| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| J T García Navia, M A Burguillos, A Ramón-Cueto, A Machado, J Cano, J L Vener. Regional-specific regulation of BDNF and trkB correlates with nigral dopaminergic cell sprouting following unilateral nigrostriatal axotomy. Journal of neuroscience research. vol 86. issue 9. 2008-08-20. PMID:18338800. |
tyrosine hydroxylase immunohistochemistry revealed the existence of sprouting mechanisms in the axotomized substantia nigra (sn). |
2008-08-20 |
2023-08-12 |
Not clear |
| Nicholas R Franich, Helen L Fitzsimons, Dahna M Fong, Matthias Klugmann, Matthew J During, Deborah Youn. AAV vector-mediated RNAi of mutant huntingtin expression is neuroprotective in a novel genetic rat model of Huntington's disease. Molecular therapy : the journal of the American Society of Gene Therapy. vol 16. issue 5. 2008-08-19. PMID:18388917. |
moreover, aav vectors exhibited nonuniform transduction patterns in striatal neuronal populations, as well as axonal transport leading to transduction and neuronal cell death in the globus pallidus and substantia nigra (sn). |
2008-08-19 |
2023-08-12 |
mouse |
| Erin R Foster, Kevin J Black, Jo Ann V Antenor-Dorsey, Joel S Perlmutter, Tamara Hershe. Motor asymmetry and substantia nigra volume are related to spatial delayed response performance in Parkinson disease. Brain and cognition. vol 67. issue 1. 2008-08-13. PMID:18022303. |
some participants also had magnetic resonance imaging for measurement of their substantia nigra (sn) volumes. |
2008-08-13 |
2023-08-12 |
human |
| Kristi L Haik, Deborah A Shear, Chad Hargrove, Jared Patton, Michelle Mazei-Robison, Michael I Sandstrom, Gary L Dunba. 7-nitroindazole attenuates 6-hydroxydopamine-induced spatial learning deficits and dopamine neuron loss in a presymptomatic animal model of Parkinson's disease. Experimental and clinical psychopharmacology. vol 16. issue 2. 2008-08-13. PMID:18489022. |
parkinson's disease (pd) is a neurodegenerative disorder in which loss of dopaminergic (da) neurons (>50%) in the substantia nigra (sn) precedes most of the overt motor symptoms, making early diagnosis and treatment interventions difficult. |
2008-08-13 |
2023-08-12 |
rat |
| Tapan K Mondal, Sam K Saha, Veronica M Miller, Richard F Seegal, David A Lawrenc. Autoantibody-mediated neuroinflammation: pathogenesis of neuropsychiatric systemic lupus erythematosus in the NZM88 murine model. Brain, behavior, and immunity. vol 22. issue 6. 2008-08-12. PMID:18411022. |
there was a substantial increase of igg in the substantia nigra (sn) and hypothalamus (ht) of brains from nzm88 mice compared to control nzw and balb/c mice, whereas nzm2758 mice had more igg in the cortex. |
2008-08-12 |
2023-08-12 |
mouse |
| Cheng-Fang Huang, Gang Li, Rong Ma, Sheng-Gang Sun, Jian-Guo Che. Thrombin-induced microglial activation contributes to the degeneration of nigral dopaminergic neurons in vivo. Neuroscience bulletin. vol 24. issue 2. 2008-08-11. PMID:18369384. |
to evaluate the role of thrombin-activated microglia in the neurodegeneration of nigral dopaminergic neurons in the rat substantia nigra (sn) in vivo. |
2008-08-11 |
2023-08-12 |
rat |
| Gay Rudow, Richard O'Brien, Alena V Savonenko, Susan M Resnick, Alan B Zonderman, Olga Pletnikova, Laura Marsh, Ted M Dawson, Barbara J Crain, Mark J West, Juan C Troncos. Morphometry of the human substantia nigra in ageing and Parkinson's disease. Acta neuropathologica. vol 115. issue 4. 2008-08-01. PMID:18297291. |
to investigate the relation between the loss of substantia nigra (sn) neurons in normal ageing and parkinson's disease (pd), we measured the total number and the cell body volume of pigmented (neuromelanin) neurons in the sn. |
2008-08-01 |
2023-08-12 |
human |
| Alexandra Gaenslen, Barbara Unmuth, Jana Godau, Inga Liepelt, Adriana Di Santo, Katherine Johanna Schweitzer, Thomas Gasser, Hans-Jürgen Machulla, Matthias Reimold, Kenneth Marek, Daniela Ber. The specificity and sensitivity of transcranial ultrasound in the differential diagnosis of Parkinson's disease: a prospective blinded study. The Lancet. Neurology. vol 7. issue 5. 2008-08-01. PMID:18394965. |
increased echogenicity of the substantia nigra (sn), as determined by transcranial sonography (tcs), is characteristic of idiopathic parkinson's disease (ipd). |
2008-08-01 |
2023-08-12 |
Not clear |
| J R Sladek, K B Bjugstad, T J Collier, E A Bundock, B C Blanchard, J D Elsworth, R H Roth, D E Redmon. Embryonic substantia nigra grafts show directional outgrowth to cografted striatal grafts and potential for pathway reconstruction in nonhuman primate. Cell transplantation. vol 17. issue 4. 2008-07-29. PMID:18522245. |
most studies placed da neurons into the striatum instead of the substantia nigra (sn). |
2008-07-29 |
2023-08-12 |
monkey |
| Muralikrishnan Dhanasekaran, Christian B Albano, Lori Pellet, Senthilkumar S Karuppagounder, Subramaniam Uthayathas, Vishnu Suppiramaniam, Holly Brown-Borg, Manuchair Ebad. Role of lipoamide dehydrogenase and metallothionein on 1-methyl-4-phenyl-1,2,3,6- tetrahydropyridine-induced neurotoxicity. Neurochemical research. vol 33. issue 6. 2008-07-24. PMID:17768676. |
metallothionein content was significantly reduced in the substantia nigra (sn), and not in the nucleus caudatus putamen (ncp) following a single administration of mptp (30 mg/kg, i.p.). |
2008-07-24 |
2023-08-12 |
mouse |
| Patrick L McGeer, Edith G McGee. Glial reactions in Parkinson's disease. Movement disorders : official journal of the Movement Disorder Society. vol 23. issue 4. 2008-07-22. PMID:18044695. |
reactive astrocytes and reactive microglia are abundant in the substantia nigra (sn) of pd cases indicating a robust inflammatory state. |
2008-07-22 |
2023-08-12 |
Not clear |
| Shtarkshall Revital, Bergman Hagai, Goelman Gad. Evidence for the coexistence of segregated and integrated functional connections from the striatum to the substantia nigra in rats. NeuroImage. vol 40. issue 2. 2008-07-15. PMID:18221893. |
using manganese enhanced mri together with a unique principal component analysis method, we present evidence that connectivity from the striatum (the caudomedial part of the caudate putemen (cpu) in rats) to the substantia nigra (sn) is composed of both segregated and integrated projections. |
2008-07-15 |
2023-08-12 |
human |
| Jyothi K Mallajosyula, Deepinder Kaur, Shankar J Chinta, Subramanian Rajagopalan, Anand Rane, David G Nicholls, Donato A Di Monte, Heather Macarthur, Julie K Anderse. MAO-B elevation in mouse brain astrocytes results in Parkinson's pathology. PloS one. vol 3. issue 2. 2008-07-15. PMID:18286173. |
elevated astrocytic mao-b mimicking age related increase resulted in specific, selective and progressive loss of dopaminergic neurons in the substantia nigra (sn), the same subset of neurons primarily impacted in the human condition. |
2008-07-15 |
2023-08-12 |
mouse |
| Jun He, Fulton T Crew. Increased MCP-1 and microglia in various regions of the human alcoholic brain. Experimental neurology. vol 210. issue 2. 2008-06-20. PMID:18190912. |
since mcp-1 is a key proinflammatory cytokine induced by chronic alcohol treatment of mice, and known to regulate drinking behavior in mice, mcp-1 protein levels from human brain homogenate were measured using elisa, and indicated increased mcp-1 concentration in ventral tegmental area (vta), substantia nigra (sn), hippocampus and amygdala of alcoholic brains as compared with controls. |
2008-06-20 |
2023-08-12 |
mouse |
| Sara Batelli, Diego Albani, Raffaela Rametta, Letizia Polito, Francesca Prato, Marzia Pesaresi, Alessandro Negro, Gianluigi Forlon. DJ-1 modulates alpha-synuclein aggregation state in a cellular model of oxidative stress: relevance for Parkinson's disease and involvement of HSP70. PloS one. vol 3. issue 4. 2008-06-10. PMID:18382667. |
the gene coding for alpha-synuclein (alpha-syn) (park1) has been investigated as alpha-syn is located in lewy bodies (lb), intraneuronal inclusions in the substantia nigra (sn) of pd patients. |
2008-06-10 |
2023-08-12 |
Not clear |
| H Niazi Shahabi, D R Andersson, H Nissbrand. Cytochrome P450 2E1 in the substantia nigra: relevance for dopaminergic neurotransmission and free radical production. Synapse (New York, N.Y.). vol 62. issue 5. 2008-06-03. PMID:18288650. |
cytochrome p450 2e1 (cyp2e1) has been detected in brain regions which are of relevance for the pathophysiology of parkinson's disease, such as the substantia nigra (sn). |
2008-06-03 |
2023-08-12 |
rat |
| R A Armstrong, P L Lantos, N J Cairn. Progressive supranuclear palsy (PSP): a quantitative study of the pathological changes in cortical and subcortical regions of eight cases. Journal of neural transmission (Vienna, Austria : 1996). vol 114. issue 12. 2008-05-28. PMID:17680229. |
in eight cases of progressive supranuclear palsy (psp), neurofibrillary tangles (nft) were numerous in the substantia nigra (sn), red nucleus (rn), locus caeruleus (lc), pontine nuclei (pn), and inferior olivary nucleus (ion) and abnormally enlarged neurons (en) in the ion, lc and pn. |
2008-05-28 |
2023-08-12 |
Not clear |
| William J Burke, Vijaya B Kumar, Neeraj Pandey, W Michael Panneton, Qi Gan, Mark W Franko, Mark O'Dell, Shu Wen Li, Yi Pan, Hyung D Chung, James E Galvi. Aggregation of alpha-synuclein by DOPAL, the monoamine oxidase metabolite of dopamine. Acta neuropathologica. vol 115. issue 2. 2008-05-21. PMID:17965867. |
parkinson's disease (pd) is a neurodegenerative disease characterized by the selective loss of dopamine (da) neurons and the presence of alpha-synuclein (as) aggregates as lewy bodies (lbs) in the remaining substantia nigra (sn) neurons. |
2008-05-21 |
2023-08-12 |
rat |
| Sergio E Meza-Toledo, Norman G Bower. Reversal of GABA-mediated inhibition of the electrically and potassium chloride evoked [3H]-GABA release from rat substantia nigra slices by DL-3-hydroxy-3-phenyl pentanamide. Arzneimittel-Forschung. vol 58. issue 2. 2008-05-14. PMID:18412018. |
the electrically and potassium chloride (15 mmol/l) evoked [3h]-gaba release in the presence of dl-hepp, gaba and gabab receptor ligands from rat brain substantia nigra (sn) slices was studied. |
2008-05-14 |
2023-08-12 |
rat |
| Florian Doepp, Michail Plotkin, Lara Siegel, Anatol Kivi, Doreen Gruber, Elmar Lobsien, Andreas Kupsch, Stephan J Schreibe. Brain parenchyma sonography and 123I-FP-CIT SPECT in Parkinson's disease and essential tremor. Movement disorders : official journal of the Movement Disorder Society. vol 23. issue 3. 2008-05-08. PMID:18067184. |
the echogenicity of the substantia nigra (sn) and the striatal binding of dopamine transporters (dat) were evaluated by tcs and fp-cit spect, respectively. |
2008-05-08 |
2023-08-12 |
Not clear |