| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yalan Chen, Junxin Kuang, Yimei Niu, Hongyao Zhu, Xiaoxia Chen, Kwok-Fai So, Anding Xu, Lingling Sh. Multiple factors to assist human-derived induced pluripotent stem cells to efficiently differentiate into midbrain dopaminergic neurons. Neural regeneration research. vol 19. issue 4. 2023-10-16. PMID:37843228. |
in vitro differentiation of functional midbrain dopaminergic neurons provides an accessible platform to study midbrain neuronal dysfunction and can be used to examine obstacles to dopaminergic neuronal development. |
2023-10-16 |
2023-11-08 |
human |
| Yalan Chen, Junxin Kuang, Yimei Niu, Hongyao Zhu, Xiaoxia Chen, Kwok-Fai So, Anding Xu, Lingling Sh. Multiple factors to assist human-derived induced pluripotent stem cells to efficiently differentiate into midbrain dopaminergic neurons. Neural regeneration research. vol 19. issue 4. 2023-10-16. PMID:37843228. |
we further optimized the induction protocol by applying the small molecule inhibitor, chir99021 (chir).this helped facilitate the generation of midbrain dopaminergic neurons, and we obtained 31-74% midbrain dopaminergic neurons based on tyrosine hydroxylase and foxa2 staining. |
2023-10-16 |
2023-11-08 |
human |
| Yalan Chen, Junxin Kuang, Yimei Niu, Hongyao Zhu, Xiaoxia Chen, Kwok-Fai So, Anding Xu, Lingling Sh. Multiple factors to assist human-derived induced pluripotent stem cells to efficiently differentiate into midbrain dopaminergic neurons. Neural regeneration research. vol 19. issue 4. 2023-10-16. PMID:37843228. |
based on tyrosine hydroxylase and foxa2 immunostaining analysis, the chir, shh, and fgf8 combined protocol produces a much higher proportion of midbrain dopaminergic neurons, which could be an ideal resource for tackling midbrain-related diseases. |
2023-10-16 |
2023-11-08 |
human |
| Jinmei Sun, Wei Zhang, Zheng Zachory Wei, Xiaopeng Song, Liu Jian, Feng Jiang, Shuanglin Wang, Haibo Li, Yongbo Zhang, Houzhen Tu. Mesenchymal stromal cell biotherapy for Parkinson's disease premotor symptoms. Chinese neurosurgical journal. vol 9. issue 1. 2023-10-14. PMID:37833807. |
pathological change of progressive pd includes degeneration and loss of dopaminergic neurons in the substantia nigra of the midbrain. |
2023-10-14 |
2023-10-15 |
Not clear |
| Xiang Ma, Liang-Liang Zhao, Yi-Chun Yu, Yan Chen. Engrailed: Pathological and physiological effects of a multifunctional developmental gene. Genesis (New York, N.Y. : 2000). 2023-10-13. PMID:37830136. |
after birth, en1 still plays a role in the development and physiology of the body; for example, it exerts a protective effect on midbrain dopaminergic (mda) neurons, and loss of en1 causes mda neurons in the ventral midbrain to gradually die approximately 6 weeks after birth, resulting in motor and nonmotor symptoms similar to those observed in parkinson's disease. |
2023-10-13 |
2023-10-15 |
Not clear |
| Surjeet Mastwal, Xinjian Li, Rianne Stowell, Matthew Manion, Wenyu Zhang, Nam-Shik Kim, Ki-Jun Yoon, Hongjun Song, Guo-Li Ming, Kuan Hong Wan. Adolescent neurostimulation of dopamine circuit reverses genetic deficits in frontal cortex function. eLife. vol 12. 2023-10-13. PMID:37830916. |
the frontal cortex and its dopaminergic input from the midbrain are implicated in cognitive functions and undergo maturational changes during adolescence. |
2023-10-13 |
2023-10-15 |
mouse |
| Hao Liu, Haibin Dong, Chunxiao Wang, Wenjuan Jia, Guangqiang Wang, Hua Wang, Lin Zhong, Lei Gon. Key Subdomains of Cerebral Dopamine Neurotrophic Factor Regulate Its Protective Function in 6-Hydroxydopamine-Lesioned PC12 Cells. DNA and cell biology. 2023-10-10. PMID:37815547. |
cerebral dopamine neurotrophic factor (cdnf) is a unique neurotrophic factor (ntf) that has shown significant neuroprotective and neurorestorative functions on midbrain dopaminergic neurons. |
2023-10-10 |
2023-10-15 |
human |
| Chia-Yueh Chang, Yu-Chen Chan, Hsueh-Chih Che. The differential processing of verbal jokes by neural substrates in Indigenous and Han Chinese populations: An fMRI study. Behavioural brain research. 2023-10-09. PMID:37813282. |
ind participants when encountered with jokes displayed a greater activation of the mesolimbic dopaminergic reward system, including the amygdala, midbrain, and nucleus accumbens than han participants. |
2023-10-09 |
2023-10-15 |
human |
| Heidi Kleven, Ingvild E Bjerke, Francisco Clascá, Henk J Groenewegen, Jan G Bjaalie, Trygve B Leergaar. Waxholm Space atlas of the rat brain: a 3D atlas supporting data analysis and integration. Nature methods. 2023-10-02. PMID:37783883. |
it provides a detailed map of the cerebral cortex, hippocampal region, striatopallidal areas, midbrain dopaminergic system, thalamic cell groups, the auditory system and main fiber tracts. |
2023-10-02 |
2023-10-07 |
rat |
| Yassir Boulaamane, Iman Touati, Nainee Goyal, Anshuman Chandra, Lokesh Kori, Mahmoud A A Ibrahim, Mohammed Reda Britel, Amal Maurad. Exploring natural products as multi-target-directed drugs for Parkinson's disease: an Journal of biomolecular structure & dynamics. 2023-09-27. PMID:37753798. |
exploring natural products as multi-target-directed drugs for parkinson's disease: an parkinson's disease is a neurodegenerative disorder characterized by the progressive loss of dopaminergic neurons in the midbrain. |
2023-09-27 |
2023-10-07 |
Not clear |
| Apostolos Papandreou, Nivedita Singh, Lorita Gianfrancesco, Dimitri Budinger, Katy Barwick, Alexander Agrotis, Christin Luft, Ying Shao, An-Sofie Lenaerts, Allison Gregory, Suh Young Jeong, Penelope Hogarth, Susan Hayflick, Serena Barral, Janos Kriston-Vizi, Paul Gissen, Manju A Kurian, Robin Kettele. Cardiac glycosides restore autophagy flux in an iPSC-derived neuronal model of WDR45 deficiency. bioRxiv : the preprint server for biology. 2023-09-25. PMID:37745522. |
we have developed a patient-derived, induced pluripotent stem cell (ipsc)-based midbrain dopaminergic neuronal cell model of bpan (3 patient, 2 age-matched controls and 2 isogenic control lines) which shows defective autophagy and aberrant gene expression in key neurodegenerative, neurodevelopmental and collagen pathways. |
2023-09-25 |
2023-10-07 |
Not clear |
| Eun A Ra, Min Seong Kim, Gabsang Le. Optogenetic induction of alpha-synuclein aggregation in human dopaminergic neurons to model Parkinson's disease pathology. STAR protocols. vol 4. issue 4. 2023-09-24. PMID:37742181. |
here, we present a protocol for optogenetic induction of α-syn aggregation in human midbrain dopaminergic (mda) neurons, facilitating a detailed pd pathology study. |
2023-09-24 |
2023-10-07 |
human |
| Sibylle Frase, Julius Steddin, Enya Paschen, Maximilian Lenz, Pasquale Conforti, Carola A Haas, Andreas Vlachos, Christian Schachtrup, Jonas A Hos. Dense dopaminergic innervation of the peri-infarct cortex despite dopaminergic cell loss after a pure motor-cortical stroke in rats. Journal of neurochemistry. 2023-09-22. PMID:37735852. |
however, ischemic stroke also leads to the remote degeneration of dopaminergic midbrain neurons, possibly interfering with this beneficial effect. |
2023-09-22 |
2023-10-07 |
rat |
| Sibylle Frase, Julius Steddin, Enya Paschen, Maximilian Lenz, Pasquale Conforti, Carola A Haas, Andreas Vlachos, Christian Schachtrup, Jonas A Hos. Dense dopaminergic innervation of the peri-infarct cortex despite dopaminergic cell loss after a pure motor-cortical stroke in rats. Journal of neurochemistry. 2023-09-22. PMID:37735852. |
thus, dopaminergic midbrain neurons projecting into the pic were identified based on mr signal and immunoreactivity against tyrosine hydroxylase (th), a marker for dopaminergic neurons. |
2023-09-22 |
2023-10-07 |
rat |
| Sibylle Frase, Julius Steddin, Enya Paschen, Maximilian Lenz, Pasquale Conforti, Carola A Haas, Andreas Vlachos, Christian Schachtrup, Jonas A Hos. Dense dopaminergic innervation of the peri-infarct cortex despite dopaminergic cell loss after a pure motor-cortical stroke in rats. Journal of neurochemistry. 2023-09-22. PMID:37735852. |
despite a 25% ipsilesional loss of dopaminergic midbrain neurons after pts, the number and spatial distribution of dopaminergic neurons projecting to the pic was not different compared to sham controls. |
2023-09-22 |
2023-10-07 |
rat |
| Fernando Falkenburger Melleu, Newton Sabino Cantera. Pathways from the Superior Colliculus to the Basal Ganglia. Current neuropharmacology. 2023-09-13. PMID:37702174. |
moreover, we discuss how information from the sc might also be relayed to the basal ganglia through midbrain tectonigral and tectotegmental projections directed at the substantia nigra compacta and ventrotegmental area, respectively, influencing the dopaminergic outflow to the dorsal and ventral striatum. |
2023-09-13 |
2023-10-07 |
Not clear |
| Megan Caldwell, Vanessa Ayo-Jibunoh, Josue Criollo Mendoza, Katherine R Brimblecombe, Lauren M Reynolds, Xin Yan Zhu Jiang, Colin Alarcon, Elizabeth Fiore, Jacquelyn N Tomaio, Greg R Phillips, Susana Mingote, Cecilia Flores, Patrizia Casaccia, Jia Liu, Stephanie J Cragg, Dan P McCloskey, Leora Yetnikof. Axo-glial interactions between midbrain dopamine neurons and oligodendrocyte lineage cells in the anterior corpus callosum. Brain structure & function. 2023-09-05. PMID:37668732. |
dopaminergic axon terminals were identified in the corpus callosum of dat-cre mice after injection of an eyfp reporter virus into the midbrain. |
2023-09-05 |
2023-09-07 |
mouse |
| Shannon N Bennett, Austin B Chang, Forrest D Rogers, Parker Jones, Catherine Jensen Peñ. Thyroid hormones mediate the impact of early-life stress on ventral tegmental area gene expression and behavior. bioRxiv : the preprint server for biology. 2023-09-04. PMID:37662236. |
we hypothesized that thyroid hormone signaling may link experience of els with transcriptional dysregulation within the dopaminergic midbrain, and ultimately behavior. |
2023-09-04 |
2023-09-07 |
mouse |
| Yongyi Li, Mingwei Zhu, Wen-Xiong Chen, Jing Luo, Xin Li, Yangyang Cao, Meng Zheng, Shanshan Ma, Zhilan Xiao, Yani Zhang, Linyan Jiang, Xiumin Wang, Ting Tan, Xia Li, Qian Gong, Xiaoli Xiong, Jun Wang, Mingxi Tang, Mingtao Li, Ya-Ping Tan. A novel mutation in intron 1 of Wnt1 causes developmental loss of dopaminergic neurons in midbrain and ASD-like behaviors in rats. Molecular psychiatry. 2023-09-01. PMID:37658228. |
a novel mutation in intron 1 of wnt1 causes developmental loss of dopaminergic neurons in midbrain and asd-like behaviors in rats. |
2023-09-01 |
2023-09-07 |
rat |
| Louisa A Christie, Nicola L Brice, Anna Rowland, Louise Dickson, Rishi Anand, Martin Teall, Kevin J Doyle, Lakshminarayana Narayana, Christine Mitchell, Jenna R M Harvey, Victoria Mulligan, Lee A Dawson, Stephanie J Cragg, Mark Carlton, Roland W Bürl. Discovery of Journal of medicinal chemistry. 2023-08-31. PMID:37651656. |
discovery of nicotinic acetylcholine receptor (nachr) α6 subunit rna expression is relatively restricted to midbrain regions and is located presynaptically on dopaminergic neurons projecting to the striatum. |
2023-08-31 |
2023-09-07 |
Not clear |