| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Tian Shen, Xingyu Li, Lei Chen, Zimu Chen, Tingting Tan, Tiantian Hua, Bingwei Chen, Yonggui Yuan, Zhijun Zhang, Liz Kuney, Zhi X. The relationship of tryptophan hydroxylase-2 methylation to early-life stress and its impact on short-term antidepressant treatment response. Journal of affective disorders. vol 276. 2021-02-15. PMID:32738671. |
the gene tryptophan hydroxylase 2 (tph2) encodes the associated rate-limiting enzyme in the biosynthesis 5-ht (serotonin). |
2021-02-15 |
2023-08-13 |
Not clear |
| Shunpei Moriya, Akira Yamashita, Daiki Masukawa, Yuki Kambe, Junichi Sakaguchi, Honami Setoyama, Akihiro Yamanaka, Tomoyuki Kuwak. Involvement of supralemniscal nucleus (B9) 5-HT neuronal system in nociceptive processing: a fiber photometry study. Molecular brain. vol 13. issue 1. 2021-02-12. PMID:32005128. |
we introduced the g-camp6 in b9 5-ht neurons using transgenic mice carrying a tetracycline-controlled transactivator transgene (tta) under the control of a tryptophan hydroxylase-2 (tph2) promoter and site-specific injection of adeno associated virus (aav-teto(3g)-g-camp6). |
2021-02-12 |
2023-08-13 |
mouse |
| Nina C Donner, Sofia M Davies, Stephanie D Fitz, Drake M Kienzle, Anantha Shekhar, Christopher A Lowr. Crh receptor priming in the bed nucleus of the stria terminalis (BNST) induces tph2 gene expression in the dorsomedial dorsal raphe nucleus and chronic anxiety. Progress in neuro-psychopharmacology & biological psychiatry. vol 96. 2021-01-04. PMID:31415826. |
since the bnst projects heavily to the dorsal raphe nucleus (dr), the main source of brain serotonin, we here tested the hypothesis that such repeated, anxiety-inducing activation of crh receptors in the bnst alters the expression of serotonergic genes in the dr, including tph2, the gene encoding the rate-limiting enzyme for brain serotonin synthesis, and slc6a4, the gene encoding the serotonin transporter (sert). |
2021-01-04 |
2023-08-13 |
rat |
| Nibal Betari, Kristoffer Sahlholm, Xavier Morató, Héctor Godoy-Marín, Olga Jáuregui, Knut Teigen, Francisco Ciruela, Jan Haavi. Inhibition of Tryptophan Hydroxylases and Monoamine Oxidase-A by the Proton Pump Inhibitor, Omeprazole- Frontiers in pharmacology. vol 11. 2020-12-17. PMID:33324221. |
5-ht synthesis is catalyzed by tryptophan hydroxylase (tph) which exists as two distinct isoforms; tph1 and tph2, which are responsible for peripheral and central 5-ht, respectively. |
2020-12-17 |
2023-08-13 |
Not clear |
| Nibal Betari, Kristoffer Sahlholm, Xavier Morató, Héctor Godoy-Marín, Olga Jáuregui, Knut Teigen, Francisco Ciruela, Jan Haavi. Inhibition of Tryptophan Hydroxylases and Monoamine Oxidase-A by the Proton Pump Inhibitor, Omeprazole- Frontiers in pharmacology. vol 11. 2020-12-17. PMID:33324221. |
the s-enantiomer of omeprazole, esomeprazole, has recently also been described as an inhibitor of monoamine oxidase-a (mao-a), the main enzyme responsible for 5-ht degradation, albeit with lower potency compared to the effect on tph1 and tph2. |
2020-12-17 |
2023-08-13 |
Not clear |
| Michael Bade. Inhibition of serotonin synthesis: A novel therapeutic paradigm. Pharmacology & therapeutics. vol 205. 2020-12-10. PMID:31629717. |
there are two independent serotonin systems in the body characterized by two isoforms of tph, tph1 and tph2. |
2020-12-10 |
2023-08-13 |
mouse |
| Michael Bade. Inhibition of serotonin synthesis: A novel therapeutic paradigm. Pharmacology & therapeutics. vol 205. 2020-12-10. PMID:31629717. |
while tph2 synthesizes serotonin in the brain, tph1 is expressed in the gut and in other peripheral tissues and supplies platelets in the circulation with serotonin. |
2020-12-10 |
2023-08-13 |
mouse |
| Tadashi Takada, Naoki Yoneda, Tetsushi Hirano, Kanoko Onaru, Youhei Mantani, Toshifumi Yokoyama, Hiroshi Kitagawa, Yoshiaki Tabuchi, Collins Nimako, Mayumi Ishizuka, Yoshinori Ikenaka, Nobuhiko Hosh. Combined exposure to dinotefuran and chronic mild stress counteracts the change of the emotional and monoaminergic neuronal activity induced by either exposure singly despite corticosterone elevation in mice. The Journal of veterinary medical science. vol 82. issue 3. 2020-11-16. PMID:31983702. |
in addition, serotonin (5-ht) and tryptophan hydroxylase 2 (tph2) of the dorsal raphe nuclei (drn) and median raphe nuclei (mrn) and tyrosine hydroxylase (th) of the ventral tegmental area and substantia nigra (sn) were evaluated immunohistochemically. |
2020-11-16 |
2023-08-13 |
mouse |
| Tadashi Takada, Naoki Yoneda, Tetsushi Hirano, Kanoko Onaru, Youhei Mantani, Toshifumi Yokoyama, Hiroshi Kitagawa, Yoshiaki Tabuchi, Collins Nimako, Mayumi Ishizuka, Yoshinori Ikenaka, Nobuhiko Hosh. Combined exposure to dinotefuran and chronic mild stress counteracts the change of the emotional and monoaminergic neuronal activity induced by either exposure singly despite corticosterone elevation in mice. The Journal of veterinary medical science. vol 82. issue 3. 2020-11-16. PMID:31983702. |
a noel dose of din or cums alone increased of the total distance in oft, decreased or increased the immobility time in tst or fst, respectively, and increased the positive intensity of 5-ht and tph2 in the drn/mrn, and th in the sn. |
2020-11-16 |
2023-08-13 |
mouse |
| Meiju Zhu, Hongzhu Zhu, Xiaomin Ding, Shaosheng Liu, Yuanhua Zo. Analysis of the anti-fatigue activity of polysaccharides from Spirulina platensis: role of central 5-hydroxytryptamine mechanisms. Food & function. vol 11. issue 2. 2020-10-19. PMID:32057057. |
this study evaluated the effects of polysaccharides from spirulina platensis (psp) on endurance during treadmill exercise; levels of some biochemical indicators including hemoglobin (hb), lactic acid (la), creatine kinase (ck), and blood urea nitrogen (bun); concentrations of 5-hydroxytryptamine (5-ht); and expressions of second isoforms of tryptophan hydroxylase (tph2) and serotonergic type 1b inhibitory autoreceptor (5-ht1b) in the caudate putamen of exercising rats. |
2020-10-19 |
2023-08-13 |
rat |
| Meiju Zhu, Hongzhu Zhu, Xiaomin Ding, Shaosheng Liu, Yuanhua Zo. Analysis of the anti-fatigue activity of polysaccharides from Spirulina platensis: role of central 5-hydroxytryptamine mechanisms. Food & function. vol 11. issue 2. 2020-10-19. PMID:32057057. |
the results demonstrated that psp prolonged the time to exhaustion during the treadmill exercise; increased hb levels; decreased la, bun, and ck levels in the blood; suppressed the exercise-induced increase of 5-ht concentrations and tph2 expression; and prevented the exercise-induced decrease of 5-ht1b expression in the caudate putamen. |
2020-10-19 |
2023-08-13 |
rat |
| Meiju Zhu, Hongzhu Zhu, Xiaomin Ding, Shaosheng Liu, Yuanhua Zo. Analysis of the anti-fatigue activity of polysaccharides from Spirulina platensis: role of central 5-hydroxytryptamine mechanisms. Food & function. vol 11. issue 2. 2020-10-19. PMID:32057057. |
these results suggest that the mechanism of promotion of physical performance by psp might be related to increase in hb levels; decrease in la, bun, and ck levels in the blood; inhibition of the exercise-induced 5-ht and tph2 expressions; and the increase in the 5-ht1b expression in the caudate putamen of exercised rats. |
2020-10-19 |
2023-08-13 |
rat |
| Feng Wang, Nana Li, Xixi Wei, Xiaojian Jia, Huanhuan Liu, Yongling Wang, Yu Shi, Min Pan, Yue Wang, Yaling Yin, Fei Yan, Yun Che. MRI-Guided Focused Ultrasound-Induced Blood Brain Barrier Disruption to Deliver Glial Cell Line Derived Neurotropic Factor Proteins into Brain to Treat Rat Depression. Journal of biomedical nanotechnology. vol 16. issue 5. 2020-10-19. PMID:32919483. |
behavioral tests demonstrated the increased gdnf could reverse the depressive-like behaviors induced by chronic mild stress, improve the expression of 5-ht 1b receptor and the protein p11, and increase the number of 5-ht or tph2 immunoreactive neurons. |
2020-10-19 |
2023-08-13 |
rat |
| Emiliano Tesoro-Cruz, Norma Oviedo, Leticia Manuel-Apolinar, Sandra Orozco-Suárez, Miguel Pérez de la Mora, Gloria Martínez-Pérez, Francisco Xavier Guerra-Castillo, Charmina Aguirre-Alvarado, Vilma Carolina Bekker-Ménde. Ophthalmic Administration of a DNA Plasmid Harboring the Murine Tph2 Gene: Evidence of Recombinant Tph2-FLAG in Brain Structures. Molecular biotechnology. vol 62. issue 3. 2020-10-08. PMID:32030628. |
tryptophan hydroxylase-type 2 (tph2) is the first rate-limiting step in the biosynthesis of serotonin (5-ht) in the brain. |
2020-10-08 |
2023-08-13 |
mouse |
| Emiliano Tesoro-Cruz, Norma Oviedo, Leticia Manuel-Apolinar, Sandra Orozco-Suárez, Miguel Pérez de la Mora, Gloria Martínez-Pérez, Francisco Xavier Guerra-Castillo, Charmina Aguirre-Alvarado, Vilma Carolina Bekker-Ménde. Ophthalmic Administration of a DNA Plasmid Harboring the Murine Tph2 Gene: Evidence of Recombinant Tph2-FLAG in Brain Structures. Molecular biotechnology. vol 62. issue 3. 2020-10-08. PMID:32030628. |
in conclusion, this study showed the feasibility of delivering therapeutic genes, such as the tph2, the first enzyme, rate-limiting step in the 5-ht biosynthesis. |
2020-10-08 |
2023-08-13 |
mouse |
| Ryoko Hiroi, Giulia Weyrich, Stephanie V Koebele, Sarah E Mennenga, Joshua S Talboom, Lauren T Hewitt, Courtney N Lavery, Perla Mendoza, Ambra Jordan, Heather A Bimonte-Nelso. Benefits of Hormone Therapy Estrogens Depend on Estrogen Type: 17β-Estradiol and Conjugated Equine Estrogens Have Differential Effects on Cognitive, Anxiety-Like, and Depressive-Like Behaviors and Increase Tryptophan Hydroxylase-2 mRNA Levels in Dorsal Raphe Nucleus Subregions. Frontiers in neuroscience. vol 10. 2020-10-01. PMID:28008302. |
in particular, polymorphisms of tryptophan hydroxylase-2 (tph2, the brain-specific, rate-limiting enzyme for 5-ht biosynthesis) are implicated in cognitive and affective disorders. |
2020-10-01 |
2023-08-13 |
rat |
| Nina C Donner, Kenneth H Kubala, James E Hassell, Margaret W Lieb, Kadi T Nguyen, Jared D Heinze, Robert C Drugan, Steven F Maier, Christopher A Lowr. Two models of inescapable stress increase Neurobiology of stress. vol 8. 2020-10-01. PMID:29520369. |
two models of inescapable stress increase expression of tph2, the rate-limiting enzyme for brain serotonin synthesis, is elevated in the dorsal raphe nucleus (dr) of depressed suicide victims. |
2020-10-01 |
2023-08-13 |
Not clear |
| Magdalena T Weidner, Roy Lardenoije, Lars Eijssen, Floriana Mogavero, Lilian P M T De Groodt, Sandy Popp, Rupert Palme, Konrad U Förstner, Tatyana Strekalova, Harry W M Steinbusch, Angelika G Schmitt-Böhrer, Jeffrey C Glennon, Jonas Waider, Daniel L A van den Hove, Klaus-Peter Lesc. Identification of Cholecystokinin by Genome-Wide Profiling as Potential Mediator of Serotonin-Dependent Behavioral Effects of Maternal Separation in the Amygdala. Frontiers in neuroscience. vol 13. 2020-10-01. PMID:31133792. |
converging evidence suggests a role of serotonin (5-hydroxytryptamine, 5-ht) and tryptophan hydroxylase 2 (tph2), the rate-limiting enzyme of 5-ht synthesis in the brain, in modulating long-term, neurobiological effects of early-life adversity. |
2020-10-01 |
2023-08-13 |
Not clear |
| Paola Brivio, Giulia Sbrini, Polina Peeva, Mihail Todiras, Michael Bader, Natalia Alenina, Francesca Calabres. TPH2 Deficiency Influences Neuroplastic Mechanisms and Alters the Response to an Acute Stress in a Sex Specific Manner. Frontiers in molecular neuroscience. vol 11. 2020-09-30. PMID:30425618. |
we took advantage of tryptophan hydroxylase 2 (tph2) deficient rats, lacking serotonin specifically in the brain, to investigate whether a vulnerable genotype can be associated with alterations of neuronal plasticity from the early stage of maturation of the brain until adulthood. |
2020-09-30 |
2023-08-13 |
rat |
| Hong-Ru Pan, Miao Tian, Jian-Bo Xue, Song-Min Li, Xiao-Cui Luo, Xiao Huang, Zhen-Huang Chen, Liquan Huan. Mammalian Taste Bud Cells Utilize Extragemmal 5-Hydroxy-L-Tryptophan to Biosynthesize the Neurotransmitter Serotonin. Frontiers in cellular neuroscience. vol 12. 2020-09-30. PMID:30534058. |
first, we verified that the rate-limiting enzyme tryptophan hydroxylase (tph2) responsible for converting l-tryptophan into the intermediate 5-hydroxy-l-tryptophan (5-htp) is expressed in a subset of type ii taste bud cells (tbcs) whereas the enzyme aromatic l-aromatic amino acid decarboxylase (aadc) capable of converting 5-htp into 5-ht is found in type iii tbcs. |
2020-09-30 |
2023-08-13 |
mouse |