| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| D Ber. Transcranial sonography in the early and differential diagnosis of Parkinson's disease. Journal of neural transmission. Supplementum. issue 70. 2006-10-24. PMID:17017537. |
using tcs, our group discovered changes of the echotexture--namely increased echogenicity--at the substantia nigra (sn) in about 90% of patients with parkinson's disease (pd). |
2006-10-24 |
2023-08-12 |
human |
| H Mochizuki, M Yamada, Y Mizun. Alpha-synuclein overexpression model. Journal of neural transmission. Supplementum. issue 70. 2006-10-24. PMID:17017543. |
to elucidate the role of alpha-synuclein in the pathogenesis of parkinson's disease (pd), both human alpha-synuclein transgenic mice and targeted overexpression of human alpha-synuclein in rat substantia nigra (sn) by viral vector-based methods have been studied, however little is known about the pathogenetic changes of dopaminergic neuron loss. |
2006-10-24 |
2023-08-12 |
mouse |
| M Sawada, K Imamura, T Nagats. Role of cytokines in inflammatory process in Parkinson's disease. Journal of neural transmission. Supplementum. issue 70. 2006-10-24. PMID:17017556. |
we investigated whether the cytokines produced in activated microglia in the substantia nigra (sn) and putamen in sporadic parkinson's disease (pd) are neuroprotective or neurotoxic. |
2006-10-24 |
2023-08-12 |
mouse |
| M J Zigmon. Triggering endogenous neuroprotective mechanisms in Parkinson's disease: studies with a cellular model. Journal of neural transmission. Supplementum. issue 70. 2006-10-24. PMID:17017565. |
we have now shown that gdnf can also protect against the effects of 6-hydroxydopamine (6-ohda) in a dopaminergic cell line and in cultures of primary da neurons prepared from rat substantia nigra (sn). |
2006-10-24 |
2023-08-12 |
rat |
| Marcelo de Meira Santos Lima, Angela Braga Reksidler, Sílvio Marques Zanata, Hidevaldo Bueno Machado, Sergio Tufik, Maria A B F Vita. Different parkinsonism models produce a time-dependent induction of COX-2 in the substantia nigra of rats. Brain research. vol 1101. issue 1. 2006-09-19. PMID:16781689. |
results indicate that lps produced an increase in locomotion frequency (3 and 7 days after surgery) and a strong up-regulation of cox-2 protein 16 and 24 h after surgery, as observed in the substantia nigra (sn). |
2006-09-19 |
2023-08-12 |
rat |
| Fumiaki Mori, Makoto Nishie, Akiyoshi Kakita, Makoto Yoshimoto, Hitoshi Takahashi, Koichi Wakabayash. Relationship among alpha-synuclein accumulation, dopamine synthesis, and neurodegeneration in Parkinson disease substantia nigra. Journal of neuropathology and experimental neurology. vol 65. issue 8. 2006-09-15. PMID:16896314. |
the histologic hallmark of parkinson disease (pd) is loss of pigmented neurons in the substantia nigra (sn) and locus ceruleus (lc) with accumulation of alpha-synuclein (alphas). |
2006-09-15 |
2023-08-12 |
human |
| Tae-Beom Ahn, Beom S Jeo. Protective role of heat shock and heat shock protein 70 in lactacystin-induced cell death both in the rat substantia nigra and PC12 cells. Brain research. vol 1087. issue 1. 2006-08-25. PMID:16626658. |
in in vivo study, we infused lactacystin into the unilateral substantia nigra (sn) of sprague-dawley rats with or without preceding whole body hyperthermia (wbh). |
2006-08-25 |
2023-08-12 |
rat |
| Karuppagounder S Saravanan, Kizhakke M Sindhu, Karuppagounder S Senthilkumar, Kochupurackal P Mohanakuma. L-deprenyl protects against rotenone-induced, oxidative stress-mediated dopaminergic neurodegeneration in rats. Neurochemistry international. vol 49. issue 1. 2006-08-24. PMID:16490285. |
unilateral stereotaxic intranigral infusion of rotenone caused significant decrease of striatal dopamine levels as measured employing hplc-electrochemistry, and loss of tyrosine hydroxylase immunoreactivity in the perikarya of ipsilateral substantia nigra (sn) neurons and their terminals in the striatum. |
2006-08-24 |
2023-08-12 |
rat |
| Aideen M Sullivan, Gerard W O'Keeff. The role of growth/differentiation factor 5 (GDF5) in the induction and survival of midbrain dopaminergic neurones: relevance to Parkinson's disease treatment. Journal of anatomy. vol 207. issue 3. 2006-08-21. PMID:16185246. |
gdf5 is under investigation as a potential therapeutic agent for parkinson's disease (pd), which is caused by the progressive degeneration of dopaminergic neurones projecting from the substantia nigra (sn) to the striatum. |
2006-08-21 |
2023-08-12 |
rat |
| Gustavo R Morel, Oscar A Brown, Paula C Reggiani, Claudia B Hereñú, Enrique L Portiansky, Gustavo O Zuccolilli, Jean M Pléau, Mireille Dardenne, Rodolfo G Goy. Peripheral and mesencephalic transfer of a synthetic gene for the thymic peptide thymulin. Brain research bulletin. vol 69. issue 6. 2006-08-04. PMID:16716832. |
reporter gene expression in the substantia nigra (sn) was quantitated by enzymohistochemistry or fluorescence microscopy using an appropriate image analysis software. |
2006-08-04 |
2023-08-12 |
rat |
| Paola Tortorella, Maria A Rocca, Bruno Colombo, Pietro Annovazzi, Giancarlo Comi, Massimo Filipp. Assessment of MRI abnormalities of the brainstem from patients with migraine and multiple sclerosis. Journal of the neurological sciences. vol 244. issue 1-2. 2006-07-28. PMID:16530789. |
in patients with migraine, functional changes have been described in the red nucleus (rn), substantia nigra (sn) and periaqueductal gray matter (pag). |
2006-07-28 |
2023-08-12 |
Not clear |
| Theo Hatzipetros, Bryan K Yamamot. Dopaminergic and GABAergic modulation of glutamate release from rat subthalamic nucleus efferents to the substantia nigra. Brain research. vol 1076. issue 1. 2006-07-25. PMID:16680828. |
the regulation of the glutamatergic projection from the subthalamic nucleus (stn) to the substantia nigra (sn) was investigated using dual-probe microdialysis in the awake behaving rat. |
2006-07-25 |
2023-08-12 |
rat |
| José García Dopico, Tomás González-Hernández, Ingrid Morales Pérez, Isabel Gómez García, Antonio Milena Abril, José Obeso Inchausti, Manuel Rodríguez Día. Glycine release in the substantia nigra: Interaction with glutamate and GABA. Neuropharmacology. vol 50. issue 5. 2006-07-06. PMID:16337663. |
previous studies have reported a high number of glycine (gly) receptors in the substantia nigra (sn) but a low number of gly-neurons, suggesting that taurine, a partial agonist of gly-receptors, is the natural substrate for sn gly-receptors. |
2006-07-06 |
2023-08-12 |
rat |
| Takao Yagi, Byoung Boo Seo, Eiko Nakamaru-Ogiso, Mathieu Marella, Jennifer Barber-Singh, Tetsuo Yamashita, Mou-Chieh Kao, Akemi Matsuno-Yag. Can a single subunit yeast NADH dehydrogenase (Ndi1) remedy diseases caused by respiratory complex I defects? Rejuvenation research. vol 9. issue 2. 2006-07-06. PMID:16706641. |
the ndi1 protein expressed in the substantia nigra (sn) elicited protective effects against neurodegeneration caused by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine treatment. |
2006-07-06 |
2023-08-12 |
human |
| Katherine J Schweitzer, Rüdiger Hilker, Uwe Walter, Lothar Burghaus, Daniela Ber. Substantia nigra hyperechogenicity as a marker of predisposition and slower progression in Parkinson's disease. Movement disorders : official journal of the Movement Disorder Society. vol 21. issue 1. 2006-07-03. PMID:16114024. |
increased echogenic size (hyperechogenicity) of the substantia nigra (sn) is a characteristic transcranial sonography finding in patients with parkinson's disease (pd). |
2006-07-03 |
2023-08-12 |
Not clear |
| M E Olds, D B Jacques, O Kopyo. Relation between rotation in the 6-OHDA lesioned rat and dopamine loss in striatal and substantia nigra subregions. Synapse (New York, N.Y.). vol 59. issue 8. 2006-06-16. PMID:16565974. |
the relation between the rotation response to drug-induced activation of the dopamine (da) receptor in the rat unilaterally lesioned with 6-hydroxydopamine (6-ohda) in the substantia nigra (sn) and the loss of da in subregions of the sn and caudate-putamen (c/put) is not clear. |
2006-06-16 |
2023-08-12 |
rat |
| Jörg Spiegel, Dirk Hellwig, Marc-Oliver Möllers, Stefanie Behnke, Wolfgang Jost, Klaus Fassbender, Samuel Samnick, Ulrich Dillmann, Georg Becker, Carl-Martin Kirsc. Transcranial sonography and [123I]FP-CIT SPECT disclose complementary aspects of Parkinson's disease. Brain : a journal of neurology. vol 129. issue Pt 5. 2006-05-31. PMID:16513685. |
hyperechogenic signal of substantia nigra (sn) in transcranial sonography (tcs) and reduced striatal uptake in fp-cit spect are common findings in idiopathic parkinson's disease (pd). |
2006-05-31 |
2023-08-12 |
Not clear |
| S Zechel, J Jarosik, I Kiprianova, A Schober, K Unsicker, O von Bohlen und Halbac. FGF-2 deficiency does not alter vulnerability of the dopaminergic nigrostriatal system towards MPTP intoxication in mice. The European journal of neuroscience. vol 23. issue 6. 2006-05-30. PMID:16553632. |
to address the putative physiological relevance of endogenous fgf-2 for midbrain dopaminergic neurons, we have analysed densities of tyrosine hydroxylase (th)-positive cells in the substantia nigra (sn) and th-positive fibers in the striatum and amygdala of adult fgf-2-deficient mice. |
2006-05-30 |
2023-08-12 |
mouse |
| B-Y Zeng, M M Iravani, S-T Lin, M Irifune, M Kuoppamäki, G Al-Barghouthy, L Smith, M J Jackson, S Rose, A D Medhurst, P Jenne. MPTP treatment of common marmosets impairs proteasomal enzyme activity and decreases expression of structural and regulatory elements of the 26S proteasome. The European journal of neuroscience. vol 23. issue 7. 2006-05-30. PMID:16623833. |
dysfunction of the ubiquitin-proteasome system occurs in the substantia nigra (sn) in parkinson's disease (pd). |
2006-05-30 |
2023-08-12 |
marmoset |
| Martine Barkats, Philippe Horellou, Philippe Colin, Stéphanie Millecamps, Nicole Faucon-Biguet, Jacques Malle. 1-methyl-4-phenylpyridinium neurotoxicity is attenuated by adenoviral gene transfer of human Cu/Zn superoxide dismutase. Journal of neuroscience research. vol 83. issue 2. 2006-05-25. PMID:16353238. |
we investigated the neuroprotective potential of cu/zn superoxide dismutase (sod1) overexpression in the rat substantia nigra (sn) following adenovirus-mediated gene transfer. |
2006-05-25 |
2023-08-12 |
human |