| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jana Godau, Katherine J Schweitzer, Inga Liepelt, Christian Gerloff, Daniela Ber. Substantia nigra hypoechogenicity: definition and findings in restless legs syndrome. Movement disorders : official journal of the Movement Disorder Society. vol 22. issue 2. 2007-03-23. PMID:17133515. |
pathological studies demonstrate a decreased iron content in the substantia nigra (sn) contributing to the pathophysiology of restless legs syndrome (rls). |
2007-03-23 |
2023-08-12 |
Not clear |
| V Sava, O Reunova, A Velasquez, S Song, J Sanchez-Ramo. Neuroanatomical mapping of DNA repair and antioxidative responses in mouse brain: Effects of a single dose of MPTP. Neurotoxicology. vol 27. issue 6. 2007-03-21. PMID:16831462. |
in some sampled loci, notably the substantia nigra (sn) and hippocampus, the heightened dna repair and antioxidant responses were not maintained beyond 48h. |
2007-03-21 |
2023-08-12 |
mouse |
| Oliver Biehlmaier, Mesbah Alam, Werner J Schmid. A rat model of Parkinsonism shows depletion of dopamine in the retina. Neurochemistry international. vol 50. issue 1. 2007-03-20. PMID:16962686. |
neurochemically, rotenone treated rats showed a depletion of da in the striatum and substantia nigra (sn). |
2007-03-20 |
2023-08-12 |
rat |
| Liya Qin, Xuefei Wu, Michelle L Block, Yuxin Liu, George R Breese, Jau-Shyong Hong, Darin J Knapp, Fulton T Crew. Systemic LPS causes chronic neuroinflammation and progressive neurodegeneration. Glia. vol 55. issue 5. 2007-03-20. PMID:17203472. |
further, lps reduced the number of tyrosine hydroxylase-immunoreactive neurons in the substantia nigra (sn) by 23% at 7-months post-treatment, which progressed to 47% at 10 months. |
2007-03-20 |
2023-08-12 |
mouse |
| Laure Sonnier, Gwenaëlle Le Pen, Andreas Hartmann, Jean-Charles Bizot, Fabrice Trovero, Marie-Odile Krebs, Alain Prochiant. Progressive loss of dopaminergic neurons in the ventral midbrain of adult mice heterozygote for Engrailed1. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 27. issue 5. 2007-03-16. PMID:17267560. |
en1 and, to a lesser degree, en2 also are expressed in the adult substantia nigra (sn) and ventral tegmental area (vta), two dopaminergic (da) nuclei of the ventral midbrain. |
2007-03-16 |
2023-08-12 |
mouse |
| Jun Mo Kang, Hi Joon Park, Yeong Gon Choi, Il Hwan Choe, Jae Hyun Park, Yong Sik Kim, Sabina Li. Acupuncture inhibits microglial activation and inflammatory events in the MPTP-induced mouse model. Brain research. vol 1131. issue 1. 2007-03-09. PMID:17173870. |
these experiments demonstrated that acupuncture inhibited the decreased of the tyrosine hydroxylase (th) immunoreactivity (ir) and generated a neuroprotective effects in the striatum (st) and the substantia nigra (sn) on days 1, 3, and 7 post-mptp injections. |
2007-03-09 |
2023-08-12 |
mouse |
| Elisabetta Baldi, Chiara Mariottini, Corrado Bucherell. Substantia nigra role in fear conditioning consolidation. Neurobiology of learning and memory. vol 87. issue 1. 2007-02-22. PMID:16978887. |
the substantia nigra (sn) is known to be involved in the memorization of several conditioned responses. |
2007-02-22 |
2023-08-12 |
rat |
| Hee Soon Choi, Jae Jin An, So Young Kim, Sun Hwa Lee, Dae Won Kim, Ki-Yeon Yoo, Moo Ho Won, Tae-Cheon Kang, Hyung Joo Kwon, Jung Hoon Kang, Sung-Woo Cho, Oh-Shin Kwon, Jinseu Park, Won Sik Eum, Soo Young Cho. PEP-1-SOD fusion protein efficiently protects against paraquat-induced dopaminergic neuron damage in a Parkinson disease mouse model. Free radical biology & medicine. vol 41. issue 7. 2007-02-16. PMID:16962931. |
parkinson disease (pd) is a common neurodegenerative disorder characterized by the progressive loss of dopaminergic neurons in the substantia nigra (sn). |
2007-02-16 |
2023-08-12 |
mouse |
| Javorina Milosevic, Martina Maisel, Florian Wegner, Julia Leuchtenberger, Roland H Wenger, Manfred Gerlach, Alexander Storch, Johannes Schwar. Lack of hypoxia-inducible factor-1 alpha impairs midbrain neural precursor cells involving vascular endothelial growth factor signaling. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 27. issue 2. 2007-02-02. PMID:17215402. |
in substantia nigra (sn) of adult hif-1alpha cko mice, protein levels of dopaminergic marker molecules such as tyrosine hydroxylase (th) and aldehyde dehydrogenase were reduced by 41 and 61%, respectively. |
2007-02-02 |
2023-08-12 |
mouse |
| James E Galvi. Interaction of alpha-synuclein and dopamine metabolites in the pathogenesis of Parkinson's disease: a case for the selective vulnerability of the substantia nigra. Acta neuropathologica. vol 112. issue 2. 2007-02-01. PMID:16791599. |
major disease symptoms are due to the loss of dopaminergic (da) neurons in substantia nigra (sn). |
2007-02-01 |
2023-08-12 |
mouse |
| V Sava, O Reunova, A Velasquez, R Harbison, J Sánchez-Ramo. Acute neurotoxic effects of the fungal metabolite ochratoxin-A. Neurotoxicology. vol 27. issue 1. 2007-01-30. PMID:16140385. |
a single dose of 3.5 mg/kg decreased the intensity of tyrosine hydroxylase immunoreactivity (th(+)) in fibers of striatum, th(+) cells in substantia nigra (sn) and th(+) cells of the locus ceruleus. |
2007-01-30 |
2023-08-12 |
mouse |
| C A Frye, M E Rhode. Infusions of 5alpha-pregnan-3alpha-ol-20-one (3alpha,5alpha-THP) to the ventral tegmental area, but not the substantia nigra, enhance exploratory, anti-anxiety, social and sexual behaviours and concomitantly increase 3alpha,5alpha-THP concentrations in the hippocampus, diencephalon and cortex of ovariectomised oestrogen-primed rats. Journal of neuroendocrinology. vol 18. issue 12. 2007-01-30. PMID:17076771. |
we investigated the effects of 3alpha,5alpha-thp infusions to the vta, and a control site, the substantia nigra (sn), on exploratory, anti-anxiety, social and sexual behaviours (socio-sexual behaviours) and hormone levels in the midbrain and other regions (hippocampus, diencephalon and cortex) that may mediate these functions. |
2007-01-30 |
2023-08-12 |
rat |
| Andrzej Friedman, Jolanta Galazka-Friedman, Erika R Bauminger, Dariusz Koziorowsk. Iron and ferritin in hippocampal cortex and substantia nigra in human brain--implications for the possible role of iron in dementia. Journal of the neurological sciences. vol 248. issue 1-2. 2007-01-23. PMID:16797029. |
the concentrations of iron and of ferritin, the main iron-binding compound in the brain, as well as the sizes of the iron cores of ferritin were assessed in hippocampal cortex (hip) and substantia nigra (sn) from human control brains, using mössbauer spectroscopy (ms), elisa and electron microscopy. |
2007-01-23 |
2023-08-12 |
human |
| L Li, Y Su, C Zhao, H Zhao, G Liu, J Wang, Q X. The role of Ret receptor tyrosine kinase in dopaminergic neuron development. Neuroscience. vol 142. issue 2. 2007-01-23. PMID:16879925. |
additionally, some da neurons in the substantia nigra (sn) underwent apoptotic cell death following the ret-as-odn treatment. |
2007-01-23 |
2023-08-12 |
rat |
| Joanna Iczkiewicz, Michael J Jackson, Lance A Smith, Sarah Rose, Peter Jenne. Osteopontin expression in substantia nigra in MPTP-treated primates and in Parkinson's disease. Brain research. vol 1118. issue 1. 2007-01-23. PMID:16962083. |
parkinson's disease (pd) is characterised by the loss of dopaminergic neurones in the substantia nigra (sn) but the pathogenic mechanism remains unknown. |
2007-01-23 |
2023-08-12 |
human |
| Sung Jae Kim, Sung Yul Kim, Young-Soon Na, Hyun Jung Lee, Kwang Chul Chung, Ja-Hyun Bai. Alpha-synuclein enhances dopamine D2 receptor signaling. Brain research. vol 1124. issue 1. 2007-01-23. PMID:17087919. |
parkinson's disease (pd) is characterized by a selective loss of dopamine-producing neurons in the substantia nigra (sn), which in turn results in dopamine depletion in the striatum, and the presence of neuronal cytoplasmic inclusions known as lewy bodies (lbs). |
2007-01-23 |
2023-08-12 |
Not clear |
| Xiaoyang Shan, Liying Chi, Michael Bishop, Chun Luo, Lindsey Lien, Zheng Zhang, Rugao Li. Enhanced de novo neurogenesis and dopaminergic neurogenesis in the substantia nigra of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced Parkinson's disease-like mice. Stem cells (Dayton, Ohio). vol 24. issue 5. 2007-01-18. PMID:16424396. |
research reports on de novo neurogenesis, particularly dopaminergic (da) neurogenesis in the adult mammalian substantia nigra (sn), remain very controversial. |
2007-01-18 |
2023-08-12 |
mouse |
| D C Duke, L B Moran, M E Kalaitzakis, M Deprez, D T Dexter, R K B Pearce, M B Graebe. Transcriptome analysis reveals link between proteasomal and mitochondrial pathways in Parkinson's disease. Neurogenetics. vol 7. issue 3. 2007-01-12. PMID:16699787. |
we examined gene expression in medial and lateral substantia nigra (sn) as well as in frontal cortex using whole genome dna oligonucleotide microarrays. |
2007-01-12 |
2023-08-12 |
Not clear |
| Supriti Samantaray, Swapan K Ray, Syed F Ali, Naren L Bani. Calpain activation in apoptosis of motoneurons in cell culture models of experimental parkinsonism. Annals of the New York Academy of Sciences. vol 1074. 2007-01-10. PMID:17105932. |
parkinson's disease (pd) is a movement disorder characterized by progressive degeneration of primarily the dopaminergic neurons in the substantia nigra (sn). |
2007-01-10 |
2023-08-12 |
Not clear |
| Trond Myhrer, Nga H T Nguyen, Siri Enger, Pål Aa. Anticonvulsant effects of GABA(A) modulators microinfused into area tempestas or substantia nigra in rats exposed to soman. Archives of toxicology. vol 80. issue 8. 2006-12-14. PMID:16525814. |
in the present study, gaba(a) modulating drugs (1 microl) were microinfused bilaterally into the seizure controlling substrates, substantia nigra (sn) or area tempestas (at), of rats subjected to seizures induced systemically by soman (100 microg/kg). |
2006-12-14 |
2023-08-12 |
rat |