| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Kareem A Zaghloul, Justin A Blanco, Christoph T Weidemann, Kathryn McGill, Jurg L Jaggi, Gordon H Baltuch, Michael J Kahan. Human substantia nigra neurons encode unexpected financial rewards. Science (New York, N.Y.). vol 323. issue 5920. 2009-04-01. PMID:19286561. |
we used microelectrode recordings during deep brain stimulation surgery to study neuronal activity in the human substantia nigra (sn) while patients with parkinson's disease engaged in a probabilistic learning task motivated by virtual financial rewards. |
2009-04-01 |
2023-08-12 |
human |
| Begoña Sanchez, Jose L Relova, Rosalia Gallego, Isabel Ben-Batalla, Roman Perez-Fernande. 1,25-Dihydroxyvitamin D3 administration to 6-hydroxydopamine-lesioned rats increases glial cell line-derived neurotrophic factor and partially restores tyrosine hydroxylase expression in substantia nigra and striatum. Journal of neuroscience research. vol 87. issue 3. 2009-03-31. PMID:18816795. |
this study was carried out to explore the effects of 1,25(oh)(2)d(3) administration in a 6-ohda-lesioned rat model of parkinson's disease on gdnf and tyrosine hydroxylase (th) expression in substantia nigra (sn) and striatum. |
2009-03-31 |
2023-08-12 |
rat |
| Yeong-Gon Choi, Jae-Hyun Park, Sabina Li. Acupuncture inhibits ferric iron deposition and ferritin-heavy chain reduction in an MPTP-induced parkinsonism model. Neuroscience letters. vol 450. issue 2. 2009-03-24. PMID:19056464. |
the presence of ferric iron (fe(3+)), but not ferrous iron (fe(2+)), was strongly increased in the substantia nigra (sn) as a result of chronic loading of mptp, whereas the ferritin-heavy chain (f-h) was significantly decreased. |
2009-03-24 |
2023-08-12 |
mouse |
| Joanna Chwiej, Dariusz Adamek, Magdalena Szczerbowska-Boruchowska, Anna Krygowska-Wajs, Sylvain Bohic, Marek Lankos. Study of Cu chemical state inside single neurons from Parkinson's disease and control substantia nigra using the micro-XANES technique. Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS). vol 22. issue 3. 2009-02-23. PMID:18755393. |
however, a few processes such as oxidative stress, protein aggregation and mitochondrial dysfunction are suspected to lead to the atrophy and death of substantia nigra (sn) neurons in case of this neurodegenerative disorder. |
2009-02-23 |
2023-08-12 |
Not clear |
| Jiro Fukae, Shigeto Sato, Kahori Shiba, Ken-ichi Sato, Hideo Mori, Philip A Sharp, Yoshikuni Mizuno, Nobutaka Hattor. Programmed cell death-2 isoform1 is ubiquitinated by parkin and increased in the substantia nigra of patients with autosomal recessive Parkinson's disease. FEBS letters. vol 583. issue 3. 2009-02-16. PMID:19146857. |
accumulation of its substrate may induce dopaminergic neurodegeneration in the substantia nigra (sn) of arpd. |
2009-02-16 |
2023-08-12 |
Not clear |
| Zita Márkus, Gabriella Eördegh, Zsuzsanna Paróczy, G Benedek, A Nag. Modality distribution of sensory neurons in the feline caudate nucleus and the substantia nigra. Acta biologica Hungarica. vol 59. issue 3. 2009-02-11. PMID:18839694. |
despite extensive analysis of the motor functions of the basal ganglia and the fact that multisensory information processing appears critical for the execution of their behavioral action, little is known concerning the sensory functions of the caudate nucleus (cn) and the substantia nigra (sn). |
2009-02-11 |
2023-08-12 |
Not clear |
| Jana Godau, Anne-Kathrin Wevers, Alexandra Gaenslen, Adriana Di Santo, Inga Liepelt, Thomas Gasser, Daniela Ber. Sonographic abnormalities of brainstem structures in restless legs syndrome. Sleep medicine. vol 9. issue 7. 2009-02-02. PMID:18024170. |
using transcranial b-mode sonography (tcs), the first morphological marker for restless legs syndrome (rls), hypoechogenicity of the substantia nigra (sn) has been found. |
2009-02-02 |
2023-08-12 |
Not clear |
| Vandana Zaman, Heather A Boger, Ann-Charlotte Granholm, Baerbel Rohrer, Alfred Moore, Mona Buhusi, Greg A Gerhardt, Barry J Hoffer, Lawrence D Middaug. The nigrostriatal dopamine system of aging GFRalpha-1 heterozygous mice: neurochemistry, morphology and behavior. The European journal of neuroscience. vol 28. issue 8. 2009-01-26. PMID:18973577. |
monoamine concentrations and dopaminergic nerve terminals in the striatum and the number of dopaminergic neurons in the substantia nigra (sn) were assessed. |
2009-01-26 |
2023-08-12 |
mouse |
| Yuxin Liu, Liya Qin, Belinda Wilson, Xuefei Wu, Li Qian, Ann-Charlotte Granholm, Fulton T Crews, Jau-Shyong Hon. Endotoxin induces a delayed loss of TH-IR neurons in substantia nigra and motor behavioral deficits. Neurotoxicology. vol 29. issue 5. 2009-01-23. PMID:18471886. |
), causes a delayed and progressive loss of th-ir neurons in the substantia nigra (sn) in c57bl/six male mice. |
2009-01-23 |
2023-08-12 |
mouse |
| Noelia Granado, Esther O'Shea, Jordi Bove, Miquel Vila, Ma Isabel Colado, Rosario Moratall. Persistent MDMA-induced dopaminergic neurotoxicity in the striatum and substantia nigra of mice. Journal of neurochemistry. vol 107. issue 4. 2009-01-15. PMID:18823368. |
our results include the novel finding that mdma produces a significant decrease in the number of th-immunoreactive neurons in the substantia nigra (sn). |
2009-01-15 |
2023-08-12 |
mouse |
| Songhee Jeon, Youn Jung Kim, Seung-Tae Kim, Woongjoon Moon, Younbyoung Chae, Minjeong Kang, Mi-Young Chung, Hyangsook Lee, Mi-Sook Hong, Joo-Ho Chung, Tong H Joh, Hyejung Lee, Hi-Joon Par. Proteomic analysis of the neuroprotective mechanisms of acupuncture treatment in a Parkinson's disease mouse model. Proteomics. vol 8. issue 22. 2009-01-13. PMID:18942673. |
acupuncture is frequently used as an alternative therapy for parkinson's disease (pd), and it attenuates dopaminergic (da) neurodegeneration in the substantia nigra (sn) in pd animal models. |
2009-01-13 |
2023-08-12 |
mouse |
| Ilya D Iono. Self-amplification of nigral degeneration in Parkinson's disease: a hypothesis. The International journal of neuroscience. vol 118. issue 12. 2009-01-08. PMID:18937118. |
in normal brain, a specific interplay among the blood-brain barrier (bbb), substantia nigra (sn), and locus coeruleus (lc) creates the condition for a self-accelerating damage to the sn. |
2009-01-08 |
2023-08-12 |
Not clear |
| Julio Salazar, Natalia Mena, Stephane Hunot, Annick Prigent, Daniel Alvarez-Fischer, Miguel Arredondo, Charles Duyckaerts, Veronique Sazdovitch, Lin Zhao, Laura M Garrick, Marco T Nuñez, Michael D Garrick, Rita Raisman-Vozari, Etienne C Hirsc. Divalent metal transporter 1 (DMT1) contributes to neurodegeneration in animal models of Parkinson's disease. Proceedings of the National Academy of Sciences of the United States of America. vol 105. issue 47. 2009-01-07. PMID:19011085. |
dopaminergic cell death in the substantia nigra (sn) is central to parkinson's disease (pd), but the neurodegenerative mechanisms have not been completely elucidated. |
2009-01-07 |
2023-08-12 |
mouse |
| C A Frye, J J Paris, M E Rhode. Estrogen is necessary for 5alpha-pregnan-3alpha-ol-20-one (3alpha,5alpha-THP) infusion to the ventral tegmental area to facilitate social and sexual, but neither exploratory nor affective behavior of ovariectomized rats. Pharmacology, biochemistry, and behavior. vol 91. issue 2. 2009-01-06. PMID:18786558. |
ovx rats were primed with systemic 17beta-estradiol (10 microg) or oil vehicle and were infused 44 h later with 3alpha,5alpha-thp (100 ng) or beta-cyclodextrin vehicle to the vta, substantia nigra (sn), or central grey (cg). |
2009-01-06 |
2023-08-12 |
rat |
| Wen-Wei Li, Ru Yang, Ding-Fang Ca. [Protective effects of Cistanche total glycosides on dopaminergic neuron in substantia nigra of model mice of Parkinson's disease]. Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine. vol 28. issue 3. 2009-01-05. PMID:18476428. |
to investigate the protective effects of cistanche total glycosides (ctg) on dopaminergic neuron in substantia nigra (sn) of model mice of parkinson's disease (pd). |
2009-01-05 |
2023-08-12 |
mouse |
| Christopher D Herzog, Biplob Dass, Mehdi Gasmi, Roy Bakay, James E Stansell, Mark Tuszynski, Krystof Bankiewicz, Er-Yun Chen, Yaping Chu, Kathie Bishop, Jeffrey H Kordower, Raymond T Bartu. Transgene expression, bioactivity, and safety of CERE-120 (AAV2-neurturin) following delivery to the monkey striatum. Molecular therapy : the journal of the American Society of Gene Therapy. vol 16. issue 10. 2008-12-12. PMID:18728639. |
we report here, for the first time, a dose-related: increase in ntn protein expression within the striatum and substantia nigra (sn) pars compacta of nonhuman primates; increase in nigrostriatal tyrosine hydroxylase (th), (the rate-limited enzyme for dopamine); and activation of phosphorylated signal-regulated kinase (a common neurotrophic signaling event). |
2008-12-12 |
2023-08-12 |
human |
| Lars M Ittner, Thomas Fath, Yazi D Ke, Mian Bi, Janet van Eersel, Kong M Li, Peter Gunning, Jürgen Göt. Parkinsonism and impaired axonal transport in a mouse model of frontotemporal dementia. Proceedings of the National Academy of Sciences of the United States of America. vol 105. issue 41. 2008-11-24. PMID:18832465. |
different from our previously generated tau transgenic strains, the k3 mice express the transgene in the substantia nigra (sn) and show an early-onset motor phenotype that reproduces parkinsonism with tremor, bradykinesia, abnormal gait, and postural instability. |
2008-11-24 |
2023-08-12 |
mouse |
| Takashi Matsuwaki, Keitaro Yamanouchi, Masugi Nishihar. The effect of glucocorticoids on bradykinesia induced by immobilization stress. Hormones and behavior. vol 54. issue 1. 2008-11-18. PMID:18342862. |
it was also recently reported that imo damages dopaminergic (da) neurons in the substantia nigra (sn), which is known to cause symptoms similar to parkinson's disease (pd). |
2008-11-18 |
2023-08-12 |
mouse |
| Tianhong Pan, Wen Zhu, Hongru Zhao, Hao Deng, Wenjie Xie, Joseph Jankovic, Weidong L. Nurr1 deficiency predisposes to lactacystin-induced dopaminergic neuron injury in vitro and in vivo. Brain research. vol 1222. 2008-11-12. PMID:18579122. |
at same time, we found that there was a severer loss of tyrosine hydroxylase (th)-positive neurons in substantia nigra (sn) and greater reduction of striatal dopamine (da) levels in nurr1 +/- mice as compared with that in nurr1 +/+ mice. |
2008-11-12 |
2023-08-12 |
mouse |
| Amjad Abuirmeileh, Alexander Harkavyi, Ann Kingsbury, Rebecca Lever, Peter S Whitto. The CRF-like peptide urocortin produces a long-lasting recovery in rats made hemiparkinsonian by 6-hydroxydopamine or lipopolysaccharide. Journal of the neurological sciences. vol 271. issue 1-2. 2008-11-05. PMID:18508084. |
the following day rats were dialysed to estimate extracellular striatal dopamine (da) and then sacrificed for estimation of striatal tissue da and subsequent immunohistochemistry of th(+) cells in the substantia nigra (sn). |
2008-11-05 |
2023-08-12 |
rat |