| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Christopher J Earley, Peter B Barker, Alena Horská, Richard P Alle. MRI-determined regional brain iron concentrations in early- and late-onset restless legs syndrome. Sleep medicine. vol 7. issue 5. 2006-12-14. PMID:16740411. |
in this study our primary hypothesis was that substantia nigra (sn) iron index would be decreased in early-onset rls compared to controls. |
2006-12-14 |
2023-08-12 |
Not clear |
| Hong Jiang, Zhuo Luan, Jun Wang, Junxia Xi. Neuroprotective effects of iron chelator Desferal on dopaminergic neurons in the substantia nigra of rats with iron-overload. Neurochemistry international. vol 49. issue 6. 2006-12-12. PMID:16806586. |
the aim of the present study was to investigate whether the iron chelator desferal prevents the degeneration of dopaminergic neurons in the substantia nigra (sn) induced by iron-overload in rats. |
2006-12-12 |
2023-08-12 |
rat |
| Rachel L Nosheny, Alessia Bachis, Sadia A Aden, Maria A De Bernardi, Italo Mocchett. Intrastriatal administration of human immunodeficiency virus-1 glycoprotein 120 reduces glial cell-line derived neurotrophic factor levels and causes apoptosis in the substantia nigra. Journal of neurobiology. vol 66. issue 12. 2006-12-11. PMID:16967504. |
uninfected neurons of the substantia nigra (sn) degenerate in human immunodeficiency virus (hiv)-positive patients through an unknown etiology. |
2006-12-11 |
2023-08-12 |
human |
| Veljko Puskovic, Darren Wolfe, James Wechuck, David Krisky, Jeff Collins, Joseph C Glorioso, David J Fink, Marina Mat. HSV-mediated delivery of erythropoietin restores dopaminergic function in MPTP-treated mice. Molecular therapy : the journal of the American Society of Gene Therapy. vol 14. issue 5. 2006-11-22. PMID:16949343. |
inoculation with dhepo prior to mptp intoxication preserved behavioral function measured by pellet retrieval and the histological markers of tyrosine hydroxylase-immunoreactive (th-ir) neuronal cell bodies in the substantia nigra (sn) and th-ir and dopamine transporter-immunoreactive (dat-ir) terminals in striatum. |
2006-11-22 |
2023-08-12 |
mouse |
| Zhiming Zhang, Anders H Andersen, Yi Ai, Aaron Loveland, Peter A Hardy, Greg A Gerhardt, Don M Gas. Assessing nigrostriatal dysfunctions by pharmacological MRI in parkinsonian rhesus macaques. NeuroImage. vol 33. issue 2. 2006-11-21. PMID:16949305. |
the primary findings were (1) the putamen and substantia nigra (sn) but not the caudate nucleus displayed significant bold responses to these dopaminergic drugs; (2) a significant relationship was found between amphetamine-evoked activation and the number of surviving dopamine neurons in the sn, which was also correlated with bradykinesia; and (3) inverse relationships were seen in response to apomorphine and amphetamine stimulation between the mptp-lesioned and unlesioned putamen and sn. |
2006-11-21 |
2023-08-12 |
monkey |
| Nilgün Akbas, Helmine Hochstrasser, Joelle Deplazes, Jürgen Tomiuk, Peter Bauer, Uwe Walter, Stefanie Behnke, Olaf Riess, Daniela Ber. Screening for mutations of the HFE gene in Parkinson's disease patients with hyperechogenicity of the substantia nigra. Neuroscience letters. vol 407. issue 1. 2006-11-14. PMID:16935420. |
in this study, analyzing the whole coding region of the hfe gene by dhplc in 278 pd patients, priorly characterized by transcranial sonography for increased iron content of the substantia nigra (sn), we did not find an association of the common hfe mutations and pd. |
2006-11-14 |
2023-08-12 |
Not clear |
| Carina Cintia Ferrari, María Clara Pott Godoy, Rodolfo Tarelli, Mariela Chertoff, Amaicha Mara Depino, Fernando Juan Pitoss. Progressive neurodegeneration and motor disabilities induced by chronic expression of IL-1beta in the substantia nigra. Neurobiology of disease. vol 24. issue 1. 2006-11-07. PMID:16901708. |
the functional role of the long-lasting inflammation found in the substantia nigra (sn) of parkinson's disease (pd) patients and animal models is unclear. |
2006-11-07 |
2023-08-12 |
rat |
| Matthew Maingay, Marina Romero-Ramos, Manolo Carta, Deniz Kiri. Ventral tegmental area dopamine neurons are resistant to human mutant alpha-synuclein overexpression. Neurobiology of disease. vol 23. issue 3. 2006-11-01. PMID:16806952. |
in the midbrain, the degeneration of the substantia nigra (sn) da neurons is severe, whereas the involvement of the ventral tegmental area (vta) neurons is relatively spared. |
2006-11-01 |
2023-08-12 |
human |
| Alessandro Martorana, Carmela Giampà, Zena DeMarch, Maria Teresa Viscomi, Stefano Patassini, Giuseppe Sancesario, Giorgio Bernardi, Francesca R Fusc. Distribution of TRPC1 receptors in dendrites of rat substantia nigra: a confocal and electron microscopy study. The European journal of neuroscience. vol 24. issue 3. 2006-11-01. PMID:16930403. |
the expression, at mrna level, of several trpcs has been demonstrated recently in dopaminergic neurons of the substantia nigra (sn). |
2006-11-01 |
2023-08-12 |
rat |
| Attila Nagy, Gabriella Eördegh, Zsuzsanna Paróczy, Zita Márkus, György Benede. Multisensory integration in the basal ganglia. The European journal of neuroscience. vol 24. issue 3. 2006-11-01. PMID:16930419. |
to investigate the underlying multisensory information processing, we recorded the neuronal responses in the caudate nucleus (cn) and substantia nigra (sn) of anaesthetized cats to visual, auditory or somatosensory stimulation alone and also to their combinations, i.e. |
2006-11-01 |
2023-08-12 |
Not clear |
| L Zecca, F A Zucca, A Albertini, E Rizzio, R G Fariell. A proposed dual role of neuromelanin in the pathogenesis of Parkinson's disease. Neurology. vol 67. issue 7 Suppl 2. 2006-10-30. PMID:17030740. |
in many parkinsonian syndromes, neuromelanin (nm)-containing dopaminergic neurons of the substantia nigra (sn) are selectively targeted by the noxius pathogens. |
2006-10-30 |
2023-08-12 |
human |
| James G Green. Gene expression profiles of brain dopamine neurons and relevance to neuropsychiatric disease. The Journal of physiology. vol 575. issue Pt 2. 2006-10-26. PMID:16740610. |
specifically, dopamine neurons in the substantia nigra (sn), which are prone to degenerate in parkinson's disease, express high levels of transcripts related to energy metabolism, mitochondria and phosphate signalling pathways. |
2006-10-26 |
2023-08-12 |
Not clear |
| R E Burk. GDNF as a candidate striatal target-derived neurotrophic factor for the development of substantia nigra dopamine neurons. Journal of neural transmission. Supplementum. issue 70. 2006-10-24. PMID:17017507. |
glial cell line-derived neurotrophic factor (gdnf) has been known for many years to protect and restore dopamine neurons of the substantia nigra (sn) in lesion models of parkinsonism, but much less has been known of its normal physiologic role. |
2006-10-24 |
2023-08-12 |
mouse |
| M Gerlach, K L Double, M B H Youdim, P Riedere. Potential sources of increased iron in the substantia nigra of parkinsonian patients. Journal of neural transmission. Supplementum. issue 70. 2006-10-24. PMID:17017520. |
histopathological, biochemical and in vivo brain imaging techniques, such as magnetic resonance imaging and transcranial sonography, revealed a consistent increase of substantia nigra (sn) iron in parkinson's disease (pd). |
2006-10-24 |
2023-08-12 |
Not clear |
| D Ber. Transcranial sonography in the early and differential diagnosis of Parkinson's disease. Journal of neural transmission. Supplementum. issue 70. 2006-10-24. PMID:17017537. |
using tcs, our group discovered changes of the echotexture--namely increased echogenicity--at the substantia nigra (sn) in about 90% of patients with parkinson's disease (pd). |
2006-10-24 |
2023-08-12 |
human |
| H Mochizuki, M Yamada, Y Mizun. Alpha-synuclein overexpression model. Journal of neural transmission. Supplementum. issue 70. 2006-10-24. PMID:17017543. |
to elucidate the role of alpha-synuclein in the pathogenesis of parkinson's disease (pd), both human alpha-synuclein transgenic mice and targeted overexpression of human alpha-synuclein in rat substantia nigra (sn) by viral vector-based methods have been studied, however little is known about the pathogenetic changes of dopaminergic neuron loss. |
2006-10-24 |
2023-08-12 |
mouse |
| M Sawada, K Imamura, T Nagats. Role of cytokines in inflammatory process in Parkinson's disease. Journal of neural transmission. Supplementum. issue 70. 2006-10-24. PMID:17017556. |
we investigated whether the cytokines produced in activated microglia in the substantia nigra (sn) and putamen in sporadic parkinson's disease (pd) are neuroprotective or neurotoxic. |
2006-10-24 |
2023-08-12 |
mouse |
| M J Zigmon. Triggering endogenous neuroprotective mechanisms in Parkinson's disease: studies with a cellular model. Journal of neural transmission. Supplementum. issue 70. 2006-10-24. PMID:17017565. |
we have now shown that gdnf can also protect against the effects of 6-hydroxydopamine (6-ohda) in a dopaminergic cell line and in cultures of primary da neurons prepared from rat substantia nigra (sn). |
2006-10-24 |
2023-08-12 |
rat |
| Marcelo de Meira Santos Lima, Angela Braga Reksidler, Sílvio Marques Zanata, Hidevaldo Bueno Machado, Sergio Tufik, Maria A B F Vita. Different parkinsonism models produce a time-dependent induction of COX-2 in the substantia nigra of rats. Brain research. vol 1101. issue 1. 2006-09-19. PMID:16781689. |
results indicate that lps produced an increase in locomotion frequency (3 and 7 days after surgery) and a strong up-regulation of cox-2 protein 16 and 24 h after surgery, as observed in the substantia nigra (sn). |
2006-09-19 |
2023-08-12 |
rat |
| Fumiaki Mori, Makoto Nishie, Akiyoshi Kakita, Makoto Yoshimoto, Hitoshi Takahashi, Koichi Wakabayash. Relationship among alpha-synuclein accumulation, dopamine synthesis, and neurodegeneration in Parkinson disease substantia nigra. Journal of neuropathology and experimental neurology. vol 65. issue 8. 2006-09-15. PMID:16896314. |
the histologic hallmark of parkinson disease (pd) is loss of pigmented neurons in the substantia nigra (sn) and locus ceruleus (lc) with accumulation of alpha-synuclein (alphas). |
2006-09-15 |
2023-08-12 |
human |