| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Joanna Chwiej, Dariusz Adamek, Magdalena Szczerbowska-Boruchowska, Anna Krygowska-Wajs, Slawomir Wojcik, Gerald Falkenberg, Anna Manka, Marek Lankos. Investigations of differences in iron oxidation state inside single neurons from substantia nigra of Parkinson's disease and control patients using the micro-XANES technique. Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry. vol 12. issue 2. 2007-04-10. PMID:17120075. |
x-ray absorption near edge structure spectroscopy was applied in order to investigate differences in iron chemical state between the nerve cells of substantia nigra (sn) representing parkinson's disease (pd) and those of control cases. |
2007-04-10 |
2023-08-12 |
Not clear |
| Uwe Walter, Dirk Dressler, Alexander Wolters, Matthias Wittstock, Reiner Beneck. Transcranial brain sonography findings in clinical subgroups of idiopathic Parkinson's disease. Movement disorders : official journal of the Movement Disorder Society. vol 22. issue 1. 2007-04-05. PMID:17083096. |
substantia nigra (sn) hyperechogenicity was found in 96% of assessable patients. |
2007-04-05 |
2023-08-12 |
Not clear |
| Hong Qu Yan, Xiecheng Ma, Xiangbai Chen, Youming Li, Lifang Shao, C Edward Dixo. Delayed increase of tyrosine hydroxylase expression in rat nigrostriatal system after traumatic brain injury. Brain research. vol 1134. issue 1. 2007-04-05. PMID:17196177. |
injured (n=6) and sham animals (n=6) were sacrificed and coronally sectioned (35 microm thick) through the striatum and substantia nigra (sn) for immunohistochemistry. |
2007-04-05 |
2023-08-12 |
rat |
| Kazuhiko Nakadate, Takahiro Noda, Shin-Ichi Sakakibara, Kenzo Kumamoto, Tadao Matsuura, Jeffery N Joyce, Shuichi Ued. Progressive dopaminergic neurodegeneration of substantia nigra in the zitter mutant rat. Acta neuropathologica. vol 112. issue 1. 2007-03-29. PMID:16609850. |
zitter mutant rats exhibit abnormal metabolism of superoxide species and demonstrate progressive degeneration of dopamine (da) neurons in the substantia nigra (sn). |
2007-03-29 |
2023-08-12 |
rat |
| S Dey, C F Mactutus, R M Booze, D M Sno. Cocaine exposure in vitro induces apoptosis in fetal locus coeruleus neurons by altering the Bax/Bcl-2 ratio and through caspase-3 apoptotic signaling. Neuroscience. vol 144. issue 2. 2007-03-28. PMID:17084983. |
dissociated fetal lc neurons or substantia nigra (sn) neurons (control) were exposed in vitro to a pharmacologically active dose of cocaine hydrochloride (500 ng/ml) and assayed for apoptosis using terminal deoxynucleotidyl transferase mediated dna nick end labeling and hoechst methodologies. |
2007-03-28 |
2023-08-12 |
rat |
| Diane Stephenson, Andres Ramirez, Jill Long, Nestor Barrezueta, Eva Hajos-Korcsok, Curt Matherne, Dan Gallagher, Anne Ryan, Ricardo Ochoa, Frank Menniti, James Ya. Quantification of MPTP-induced dopaminergic neurodegeneration in the mouse substantia nigra by laser capture microdissection. Journal of neuroscience methods. vol 159. issue 2. 2007-03-27. PMID:16949674. |
this reduction corresponded to decreases in striatal dopamine and loss of immunocytochemically detected th but not beta-actin in the substantia nigra (sn). |
2007-03-27 |
2023-08-12 |
mouse |
| Jana Godau, Katherine J Schweitzer, Inga Liepelt, Christian Gerloff, Daniela Ber. Substantia nigra hypoechogenicity: definition and findings in restless legs syndrome. Movement disorders : official journal of the Movement Disorder Society. vol 22. issue 2. 2007-03-23. PMID:17133515. |
pathological studies demonstrate a decreased iron content in the substantia nigra (sn) contributing to the pathophysiology of restless legs syndrome (rls). |
2007-03-23 |
2023-08-12 |
Not clear |
| V Sava, O Reunova, A Velasquez, S Song, J Sanchez-Ramo. Neuroanatomical mapping of DNA repair and antioxidative responses in mouse brain: Effects of a single dose of MPTP. Neurotoxicology. vol 27. issue 6. 2007-03-21. PMID:16831462. |
in some sampled loci, notably the substantia nigra (sn) and hippocampus, the heightened dna repair and antioxidant responses were not maintained beyond 48h. |
2007-03-21 |
2023-08-12 |
mouse |
| Oliver Biehlmaier, Mesbah Alam, Werner J Schmid. A rat model of Parkinsonism shows depletion of dopamine in the retina. Neurochemistry international. vol 50. issue 1. 2007-03-20. PMID:16962686. |
neurochemically, rotenone treated rats showed a depletion of da in the striatum and substantia nigra (sn). |
2007-03-20 |
2023-08-12 |
rat |
| Liya Qin, Xuefei Wu, Michelle L Block, Yuxin Liu, George R Breese, Jau-Shyong Hong, Darin J Knapp, Fulton T Crew. Systemic LPS causes chronic neuroinflammation and progressive neurodegeneration. Glia. vol 55. issue 5. 2007-03-20. PMID:17203472. |
further, lps reduced the number of tyrosine hydroxylase-immunoreactive neurons in the substantia nigra (sn) by 23% at 7-months post-treatment, which progressed to 47% at 10 months. |
2007-03-20 |
2023-08-12 |
mouse |
| Laure Sonnier, Gwenaëlle Le Pen, Andreas Hartmann, Jean-Charles Bizot, Fabrice Trovero, Marie-Odile Krebs, Alain Prochiant. Progressive loss of dopaminergic neurons in the ventral midbrain of adult mice heterozygote for Engrailed1. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 27. issue 5. 2007-03-16. PMID:17267560. |
en1 and, to a lesser degree, en2 also are expressed in the adult substantia nigra (sn) and ventral tegmental area (vta), two dopaminergic (da) nuclei of the ventral midbrain. |
2007-03-16 |
2023-08-12 |
mouse |
| Jun Mo Kang, Hi Joon Park, Yeong Gon Choi, Il Hwan Choe, Jae Hyun Park, Yong Sik Kim, Sabina Li. Acupuncture inhibits microglial activation and inflammatory events in the MPTP-induced mouse model. Brain research. vol 1131. issue 1. 2007-03-09. PMID:17173870. |
these experiments demonstrated that acupuncture inhibited the decreased of the tyrosine hydroxylase (th) immunoreactivity (ir) and generated a neuroprotective effects in the striatum (st) and the substantia nigra (sn) on days 1, 3, and 7 post-mptp injections. |
2007-03-09 |
2023-08-12 |
mouse |
| Elisabetta Baldi, Chiara Mariottini, Corrado Bucherell. Substantia nigra role in fear conditioning consolidation. Neurobiology of learning and memory. vol 87. issue 1. 2007-02-22. PMID:16978887. |
the substantia nigra (sn) is known to be involved in the memorization of several conditioned responses. |
2007-02-22 |
2023-08-12 |
rat |
| Hee Soon Choi, Jae Jin An, So Young Kim, Sun Hwa Lee, Dae Won Kim, Ki-Yeon Yoo, Moo Ho Won, Tae-Cheon Kang, Hyung Joo Kwon, Jung Hoon Kang, Sung-Woo Cho, Oh-Shin Kwon, Jinseu Park, Won Sik Eum, Soo Young Cho. PEP-1-SOD fusion protein efficiently protects against paraquat-induced dopaminergic neuron damage in a Parkinson disease mouse model. Free radical biology & medicine. vol 41. issue 7. 2007-02-16. PMID:16962931. |
parkinson disease (pd) is a common neurodegenerative disorder characterized by the progressive loss of dopaminergic neurons in the substantia nigra (sn). |
2007-02-16 |
2023-08-12 |
mouse |
| Javorina Milosevic, Martina Maisel, Florian Wegner, Julia Leuchtenberger, Roland H Wenger, Manfred Gerlach, Alexander Storch, Johannes Schwar. Lack of hypoxia-inducible factor-1 alpha impairs midbrain neural precursor cells involving vascular endothelial growth factor signaling. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 27. issue 2. 2007-02-02. PMID:17215402. |
in substantia nigra (sn) of adult hif-1alpha cko mice, protein levels of dopaminergic marker molecules such as tyrosine hydroxylase (th) and aldehyde dehydrogenase were reduced by 41 and 61%, respectively. |
2007-02-02 |
2023-08-12 |
mouse |
| James E Galvi. Interaction of alpha-synuclein and dopamine metabolites in the pathogenesis of Parkinson's disease: a case for the selective vulnerability of the substantia nigra. Acta neuropathologica. vol 112. issue 2. 2007-02-01. PMID:16791599. |
major disease symptoms are due to the loss of dopaminergic (da) neurons in substantia nigra (sn). |
2007-02-01 |
2023-08-12 |
mouse |
| V Sava, O Reunova, A Velasquez, R Harbison, J Sánchez-Ramo. Acute neurotoxic effects of the fungal metabolite ochratoxin-A. Neurotoxicology. vol 27. issue 1. 2007-01-30. PMID:16140385. |
a single dose of 3.5 mg/kg decreased the intensity of tyrosine hydroxylase immunoreactivity (th(+)) in fibers of striatum, th(+) cells in substantia nigra (sn) and th(+) cells of the locus ceruleus. |
2007-01-30 |
2023-08-12 |
mouse |
| C A Frye, M E Rhode. Infusions of 5alpha-pregnan-3alpha-ol-20-one (3alpha,5alpha-THP) to the ventral tegmental area, but not the substantia nigra, enhance exploratory, anti-anxiety, social and sexual behaviours and concomitantly increase 3alpha,5alpha-THP concentrations in the hippocampus, diencephalon and cortex of ovariectomised oestrogen-primed rats. Journal of neuroendocrinology. vol 18. issue 12. 2007-01-30. PMID:17076771. |
we investigated the effects of 3alpha,5alpha-thp infusions to the vta, and a control site, the substantia nigra (sn), on exploratory, anti-anxiety, social and sexual behaviours (socio-sexual behaviours) and hormone levels in the midbrain and other regions (hippocampus, diencephalon and cortex) that may mediate these functions. |
2007-01-30 |
2023-08-12 |
rat |
| Andrzej Friedman, Jolanta Galazka-Friedman, Erika R Bauminger, Dariusz Koziorowsk. Iron and ferritin in hippocampal cortex and substantia nigra in human brain--implications for the possible role of iron in dementia. Journal of the neurological sciences. vol 248. issue 1-2. 2007-01-23. PMID:16797029. |
the concentrations of iron and of ferritin, the main iron-binding compound in the brain, as well as the sizes of the iron cores of ferritin were assessed in hippocampal cortex (hip) and substantia nigra (sn) from human control brains, using mössbauer spectroscopy (ms), elisa and electron microscopy. |
2007-01-23 |
2023-08-12 |
human |
| L Li, Y Su, C Zhao, H Zhao, G Liu, J Wang, Q X. The role of Ret receptor tyrosine kinase in dopaminergic neuron development. Neuroscience. vol 142. issue 2. 2007-01-23. PMID:16879925. |
additionally, some da neurons in the substantia nigra (sn) underwent apoptotic cell death following the ret-as-odn treatment. |
2007-01-23 |
2023-08-12 |
rat |