| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Stephano J Chang, Ruth Mitchell, Juliette Hukin, Ash Singha. Treatment-responsive Holmes tremor in a child with low-pressure hydrocephalus: video case report and systematic review of the literature. Journal of neurosurgery. Pediatrics. 2022-02-11. PMID:35148507. |
mechanistically, the combined rest and action tremor is thought to require a double lesion of both the dopaminergic nigrostriatal system and the dentatorubrothalamic pathways, often near the midbrain where both pathways converge. |
2022-02-11 |
2023-08-13 |
Not clear |
| Qiang Miao, Zhi Chai, Li-Juan Song, Qing Wang, Guo-Bin Song, Jing Wang, Jie-Zhong Yu, Bao-Guo Xiao, Cun-Gen M. The neuroprotective effects and transdifferentiation of astrocytes into dopaminergic neurons of Ginkgolide K on Parkinson' disease mice. Journal of neuroimmunology. vol 364. 2022-02-05. PMID:35121334. |
parkinson's disease (pd) is a chronic and progressive movement disorder caused by the selective loss of midbrain dopaminergic neurons of unknown etiology. |
2022-02-05 |
2023-08-13 |
mouse |
| Pik-Shan Lo, Vladimir V Rymar, Timothy E Kennedy, Abbas F Sadiko. The Netrin-1 Receptor DCC Promotes the Survival of a Subpopulation of Midbrain Dopaminergic Neurons: Relevance for Ageing and Parkinson's Disease. Journal of neurochemistry. 2022-02-04. PMID:35118677. |
the netrin-1 receptor dcc promotes the survival of a subpopulation of midbrain dopaminergic neurons: relevance for ageing and parkinson's disease. |
2022-02-04 |
2023-08-13 |
mouse |
| Pik-Shan Lo, Vladimir V Rymar, Timothy E Kennedy, Abbas F Sadiko. The Netrin-1 Receptor DCC Promotes the Survival of a Subpopulation of Midbrain Dopaminergic Neurons: Relevance for Ageing and Parkinson's Disease. Journal of neurochemistry. 2022-02-04. PMID:35118677. |
mechanisms that determine the survival of midbrain dopaminergic (mda) neurons in the adult central nervous system (cns) are not fully understood. |
2022-02-04 |
2023-08-13 |
mouse |
| Camilo A Sanchez, Jackson Brougher, Deepika G Krishnan, Catherine A Thor. Longitudinal Assessment of Skilled Forelimb Motor Impairments in DJ-1 Knockout Rats. Behavioural brain research. 2022-02-01. PMID:35101457. |
50% loss of midbrain dopaminergic neurons appearing around 6-8 months of age. |
2022-02-01 |
2023-08-13 |
rat |
| Benjamin D Hobson, Se Joon Choi, Eugene V Mosharov, Rajesh K Soni, David Sulzer, Peter Sim. Subcellular proteomics of dopamine neurons in the mouse brain. eLife. vol 11. 2022-01-31. PMID:35098924. |
by combining apex2 biotinylation with mass spectrometry, we mapped the somatodendritic and axonal proteomes of midbrain dopaminergic neurons. |
2022-01-31 |
2023-08-13 |
mouse |
| Javed Ahmed Ujjan, William Morani, Naz Memon, Sugumar Mohanasundaram, Shibili Nuhmani, Bhupesh Kumar Sing. Force Platform-Based Intervention Program for Individuals Suffering with Neurodegenerative Diseases like Parkinson. Computational and mathematical methods in medicine. vol 2022. 2022-01-27. PMID:35082910. |
substantia nigra (a midbrain dopaminergic nucleus) with lack of hormone called dopamine causes parkinson's disease (pd), a neurological disorder. |
2022-01-27 |
2023-08-13 |
human |
| Adriana Trapani, Stefania Cometa, Elvira De Giglio, Filomena Corbo, Roberta Cassano, Maria Luisa Di Gioia, Sonia Trombino, Md Niamat Hossain, Sante Di Gioia, Giuseppe Trapani, Massimo Cones. Novel Nanoparticles Based on Pharmaceutics. vol 14. issue 1. 2022-01-21. PMID:35057043. |
as for parkinson's disease (pd), characterized by dopaminergic midbrain neurons degeneration, currently there is no disease modifying therapy. |
2022-01-21 |
2023-08-13 |
Not clear |
| Muhammad O Chohan, Jared M Kopelman, Hannah Yueh, Zeinab Fazlali, Natasha Greene, Alexander Z Harris, Peter D Balsam, E David Leonardo, Edgar R Kramer, Jeremy Veenstra-VanderWeele, Susanne E Ahmar. Developmental impact of glutamate transporter overexpression on dopaminergic neuron activity and stereotypic behavior. Molecular psychiatry. 2022-01-21. PMID:35058566. |
in mice, midbrain slc1a1 expression supports repetitive behavior in response to dopaminergic agonists, aligning with neuroimaging and pharmacologic challenge studies that have implicated the dopaminergic system in ocd. |
2022-01-21 |
2023-08-13 |
mouse |
| Markus Westphal, Paolo Panza, Edda Kastenhuber, Johanna Wehrle, Wolfgang Drieve. Wnt/β-catenin signaling promotes neurogenesis in the diencephalospinal dopaminergic system of embryonic zebrafish. Scientific reports. vol 12. issue 1. 2022-01-20. PMID:35046434. |
wnt/β-catenin signaling is important for mammalian midbrain dopaminergic neurogenesis, while little is known about its role in ventral forebrain dopaminergic development. |
2022-01-20 |
2023-08-13 |
zebrafish |
| Francesca Garretti, Connor Monahan, Alessandro Sette, Dritan Agalliu, David Sulze. T cells, α-synuclein and Parkinson disease. Handbook of clinical neurology. vol 184. 2022-01-17. PMID:35034753. |
the notion that autoimmune responses to α-synuclein may be involved in the pathogenesis of this disorder stems from reports that mutations in α-synuclein or certain alleles of the major histocompatibility complex (mhc) are associated with the disease and that dopaminergic and norepinephrinergic neurons in the midbrain can present antigenic epitopes. |
2022-01-17 |
2023-08-13 |
Not clear |
| Gabriela Novak, Dimitrios Kyriakis, Kamil Grzyb, Michela Bernini, Sophie Rodius, Gunnar Dittmar, Steven Finkbeiner, Alexander Skupi. Single-cell transcriptomics of human iPSC differentiation dynamics reveal a core molecular network of Parkinson's disease. Communications biology. vol 5. issue 1. 2022-01-14. PMID:35027645. |
parkinson's disease (pd) is the second-most prevalent neurodegenerative disorder, characterized by the loss of dopaminergic neurons (mda) in the midbrain. |
2022-01-14 |
2023-08-13 |
human |
| Benjamin D Hobson, Linghao Kong, Maria Florencia Angelo, Ori J Lieberman, Eugene V Mosharov, Etienne Herzog, David Sulzer, Peter A Sim. Subcellular and regional localization of mRNA translation in midbrain dopamine neurons. Cell reports. vol 38. issue 2. 2022-01-12. PMID:35021090. |
midbrain dopaminergic (mda) neurons exhibit extensive dendritic and axonal arborizations, but local protein synthesis is not characterized in these neurons. |
2022-01-12 |
2023-08-13 |
Not clear |
| Fubo Cheng, Wenxu Zheng, Peter Antony Barbuti, Paola Bonsi, Change Liu, Nicolas Casadei, Giulia Ponterio, Maria Meringolo, Jakob Admard, Claire Marie Dording, Libo Yu-Taeger, Huu Phuc Nguyen, Kathrin Grundmann-Hauser, Thomas Ott, Henry Houlden, Antonio Pisani, Rejko Krüger, Olaf Ries. DYT6 mutated THAP1 is a cell type dependent regulator of the SP1 family. Brain : a journal of neurology. 2022-01-11. PMID:35015830. |
in this study we used epigenetic and transcriptomic approaches combined with multiple model systems (thap1 patients' frontal cortex, thap1 patients' ipscs derived midbrain dopaminergic neurons, thap1 heterozygous knock-out rat model, and thap1 heterozygous knock-out sh-sy5y cell lines) to uncover a novel function of thap1 and the potential pathogenesis of dyt6 dystonia. |
2022-01-11 |
2023-08-13 |
mouse |
| Fubo Cheng, Wenxu Zheng, Peter Antony Barbuti, Paola Bonsi, Change Liu, Nicolas Casadei, Giulia Ponterio, Maria Meringolo, Jakob Admard, Claire Marie Dording, Libo Yu-Taeger, Huu Phuc Nguyen, Kathrin Grundmann-Hauser, Thomas Ott, Henry Houlden, Antonio Pisani, Rejko Krüger, Olaf Ries. DYT6 mutated THAP1 is a cell type dependent regulator of the SP1 family. Brain : a journal of neurology. 2022-01-11. PMID:35015830. |
comparing global differentially expressed genes detected in thap1 patients' ipscs derived midbrain dopaminergic neurons and thap1 heterozygous knock-out rat striatum, we observed many common dysregulated genes and 61 of them are involved in dystonic syndromes related pathways, like synaptic transmission, nervous system development, and locomotor behavior. |
2022-01-11 |
2023-08-13 |
mouse |
| Jackson Brougher, Umaymah Aziz, Nikitha Adari, Muskaan Chaturvedi, Aryela Jules, Iqra Shah, Saba Syed, Catherine A Thor. Self-Administration of Right Vagus Nerve Stimulation Activates Midbrain Dopaminergic Nuclei. Frontiers in neuroscience. vol 15. 2022-01-03. PMID:34975384. |
self-administration of right vagus nerve stimulation activates midbrain dopaminergic nuclei. |
2022-01-03 |
2023-08-13 |
Not clear |
| Marios G Krokidis, Themis Exarchos, Panayiotis Vlamo. Bioinformatics Approaches for Parkinson's Disease in Clinical Practice: Data-Driven Biomarkers and Pharmacological Treatment. Advances in experimental medicine and biology. vol 1338. 2022-01-01. PMID:34973025. |
parkinson's disease is a gradually progressive neurodegenerative disorder characterized by a selective loss of dopaminergic neurons in the midbrain area called the substantia nigra pars compacta and cytoplasmic alpha-synuclein-rich inclusions termed lewy bodies. |
2022-01-01 |
2023-08-13 |
Not clear |
| Anindita Das, Jesse H Goldber. Songbird subthalamic neurons project to dopaminergic midbrain and exhibit singing-related activity. Journal of neurophysiology. 2021-12-30. PMID:34965747. |
songbird subthalamic neurons project to dopaminergic midbrain and exhibit singing-related activity. |
2021-12-30 |
2023-08-13 |
Not clear |
| Isao Nagata, Mika Sasaki, Tomoyuki Miyazaki, Kensuke Saeki, Ken-Ichi Ogawa, Yoshinori Kamiy. Subanesthetic Dose of Propofol Activates the Reward System in Rats. Anesthesia and analgesia. 2021-12-27. PMID:34958308. |
activation of the dopaminergic circuits of the midbrain reward system, including the ventral tegmental area (vta) and nac, plays a crucial role in addiction. |
2021-12-27 |
2023-08-13 |
rat |
| Leonie M Heger, Rachel M Wise, J Tabitha Hees, Angelika B Harbauer, Lena F Burbull. Mitochondrial Phenotypes in Parkinson's Diseases-A Focus on Human iPSC-Derived Dopaminergic Neurons. Cells. vol 10. issue 12. 2021-12-24. PMID:34943944. |
furthermore, we summarize the distinguishing characteristics of vulnerable midbrain dopaminergic neurons in pd and report the unique advantages and challenges of ipsc disease modeling at present, and for future mechanistic and therapeutic applications. |
2021-12-24 |
2023-08-13 |
human |