| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| David Sulzer, Yvonne Schmit. Parkinson's disease: return of an old prime suspect. Neuron. vol 55. issue 1. 2007-09-12. PMID:17610813. |
pacemaking activity in adult substantia nigra (sn) dopamine neurons relies on l-type ca2+ channels, but a surprising study in nature by chan et al. |
2007-09-12 |
2023-08-12 |
Not clear |
| Anya M Y Lin, S F Fang, P L Chao, C H Yan. Melatonin attenuates arsenite-induced apoptosis in rat brain: involvement of mitochondrial and endoplasmic reticulum pathways and aggregation of alpha-synuclein. Journal of pineal research. vol 43. issue 2. 2007-09-07. PMID:17645694. |
local infusion of arsenite elevated lipid peroxidation and depleted glutathione content in the infused substantia nigra (sn), as well as reduced striatal dopamine content. |
2007-09-07 |
2023-08-12 |
rat |
| D Eugene Redmond, Kimberly B Bjugstad, Yang D Teng, Vaclav Ourednik, Jitka Ourednik, Dustin R Wakeman, Xuejun H Parsons, Rodolfo Gonzalez, Barbara C Blanchard, Seung U Kim, Zezong Gu, Stuart A Lipton, Eleni A Markakis, Robert H Roth, John D Elsworth, John R Sladek, Richard L Sidman, Evan Y Snyde. Behavioral improvement in a primate Parkinson's model is associated with multiple homeostatic effects of human neural stem cells. Proceedings of the National Academy of Sciences of the United States of America. vol 104. issue 29. 2007-08-30. PMID:17586681. |
stem cells have been widely assumed to be capable of replacing lost or damaged cells in a number of diseases, including parkinson's disease (pd), in which neurons of the substantia nigra (sn) die and fail to provide the neurotransmitter, dopamine (da), to the striatum. |
2007-08-30 |
2023-08-12 |
human |
| Chee Yeun Chung, James B Koprich, Shogo Endo, Ole Isacso. An endogenous serine/threonine protein phosphatase inhibitor, G-substrate, reduces vulnerability in models of Parkinson's disease. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 27. issue 31. 2007-08-28. PMID:17670978. |
in parkinson's disease, dopaminergic (da) neurons in the substantia nigra (sn) (a9) are particularly vulnerable, whereas adjacent da neurons within the ventral tegmental area (a10) are essentially spared. |
2007-08-28 |
2023-08-12 |
human |
| Michael D Boska, Khader M Hasan, Danette Kibuule, Rebecca Banerjee, Erin McIntyre, Jay A Nelson, Theresa Hahn, Howard E Gendelman, R Lee Mosle. Quantitative diffusion tensor imaging detects dopaminergic neuronal degeneration in a murine model of Parkinson's disease. Neurobiology of disease. vol 26. issue 3. 2007-08-24. PMID:17428671. |
we now demonstrate increased average diffusion (p<0.005) and decreased fractional anisotropy (p<0.03) in the substantia nigra (sn) of 5- to 7-day mptp-treated animals when compared to saline controls. |
2007-08-24 |
2023-08-12 |
Not clear |
| Arnulfo Quesada, Horacio E Romeo, Paul Micevyc. Distribution and localization patterns of estrogen receptor-beta and insulin-like growth factor-1 receptors in neurons and glial cells of the female rat substantia nigra: localization of ERbeta and IGF-1R in substantia nigra. The Journal of comparative neurology. vol 503. issue 1. 2007-08-15. PMID:17480015. |
e2 neuroprotective effects in the substantia nigra (sn) da system have been shown to be dependent on igf-1. |
2007-08-15 |
2023-08-12 |
rat |
| Andreas Hald, Johan Van Beek, Julie Lothariu. Inflammation in Parkinson's disease: causative or epiphenomenal? Sub-cellular biochemistry. vol 42. 2007-08-06. PMID:17612055. |
parkinson's disease (pd) is a neurodegenerative disorder characterized by a dramatic loss of dopaminergic neurons in the substantia nigra (sn). |
2007-08-06 |
2023-08-12 |
human |
| A Brent Richards, Tracy A Scheel, Kan Wang, Mark Henkemeyer, Lawrence F Krome. EphB1 null mice exhibit neuronal loss in substantia nigra pars reticulata and spontaneous locomotor hyperactivity. The European journal of neuroscience. vol 25. issue 9. 2007-07-25. PMID:17561836. |
eph receptor tyrosine kinases are potential participants in this process as they regulate development of other cns regions and are expressed in basal ganglia nuclei, such as the substantia nigra (sn) and striatum. |
2007-07-25 |
2023-08-12 |
mouse |
| Jun Wang, Hong Jiang, Jun-Xia Xi. Ferroportin1 and hephaestin are involved in the nigral iron accumulation of 6-OHDA-lesioned rats. The European journal of neuroscience. vol 25. issue 9. 2007-07-25. PMID:17561842. |
elevated iron levels in the substantia nigra (sn) participate in neuronal death in parkinson's disease (pd). |
2007-07-25 |
2023-08-12 |
rat |
| Uwe Walter, Jacqueline Hoeppner, Lara Prudente-Morrissey, Sebastian Horowski, Sabine C Herpertz, Reiner Beneck. Parkinson's disease-like midbrain sonography abnormalities are frequent in depressive disorders. Brain : a journal of neurology. vol 130. issue Pt 7. 2007-07-24. PMID:17329323. |
substantia nigra (sn) hyperechogenicity is a characteristic transcranial sonography (tcs) finding in idiopathic parkinson's disease. |
2007-07-24 |
2023-08-12 |
human |
| Vittorio Calabrese, Cesare Mancuso, Agrippino Ravagna, Marzia Perluigi, Chiara Cini, Carlo De Marco, D Allan Butterfield, Anna Maria Giuffrida Stell. In vivo induction of heat shock proteins in the substantia nigra following L-DOPA administration is associated with increased activity of mitochondrial complex I and nitrosative stress in rats: regulation by glutathione redox state. Journal of neurochemistry. vol 101. issue 3. 2007-07-18. PMID:17241115. |
parkinson's disease (pd) is a neurodegenerative disease characterized by a severe depletion in number of dopaminergic cells of the substantia nigra (sn). |
2007-07-18 |
2023-08-12 |
rat |
| Dariusz Koziorowski, Andrzej Friedman, Paolo Arosio, Paolo Santambrogio, Dorota Dziewulsk. ELISA reveals a difference in the structure of substantia nigra ferritin in Parkinson's disease and incidental Lewy body compared to control. Parkinsonism & related disorders. vol 13. issue 4. 2007-07-18. PMID:17275395. |
we compared with the use of elisa the structure of ferritin (concentrations of h and l ferritins) in substantia nigra (sn) in ten cases of pd, six of incidental lewy body (ilb) cases and 20 controls. |
2007-07-18 |
2023-08-12 |
Not clear |
| Jiro Fukae, Yoshikuni Mizuno, Nobutaka Hattor. Mitochondrial dysfunction in Parkinson's disease. Mitochondrion. vol 7. issue 1-2. 2007-07-11. PMID:17300997. |
the primary cause of pd is still unknown, but oxidative stress and mitochondrial dysfunction have been implicated as important contributors to neuronal death in substantia nigra (sn) of pd. |
2007-07-11 |
2023-08-12 |
human |
| Benjamin Sredni, Revital Geffen-Aricha, Wenzhen Duan, Michael Albeck, Frances Shalit, Harry M Lander, Noa Kinor, Ortal Sagi, Amnon Albeck, Sigal Yosef, Miri Brodsky, Dvora Sredni-Kenigsbuch, Tali Sonino, Dan L Longo, Mark P Mattson, Gal Yadi. Multifunctional tellurium molecule protects and restores dopaminergic neurons in Parkinson's disease models. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 21. issue 8. 2007-07-03. PMID:17314138. |
in parkinson's disease (pd) dopaminergic neurons in the substantia nigra (sn) become dysfunctional and many ultimately die. |
2007-07-03 |
2023-08-12 |
Not clear |
| Y-Q Xue, L-R Zhao, W-P Guo, W-M Dua. Intrastriatal administration of erythropoietin protects dopaminergic neurons and improves neurobehavioral outcome in a rat model of Parkinson's disease. Neuroscience. vol 146. issue 3. 2007-07-03. PMID:17363174. |
the number of tyrosine hydroxylase (th)-immunoreactive (ir) neurons in the ipsilateral substantia nigra (sn) was significantly larger in intrastriatal rhepo-treated rats than that in control rats. |
2007-07-03 |
2023-08-12 |
mouse |
| N A Do Thi, P Saillour, L Ferrero, T Paunio, J Malle. Does neuronal expression of GDNF effectively protect dopaminergic neurons in a rat model of Parkinson's disease? Gene therapy. vol 14. issue 5. 2007-06-29. PMID:17093508. |
we found that (i) the nse promoter can restrict transgene expression in neurons; (ii) ad-nse-gdnf significantly protected dopaminergic (da) neurons in the substantia nigra (sn) but did not reverse the impairments of amphetamine-induced rotational behavior in lesioned rats. |
2007-06-29 |
2023-08-12 |
rat |
| Uwe Walter, Stefanie Behnke, Jens Eyding, Ludwig Niehaus, Thomas Postert, Günter Seidel, Daniela Ber. Transcranial brain parenchyma sonography in movement disorders: state of the art. Ultrasound in medicine & biology. vol 33. issue 1. 2007-06-28. PMID:17189043. |
tcs of distinct infra- and supratentorial brain structures detects characteristic changes in several movement disorders, such as abnormal hyperechogenicity of substantia nigra (sn) in parkinson's disease and of lenticular nucleus in dystonia, wilson's disease and atypical parkinsonian disorders. |
2007-06-28 |
2023-08-12 |
Not clear |
| Yu-Wen Huang, Jiann-Shing Jeng, Chung-Fen Tsai, Li-Ling Chen, Ruey-Meei W. Transcranial imaging of substantia nigra hyperechogenicity in a Taiwanese cohort of Parkinson's disease. Movement disorders : official journal of the Movement Disorder Society. vol 22. issue 4. 2007-06-22. PMID:17260344. |
transcranial doppler imaging (tcdi) has been used as a noninvasive diagnostic tool to differentiate parkinson's disease (pd) from atypical parkinsonism by detecting hyperechogenicity in the substantia nigra (sn). |
2007-06-22 |
2023-08-12 |
Not clear |
| Ingrid Morales, Jose G Dopico, Magdalena Sabate, Tomas Gonzalez-Hernandez, Manuel Rodrigue. Substantia nigra osmoregulation: taurine and ATP involvement. American journal of physiology. Cell physiology. vol 292. issue 5. 2007-06-21. PMID:17215320. |
an extracellular nonsynaptic taurine pool of glial origin was recently reported in the substantia nigra (sn). |
2007-06-21 |
2023-08-12 |
rat |
| Claudia Grothe, Marco Timme. The physiological and pharmacological role of basic fibroblast growth factor in the dopaminergic nigrostriatal system. Brain research reviews. vol 54. issue 1. 2007-06-21. PMID:17229467. |
fgf-2 and its high-affinity receptors (fgfr) display an expression in the developing, postnatal, and adult substantia nigra (sn) and in the striatum. |
2007-06-21 |
2023-08-12 |
mouse |