| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Michael Fiske, Michael White, Stephanie Valtierra, Sara Herrera, Keith Solvang, Alina Konnikova, Shubhik Debburma. Familial Parkinson's Disease Mutant E46K α-Synuclein Localizes to Membranous Structures, Forms Aggregates, and Induces Toxicity in Yeast Models. ISRN neurology. vol 2011. 2012-08-23. PMID:22389823. |
in parkinson's disease (pd), midbrain dopaminergic neuronal death is linked to the accumulation of aggregated α-synuclein. |
2012-08-23 |
2023-08-12 |
Not clear |
| Kaia Achim, Paula Peltopuro, Laura Lahti, James Li, Marjo Salminen, Juha Partane. Distinct developmental origins and regulatory mechanisms for GABAergic neurons associated with dopaminergic nuclei in the ventral mesodiencephalic region. Development (Cambridge, England). vol 139. issue 13. 2012-08-15. PMID:22627282. |
we recently showed that molecular regulation of differentiation of the gabaergic neurons associated with the dopaminergic nuclei in the ventral midbrain (vta and snpr) is distinct from the rest of midbrain, but the reason for this difference remained elusive. |
2012-08-15 |
2023-08-12 |
mouse |
| José-Manuel Baizabal, Agustina Cano-Martínez, Concepción Valencia, Jesús Santa-Olalla, Kaylene M Young, Rodney L Rietze, Perry F Bartlett, Luis Covarrubia. Glial commitment of mesencephalic neural precursor cells expanded as neurospheres precludes their engagement in niche-dependent dopaminergic neurogenesis. Stem cells and development. vol 21. issue 7. 2012-08-10. PMID:21615282. |
to address this issue, we generated primary neurospheres from the dopaminergic niche of the ventral mesencephalon and then transplanted these cells to their original niche within mesencephalic explant cultures. |
2012-08-10 |
2023-08-12 |
Not clear |
| Yuh-Lih Chang, Shih-Jen Chen, Chung-Lan Kao, Shih-Chieh Hung, Dah-Ching Ding, Cheng-Chia Yu, Yi-Jen Chen, Hung-Hai Ku, Chin-Po Lin, Kun-Hsiung Lee, Yu-Chih Chen, Jhi-Joung Wang, Chuan-Chih Hsu, Liang-Kung Chen, Hsin-Yang Li, Shih-Hwa Chio. Docosahexaenoic acid promotes dopaminergic differentiation in induced pluripotent stem cells and inhibits teratoma formation in rats with Parkinson-like pathology. Cell transplantation. vol 21. issue 1. 2012-08-01. PMID:21669041. |
parkinson's disease (pd) is a neurodegenerative disorder characterized by the degeneration of dopaminergic (da) neurons in the midbrain. |
2012-08-01 |
2023-08-12 |
rat |
| Yukio Ago, Toshiyuki Kawasaki, Tetsuaki Nashida, Yuki Ota, Yana Cong, Mari Kitamoto, Teisuke Takahashi, Kazuhiro Takuma, Toshio Matsud. SEA0400, a specific Na+/Ca2+ exchange inhibitor, prevents dopaminergic neurotoxicity in an MPTP mouse model of Parkinson's disease. Neuropharmacology. vol 61. issue 8. 2012-08-01. PMID:21903118. |
sea0400 protected against the dopaminergic neurotoxicity (determined by dopamine levels in the midbrain and striatum, tyrosine hydroxylase immunoreactivity in the substantia nigra and striatum, striatal dopamine release, and motor deficits) in mptp-treated mice. |
2012-08-01 |
2023-08-12 |
mouse |
| Ken-ichi Okada, Kae Nakamura, Yasushi Kobayash. A neural correlate of predicted and actual reward-value information in monkey pedunculopontine tegmental and dorsal raphe nucleus during saccade tasks. Neural plasticity. vol 2011. 2012-07-31. PMID:22013541. |
while the response pattern of midbrain dopaminergic neurons and its specific role in reinforcement learning have been revealed, the role of the other neuromodulators remains rather elusive. |
2012-07-31 |
2023-08-12 |
monkey |
| Xuefeng Shen, Xiaoguo Ruan, Hua Zha. Stimulation of midbrain dopaminergic structures modifies firing rates of rat lateral habenula neurons. PloS one. vol 7. issue 4. 2012-07-27. PMID:22485164. |
stimulation of midbrain dopaminergic structures modifies firing rates of rat lateral habenula neurons. |
2012-07-27 |
2023-08-12 |
rat |
| Xuefeng Shen, Xiaoguo Ruan, Hua Zha. Stimulation of midbrain dopaminergic structures modifies firing rates of rat lateral habenula neurons. PloS one. vol 7. issue 4. 2012-07-27. PMID:22485164. |
we conclude that lhb pain-activated neurons can receive diverse reward-related signals originating from midbrain dopaminergic structures, and thus participate in the regulation of the brain reward system via both positive and negative feedback mechanisms. |
2012-07-27 |
2023-08-12 |
rat |
| Houbo Jiang, Yong Ren, Eunice Y Yuen, Ping Zhong, Mahboobe Ghaedi, Zhixing Hu, Gissou Azabdaftari, Kazuhiro Nakaso, Zhen Yan, Jian Fen. Parkin controls dopamine utilization in human midbrain dopaminergic neurons derived from induced pluripotent stem cells. Nature communications. vol 3. 2012-07-26. PMID:22314364. |
parkin controls dopamine utilization in human midbrain dopaminergic neurons derived from induced pluripotent stem cells. |
2012-07-26 |
2023-08-12 |
mouse |
| Alexander Kurz, Caroline May, Oliver Schmidt, Thorsten Müller, Christian Stephan, Helmut E Meyer, Suzana Gispert, Georg Auburger, Katrin Marcu. A53T-alpha-synuclein-overexpression in the mouse nigrostriatal pathway leads to early increase of 14-3-3 epsilon and late increase of GFAP. Journal of neural transmission (Vienna, Austria : 1996). vol 119. issue 3. 2012-07-23. PMID:21960009. |
only for 14-3-3 epsilon a corresponding mrna increase was observed in midbrain, suggesting it is transcribed in dopaminergic perikarya and accumulates as protein in presynapses, together with a53t-snca. |
2012-07-23 |
2023-08-12 |
mouse |
| K Misono, A Lessar. Apomorphine-evoked redistribution of neurokinin-3 receptors in dopaminergic dendrites and neuronal nuclei of the rat ventral tegmental area. Neuroscience. vol 203. 2012-07-19. PMID:22200547. |
mammalian neurokinin-3 (nk(3)) receptors of the tachykinin family of neuropeptides have been shown to activate dopaminergic neurons of the ventral tegmental area (vta), a midbrain area displaying dopaminergic dysfunctional activity in schizophrenia. |
2012-07-19 |
2023-08-12 |
rat |
| R Al-Hasani, J D Foster, A Metaxas, C Ledent, S M O Hourani, I Kitchen, Y Che. Increased desensitization of dopamine D₂ receptor-mediated response in the ventral tegmental area in the absence of adenosine A(2A) receptors. Neuroscience. vol 190. 2012-07-05. PMID:21669258. |
the a(2a) receptor agonist, cgs21680, did not exert any effect on dopamine neuron firing or response to quinpirole, revealing a novel non-pharmacological interaction between adenosine a(2a) receptors and dopaminergic neurotransmission in midbrain dopamine neurons. |
2012-07-05 |
2023-08-12 |
mouse |
| Floriana Volpicelli, Roberto De Gregorio, Salvatore Pulcrano, Carla Perrone-Capano, Umberto di Porzio, Gian Carlo Bellench. Direct regulation of Pitx3 expression by Nurr1 in culture and in developing mouse midbrain. PloS one. vol 7. issue 2. 2012-06-29. PMID:22363463. |
moreover, we show that there is a direct interaction between nurr1 and the pitx3 gene promoter in dopaminergic cell cultures and midbrain embryonic tissue. |
2012-06-29 |
2023-08-12 |
mouse |
| N R Ferreira, M Mitkovski, W Stühmer, L A Pardo, E A Del Be. Ether-à-go-go 1 (Eag1) potassium channel expression in dopaminergic neurons of basal ganglia is modulated by 6-hydroxydopamine lesion. Neurotoxicity research. vol 21. issue 3. 2012-06-26. PMID:22048886. |
the eag1-k(+) channel expression in dopaminergic cells suggests that these channels are part of the diversified group of ion channels that generate and maintain the electrophysiological activity pattern of dopaminergic midbrain neurons. |
2012-06-26 |
2023-08-12 |
rat |
| Syed F Ali, Zbigniew K Binienda, Syed Z Ima. Molecular aspects of dopaminergic neurodegeneration: gene-environment interaction in parkin dysfunction. International journal of environmental research and public health. vol 8. issue 12. 2012-06-19. PMID:22408597. |
parkinson's disease (pd) is a common neurodegenerative movement disorder that is characterized pathologically by a progressive loss of midbrain dopaminergic neurons and by protein inclusions, designated lewy bodies and lewy neurites. |
2012-06-19 |
2023-08-12 |
mouse |
| David Ramonet, Agata Podhajska, Klodjan Stafa, Sarah Sonnay, Alzbeta Trancikova, Elpida Tsika, Olga Pletnikova, Juan C Troncoso, Liliane Glauser, Darren J Moor. PARK9-associated ATP13A2 localizes to intracellular acidic vesicles and regulates cation homeostasis and neuronal integrity. Human molecular genetics. vol 21. issue 8. 2012-06-18. PMID:22186024. |
using short hairpin rna-mediated silencing or overexpression to explore the function of atp13a2, we find that modulating the expression of atp13a2 reduces the neurite outgrowth of cultured midbrain dopaminergic neurons. |
2012-06-18 |
2023-08-12 |
human |
| Gabriela Oana Bodea, Sandra Blaes. Organotypic slice cultures of embryonic ventral midbrain: a system to study dopaminergic neuronal development in vitro. Journal of visualized experiments : JoVE. issue 59. 2012-06-18. PMID:22314556. |
organotypic slice cultures of embryonic ventral midbrain: a system to study dopaminergic neuronal development in vitro. |
2012-06-18 |
2023-08-12 |
mouse |
| Gabriela Oana Bodea, Sandra Blaes. Organotypic slice cultures of embryonic ventral midbrain: a system to study dopaminergic neuronal development in vitro. Journal of visualized experiments : JoVE. issue 59. 2012-06-18. PMID:22314556. |
the ventral midbrain is not only a good model system for ventral brain development, but also contains neuronal populations such as dopaminergic neurons that are relevant in disease processes. |
2012-06-18 |
2023-08-12 |
mouse |
| Gabriela Oana Bodea, Sandra Blaes. Organotypic slice cultures of embryonic ventral midbrain: a system to study dopaminergic neuronal development in vitro. Journal of visualized experiments : JoVE. issue 59. 2012-06-18. PMID:22314556. |
in these experiments, ventral midbrain precursors (including dopaminergic precursors) and their descendants were labeled in a mosaic manner using a cre/loxp based inducible fate mapping system (6). |
2012-06-18 |
2023-08-12 |
mouse |
| Celine Ullrich, Nina Daschil, Christian Humpe. Organotypic vibrosections: novel whole sagittal brain cultures. Journal of neuroscience methods. vol 201. issue 1. 2012-06-12. PMID:21835204. |
dopaminergic nerve fibers extended from the mesencephalon, but in the striato-nigral tract and in the striatum only strong dense varicosities were found. |
2012-06-12 |
2023-08-12 |
rat |