dopaminergic neuron in substantia nigra (sn) of model mice of parkinson's disease (pd). |
2009-01-05 |
2023-08-12 |
mouse |
| Christopher D Herzog, Biplob Dass, Mehdi Gasmi, Roy Bakay, James E Stansell, Mark Tuszynski, Krystof Bankiewicz, Er-Yun Chen, Yaping Chu, Kathie Bishop, Jeffrey H Kordower, Raymond T Bartu. Transgene expression, bioactivity, and safety of CERE-120 (AAV2-neurturin) following delivery to the monkey striatum. Molecular therapy : the journal of the American Society of Gene Therapy. vol 16. issue 10. 2008-12-12. PMID:18728639. |
we report here, for the first time, a dose-related: increase in ntn protein expression within the striatum and substantia nigra (sn) pars compacta of nonhuman primates; increase in nigrostriatal tyrosine hydroxylase (th), (the rate-limited enzyme for dopamine); and activation of phosphorylated signal-regulated kinase (a common neurotrophic signaling event). |
2008-12-12 |
2023-08-12 |
human |
| Lars M Ittner, Thomas Fath, Yazi D Ke, Mian Bi, Janet van Eersel, Kong M Li, Peter Gunning, Jürgen Göt. Parkinsonism and impaired axonal transport in a mouse model of frontotemporal dementia. Proceedings of the National Academy of Sciences of the United States of America. vol 105. issue 41. 2008-11-24. PMID:18832465. |
different from our previously generated tau transgenic strains, the k3 mice express the transgene in the substantia nigra (sn) and show an early-onset motor phenotype that reproduces parkinsonism with tremor, bradykinesia, abnormal gait, and postural instability. |
2008-11-24 |
2023-08-12 |
mouse |
| Takashi Matsuwaki, Keitaro Yamanouchi, Masugi Nishihar. The effect of glucocorticoids on bradykinesia induced by immobilization stress. Hormones and behavior. vol 54. issue 1. 2008-11-18. PMID:18342862. |
it was also recently reported that imo damages dopaminergic (da) neurons in the substantia nigra (sn), which is known to cause symptoms similar to parkinson's disease (pd). |
2008-11-18 |
2023-08-12 |
mouse |
| Tianhong Pan, Wen Zhu, Hongru Zhao, Hao Deng, Wenjie Xie, Joseph Jankovic, Weidong L. Nurr1 deficiency predisposes to lactacystin-induced dopaminergic neuron injury in vitro and in vivo. Brain research. vol 1222. 2008-11-12. PMID:18579122. |
at same time, we found that there was a severer loss of tyrosine hydroxylase (th)-positive neurons in substantia nigra (sn) and greater reduction of striatal dopamine (da) levels in nurr1 +/- mice as compared with that in nurr1 +/+ mice. |
2008-11-12 |
2023-08-12 |
mouse |
| Amjad Abuirmeileh, Alexander Harkavyi, Ann Kingsbury, Rebecca Lever, Peter S Whitto. The CRF-like peptide urocortin produces a long-lasting recovery in rats made hemiparkinsonian by 6-hydroxydopamine or lipopolysaccharide. Journal of the neurological sciences. vol 271. issue 1-2. 2008-11-05. PMID:18508084. |
the following day rats were dialysed to estimate extracellular striatal dopamine (da) and then sacrificed for estimation of striatal tissue da and subsequent immunohistochemistry of th(+) cells in the substantia nigra (sn). |
2008-11-05 |
2023-08-12 |
rat |
| Emilce Carrasco, Peter Werner, Diana Caspe. Prostaglandin receptor EP2 protects dopaminergic neurons against 6-OHDA-mediated low oxidative stress. Neuroscience letters. vol 441. issue 1. 2008-11-05. PMID:18597941. |
dopaminergic neurons in the substantia nigra (sn) selectively die in parkinson's disease (pd), but it is unclear how and why this occurs. |
2008-11-05 |
2023-08-12 |
human |
| Supriti Samantaray, Swapan K Ray, Naren L Bani. Calpain as a potential therapeutic target in Parkinson's disease. CNS & neurological disorders drug targets. vol 7. issue 3. 2008-11-05. PMID:18673214. |
pathophysiology of idiopathic parkinson's disease (pd) is associated with degeneration of dopaminergic neurons and inflammatory responses in the mid-brain substantia nigra (sn). |
2008-11-05 |
2023-08-12 |
Not clear |
| Jun Mo Kang, Jae-Chul Jung, Heejeong Kim, Heena Lim, Soyong Jang, Seikwan O. Neuroprotective effect of benzylideneacetophenone derivative on the MPTP model of neurodegeneration in mice. Archives of pharmacal research. vol 31. issue 9. 2008-10-28. PMID:18806951. |
immunohistochemistry and western blot were used to determine the expression levels of tyrosine hydroxylase (th), dopamine transporter (dat), ox-42 (a marker of microglial activation), and glial fibrillary acid protein (gfap, a marker of astrocyte activation) in the substantia nigra (sn) and striatum (st). |
2008-10-28 |
2023-08-12 |
mouse |
| María Clara Pott Godoy, Rodolfo Tarelli, Carina Cintia Ferrari, Maria Inés Sarchi, Fernando Juan Pitoss. Central and systemic IL-1 exacerbates neurodegeneration and motor symptoms in a model of Parkinson's disease. Brain : a journal of neurology. vol 131. issue Pt 7. 2008-10-22. PMID:18504291. |
activated microglial cells in the substantia nigra (sn) are found in all animal models of parkinson's disease and patients with the illness. |
2008-10-22 |
2023-08-12 |
Not clear |
| Jana Godau, Uwe Klose, Adriana Di Santo, Katherine Schweitzer, Daniela Ber. Multiregional brain iron deficiency in restless legs syndrome. Movement disorders : official journal of the Movement Disorder Society. vol 23. issue 8. 2008-10-20. PMID:18442125. |
evidence for tissue iron deficiency in restless legs syndrome (rls) is limited to the substantia nigra (sn). |
2008-10-20 |
2023-08-12 |
Not clear |
| Luigi Zecca, Henrik Wilms, Sebastian Geick, Jan-Hendrik Claasen, Lars-Ove Brandenburg, Christian Holzknecht, Michele L Panizza, Fabio A Zucca, Günther Deuschl, Jobst Sievers, Ralph Luciu. Human neuromelanin induces neuroinflammation and neurodegeneration in the rat substantia nigra: implications for Parkinson's disease. Acta neuropathologica. vol 116. issue 1. 2008-10-14. PMID:18343932. |
parkinson's disease (pd) is a common neurodegenerative disorder characterized by a selective loss of dopaminergic neurons in the substantia nigra (sn). |
2008-10-14 |
2023-08-12 |
human |
| Luigi Zecca, Henrik Wilms, Sebastian Geick, Jan-Hendrik Claasen, Lars-Ove Brandenburg, Christian Holzknecht, Michele L Panizza, Fabio A Zucca, Günther Deuschl, Jobst Sievers, Ralph Luciu. Human neuromelanin induces neuroinflammation and neurodegeneration in the rat substantia nigra: implications for Parkinson's disease. Acta neuropathologica. vol 116. issue 1. 2008-10-14. PMID:18343932. |
after different survival times (1, 8 or 12 weeks), brain slices from the cerebral cortex or substantia nigra (sn, 1 week) were stained with iba-1 and/or gfap antibody to monitor microglial and astrocytic reaction, and with tyrosine hydroxylase (th) to monitor dopaminergic cell survival (sn group only). |
2008-10-14 |
2023-08-12 |
human |