| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Tiziana Florio, Eugenio Scarnati, Giuseppina Confalone, Daniela Minchella, Salvatore Galati, Paolo Stanzione, Alessandro Stefani, Paolo Mazzon. High-frequency stimulation of the subthalamic nucleus modulates the activity of pedunculopontine neurons through direct activation of excitatory fibres as well as through indirect activation of inhibitory pallidal fibres in the rat. The European journal of neuroscience. vol 25. issue 4. 2007-05-17. PMID:17331213. |
because the ppn receives fibres from the subthalamic nucleus (stn), we investigated the effects of stn-high-frequency stimulation (hfs) on ppn neuronal activity in intact rats and in rats bearing either an ibotenate lesion of the entopeduncular nucleus (ep) or a lesion of the substantia nigra (sn). |
2007-05-17 |
2023-08-12 |
rat |
| E Sofic, A Sapcanin, I Tahirovic, I Gavrankapetanovic, K Jellinger, G P Reynolds, T Tatschner, P Riedere. Antioxidant capacity in postmortem brain tissues of Parkinson's and Alzheimer's diseases. Journal of neural transmission. Supplementum. issue 71. 2007-05-17. PMID:17447414. |
the aim of this study was to investigate the antioxidant capacity in postmortem motor cortex (mc), nucleus caudatus (nc), gyrus temporalis (gt) and substantia nigra (sn) from controls (c) and patients with pd and ad. |
2007-05-17 |
2023-08-12 |
human |
| J Salazar, N Mena, M T Núñe. Iron dyshomeostasis in Parkinson's disease. Journal of neural transmission. Supplementum. issue 71. 2007-05-17. PMID:17447431. |
the work of youdim and collaborators has been fundamental in describing the accumulation of iron confined to the substantia nigra (sn) in parkinson's disease (pd) and to clarify iron toxicity pathways and oxidative damage in dopaminergic neurons. |
2007-05-17 |
2023-08-12 |
Not clear |
| Wei-Guo Liu, Guo-Qiang Lu, Biao Li, Sheng-Di Che. Dopaminergic neuroprotection by neurturin-expressing c17.2 neural stem cells in a rat model of Parkinson's disease. Parkinsonism & related disorders. vol 13. issue 2. 2007-05-15. PMID:16963309. |
in addition, inverse transfer of ntn protein into the substantia nigra (sn) was able to protect dopaminergic neurons from 6-ohda toxicity. |
2007-05-15 |
2023-08-12 |
rat |
| F Tribl, K Marcus, H E Meyer, G Bringmann, M Gerlach, P Riedere. Subcellular proteomics reveals neuromelanin granules to be a lysosome-related organelle. Journal of neural transmission (Vienna, Austria : 1996). vol 113. issue 6. 2007-05-08. PMID:16755378. |
nm granules are pigmented organelles, which are mainly found in the catecholaminergic neurons of the human substantia nigra (sn) pars compacta and the locus coeruleus. |
2007-05-08 |
2023-08-12 |
human |
| F A Zucca, C Bellei, S Giannelli, M R Terreni, M Gallorini, E Rizzio, G Pezzoli, A Albertini, L Zecc. Neuromelanin and iron in human locus coeruleus and substantia nigra during aging: consequences for neuronal vulnerability. Journal of neural transmission (Vienna, Austria : 1996). vol 113. issue 6. 2007-05-08. PMID:16755380. |
in this study a comparative analysis of iron molecules during aging was performed in locus coeruleus (lc) and substantia nigra (sn), known targets of parkinson's disease (pd) and related disorders. |
2007-05-08 |
2023-08-12 |
human |
| D Ber. In vivo detection of iron and neuromelanin by transcranial sonography--a new approach for early detection of substantia nigra damage. Journal of neural transmission (Vienna, Austria : 1996). vol 113. issue 6. 2007-05-08. PMID:16755382. |
in more than 90% of patients with idiopathic parkinson's disease (pd) hyperechogenicity of the substantia nigra (sn) can be found by transcranial sonography (tcs) as a typical, stable sign. |
2007-05-08 |
2023-08-12 |
human |
| Chaohui Zhao, Zaodung Ling, Mary B Newman, Ankush Bhatia, Paul M Carve. TNF-alpha knockout and minocycline treatment attenuates blood-brain barrier leakage in MPTP-treated mice. Neurobiology of disease. vol 26. issue 1. 2007-05-08. PMID:17234424. |
following intraparenchymal injection of the dopamine (da) neurotoxin 6-hydroxydopamine, we previously demonstrated passage of fluoresceinisothiocyanate-labeled albumin (fitc-la) from blood into the substantia nigra (sn) and striatum suggesting damage to the blood-brain barrier (bbb). |
2007-05-08 |
2023-08-12 |
mouse |
| Shalom Michaeli, Gülin Oz, Dennis J Sorce, Michael Garwood, Kamil Ugurbil, Stacy Majestic, Paul Tuit. Assessment of brain iron and neuronal integrity in patients with Parkinson's disease using novel MRI contrasts. Movement disorders : official journal of the Movement Disorder Society. vol 22. issue 3. 2007-05-01. PMID:17149719. |
postmortem demonstration of increased iron in the substantia nigra (sn) is a well-appreciated finding in parkinson's disease (pd). |
2007-05-01 |
2023-08-12 |
human |
| Heike Stockner, Martin Sojer, Klaus Seppi K, Joerg Mueller, Gregor K Wenning, Christoph Schmidauer, Werner Poew. Midbrain sonography in patients with essential tremor. Movement disorders : official journal of the Movement Disorder Society. vol 22. issue 3. 2007-05-01. PMID:17226854. |
hyperechogenicity of the substantia nigra (sn) is a common transcranial sonography (tcs) finding in pd and has been suggested as a pd risk-marker in nonparkinsonian subjects. |
2007-05-01 |
2023-08-12 |
human |
| Jeong-Min Kim, Kyu-Hwa Lee, Yeo-Jin Jeon, Jung-Hwa Oh, So-Young Jeong, In-Sung Song, Jin-Man Kim, Dong-Seok Lee, Nam-Soon Ki. Identification of genes related to Parkinson's disease using expressed sequence tags. DNA research : an international journal for rapid publication of reports on genes and genomes. vol 13. issue 6. 2007-04-26. PMID:17213182. |
in a search for novel target genes related to parkinson's disease (pd), two full-length cdna libraries were constructed from a human normal substantia nigra (sn) and a pd patient's sn. |
2007-04-26 |
2023-08-12 |
mouse |
| B F Boeve, D W Dickson, E J Olson, J W Shepard, M H Silber, T J Ferman, J E Ahlskog, E E Benarroc. Insights into REM sleep behavior disorder pathophysiology in brainstem-predominant Lewy body disease. Sleep medicine. vol 8. issue 1. 2007-04-20. PMID:17157062. |
due to the severe neuronal loss and gliosis in the substantia nigra (sn) and locus ceruleus (lc) in this case, degeneration of brainstem monoaminergic neurons was postulated as the underlying substrate for rbd. |
2007-04-20 |
2023-08-12 |
human |
| S Urakawa, H Hida, T Masuda, S Misumi, T-S Kim, H Nishin. Environmental enrichment brings a beneficial effect on beam walking and enhances the migration of doublecortin-positive cells following striatal lesions in rats. Neuroscience. vol 144. issue 3. 2007-04-11. PMID:17161913. |
striatal damage was induced at an age of 8 weeks by injection of the neuro-toxins 6-hydroxydopamine (6-ohda) or quinolinic acid (qa) into the striatum, or by injection of 6-ohda into the substantia nigra (sn), which depleted nigrostriatal dopaminergic innervation. |
2007-04-11 |
2023-08-12 |
rat |
| T M Korotkova, B P Klyuch, A A Ponomarenko, J S Lin, H L Haas, O A Sergeev. Modafinil inhibits rat midbrain dopaminergic neurons through D2-like receptors. Neuropharmacology. vol 52. issue 2. 2007-04-10. PMID:17070873. |
we investigated the modafinil action on identified dopaminergic and gabaergic neurons in the ventral tegmental area (vta) and substantia nigra (sn) of rat brain slices. |
2007-04-10 |
2023-08-12 |
rat |
| Joanna Chwiej, Dariusz Adamek, Magdalena Szczerbowska-Boruchowska, Anna Krygowska-Wajs, Slawomir Wojcik, Gerald Falkenberg, Anna Manka, Marek Lankos. Investigations of differences in iron oxidation state inside single neurons from substantia nigra of Parkinson's disease and control patients using the micro-XANES technique. Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry. vol 12. issue 2. 2007-04-10. PMID:17120075. |
x-ray absorption near edge structure spectroscopy was applied in order to investigate differences in iron chemical state between the nerve cells of substantia nigra (sn) representing parkinson's disease (pd) and those of control cases. |
2007-04-10 |
2023-08-12 |
Not clear |
| Uwe Walter, Dirk Dressler, Alexander Wolters, Matthias Wittstock, Reiner Beneck. Transcranial brain sonography findings in clinical subgroups of idiopathic Parkinson's disease. Movement disorders : official journal of the Movement Disorder Society. vol 22. issue 1. 2007-04-05. PMID:17083096. |
substantia nigra (sn) hyperechogenicity was found in 96% of assessable patients. |
2007-04-05 |
2023-08-12 |
Not clear |
| Hong Qu Yan, Xiecheng Ma, Xiangbai Chen, Youming Li, Lifang Shao, C Edward Dixo. Delayed increase of tyrosine hydroxylase expression in rat nigrostriatal system after traumatic brain injury. Brain research. vol 1134. issue 1. 2007-04-05. PMID:17196177. |
injured (n=6) and sham animals (n=6) were sacrificed and coronally sectioned (35 microm thick) through the striatum and substantia nigra (sn) for immunohistochemistry. |
2007-04-05 |
2023-08-12 |
rat |
| Kazuhiko Nakadate, Takahiro Noda, Shin-Ichi Sakakibara, Kenzo Kumamoto, Tadao Matsuura, Jeffery N Joyce, Shuichi Ued. Progressive dopaminergic neurodegeneration of substantia nigra in the zitter mutant rat. Acta neuropathologica. vol 112. issue 1. 2007-03-29. PMID:16609850. |
zitter mutant rats exhibit abnormal metabolism of superoxide species and demonstrate progressive degeneration of dopamine (da) neurons in the substantia nigra (sn). |
2007-03-29 |
2023-08-12 |
rat |
| S Dey, C F Mactutus, R M Booze, D M Sno. Cocaine exposure in vitro induces apoptosis in fetal locus coeruleus neurons by altering the Bax/Bcl-2 ratio and through caspase-3 apoptotic signaling. Neuroscience. vol 144. issue 2. 2007-03-28. PMID:17084983. |
dissociated fetal lc neurons or substantia nigra (sn) neurons (control) were exposed in vitro to a pharmacologically active dose of cocaine hydrochloride (500 ng/ml) and assayed for apoptosis using terminal deoxynucleotidyl transferase mediated dna nick end labeling and hoechst methodologies. |
2007-03-28 |
2023-08-12 |
rat |
| Diane Stephenson, Andres Ramirez, Jill Long, Nestor Barrezueta, Eva Hajos-Korcsok, Curt Matherne, Dan Gallagher, Anne Ryan, Ricardo Ochoa, Frank Menniti, James Ya. Quantification of MPTP-induced dopaminergic neurodegeneration in the mouse substantia nigra by laser capture microdissection. Journal of neuroscience methods. vol 159. issue 2. 2007-03-27. PMID:16949674. |
this reduction corresponded to decreases in striatal dopamine and loss of immunocytochemically detected th but not beta-actin in the substantia nigra (sn). |
2007-03-27 |
2023-08-12 |
mouse |