| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| H J Waldvogel, K Baer, W-P Gai, R T Gilbert, M I Rees, H Mohler, R L M Faul. Differential localization of GABAA receptor subunits within the substantia nigra of the human brain: an immunohistochemical study. The Journal of comparative neurology. vol 506. issue 6. 2008-04-04. PMID:18085588. |
in this study we present the first detailed immunohistochemical investigation on the regional, cellular, and subcellular localisation of alpha(1), alpha(2), alpha(3), beta(2,3), and gamma(2) subunits of the gaba(a)r in the human substantia nigra (sn). |
2008-04-04 |
2023-08-12 |
human |
| Christine C Stichel, Xin-Ran Zhu, Verian Bader, Bettina Linnartz, Saskia Schmidt, Hermann Lübber. Mono- and double-mutant mouse models of Parkinson's disease display severe mitochondrial damage. Human molecular genetics. vol 16. issue 20. 2008-03-26. PMID:17412759. |
here we compare the ultrastructure and functional properties of mitochondria in the substantia nigra (sn), the striatum, the cerebral cortex (cx) and skeletal muscle of young (2-3 months) and aged (12-14 months) mono- and double-mutants mice. |
2008-03-26 |
2023-08-12 |
mouse |
| Ji Youn Kim, Seong Tae Kim, Seong Hee Jeon, Won Yong Le. Midbrain transcranial sonography in Korean patients with Parkinson's disease. Movement disorders : official journal of the Movement Disorder Society. vol 22. issue 13. 2008-03-21. PMID:17588240. |
to investigate the efficacy of tcs in korean pd patients and its correlation with the clinical features, we carried out midbrain tcs in 43 pd patients and 35 normal controls and evaluated the area of the substantia nigra (sn) hyperechogenicity and its ratio to the area of the whole midbrain. |
2008-03-21 |
2023-08-12 |
human |
| Koji Aoyama, Nobuko Matsumura, Masahiko Watabe, Toshio Nakak. Oxidative stress on EAAC1 is involved in MPTP-induced glutathione depletion and motor dysfunction. The European journal of neuroscience. vol 27. issue 1. 2008-03-18. PMID:18093171. |
parkinson's disease (pd) is a neurodegenerative disorder pathogenically related to oxidative stress and shows gsh depletion in the substantia nigra (sn). |
2008-03-18 |
2023-08-12 |
mouse |
| Cheryl A Frye, Madeline E Rhode. Infusions of 3alpha,5alpha-THP to the VTA enhance exploratory, anti-anxiety, social, and sexual behavior and increase levels of 3alpha,5alpha-THP in midbrain, hippocampus, diencephalon, and cortex of female rats. Behavioural brain research. vol 187. issue 1. 2008-03-11. PMID:17919744. |
infusions of 3alpha,5alpha-thp to the vta, but not control sites, such as the substantia nigra (sn) or central grey (cg), of diestrous rats produced behavioral and endocrine effects akin to that of proestrous rats and increased dhp and 3alpha,5alpha-thp levels in midbrain, hippocampus, and diencephalon. |
2008-03-11 |
2023-08-12 |
rat |
| Dae Y Song, Young C Yang, Dong H Shin, Shuei Sugama, Yoon S Kim, Bong H Lee, Tong H Joh, Byung P Ch. Axotomy-induced dopaminergic neurodegeneration is accompanied with c-Jun phosphorylation and activation transcription factor 3 expression. Experimental neurology. vol 209. issue 1. 2008-03-05. PMID:18036593. |
to elucidate the significance and functional role of these immediate-early genes during neuronal damage in the central nervous system, we examined temporal and spatial profiles of pc-jun and atf3 in dopaminergic neurons of the substantia nigra (sn) following transection of the medial forebrain bundle (mfb) in adult rats. |
2008-03-05 |
2023-08-12 |
rat |
| J M Hagenah, I R König, B Becker, R Hilker, M Kasten, K Hedrich, P P Pramstaller, C Klein, G Seide. Substantia nigra hyperechogenicity correlates with clinical status and number of Parkin mutated alleles. Journal of neurology. vol 254. issue 10. 2008-02-29. PMID:17934880. |
to further evaluate (1) transcranial sonography (tcs) for (pre)clinical diagnosis of parkinson's disease (pd) and (2) to examine asymptomatic carriers of parkin mutations we investigated substantia nigra (sn) hyperechogenicity in pd patients and unaffected subjects with and without parkin mutations. |
2008-02-29 |
2023-08-12 |
human |
| Ning Song, Hong Jiang, Jun Wang, Jun-Xia Xi. Divalent metal transporter 1 up-regulation is involved in the 6-hydroxydopamine-induced ferrous iron influx. Journal of neuroscience research. vol 85. issue 14. 2008-02-14. PMID:17663481. |
the reasons underlying the high iron content found in the substantia nigra (sn) of parkinson's disease (pd) are largely unknown. |
2008-02-14 |
2023-08-12 |
rat |
| Emilce Carrasco, Diana Casper, Peter Werne. PGE(2) receptor EP1 renders dopaminergic neurons selectively vulnerable to low-level oxidative stress and direct PGE(2) neurotoxicity. Journal of neuroscience research. vol 85. issue 14. 2008-02-14. PMID:17868147. |
oxidative stress and increased cyclooxygenase-2 (cox-2) activity are both implicated in the loss of dopaminergic neurons from the substantia nigra (sn) in idiopathic parkinson's disease (pd). |
2008-02-14 |
2023-08-12 |
rat |
| Shankar J Chinta, M J Kumar, Michael Hsu, Subramanian Rajagopalan, Deepinder Kaur, Anand Rane, David G Nicholls, Jinah Choi, Julie K Anderse. Inducible alterations of glutathione levels in adult dopaminergic midbrain neurons result in nigrostriatal degeneration. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 27. issue 51. 2008-01-14. PMID:18094238. |
parkinson's disease is a neurodegenerative disorder characterized by the preferential loss of midbrain dopaminergic neurons in the substantia nigra (sn). |
2008-01-14 |
2023-08-12 |
mouse |
| Dekel Segev, Alon Korngree. Kinetics of two voltage-gated K+ conductances in substantia nigra dopaminergic neurons. Brain research. vol 1173. 2008-01-09. PMID:17826751. |
the substantia nigra (sn) is part of the basal ganglia which is a section in the movement circuit in the brain. |
2008-01-09 |
2023-08-12 |
Not clear |
| Donald R Staine. Is Parkinson's disease an autoimmune disorder of endogenous vasoactive neuropeptides? Medical hypotheses. vol 69. issue 6. 2008-01-03. PMID:17562359. |
parkinson's disease (pd) is a motor disease including disorders of mobility, fine tremor, rigidity and posture caused by a relentless deterioration of dopaminergic cells in the substantia nigra (sn). |
2008-01-03 |
2023-08-12 |
Not clear |
| Jun Yang, Qingshan Teng, Mary E Garrity-Moses, Shearwood McClelland, Thais Federici, Erin Carlton, Jonathon Riley, Nicholas M Bouli. Reversible unilateral nigrostriatal pathway inhibition induced through expression of adenovirus-mediated clostridial light chain gene in the substantia nigra. Neuromolecular medicine. vol 9. issue 3. 2007-12-27. PMID:17914186. |
we here report the feasibility of creating a rat hemiparkinsonism model through lc gene expression in the substantia nigra (sn), inhibiting nigrostriatal transmission. |
2007-12-27 |
2023-08-12 |
rat |
| Wen Zhu, Wenjie Xie, Tianhong Pan, Pingyi Xu, Mati Fridkin, Hailin Zheng, Joseph Jankovic, Moussa B H Youdim, Weidong L. Prevention and restoration of lactacystin-induced nigrostriatal dopamine neuron degeneration by novel brain-permeable iron chelators. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 21. issue 14. 2007-12-26. PMID:17690154. |
dysfunction of the ubiquitin-proteasome system (ups) and accumulation of iron in substantia nigra (sn) are implicated in the pathogenesis of parkinson's disease (pd). |
2007-12-26 |
2023-08-12 |
mouse |
| F Tribl, T Arzberger, P Riederer, M Gerlac. Tyrosinase is not detected in human catecholaminergic neurons by immunohistochemistry and Western blot analysis. Journal of neural transmission. Supplementum. issue 72. 2007-12-10. PMID:17982878. |
catecholaminergic neurons of the primate substantia nigra (sn) pars compacta (snc) and the locus coeruleus contain neuromelanin (nm) granules as characteristic structures underlying the pigmentation of these brain areas. |
2007-12-10 |
2023-08-12 |
mouse |
| Petra Ruprecht-Dörfler, Patricia Klotz, Georg Becker, Daniela Ber. Substantia nigra hyperechogenicity correlates with subtle motor dysfunction in tap dancers. Parkinsonism & related disorders. vol 13. issue 6. 2007-12-06. PMID:17055330. |
hyperechogenicity of the substantia nigra (sn) detected by transcranial sonography is a typical finding in more than 90% of patients with parkinson's disease (pd) but may also be visible in about 9% of healthy adults. |
2007-12-06 |
2023-08-12 |
Not clear |
| Anya M Y Lin, P L Chao, S F Fang, C W Chi, C H Yan. Endoplasmic reticulum stress is involved in arsenite-induced oxidative injury in rat brain. Toxicology and applied pharmacology. vol 224. issue 2. 2007-11-28. PMID:17681577. |
arsenite was locally infused in the substantia nigra (sn) of anesthetized rat. |
2007-11-28 |
2023-08-12 |
rat |
| Jahn N O'Neil, Peter R Mouton, Yousef Tizabi, Mary Ann Ottinger, De-Liang Lei, Donald K Ingram, Kebreten F Manay. Catecholaminergic neuronal loss in locus coeruleus of aged female dtg APP/PS1 mice. Journal of chemical neuroanatomy. vol 34. issue 3-4. 2007-11-21. PMID:17658239. |
in addition to the presence of cortical senile plaques and neurofibrillary tangles, ad is characterized at autopsy by extensive degeneration of brainstem locus coeruleus (lc) neurons that provide noradrenergic innervation to cortical neuropil, together with relative stability of dopaminergic neuron number in substantia nigra (sn) and ventral tegmental area (vta). |
2007-11-21 |
2023-08-12 |
mouse |
| b' David Skoloud\\xc3\\xadk, T\\xc3\\xa1na Fadrn\\xc3\\xa1, Petra B\\xc3\\xa1rtov\\xc3\\xa1, Katerina Langov\\xc3\\xa1, Pavel Ressner, Olga Zapletalov\\xc3\\xa1, Petr Hlust\\xc3\\xadk, Roman Herzig, Petr Kannovsk\\xc3\\xb. Reproducibility of sonographic measurement of the substantia nigra. Ultrasound in medicine & biology. vol 33. issue 9. 2007-11-20. PMID:17544567.' |
the aim of this study was to evaluate inter-reader, intra-investigator and inter-investigator reproducibility and correlations in the assessment of substantia nigra (sn) echogenicity and area measurement by a physician-sonographer (ps), a sonographic laboratory assistant (sla) and a physician without sonographic experience (pn). |
2007-11-20 |
2023-08-12 |
Not clear |
| Grzegorz A Czapski, Magdalena Cakala, Malgorzata Chalimoniuk, Barbara Gajkowska, Joanna B Strosznajde. Role of nitric oxide in the brain during lipopolysaccharide-evoked systemic inflammation. Journal of neuroscience research. vol 85. issue 8. 2007-11-05. PMID:17465018. |
apoptotic/autophagic processes occurred in many neurons of the substantia nigra (sn), which coincided with exclusive enhancement of inos expression and activity in this brain region. |
2007-11-05 |
2023-08-12 |
mouse |