| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Silke Nuber, Elisabeth Petrasch-Parwez, Oscar Arias-Carrión, Leanie Koch, Zacharias Kohl, Jacqueline Schneider, Carsten Calaminus, Rolf Dermietzel, Anna Samarina, Jana Boy, Huu P Nguyen, Peter Teismann, Thirumalaisamy Palanichamy Velavan, Philipp J Kahle, Stephan von Hörsten, Markus Fendt, Rejko Krüger, Olaf Ries. Olfactory neuron-specific expression of A30P α-synuclein exacerbates dopamine deficiency and hyperactivity in a novel conditional model of early Parkinson's disease stages. Neurobiology of disease. vol 44. issue 2. 2012-06-11. PMID:21767644. |
we further showed that mutant a30p expression led to neurodegenerative changes on an ultrastructural level and a behaviorally hyperactive response correlated with novelty, odor processing and stress associated with an increased dopaminergic tone in midbrain regions. |
2012-06-11 |
2023-08-12 |
mouse |
| Xue-Feng Tan, Guo-Hua Jin, Mei-Ling Tian, Jian-Bing Qin, Lei Zhang, Hui-Xia Zhu, Hao-Ming L. The co-transduction of Nurr1 and Brn4 genes induces the differentiation of neural stem cells into dopaminergic neurons. Cell biology international. vol 35. issue 12. 2012-06-06. PMID:21663595. |
in the present study, we investigated the effect of nurr1 (nuclear receptor related factor 1), a transcription factor specific for the development and maintenance of the midbrain dopaminergic neurons on inducing the differentiation of nscs into th (tyrosine hydroxylase) immunoreactive dopaminergic neurons. |
2012-06-06 |
2023-08-12 |
Not clear |
| Hiroyuki Nawa, Kiyofumi Yamad. Experimental schizophrenia models in rodents established with inflammatory agents and cytokines. Methods in molecular biology (Clifton, N.J.). vol 829. 2012-06-04. PMID:22231831. |
the molecular and cellular targets of these agents have also been investigated and partially characterized, such as the cortical gabaergic system, midbrain dopaminergic system and hippocampal glutamate system. |
2012-06-04 |
2023-08-12 |
Not clear |
| Yun Jiao, Lu Lu, Robert W Williams, Richard J Smeyn. Genetic dissection of strain dependent paraquat-induced neurodegeneration in the substantia nigra pars compacta. PloS one. vol 7. issue 1. 2012-06-04. PMID:22291891. |
pq acts as a direct redox cycling agent to induce formation of free radicals and when administered to mice induces the cardinal symptoms of parkinsonism, including loss of th+-positive dopaminergic (da) neurons in the ventral midbrain's substantia nigra pars compacta (snpc). |
2012-06-04 |
2023-08-12 |
mouse |
| A Chocyk, A Przyborowska, D Dudys, I Majcher, M Maćkowiak, K Wędzon. The impact of maternal separation on the number of tyrosine hydroxylase-expressing midbrain neurons during different stages of ontogenesis. Neuroscience. vol 182. 2012-05-31. PMID:21396433. |
thus, in the present study, we investigated the way that early life stress, in the form of maternal separation (ms), affects the populations of tyrosine hydroxylase-immunoreactive (th-ir) dopaminergic neurons in rat midbrain structures during ontogenesis. |
2012-05-31 |
2023-08-12 |
rat |
| A Chocyk, A Przyborowska, D Dudys, I Majcher, M Maćkowiak, K Wędzon. The impact of maternal separation on the number of tyrosine hydroxylase-expressing midbrain neurons during different stages of ontogenesis. Neuroscience. vol 182. 2012-05-31. PMID:21396433. |
the results from the study herein indicate that early life stress has enduring effects on the populations of midbrain th-expressing dopaminergic neurons (especially in female rats), which are critically important for dopamine-regulated brain function throughout ontogenesis. |
2012-05-31 |
2023-08-12 |
rat |
| Lalitha Durgadoss, Prakash Nidadavolu, Rupanagudi Khader Valli, Uzma Saeed, Mamata Mishra, Pankaj Seth, Vijayalakshmi Ravindranat. Redox modification of Akt mediated by the dopaminergic neurotoxin MPTP, in mouse midbrain, leads to down-regulation of pAkt. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 26. issue 4. 2012-05-31. PMID:22198382. |
redox modification of akt mediated by the dopaminergic neurotoxin mptp, in mouse midbrain, leads to down-regulation of pakt. |
2012-05-31 |
2023-08-12 |
mouse |
| Lalitha Durgadoss, Prakash Nidadavolu, Rupanagudi Khader Valli, Uzma Saeed, Mamata Mishra, Pankaj Seth, Vijayalakshmi Ravindranat. Redox modification of Akt mediated by the dopaminergic neurotoxin MPTP, in mouse midbrain, leads to down-regulation of pAkt. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 26. issue 4. 2012-05-31. PMID:22198382. |
in the current study, we demonstrate pakt loss in ventral midbrain of mice treated with dopaminergic neurotoxin, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp), when compared to ventral midbrain of control mice treated with vehicle alone. |
2012-05-31 |
2023-08-12 |
mouse |
| R B Mythri, M M Srinivas Bharat. Curcumin: a potential neuroprotective agent in Parkinson's disease. Current pharmaceutical design. vol 18. issue 1. 2012-05-31. PMID:22211691. |
the motor symptoms in pd arise due to selective degeneration of dopaminergic neurons in the substantia nigra of the ventral midbrain thereby depleting the dopamine levels in the striatum. |
2012-05-31 |
2023-08-12 |
Not clear |
| Kyoji Ohyama, Kunihiko Yasuda, Kazuko Onga, Akira Kakizuka, Nozomu Mor. Spatio-temporal expression pattern of the NatB complex, Nat5/Mdm20 in the developing mouse brain: implications for co-operative versus non-co-operative actions of Mdm20 and Nat5. Gene expression patterns : GEP. vol 12. issue 1-2. 2012-05-30. PMID:22101279. |
by e14.5, both mdm20 and nat5 were downregulated in most ventricular zone neural progenitors, whereas both proteins were found in differentiating neurons and co-expression was maintained at e18.5 in derivatives of these cells, such as midbrain dopaminergic (da) neurons and septal neurons. |
2012-05-30 |
2023-08-12 |
mouse |
| Hee Jin Kim, Ji Young Yun, Jong-Min Kim, Yu Kyeong Kim, Gwanhee Erm, Sang Eun Kim, Beom S Jeo. Extranigral extension of structural midbrain lesions overshadows parkinsonism. Journal of neural transmission (Vienna, Austria : 1996). vol 118. issue 8. 2012-05-29. PMID:21298299. |
we report on a clinicoanatomical analysis of five patients with structural midbrain lesions who shared severe nigrostriatal dopaminergic denervation but presented different involuntary movements. |
2012-05-29 |
2023-08-12 |
Not clear |
| Hee Jin Kim, Ji Young Yun, Jong-Min Kim, Yu Kyeong Kim, Gwanhee Erm, Sang Eun Kim, Beom S Jeo. Extranigral extension of structural midbrain lesions overshadows parkinsonism. Journal of neural transmission (Vienna, Austria : 1996). vol 118. issue 8. 2012-05-29. PMID:21298299. |
structural midbrain lesions are likely to involve structures additional to nigral dopaminergic neurons. |
2012-05-29 |
2023-08-12 |
Not clear |
| Kenji Yoshimi, Yuuki Naya, Naoko Mitani, Taisuke Kato, Masato Inoue, Shihoko Natori, Toshimitu Takahashi, Adam Weitemier, Natsuko Nishikawa, Thomas McHugh, Yasuaki Einaga, Shigeru Kitazaw. Phasic reward responses in the monkey striatum as detected by voltammetry with diamond microelectrodes. Neuroscience research. vol 71. issue 1. 2012-05-22. PMID:21645558. |
reward-induced burst firing of dopaminergic neurons has mainly been studied in the primate midbrain. |
2012-05-22 |
2023-08-12 |
monkey |
| Ying Huang, Lei Zhang, Ning-Ning Song, Ze-Lan Hu, Jia-Yin Chen, Yu-Qiang Din. Distribution of Satb1 in the central nervous system of adult mice. Neuroscience research. vol 71. issue 1. 2012-05-22. PMID:21658419. |
double immunostaining showed that satb1 was expressed in midbrain dopaminergic neurons, but not in cholinergic or serotonergic neurons. |
2012-05-22 |
2023-08-12 |
mouse |
| Kohei Tanaka, Tomoyuki Furuyashiki, Shiho Kitaoka, Yuta Senzai, Yuki Imoto, Eri Segi-Nishida, Yuichi Deguchi, Richard M Breyer, Matthew D Breyer, Shuh Narumiy. Prostaglandin E2-mediated attenuation of mesocortical dopaminergic pathway is critical for susceptibility to repeated social defeat stress in mice. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 32. issue 12. 2012-05-18. PMID:22442093. |
given the reported action of ep1 that augments gabaergic inputs to midbrain dopamine neurons, we analyzed dopaminergic response upon social defeat. |
2012-05-18 |
2023-08-12 |
mouse |
| Grażyna Jerzemowska, Karolina Plucińska, Michał Kulikowski, Weronika Trojniar, Danuta Wron. Locomotor response to novelty correlates with the number of midbrain tyrosine hydroxylase positive cells in rats. Brain research bulletin. vol 87. issue 1. 2012-05-17. PMID:22056623. |
the morphology and total number of th(+) cells was analyzed for each a9 (substantia nigra) and a10 (ventral tegmental area) group of the midbrain dopaminergic cells. |
2012-05-17 |
2023-08-12 |
rat |
| Grażyna Jerzemowska, Karolina Plucińska, Michał Kulikowski, Weronika Trojniar, Danuta Wron. Locomotor response to novelty correlates with the number of midbrain tyrosine hydroxylase positive cells in rats. Brain research bulletin. vol 87. issue 1. 2012-05-17. PMID:22056623. |
we found that hrs had a higher total number of th(+) cells in the whole midbrain dopaminergic region (a9-a10) and in the a9 group only than lrs. |
2012-05-17 |
2023-08-12 |
rat |
| Grażyna Jerzemowska, Karolina Plucińska, Michał Kulikowski, Weronika Trojniar, Danuta Wron. Locomotor response to novelty correlates with the number of midbrain tyrosine hydroxylase positive cells in rats. Brain research bulletin. vol 87. issue 1. 2012-05-17. PMID:22056623. |
in particular midbrain dopaminergic groups of neurons, hr/lr differences were regionally specific: hrs had a higher total number of th(+) cells in the a9, and in the anterior part of the a10. |
2012-05-17 |
2023-08-12 |
rat |
| Grażyna Jerzemowska, Karolina Plucińska, Michał Kulikowski, Weronika Trojniar, Danuta Wron. Locomotor response to novelty correlates with the number of midbrain tyrosine hydroxylase positive cells in rats. Brain research bulletin. vol 87. issue 1. 2012-05-17. PMID:22056623. |
the results obtained indicate that the higher behavioral activation in resting conditions correlates with the higher number rather than changes in the morphology of the midbrain dopaminergic th(+) cells. |
2012-05-17 |
2023-08-12 |
rat |
| Grażyna Jerzemowska, Karolina Plucińska, Michał Kulikowski, Weronika Trojniar, Danuta Wron. Locomotor response to novelty correlates with the number of midbrain tyrosine hydroxylase positive cells in rats. Brain research bulletin. vol 87. issue 1. 2012-05-17. PMID:22056623. |
it supports findings on the higher level of dopaminergic system activation in high responders to novelty that depends on the number of midbrain dopaminergic th(+) neurons. |
2012-05-17 |
2023-08-12 |
rat |