| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Alp Ozgun, David J Lomboni, Amy Aylsworth, Allison Macdonald, William A Staines, Marzia Martina, Michael G Schlossmacher, Joseph S Tauskela, John Woulfe, Fabio Variol. Unraveling the assembloid: Real-time monitoring of dopaminergic neurites in an inter-organoid pathway connecting midbrain and striatal regions. Materials today. Bio. vol 25. 2024-02-19. PMID:38371467. |
unraveling the assembloid: real-time monitoring of dopaminergic neurites in an inter-organoid pathway connecting midbrain and striatal regions. |
2024-02-19 |
2024-02-21 |
Not clear |
| Andy Yang, Rony Chidiac, Emma Russo, Hendrik Steenland, Quinn Pauli, Robert Bonin, Levi L Blazer, Jarrett J Adams, Sachdev S Sidhu, Aleksandrina Goeva, Ali Salahpour, Stephane Anger. Exploiting spatiotemporal regulation of FZD5 during neural patterning for efficient ventral midbrain specification. Development (Cambridge, England). 2024-02-15. PMID:38358799. |
stimulation of wnt/β-catenin signaling in hpsc with a tetravalent antibody, which selectively triggers fzd5 and lrp6 clustering, leads to midbrain progenitor differentiation and give rise to functional dopaminergic neurons in vitro and in vivo. |
2024-02-15 |
2024-02-17 |
Not clear |
| Natalia Ivliev. Free will: An Example of the Dopaminergic System. Integrative psychological & behavioral science. 2024-02-14. PMID:38351379. |
using the functions of the midbrain dopaminergic system as an example, this article provides an overview of this neurophysiological basis. |
2024-02-14 |
2024-02-16 |
Not clear |
| Ana M Espinosa-Oliva, Rocío Ruiz, Manuel Sarmiento Soto, Antonio Boza-Serrano, Ana I Rodriguez-Perez, María A Roca-Ceballos, Juan García-Revilla, Marti Santiago, Sébastien Serres, Vasiliki Economopoulus, Ana E Carvajal, María D Vázquez-Carretero, Pablo García-Miranda, Oxana Klementieva, María J Oliva-Martín, Tomas Deierborg, Eloy Rivas, Nicola R Sibson, José L Labandeira-García, Alberto Machado, María J Peral, Antonio J Herrera, José L Venero, Rocío M de Pablo. Inflammatory bowel disease induces pathological α-synuclein aggregation in the human gut and brain. Neuropathology and applied neurobiology. vol 50. issue 1. 2024-02-13. PMID:38343067. |
in this work, we studied whether inflammatory bowel diseases (ibds) in humans can progress with the emergence of pathogenic α-synuclein (α-syn) in the gastrointestinal tract and midbrain dopaminergic neurons. |
2024-02-13 |
2024-02-15 |
human |
| David Zarate-Lopez, Andrea P Garzón-Partida, Oscar Gonzalez-Perez, Alma Y Gálvez-Contrera. Sex differences in autism-like behavior and dopaminergic neurons in substantia nigra of juvenile mice prenatally exposed to valproate. Developmental psychobiology. vol 66. issue 2. 2024-02-13. PMID:38351305. |
sex dimorphism in the brain, including midbrain dopaminergic circuits, can explain differences in social behavior impairment and stereotypic behaviors between male and female individuals with asd. |
2024-02-13 |
2024-02-16 |
mouse |
| Nobuyoshi Matsumoto, Miyuki Miyano, Takaya Abe, Tetsuhiko Kashima, Eriko Kato-Ishikura, Ken-Ichi Inoue, Jiayan Liu, Hiroshi Kiyonari, Haruki Takeuchi, Yuji Ikegay. Generation of Dopamine Transporter (DAT)-mCherry Knock-in Rats by CRISPR-Cas9 Genome Editing. Biological & pharmaceutical bulletin. vol 47. issue 2. 2024-02-07. PMID:38325828. |
midbrain dopaminergic neurons respond to rewards and have a crucial role in positive motivation and pleasure. |
2024-02-07 |
2024-02-10 |
rat |
| Elizabeth N Holly, Jamie Galanaugh, Marc V Fuccill. Local regulation of striatal dopamine: A diversity of circuit mechanisms for a diversity of behavioral functions? Current opinion in neurobiology. vol 85. 2024-02-03. PMID:38309106. |
we first look at historical and recent work demonstrating that striatal circuits interact with dopaminergic terminals to either initiate the release of dopamine or modulate the release of dopamine initiated by spiking in midbrain dopamine neurons, with particular attention to gabaergic and cholinergic local circuit mechanisms. |
2024-02-03 |
2024-02-06 |
Not clear |
| Mudiwa N Muwanigwa, Jennifer Modamio-Chamarro, Paul M A Antony, Gemma Gomez-Giro, Rejko Krüger, Silvia Bolognin, Jens C Schwambor. Alpha-synuclein pathology is associated with astrocyte senescence in a midbrain organoid model of familial Parkinson's disease. Molecular and cellular neurosciences. 2024-02-02. PMID:38307302. |
parkinson's disease (pd) is a complex, progressive neurodegenerative disease characterized by the loss of dopaminergic neurons in the substantia nigra pars compacta in the midbrain. |
2024-02-02 |
2024-02-05 |
human |
| Mudiwa N Muwanigwa, Jennifer Modamio-Chamarro, Paul M A Antony, Gemma Gomez-Giro, Rejko Krüger, Silvia Bolognin, Jens C Schwambor. Alpha-synuclein pathology is associated with astrocyte senescence in a midbrain organoid model of familial Parkinson's disease. Molecular and cellular neurosciences. 2024-02-02. PMID:38307302. |
to address this, here we describe the use of patient specific human midbrain organoids harboring the snca triplication to investigate mechanisms underlying dopaminergic degeneration. |
2024-02-02 |
2024-02-05 |
human |
| Mudiwa N Muwanigwa, Jennifer Modamio-Chamarro, Paul M A Antony, Gemma Gomez-Giro, Rejko Krüger, Silvia Bolognin, Jens C Schwambor. Alpha-synuclein pathology is associated with astrocyte senescence in a midbrain organoid model of familial Parkinson's disease. Molecular and cellular neurosciences. 2024-02-02. PMID:38307302. |
our midbrain organoid model recapitulates key pathological hallmarks of pd, including the aggregation of α-synuclein and the progressive loss of dopaminergic neurons. |
2024-02-02 |
2024-02-05 |
human |
| Serina Gima, Kazuya Oe, Kaneyasu Nishimura, Takashi Ohgita, Haruka Ito, Hiroyuki Kimura, Hiroyuki Saito, Kazuyuki Takat. Host-to-graft propagation of inoculated α-synuclein into transplanted human induced pluripotent stem cell-derived midbrain dopaminergic neurons. Regenerative therapy. vol 25. 2024-01-29. PMID:38283940. |
host-to-graft propagation of inoculated α-synuclein into transplanted human induced pluripotent stem cell-derived midbrain dopaminergic neurons. |
2024-01-29 |
2024-01-31 |
human |
| Etienne W Daadi, Elyas S Daadi, Thomas Oh, Mingfeng Li, Jeffrey Kim, Marcel M Daad. Combining physical & cognitive training with iPSC-derived dopaminergic neuron transplantation promotes graft integration & better functional outcome in parkinsonian marmosets. Experimental neurology. 2024-01-25. PMID:38272159. |
since pd stems from the degeneration of midbrain dopaminergic (da) neurons in a defined brain location, pd patients are considered optimal candidates for cell replacement therapy. |
2024-01-25 |
2024-01-28 |
Not clear |
| Min Seong Kim, Hyesoo Kim, Gabsang Le. Precision Medicine in Parkinson's Disease using Induced Pluripotent Stem Cells. Advanced healthcare materials. 2024-01-25. PMID:38269602. |
in this review, we will introduce new model system of pd, including two-dimensional (2d) human ipsc-derived midbrain dopaminergic (mda) neurons, 3d ipsc-derived midbrain organoids (mos) with cellular complexity, and more advanced microphysiological systems (mps) with three-dimensional (3d) organoids. |
2024-01-25 |
2024-01-27 |
human |
| Michele Salemi, Maria Ravo, Giuseppe Lanza, Francesca A Schillaci, Giovanna Maria Ventola, Giovanna Marchese, Maria Grazia Salluzzo, Graziella Cappelletti, Raffaele Ferr. Gene Expression Profiling of Post Mortem Midbrain of Parkinson's Disease Patients and Healthy Controls. International journal of molecular sciences. vol 25. issue 2. 2024-01-23. PMID:38255780. |
parkinson's disease (pd) stands as the most prevalent degenerative movement disorder, marked by the degeneration of dopaminergic neurons in the substantia nigra of the midbrain. |
2024-01-23 |
2024-01-25 |
Not clear |
| Araks Martirosyan, Rizwan Ansari, Francisco Pestana, Katja Hebestreit, Hayk Gasparyan, Razmik Aleksanyan, Silvia Hnatova, Suresh Poovathingal, Catherine Marneffe, Dietmar R Thal, Andrew Kottick, Victor J Hanson-Smith, Sebastian Guelfi, William Plumbly, T Grant Belgard, Emmanouil Metzakopian, Matthew G Hol. Unravelling cell type-specific responses to Parkinson's Disease at single cell resolution. Molecular neurodegeneration. vol 19. issue 1. 2024-01-20. PMID:38245794. |
the pathological hallmark of pd is loss of dopaminergic neurons and the presence of aggregated α-synuclein, primarily in the substantia nigra pars compacta (snpc) of the midbrain. |
2024-01-20 |
2024-01-23 |
human |
| Lucia Abela, Lorita Gianfrancesco, Erica Tagliatti, Giada Rossignoli, Katy Barwick, Clara Zourray, Kimberley M Reid, Dimitri Budinger, Joanne Ng, John Counsell, Arlo Simpson, Toni S Pearson, Simon Edvardson, Orly Elpeleg, Frances M Brodsky, Gabriele Lignani, Serena Barral, Manju A Kuria. Neurodevelopmental and synaptic defects in DNAJC6 parkinsonism, amenable to gene therapy. Brain : a journal of neurology. 2024-01-19. PMID:38242634. |
to investigate the underlying disease mechanisms in childhood-onset dnajc6 parkinsonism, we generated induced pluripotent stem cells (ipsc) from three patients harboring pathogenic loss-of-function dnajc6 mutations and subsequently developed a midbrain dopaminergic (mda) neuronal model of disease. |
2024-01-19 |
2024-01-22 |
Not clear |
| Gabriela Izowit, Magdalena Walczak, Gniewosz Drwięga, Wojciech Solecki, Tomasz Błasia. Brain state-dependent responses of midbrain dopaminergic neurons to footshock under urethane anaesthesia. The European journal of neuroscience. 2024-01-18. PMID:38233998. |
brain state-dependent responses of midbrain dopaminergic neurons to footshock under urethane anaesthesia. |
2024-01-18 |
2024-01-20 |
rat |
| Leonie Hose, Alina Katharina Langenhagen, Ekaterini Kefalakes, Theresa Schweitzer, Sabrina Kubinski, Segev Barak, Andreas Pich, Claudia Groth. A dual-omics approach on the effects of fibroblast growth factor-2 (FGF-2) on ventral tegmental area dopaminergic neurons in response to alcohol consumption in mice. The European journal of neuroscience. 2024-01-08. PMID:38185886. |
transcriptome analysis of daergic neurons revealed that fgf-2 knockout (fgf-2 ko) shifts the molecular fingerprint of midbrain dopaminergic (mda) neurons to da subtypes of the ventral tegmental area (vta). |
2024-01-08 |
2024-01-10 |
mouse |
| Borja Gomez Ramos, Jochen Ohnmacht, Nikola de Lange, Elena Valceschini, Aurélien Ginolhac, Marie Catillon, Daniele Ferrante, Aleksandar Rakovic, Rashi Halder, François Massart, Giuseppe Arena, Paul Antony, Silvia Bolognin, Christine Klein, Roland Krause, Marcel H Schulz, Thomas Sauter, Rejko Krüger, Lasse Sinkkone. Multiomics analysis identifies novel facilitators of human dopaminergic neuron differentiation. EMBO reports. 2024-01-04. PMID:38177910. |
midbrain dopaminergic neurons (mdans) control voluntary movement, cognition, and reward behavior under physiological conditions and are implicated in human diseases such as parkinson's disease (pd). |
2024-01-04 |
2024-01-07 |
human |
| Maggy Yu Hei Lau, Sana Gadiwalla, Susan Jones, Elisa Gallian. Different electrophysiological profiles of genetically labelled dopaminergic neurons in the mouse midbrain and olfactory bulb. The European journal of neuroscience. 2024-01-03. PMID:38169095. |
different electrophysiological profiles of genetically labelled dopaminergic neurons in the mouse midbrain and olfactory bulb. |
2024-01-03 |
2024-01-06 |
mouse |