| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hee Soon Choi, Jae Jin An, So Young Kim, Sun Hwa Lee, Dae Won Kim, Ki-Yeon Yoo, Moo Ho Won, Tae-Cheon Kang, Hyung Joo Kwon, Jung Hoon Kang, Sung-Woo Cho, Oh-Shin Kwon, Jinseu Park, Won Sik Eum, Soo Young Cho. PEP-1-SOD fusion protein efficiently protects against paraquat-induced dopaminergic neuron damage in a Parkinson disease mouse model. Free radical biology & medicine. vol 41. issue 7. 2007-02-16. PMID:16962931. |
parkinson disease (pd) is a common neurodegenerative disorder characterized by the progressive loss of dopaminergic neurons in the substantia nigra (sn). |
2007-02-16 |
2023-08-12 |
mouse |
| Javorina Milosevic, Martina Maisel, Florian Wegner, Julia Leuchtenberger, Roland H Wenger, Manfred Gerlach, Alexander Storch, Johannes Schwar. Lack of hypoxia-inducible factor-1 alpha impairs midbrain neural precursor cells involving vascular endothelial growth factor signaling. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 27. issue 2. 2007-02-02. PMID:17215402. |
in substantia nigra (sn) of adult hif-1alpha cko mice, protein levels of dopaminergic marker molecules such as tyrosine hydroxylase (th) and aldehyde dehydrogenase were reduced by 41 and 61%, respectively. |
2007-02-02 |
2023-08-12 |
mouse |
| James E Galvi. Interaction of alpha-synuclein and dopamine metabolites in the pathogenesis of Parkinson's disease: a case for the selective vulnerability of the substantia nigra. Acta neuropathologica. vol 112. issue 2. 2007-02-01. PMID:16791599. |
major disease symptoms are due to the loss of dopaminergic (da) neurons in substantia nigra (sn). |
2007-02-01 |
2023-08-12 |
mouse |
| V Sava, O Reunova, A Velasquez, R Harbison, J Sánchez-Ramo. Acute neurotoxic effects of the fungal metabolite ochratoxin-A. Neurotoxicology. vol 27. issue 1. 2007-01-30. PMID:16140385. |
a single dose of 3.5 mg/kg decreased the intensity of tyrosine hydroxylase immunoreactivity (th(+)) in fibers of striatum, th(+) cells in substantia nigra (sn) and th(+) cells of the locus ceruleus. |
2007-01-30 |
2023-08-12 |
mouse |
| C A Frye, M E Rhode. Infusions of 5alpha-pregnan-3alpha-ol-20-one (3alpha,5alpha-THP) to the ventral tegmental area, but not the substantia nigra, enhance exploratory, anti-anxiety, social and sexual behaviours and concomitantly increase 3alpha,5alpha-THP concentrations in the hippocampus, diencephalon and cortex of ovariectomised oestrogen-primed rats. Journal of neuroendocrinology. vol 18. issue 12. 2007-01-30. PMID:17076771. |
we investigated the effects of 3alpha,5alpha-thp infusions to the vta, and a control site, the substantia nigra (sn), on exploratory, anti-anxiety, social and sexual behaviours (socio-sexual behaviours) and hormone levels in the midbrain and other regions (hippocampus, diencephalon and cortex) that may mediate these functions. |
2007-01-30 |
2023-08-12 |
rat |
| Andrzej Friedman, Jolanta Galazka-Friedman, Erika R Bauminger, Dariusz Koziorowsk. Iron and ferritin in hippocampal cortex and substantia nigra in human brain--implications for the possible role of iron in dementia. Journal of the neurological sciences. vol 248. issue 1-2. 2007-01-23. PMID:16797029. |
the concentrations of iron and of ferritin, the main iron-binding compound in the brain, as well as the sizes of the iron cores of ferritin were assessed in hippocampal cortex (hip) and substantia nigra (sn) from human control brains, using mössbauer spectroscopy (ms), elisa and electron microscopy. |
2007-01-23 |
2023-08-12 |
human |
| L Li, Y Su, C Zhao, H Zhao, G Liu, J Wang, Q X. The role of Ret receptor tyrosine kinase in dopaminergic neuron development. Neuroscience. vol 142. issue 2. 2007-01-23. PMID:16879925. |
additionally, some da neurons in the substantia nigra (sn) underwent apoptotic cell death following the ret-as-odn treatment. |
2007-01-23 |
2023-08-12 |
rat |
| Joanna Iczkiewicz, Michael J Jackson, Lance A Smith, Sarah Rose, Peter Jenne. Osteopontin expression in substantia nigra in MPTP-treated primates and in Parkinson's disease. Brain research. vol 1118. issue 1. 2007-01-23. PMID:16962083. |
parkinson's disease (pd) is characterised by the loss of dopaminergic neurones in the substantia nigra (sn) but the pathogenic mechanism remains unknown. |
2007-01-23 |
2023-08-12 |
human |
| Sung Jae Kim, Sung Yul Kim, Young-Soon Na, Hyun Jung Lee, Kwang Chul Chung, Ja-Hyun Bai. Alpha-synuclein enhances dopamine D2 receptor signaling. Brain research. vol 1124. issue 1. 2007-01-23. PMID:17087919. |
parkinson's disease (pd) is characterized by a selective loss of dopamine-producing neurons in the substantia nigra (sn), which in turn results in dopamine depletion in the striatum, and the presence of neuronal cytoplasmic inclusions known as lewy bodies (lbs). |
2007-01-23 |
2023-08-12 |
Not clear |
| Xiaoyang Shan, Liying Chi, Michael Bishop, Chun Luo, Lindsey Lien, Zheng Zhang, Rugao Li. Enhanced de novo neurogenesis and dopaminergic neurogenesis in the substantia nigra of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced Parkinson's disease-like mice. Stem cells (Dayton, Ohio). vol 24. issue 5. 2007-01-18. PMID:16424396. |
research reports on de novo neurogenesis, particularly dopaminergic (da) neurogenesis in the adult mammalian substantia nigra (sn), remain very controversial. |
2007-01-18 |
2023-08-12 |
mouse |
| D C Duke, L B Moran, M E Kalaitzakis, M Deprez, D T Dexter, R K B Pearce, M B Graebe. Transcriptome analysis reveals link between proteasomal and mitochondrial pathways in Parkinson's disease. Neurogenetics. vol 7. issue 3. 2007-01-12. PMID:16699787. |
we examined gene expression in medial and lateral substantia nigra (sn) as well as in frontal cortex using whole genome dna oligonucleotide microarrays. |
2007-01-12 |
2023-08-12 |
Not clear |
| Supriti Samantaray, Swapan K Ray, Syed F Ali, Naren L Bani. Calpain activation in apoptosis of motoneurons in cell culture models of experimental parkinsonism. Annals of the New York Academy of Sciences. vol 1074. 2007-01-10. PMID:17105932. |
parkinson's disease (pd) is a movement disorder characterized by progressive degeneration of primarily the dopaminergic neurons in the substantia nigra (sn). |
2007-01-10 |
2023-08-12 |
Not clear |
| Trond Myhrer, Nga H T Nguyen, Siri Enger, Pål Aa. Anticonvulsant effects of GABA(A) modulators microinfused into area tempestas or substantia nigra in rats exposed to soman. Archives of toxicology. vol 80. issue 8. 2006-12-14. PMID:16525814. |
in the present study, gaba(a) modulating drugs (1 microl) were microinfused bilaterally into the seizure controlling substrates, substantia nigra (sn) or area tempestas (at), of rats subjected to seizures induced systemically by soman (100 microg/kg). |
2006-12-14 |
2023-08-12 |
rat |
| Christopher J Earley, Peter B Barker, Alena Horská, Richard P Alle. MRI-determined regional brain iron concentrations in early- and late-onset restless legs syndrome. Sleep medicine. vol 7. issue 5. 2006-12-14. PMID:16740411. |
in this study our primary hypothesis was that substantia nigra (sn) iron index would be decreased in early-onset rls compared to controls. |
2006-12-14 |
2023-08-12 |
Not clear |
| Hong Jiang, Zhuo Luan, Jun Wang, Junxia Xi. Neuroprotective effects of iron chelator Desferal on dopaminergic neurons in the substantia nigra of rats with iron-overload. Neurochemistry international. vol 49. issue 6. 2006-12-12. PMID:16806586. |
the aim of the present study was to investigate whether the iron chelator desferal prevents the degeneration of dopaminergic neurons in the substantia nigra (sn) induced by iron-overload in rats. |
2006-12-12 |
2023-08-12 |
rat |
| Rachel L Nosheny, Alessia Bachis, Sadia A Aden, Maria A De Bernardi, Italo Mocchett. Intrastriatal administration of human immunodeficiency virus-1 glycoprotein 120 reduces glial cell-line derived neurotrophic factor levels and causes apoptosis in the substantia nigra. Journal of neurobiology. vol 66. issue 12. 2006-12-11. PMID:16967504. |
uninfected neurons of the substantia nigra (sn) degenerate in human immunodeficiency virus (hiv)-positive patients through an unknown etiology. |
2006-12-11 |
2023-08-12 |
human |
| Veljko Puskovic, Darren Wolfe, James Wechuck, David Krisky, Jeff Collins, Joseph C Glorioso, David J Fink, Marina Mat. HSV-mediated delivery of erythropoietin restores dopaminergic function in MPTP-treated mice. Molecular therapy : the journal of the American Society of Gene Therapy. vol 14. issue 5. 2006-11-22. PMID:16949343. |
inoculation with dhepo prior to mptp intoxication preserved behavioral function measured by pellet retrieval and the histological markers of tyrosine hydroxylase-immunoreactive (th-ir) neuronal cell bodies in the substantia nigra (sn) and th-ir and dopamine transporter-immunoreactive (dat-ir) terminals in striatum. |
2006-11-22 |
2023-08-12 |
mouse |
| Zhiming Zhang, Anders H Andersen, Yi Ai, Aaron Loveland, Peter A Hardy, Greg A Gerhardt, Don M Gas. Assessing nigrostriatal dysfunctions by pharmacological MRI in parkinsonian rhesus macaques. NeuroImage. vol 33. issue 2. 2006-11-21. PMID:16949305. |
the primary findings were (1) the putamen and substantia nigra (sn) but not the caudate nucleus displayed significant bold responses to these dopaminergic drugs; (2) a significant relationship was found between amphetamine-evoked activation and the number of surviving dopamine neurons in the sn, which was also correlated with bradykinesia; and (3) inverse relationships were seen in response to apomorphine and amphetamine stimulation between the mptp-lesioned and unlesioned putamen and sn. |
2006-11-21 |
2023-08-12 |
monkey |
| Nilgün Akbas, Helmine Hochstrasser, Joelle Deplazes, Jürgen Tomiuk, Peter Bauer, Uwe Walter, Stefanie Behnke, Olaf Riess, Daniela Ber. Screening for mutations of the HFE gene in Parkinson's disease patients with hyperechogenicity of the substantia nigra. Neuroscience letters. vol 407. issue 1. 2006-11-14. PMID:16935420. |
in this study, analyzing the whole coding region of the hfe gene by dhplc in 278 pd patients, priorly characterized by transcranial sonography for increased iron content of the substantia nigra (sn), we did not find an association of the common hfe mutations and pd. |
2006-11-14 |
2023-08-12 |
Not clear |
| Carina Cintia Ferrari, María Clara Pott Godoy, Rodolfo Tarelli, Mariela Chertoff, Amaicha Mara Depino, Fernando Juan Pitoss. Progressive neurodegeneration and motor disabilities induced by chronic expression of IL-1beta in the substantia nigra. Neurobiology of disease. vol 24. issue 1. 2006-11-07. PMID:16901708. |
the functional role of the long-lasting inflammation found in the substantia nigra (sn) of parkinson's disease (pd) patients and animal models is unclear. |
2006-11-07 |
2023-08-12 |
rat |