| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Emilce Carrasco, Peter Werner, Diana Caspe. Prostaglandin receptor EP2 protects dopaminergic neurons against 6-OHDA-mediated low oxidative stress. Neuroscience letters. vol 441. issue 1. 2008-11-05. PMID:18597941. |
dopaminergic neurons in the substantia nigra (sn) selectively die in parkinson's disease (pd), but it is unclear how and why this occurs. |
2008-11-05 |
2023-08-12 |
human |
| Supriti Samantaray, Swapan K Ray, Naren L Bani. Calpain as a potential therapeutic target in Parkinson's disease. CNS & neurological disorders drug targets. vol 7. issue 3. 2008-11-05. PMID:18673214. |
pathophysiology of idiopathic parkinson's disease (pd) is associated with degeneration of dopaminergic neurons and inflammatory responses in the mid-brain substantia nigra (sn). |
2008-11-05 |
2023-08-12 |
Not clear |
| Jun Mo Kang, Jae-Chul Jung, Heejeong Kim, Heena Lim, Soyong Jang, Seikwan O. Neuroprotective effect of benzylideneacetophenone derivative on the MPTP model of neurodegeneration in mice. Archives of pharmacal research. vol 31. issue 9. 2008-10-28. PMID:18806951. |
immunohistochemistry and western blot were used to determine the expression levels of tyrosine hydroxylase (th), dopamine transporter (dat), ox-42 (a marker of microglial activation), and glial fibrillary acid protein (gfap, a marker of astrocyte activation) in the substantia nigra (sn) and striatum (st). |
2008-10-28 |
2023-08-12 |
mouse |
| María Clara Pott Godoy, Rodolfo Tarelli, Carina Cintia Ferrari, Maria Inés Sarchi, Fernando Juan Pitoss. Central and systemic IL-1 exacerbates neurodegeneration and motor symptoms in a model of Parkinson's disease. Brain : a journal of neurology. vol 131. issue Pt 7. 2008-10-22. PMID:18504291. |
activated microglial cells in the substantia nigra (sn) are found in all animal models of parkinson's disease and patients with the illness. |
2008-10-22 |
2023-08-12 |
Not clear |
| Jana Godau, Uwe Klose, Adriana Di Santo, Katherine Schweitzer, Daniela Ber. Multiregional brain iron deficiency in restless legs syndrome. Movement disorders : official journal of the Movement Disorder Society. vol 23. issue 8. 2008-10-20. PMID:18442125. |
evidence for tissue iron deficiency in restless legs syndrome (rls) is limited to the substantia nigra (sn). |
2008-10-20 |
2023-08-12 |
Not clear |
| Luigi Zecca, Henrik Wilms, Sebastian Geick, Jan-Hendrik Claasen, Lars-Ove Brandenburg, Christian Holzknecht, Michele L Panizza, Fabio A Zucca, Günther Deuschl, Jobst Sievers, Ralph Luciu. Human neuromelanin induces neuroinflammation and neurodegeneration in the rat substantia nigra: implications for Parkinson's disease. Acta neuropathologica. vol 116. issue 1. 2008-10-14. PMID:18343932. |
parkinson's disease (pd) is a common neurodegenerative disorder characterized by a selective loss of dopaminergic neurons in the substantia nigra (sn). |
2008-10-14 |
2023-08-12 |
human |
| Luigi Zecca, Henrik Wilms, Sebastian Geick, Jan-Hendrik Claasen, Lars-Ove Brandenburg, Christian Holzknecht, Michele L Panizza, Fabio A Zucca, Günther Deuschl, Jobst Sievers, Ralph Luciu. Human neuromelanin induces neuroinflammation and neurodegeneration in the rat substantia nigra: implications for Parkinson's disease. Acta neuropathologica. vol 116. issue 1. 2008-10-14. PMID:18343932. |
after different survival times (1, 8 or 12 weeks), brain slices from the cerebral cortex or substantia nigra (sn, 1 week) were stained with iba-1 and/or gfap antibody to monitor microglial and astrocytic reaction, and with tyrosine hydroxylase (th) to monitor dopaminergic cell survival (sn group only). |
2008-10-14 |
2023-08-12 |
human |
| Shankar J Chinta, Julie K Anderse. Redox imbalance in Parkinson's disease. Biochimica et biophysica acta. vol 1780. issue 11. 2008-10-08. PMID:18358848. |
parkinson's disease (pd) is an adult-onset neurodegenerative disorder characterized by preferential loss of dopaminergic neurons in an area of the midbrain called the substantia nigra (sn) along with occurrence of intraneuronal inclusions called lewy bodies. |
2008-10-08 |
2023-08-12 |
Not clear |
| b' Milija Mijajlovi\\xc4\\x87, Igor Petrovi\\xc4\\x87, Tanja Stojkovi\\xc4\\x87, Marina Svetel, Elka Stefanova, Vladimir S Kosti\\xc4\\x8. [Transcranial parenchymal sonography in the diagnosis of Parkinson\'s disease]. Vojnosanitetski pregled. vol 65. issue 8. 2008-09-25. PMID:18751340.' |
enlargement of the echogenic signal (hyperechogenicity) of the substantia nigra (sn) has been reported as a highly characteristic finding in idiopathic parkinson's disease (pd) and is thought to reflect increased amounts of iron, bound to proteins other than ferritin, in the sn in the course of neurodegeneration. |
2008-09-25 |
2023-08-12 |
Not clear |
| Steven R Danielson, Julie K Anderse. Oxidative and nitrative protein modifications in Parkinson's disease. Free radical biology & medicine. vol 44. issue 10. 2008-09-22. PMID:18395015. |
increased oxidative stress appears to be a common causative aspect involved in the preferential loss of dopaminergic neurons in a region of the brain prominently affected by the disorder, the substantia nigra (sn). |
2008-09-22 |
2023-08-12 |
Not clear |
| K Mukhida, M Hong, G B Miles, T Phillips, B A Baghbaderani, M McLeod, N Kobayashi, A Sen, L A Behie, R M Brownstone, I Mende. A multitarget basal ganglia dopaminergic and GABAergic transplantation strategy enhances behavioural recovery in parkinsonian rats. Brain : a journal of neurology. vol 131. issue Pt 8. 2008-09-15. PMID:18669492. |
the current transplantation paradigm for parkinson's disease that places foetal dopaminergic cells in the striatum neither normalizes neuronal activity in basal ganglia structures such as the substantia nigra (sn) and subthalamic nucleus (stn) nor leads to complete functional recovery. |
2008-09-15 |
2023-08-12 |
human |
| Jun-Ping Cao, Jing-Kao Yu, Chong Li, Yu Sun, Hong-Hua Yuan, Hong-Jun Wang, Dian-Shuai Ga. Integrin beta1 is involved in the signaling of glial cell line-derived neurotrophic factor. The Journal of comparative neurology. vol 509. issue 2. 2008-09-10. PMID:18465789. |
glial cell line-derived neurotrophic factor (gdnf) is a potent neurotrophic factor for the substantia nigra (sn) dopamine (da) neurons. |
2008-09-10 |
2023-08-12 |
Not clear |
| J M Hagenah, B Becker, N Brüggemann, A Djarmati, K Lohmann, A Sprenger, C Klein, G Seide. Transcranial sonography findings in a large family with homozygous and heterozygous PINK1 mutations. Journal of neurology, neurosurgery, and psychiatry. vol 79. issue 9. 2008-09-03. PMID:18469032. |
to investigate substantia nigra (sn) echogenicity in members of a family with homozygous and heterozygous pten induced kinase (pink1) mutations with or without signs of parkinson's disease (pd). |
2008-09-03 |
2023-08-12 |
Not clear |
| Xi Jun He, Hirofumi Yamauchi, Koji Uetsuka, Hiroyuki Nakayam. Neurotoxicity of MPTP to migrating neuroblasts: studies in acute and subacute mouse models of Parkinson's disease. Neurotoxicology. vol 29. issue 3. 2008-08-25. PMID:18387672. |
in recent years, the notion that the neurotoxicity of mptp is restricted to dopaminergic neurons in the substantia nigra (sn) has been challenged. |
2008-08-25 |
2023-08-12 |
mouse |
| J T García Navia, M A Burguillos, A Ramón-Cueto, A Machado, J Cano, J L Vener. Regional-specific regulation of BDNF and trkB correlates with nigral dopaminergic cell sprouting following unilateral nigrostriatal axotomy. Journal of neuroscience research. vol 86. issue 9. 2008-08-20. PMID:18338800. |
tyrosine hydroxylase immunohistochemistry revealed the existence of sprouting mechanisms in the axotomized substantia nigra (sn). |
2008-08-20 |
2023-08-12 |
Not clear |
| Nicholas R Franich, Helen L Fitzsimons, Dahna M Fong, Matthias Klugmann, Matthew J During, Deborah Youn. AAV vector-mediated RNAi of mutant huntingtin expression is neuroprotective in a novel genetic rat model of Huntington's disease. Molecular therapy : the journal of the American Society of Gene Therapy. vol 16. issue 5. 2008-08-19. PMID:18388917. |
moreover, aav vectors exhibited nonuniform transduction patterns in striatal neuronal populations, as well as axonal transport leading to transduction and neuronal cell death in the globus pallidus and substantia nigra (sn). |
2008-08-19 |
2023-08-12 |
mouse |
| Erin R Foster, Kevin J Black, Jo Ann V Antenor-Dorsey, Joel S Perlmutter, Tamara Hershe. Motor asymmetry and substantia nigra volume are related to spatial delayed response performance in Parkinson disease. Brain and cognition. vol 67. issue 1. 2008-08-13. PMID:18022303. |
some participants also had magnetic resonance imaging for measurement of their substantia nigra (sn) volumes. |
2008-08-13 |
2023-08-12 |
human |
| Kristi L Haik, Deborah A Shear, Chad Hargrove, Jared Patton, Michelle Mazei-Robison, Michael I Sandstrom, Gary L Dunba. 7-nitroindazole attenuates 6-hydroxydopamine-induced spatial learning deficits and dopamine neuron loss in a presymptomatic animal model of Parkinson's disease. Experimental and clinical psychopharmacology. vol 16. issue 2. 2008-08-13. PMID:18489022. |
parkinson's disease (pd) is a neurodegenerative disorder in which loss of dopaminergic (da) neurons (>50%) in the substantia nigra (sn) precedes most of the overt motor symptoms, making early diagnosis and treatment interventions difficult. |
2008-08-13 |
2023-08-12 |
rat |
| Tapan K Mondal, Sam K Saha, Veronica M Miller, Richard F Seegal, David A Lawrenc. Autoantibody-mediated neuroinflammation: pathogenesis of neuropsychiatric systemic lupus erythematosus in the NZM88 murine model. Brain, behavior, and immunity. vol 22. issue 6. 2008-08-12. PMID:18411022. |
there was a substantial increase of igg in the substantia nigra (sn) and hypothalamus (ht) of brains from nzm88 mice compared to control nzw and balb/c mice, whereas nzm2758 mice had more igg in the cortex. |
2008-08-12 |
2023-08-12 |
mouse |
| Cheng-Fang Huang, Gang Li, Rong Ma, Sheng-Gang Sun, Jian-Guo Che. Thrombin-induced microglial activation contributes to the degeneration of nigral dopaminergic neurons in vivo. Neuroscience bulletin. vol 24. issue 2. 2008-08-11. PMID:18369384. |
to evaluate the role of thrombin-activated microglia in the neurodegeneration of nigral dopaminergic neurons in the rat substantia nigra (sn) in vivo. |
2008-08-11 |
2023-08-12 |
rat |