| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Giovanni Mirabella, Andrea Pilotto, Andrea Rizzardi, Martina Montalti, Enrica Olivola, Cinzia Zatti, Veronica Di Caprio, Elisabetta Ferrari, Nicola Modugno, Alessandro Padovan. Effects of dopaminergic treatment on inhibitory control differ across Hoehn and Yahr stages of Parkinson's disease. Brain communications. vol 6. issue 1. 2024-01-01. PMID:38162902. |
a progressive loss of the midbrain's dopamine neurons characterizes parkinson's disease and causes motor features responsive to dopaminergic treatments. |
2024-01-01 |
2024-01-05 |
Not clear |
| Ramesha Hanumanthappa, Deepa Mugudthi Venugopal, Nethravathi P C, Ahesanulla Shaikh, Siddaiah B M, Geetha B Heggannavar, Akshay A Patil, Hemalatha Nanjaiah, D Suresh, Mahadevappa Y Kariduraganavar, Shamprasad Varija Raghu, Kuramkote Shivanna Devaraj. Polyvinylpyrrolidone-Capped Copper Oxide Nanoparticles-Anchored Pramipexole Attenuates the Rotenone-Induced Phenotypes in a ACS omega. vol 8. issue 50. 2023-12-25. PMID:38144104. |
the disease is characterized by the loss of dopaminergic neurons in the substantia nigra, pars compacta of the midbrain. |
2023-12-25 |
2023-12-27 |
Not clear |
| Shannon N Bennett, Austin B Chang, Forrest D Rogers, Parker Jones, Catherine Jensen Peñ. Thyroid hormones mediate the impact of early-life stress on ventral tegmental area gene expression and behavior. Hormones and behavior. vol 159. 2023-12-23. PMID:38141539. |
we hypothesized that thyroid hormone signaling may link experience of els with transcriptional dysregulation within the dopaminergic midbrain, and ultimately behavior. |
2023-12-23 |
2023-12-25 |
mouse |
| Myung Ji Kim, Su Hee Cho, Yongbo Seo, Sang-Dae Kim, Hae-Chul Park, Bum-Joon Ki. Neuro-Restorative Effect of Nimodipine and Calcitriol in 1-Methyl 4-Phenyl 1,2,3,6 Tetrahydropyridine-Induced Zebrafish Parkinson's Disease Model. Journal of Korean Neurosurgical Society. 2023-12-22. PMID:38130142. |
the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp) is known to cause a similar loss of dopaminergic neurons in the human midbrain, with corresponding parkinsonian symptoms. |
2023-12-22 |
2023-12-24 |
human |
| Lucia F Cardo, Jimena Monzón-Sandoval, Zongze Li, Caleb Webber, Meng L. Single-Cell Transcriptomics and In Vitro Lineage Tracing Reveals Differential Susceptibility of Human iPSC-Derived Midbrain Dopaminergic Neurons in a Cellular Model of Parkinson's Disease. Cells. vol 12. issue 24. 2023-12-22. PMID:38132179. |
single-cell transcriptomics and in vitro lineage tracing reveals differential susceptibility of human ipsc-derived midbrain dopaminergic neurons in a cellular model of parkinson's disease. |
2023-12-22 |
2023-12-24 |
human |
| Lucia F Cardo, Jimena Monzón-Sandoval, Zongze Li, Caleb Webber, Meng L. Single-Cell Transcriptomics and In Vitro Lineage Tracing Reveals Differential Susceptibility of Human iPSC-Derived Midbrain Dopaminergic Neurons in a Cellular Model of Parkinson's Disease. Cells. vol 12. issue 24. 2023-12-22. PMID:38132179. |
the success of these pursuits, however, relies on the use of cells most relevant to those targeted by the disease of interest, for example, midbrain dopaminergic neurons for parkinson's disease. |
2023-12-22 |
2023-12-24 |
human |
| Lucia F Cardo, Jimena Monzón-Sandoval, Zongze Li, Caleb Webber, Meng L. Single-Cell Transcriptomics and In Vitro Lineage Tracing Reveals Differential Susceptibility of Human iPSC-Derived Midbrain Dopaminergic Neurons in a Cellular Model of Parkinson's Disease. Cells. vol 12. issue 24. 2023-12-22. PMID:38132179. |
in the present study, we report the generation of a human induced pluripotent stem cell (ipsc) line capable of purifying and tracing nascent midbrain dopaminergic progenitors and their differentiated progeny via the expression of a blue fluorescent protein (bfp). |
2023-12-22 |
2023-12-24 |
human |
| Lucia F Cardo, Jimena Monzón-Sandoval, Zongze Li, Caleb Webber, Meng L. Single-Cell Transcriptomics and In Vitro Lineage Tracing Reveals Differential Susceptibility of Human iPSC-Derived Midbrain Dopaminergic Neurons in a Cellular Model of Parkinson's Disease. Cells. vol 12. issue 24. 2023-12-22. PMID:38132179. |
this was achieved by crispr/cas9-assisted knock-in of bfp and cre into the safe harbour locus aavs1 and an early midbrain dopaminergic lineage marker gene lmx1a, respectively. |
2023-12-22 |
2023-12-24 |
human |
| Isabel Rosety, Alise Zagare, Claudia Saraiva, Sarah Nickels, Paul Antony, Catarina Almeida, Enrico Glaab, Rashi Halder, Sergiy Velychko, Thomas Rauen, Hans R Schöler, Silvia Bolognin, Thomas Sauter, Javier Jarazo, Rejko Krüger, Jens C Schwambor. Impaired neuron differentiation in GBA-associated Parkinson's disease is linked to cell cycle defects in organoids. NPJ Parkinson's disease. vol 9. issue 1. 2023-12-18. PMID:38110400. |
in addition, patient-specific midbrain organoids exhibited a decrease in the number and complexity of dopaminergic neurons. |
2023-12-18 |
2023-12-21 |
Not clear |
| Yanxin Li, Zhongqiu Li, Changliang Wang, Min Yang, Ziqing He, Feiyang Wang, Yuehong Zhang, Rong Li, Yunxia Gong, Binhong Wang, Baoguang Fan, Chunyue Wang, Lei Chen, Hong Li, Peifu Shi, Nana Wang, Zhifeng Wei, Yan-Ling Wang, Lei Jin, Peng Du, Ji Dong, Jianwei Jia. Spatiotemporal transcriptome atlas reveals the regional specification of the developing human brain. Cell. 2023-12-13. PMID:38091994. |
specifically, two diencephalon-specific subtypes gave rise to glutamatergic and gabaergic neurons, whereas subtypes in ventral midbrain were associated with the dopaminergic neurons. |
2023-12-13 |
2023-12-17 |
human |
| Sanghyun Park, Chan Wook Park, Jang Hyeon Eom, Mi-Young Jo, Hye-Jin Hur, Sung Kyoung Choi, Jae Souk Lee, Seung Taek Nam, Ki-Sang Jo, Young Woo Oh, Jungil Lee, Sieun Kim, Do-Hun Kim, Chul-Yong Park, Su Jin Kim, Ho-Young Lee, Myung Soo Cho, Dae-Sung Kim, Dong-Wook Ki. Preclinical and dose-ranging assessment of hESC-derived dopaminergic progenitors for a clinical trial on Parkinson's disease. Cell stem cell. 2023-12-12. PMID:38086390. |
human embryonic stem cell (hesc)-derived midbrain dopaminergic (mda) cell transplantation is a promising therapeutic strategy for parkinson's disease (pd). |
2023-12-12 |
2023-12-17 |
human |
| Andrea Di Credico, Amélie Weiss, Massimo Corsini, Giulia Gaggi, Barbara Ghinassi, Johannes H Wilbertz, Angela Di Baldassarr. Machine learning identifies phenotypic profile alterations of human dopaminergic neurons exposed to bisphenols and perfluoroalkyls. Scientific reports. vol 13. issue 1. 2023-12-11. PMID:38081991. |
parkinson's disease (pd) is the second most common neurodegenerative disease and is characterized by the loss of midbrain dopaminergic neurons. |
2023-12-11 |
2023-12-17 |
human |
| Andrea Di Credico, Amélie Weiss, Massimo Corsini, Giulia Gaggi, Barbara Ghinassi, Johannes H Wilbertz, Angela Di Baldassarr. Machine learning identifies phenotypic profile alterations of human dopaminergic neurons exposed to bisphenols and perfluoroalkyls. Scientific reports. vol 13. issue 1. 2023-12-11. PMID:38081991. |
in this study, the effect of bps and pfs at different concentrations within the real-life exposure range (0.01, 0.1, 1, and 2 µm) on the phenotypic profile of human stem cell-derived midbrain dopaminergic neurons (mdans) was analyzed. |
2023-12-11 |
2023-12-17 |
human |
| Pedro Rifes, Marc Isaksson, Charlotte Rusimbi, Adrián Ramón Santonja, Jenny Nelander, Thomas Laurell, Agnete Kirkeb. Identifying secreted biomarkers of dopaminergic ventral midbrain progenitor cells. Stem cell research & therapy. vol 14. issue 1. 2023-12-10. PMID:38072935. |
identifying secreted biomarkers of dopaminergic ventral midbrain progenitor cells. |
2023-12-10 |
2023-12-17 |
human |
| Pedro Rifes, Marc Isaksson, Charlotte Rusimbi, Adrián Ramón Santonja, Jenny Nelander, Thomas Laurell, Agnete Kirkeb. Identifying secreted biomarkers of dopaminergic ventral midbrain progenitor cells. Stem cell research & therapy. vol 14. issue 1. 2023-12-10. PMID:38072935. |
ventral midbrain (vm) dopaminergic progenitor cells derived from human pluripotent stem cells have the potential to replace endogenously lost dopamine neurons and are currently in preclinical and clinical development for treatment of parkinson's disease (pd). |
2023-12-10 |
2023-12-17 |
human |
| Adolfo López-Ornelas, Itzel Escobedo-Avila, Gabriel Ramírez-García, Rolando Lara-Rodarte, César Meléndez-Ramírez, Beetsi Urrieta-Chávez, Tonatiuh Barrios-García, Verónica A Cáceres-Chávez, Xóchitl Flores-Ponce, Francia Carmona, Carlos Alberto Reynoso, Carlos Aguilar, Nora E Kerik, Luisa Rocha, Leticia Verdugo-Díaz, Víctor Treviño, José Bargas, Verónica Ramos-Mejía, Juan Fernández-Ruiz, Aurelio Campos-Romo, Iván Velasc. Human Embryonic Stem Cell-Derived Immature Midbrain Dopaminergic Neurons Transplanted in Parkinsonian Monkeys. Cells. vol 12. issue 23. 2023-12-09. PMID:38067166. |
human embryonic stem cell-derived immature midbrain dopaminergic neurons transplanted in parkinsonian monkeys. |
2023-12-09 |
2023-12-17 |
human |
| Adolfo López-Ornelas, Itzel Escobedo-Avila, Gabriel Ramírez-García, Rolando Lara-Rodarte, César Meléndez-Ramírez, Beetsi Urrieta-Chávez, Tonatiuh Barrios-García, Verónica A Cáceres-Chávez, Xóchitl Flores-Ponce, Francia Carmona, Carlos Alberto Reynoso, Carlos Aguilar, Nora E Kerik, Luisa Rocha, Leticia Verdugo-Díaz, Víctor Treviño, José Bargas, Verónica Ramos-Mejía, Juan Fernández-Ruiz, Aurelio Campos-Romo, Iván Velasc. Human Embryonic Stem Cell-Derived Immature Midbrain Dopaminergic Neurons Transplanted in Parkinsonian Monkeys. Cells. vol 12. issue 23. 2023-12-09. PMID:38067166. |
human embryonic stem cells (hescs) differentiate into specialized cells, including midbrain dopaminergic neurons (dans), and non-human primates (nhps) injected with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine develop some alterations observed in parkinson's disease (pd) patients. |
2023-12-09 |
2023-12-17 |
human |
| Thomas Payne, Toby Burgess, Stephen Bradley, Sarah Roscoe, Matilde Sassani, Mark J Dunning, Dena Hernandez, Sonja Scholz, Alisdair McNeill, Rosie Taylor, Li Su, Iain Wilkinson, Thomas Jenkins, Heather Mortiboys, Oliver Bandman. Multimodal assessment of mitochondrial function in Parkinson's disease. Brain : a journal of neurology. 2023-12-07. PMID:38059801. |
our data suggest that impaired oxidative phosphorylation in the striatal dopaminergic nerve terminals exceeds mitochondrial dysfunction in the midbrain of patients with early parkinson's disease. |
2023-12-07 |
2023-12-10 |
human |
| Daniel Reumann, Christian Krauditsch, Maria Novatchkova, Edoardo Sozzi, Sakurako Nagumo Wong, Michael Zabolocki, Marthe Priouret, Balint Doleschall, Kaja I Ritzau-Reid, Marielle Piber, Ilaria Morassut, Charles Fieseler, Alessandro Fiorenzano, Molly M Stevens, Manuel Zimmer, Cedric Bardy, Malin Parmar, Jürgen A Knoblic. In vitro modeling of the human dopaminergic system using spatially arranged ventral midbrain-striatum-cortex assembloids. Nature methods. 2023-12-05. PMID:38052989. |
ventral midbrain dopaminergic neurons project to the striatum as well as the cortex and are involved in movement control and reward-related cognition. |
2023-12-05 |
2023-12-10 |
human |
| Daniel Reumann, Christian Krauditsch, Maria Novatchkova, Edoardo Sozzi, Sakurako Nagumo Wong, Michael Zabolocki, Marthe Priouret, Balint Doleschall, Kaja I Ritzau-Reid, Marielle Piber, Ilaria Morassut, Charles Fieseler, Alessandro Fiorenzano, Molly M Stevens, Manuel Zimmer, Cedric Bardy, Malin Parmar, Jürgen A Knoblic. In vitro modeling of the human dopaminergic system using spatially arranged ventral midbrain-striatum-cortex assembloids. Nature methods. 2023-12-05. PMID:38052989. |
in parkinson's disease, nigrostriatal midbrain dopaminergic neurons degenerate and cause typical parkinson's disease motor-related impairments, while the dysfunction of mesocorticolimbic midbrain dopaminergic neurons is implicated in addiction and neuropsychiatric disorders. |
2023-12-05 |
2023-12-10 |
human |