| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| F Tribl, T Arzberger, P Riederer, M Gerlac. Tyrosinase is not detected in human catecholaminergic neurons by immunohistochemistry and Western blot analysis. Journal of neural transmission. Supplementum. issue 72. 2007-12-10. PMID:17982878. |
catecholaminergic neurons of the primate substantia nigra (sn) pars compacta (snc) and the locus coeruleus contain neuromelanin (nm) granules as characteristic structures underlying the pigmentation of these brain areas. |
2007-12-10 |
2023-08-12 |
mouse |
| Petra Ruprecht-Dörfler, Patricia Klotz, Georg Becker, Daniela Ber. Substantia nigra hyperechogenicity correlates with subtle motor dysfunction in tap dancers. Parkinsonism & related disorders. vol 13. issue 6. 2007-12-06. PMID:17055330. |
hyperechogenicity of the substantia nigra (sn) detected by transcranial sonography is a typical finding in more than 90% of patients with parkinson's disease (pd) but may also be visible in about 9% of healthy adults. |
2007-12-06 |
2023-08-12 |
Not clear |
| Anya M Y Lin, P L Chao, S F Fang, C W Chi, C H Yan. Endoplasmic reticulum stress is involved in arsenite-induced oxidative injury in rat brain. Toxicology and applied pharmacology. vol 224. issue 2. 2007-11-28. PMID:17681577. |
arsenite was locally infused in the substantia nigra (sn) of anesthetized rat. |
2007-11-28 |
2023-08-12 |
rat |
| Jahn N O'Neil, Peter R Mouton, Yousef Tizabi, Mary Ann Ottinger, De-Liang Lei, Donald K Ingram, Kebreten F Manay. Catecholaminergic neuronal loss in locus coeruleus of aged female dtg APP/PS1 mice. Journal of chemical neuroanatomy. vol 34. issue 3-4. 2007-11-21. PMID:17658239. |
in addition to the presence of cortical senile plaques and neurofibrillary tangles, ad is characterized at autopsy by extensive degeneration of brainstem locus coeruleus (lc) neurons that provide noradrenergic innervation to cortical neuropil, together with relative stability of dopaminergic neuron number in substantia nigra (sn) and ventral tegmental area (vta). |
2007-11-21 |
2023-08-12 |
mouse |
| b' David Skoloud\\xc3\\xadk, T\\xc3\\xa1na Fadrn\\xc3\\xa1, Petra B\\xc3\\xa1rtov\\xc3\\xa1, Katerina Langov\\xc3\\xa1, Pavel Ressner, Olga Zapletalov\\xc3\\xa1, Petr Hlust\\xc3\\xadk, Roman Herzig, Petr Kannovsk\\xc3\\xb. Reproducibility of sonographic measurement of the substantia nigra. Ultrasound in medicine & biology. vol 33. issue 9. 2007-11-20. PMID:17544567.' |
the aim of this study was to evaluate inter-reader, intra-investigator and inter-investigator reproducibility and correlations in the assessment of substantia nigra (sn) echogenicity and area measurement by a physician-sonographer (ps), a sonographic laboratory assistant (sla) and a physician without sonographic experience (pn). |
2007-11-20 |
2023-08-12 |
Not clear |
| Grzegorz A Czapski, Magdalena Cakala, Malgorzata Chalimoniuk, Barbara Gajkowska, Joanna B Strosznajde. Role of nitric oxide in the brain during lipopolysaccharide-evoked systemic inflammation. Journal of neuroscience research. vol 85. issue 8. 2007-11-05. PMID:17465018. |
apoptotic/autophagic processes occurred in many neurons of the substantia nigra (sn), which coincided with exclusive enhancement of inos expression and activity in this brain region. |
2007-11-05 |
2023-08-12 |
mouse |
| Hirohide Sawada, Ryohei Hishida, Yoko Hirata, Kenji Ono, Hiromi Suzuki, Shin-ichi Muramatsu, Imaharu Nakano, Toshiharu Nagatsu, Makoto Sawad. Activated microglia affect the nigro-striatal dopamine neurons differently in neonatal and aged mice treated with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. Journal of neuroscience research. vol 85. issue 8. 2007-11-05. PMID:17469135. |
by mptp administration to neonatal mice, the number of dopamine neurons in the substantia nigra (sn) was decreased significantly, whereas that in the mice treated with lps and mptp was recovered to normal, along with significant microglial activation. |
2007-11-05 |
2023-08-12 |
mouse |
| Masae Okawa, Hideto Miwa, Yoshinori Kajimoto, Kiwa Hama, Shuhei Morita, Ichiro Nakanishi, Tomoyoshi Kond. Transcranial sonography of the substantia nigra in Japanese patients with Parkinson's disease or atypical parkinsonism: clinical potential and limitations. Internal medicine (Tokyo, Japan). vol 46. issue 18. 2007-10-30. PMID:17878638. |
there is growing interest in the use of transcranial sonography (tcs) of the substantia nigra (sn) in patients with parkinson's disease (pd), as it has been reported that sn hyperechogenicity may be present in about 90% of pd patients. |
2007-10-30 |
2023-08-12 |
Not clear |
| Risa Sakai, Yoshifumi Irie, Takeshi Murata, Atsushi Ishige, Naoko Anjiki, Kenji Watanab. Toki-to protects dopaminergic neurons in the substantia nigra from neurotoxicity of MPTP in mice. Phytotherapy research : PTR. vol 21. issue 9. 2007-10-29. PMID:17486689. |
parkinson's disease (pd) is a neurodegenerative disease of the brain characterized by the progressive loss of dopaminergic neurons in the substantia nigra (sn). |
2007-10-29 |
2023-08-12 |
mouse |
| Johannes Attems, Magdalena Quass, Kurt A Jellinge. Tau and alpha-synuclein brainstem pathology in Alzheimer disease: relation with extrapyramidal signs. Acta neuropathologica. vol 113. issue 1. 2007-10-26. PMID:17031655. |
neuropathological examination included standardized classification of ad according to current criteria, and semiquantitative assessment of neuronal loss in substantia nigra (sn), locus coeruleus (lc), and of tau and as lesions in brainstem, and, in addition, of cerebrovascular lesions. |
2007-10-26 |
2023-08-12 |
human |
| Joanna Iczkiewicz, Sarah Rose, Peter Jenne. Osteopontin expression in activated glial cells following mechanical- or toxin-induced nigral dopaminergic cell loss. Experimental neurology. vol 207. issue 1. 2007-10-24. PMID:17643430. |
opn is present in the rat substantia nigra (sn) and both protein and mrna levels are up-regulated following a pro-inflammatory insult produced by lipopolysaccharide. |
2007-10-24 |
2023-08-12 |
rat |
| L B Moran, E Croisier, D C Duke, M E Kalaitzakis, F Roncaroli, M Deprez, D T Dexter, R K B Pearce, M B Graebe. Analysis of alpha-synuclein, dopamine and parkin pathways in neuropathologically confirmed parkinsonian nigra. Acta neuropathologica. vol 113. issue 3. 2007-10-19. PMID:17203291. |
by means of an in silico approach using a database of eukaryotic molecular interactions and a whole genome transcriptome dataset validated by qrt-pcr and histological methods, we found parkin and functionally associated genes to be up-regulated in the lateral substantia nigra (sn). |
2007-10-19 |
2023-08-12 |
Not clear |
| Hong Jiang, Ning Song, Jun Wang, Li-Ying Ren, Jun-Xia Xi. Peripheral iron dextran induced degeneration of dopaminergic neurons in rat substantia nigra. Neurochemistry international. vol 51. issue 1. 2007-10-17. PMID:17490790. |
to demonstrate the relationship between peripheral iron overload and dopaminergic neuron loss in rat substantia nigra (sn), in the present study we used fast cyclic voltammetry, tyrosine hydroxylase (th) immunohistochemistry, perls' iron staining, and high performance liquid chromatography-electrochemical detection to study the degeneration of dopaminergic neurons and increased iron content in the sn of iron dextran overloaded animals. |
2007-10-17 |
2023-08-12 |
rat |
| A K Wright, G W Arbuthnot. The influence of the subthalamic nucleus upon the damage to the dopamine system following lesions of globus pallidus in rats. The European journal of neuroscience. vol 26. issue 3. 2007-10-17. PMID:17634067. |
an ibotenic acid injection into the gp in rats removes the cells of the gp and, over the following 6 weeks, a progressive loss of dopamine cells (counted stereologically in sections stained for tyrosine hydroxylase) develops in substantia nigra (sn). |
2007-10-17 |
2023-08-12 |
rat |
| Katherine J Schweitzer, Theresa Brüssel, Petra Leitner, Rejko Krüger, Peter Bauer, Dirk Woitalla, Jürgen Tomiuk, Thomas Gasser, Daniela Ber. Transcranial ultrasound in different monogenetic subtypes of Parkinson's disease. Journal of neurology. vol 254. issue 5. 2007-10-12. PMID:17415511. |
hyperechogenicity of the substantia nigra (sn) has been found to be a typical sign in idiopathic parkinson's disease (pd), prevalent in more than 90% of affected individuals. |
2007-10-12 |
2023-08-12 |
Not clear |
| Hitoshi Kit. Globus pallidus external segment. Progress in brain research. vol 160. 2007-09-28. PMID:17499111. |
the gp(e) receives major inputs from two major basal ganglia input nuclei, the str and the subthalamic nucleus (stn), and sends its output to many basal ganglia nuclei including the stn, the str, the internal pallidal segment (gp(i)), and the substantia nigra (sn). |
2007-09-28 |
2023-08-12 |
Not clear |
| Leann P Quinn, Marion J Perren, Kim T Brackenborough, Peter L Woodhams, Martin Vidgeon-Hart, Helen Chapman, Menelas N Pangalos, Neil Upton, David J Virle. A beam-walking apparatus to assess behavioural impairments in MPTP-treated mice: pharmacological validation with R-(-)-deprenyl. Journal of neuroscience methods. vol 164. issue 1. 2007-09-27. PMID:17498809. |
in addition, mptp-treated mice were detected to have a marked depletion in striatal dopamine levels and a concomitant reduction in substantia nigra (sn) tyrosine hydroxylase (th) immunoreactivity, at 7 days post-mptp administration, indicative of dopaminergic neuronal loss. |
2007-09-27 |
2023-08-12 |
mouse |
| Chung-Fen Tsai, Ruey-Meei Wu, Yu-Weng Huang, Li-Ling Chen, Ping-Keung Yip, Jiann-Shing Jen. Transcranial color-coded sonography helps differentiation between idiopathic Parkinson's disease and vascular parkinsonism. Journal of neurology. vol 254. issue 4. 2007-09-26. PMID:17401518. |
recently, transcranial color-coded sonography (tccs) has been found to have a diagnostic value in patients with idiopathic parkinson's disease (ipd), which displays increased hyperechogenicity at the substantia nigra (sn). |
2007-09-26 |
2023-08-12 |
Not clear |
| Stamatios N Sotiropoulos, Peter N Steinmet. Assessing the direct effects of deep brain stimulation using embedded axon models. Journal of neural engineering. vol 4. issue 2. 2007-09-25. PMID:17409485. |
the model included the subthalamic nucleus (stn), substantia nigra (sn), zona incerta (zi), fields of forel h2 (ff), internal capsule (ic) and medtronic 3387/3389 electrode. |
2007-09-25 |
2023-08-12 |
Not clear |
| Toru Yasuda, Momo Fukuda-Tani, Tomoko Nihira, Keiichiro Wada, Nobutaka Hattori, Yoshikuni Mizuno, Hideki Mochizuk. Correlation between levels of pigment epithelium-derived factor and vascular endothelial growth factor in the striatum of patients with Parkinson's disease. Experimental neurology. vol 206. issue 2. 2007-09-21. PMID:17604022. |
here we investigated the level of pedf protein in the striatum and immunoreactivity for pedf in the substantia nigra (sn) of patients with pd to assess its role in the pathophysiology of pd. |
2007-09-21 |
2023-08-12 |
mouse |