| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Alexander K Song, Kaitlyn R Hay, Paula Trujillo, Megan Aumann, Adam J Stark, Yan Yan, Hakmook Kang, Manus J Donahue, David H Zald, Daniel O Claasse. Amphetamine-induced dopamine release and impulsivity in Parkinson disease. Brain : a journal of neurology. 2021-12-24. PMID:34951464. |
we hypothesized that parkinson disease patients with impulsive-compulsive behaviors would have greater ventral striatal dopaminergic response to dextroamphetamine, and that an inability to attenuate ventral striatal dopamine release via midbrain d2 autoreceptors would underlie this response. |
2021-12-24 |
2023-08-13 |
human |
| Mario Widmer, Jeremia P O Held, Frieder Wittmann, Belen Valladares, Olivier Lambercy, Christian Sturzenegger, Antonella Palla, Kai Lutz, Andreas R Luf. Reward During Arm Training Improves Impairment and Activity After Stroke: A Randomized Controlled Trial. Neurorehabilitation and neural repair. 2021-12-23. PMID:34937456. |
these mechanisms depend on dopaminergic projections from midbrain that may encode reward information. |
2021-12-23 |
2023-08-13 |
Not clear |
| Xiaodan Li, Jian Xiong, Baojian Zhang, Dongting Zhangsun, Sulan Lu. α-Conotoxin TxIB Inhibits Development of Morphine-Induced Conditioned Place Preference in Mice Frontiers in pharmacology. vol 12. 2021-12-20. PMID:34925031. |
previous studies have showed that α6β2* (* designated other subunits) nachrs are mainly distributed in dopaminergic neurons in the midbrain area, which regulates the release of dopamine. |
2021-12-20 |
2023-08-13 |
mouse |
| Neda Valian, Mansooreh Heravi, Abolhassan Ahmadiani, Leila Dargah. Comparison of Rat Primary Midbrain Neurons Cultured in DMEM/F12 and Neurobasal Mediums. Basic and clinical neuroscience. vol 12. issue 2. 2021-12-20. PMID:34925717. |
midbrain dopaminergic neurons are involved in various brain functions, including motor behavior, reinforcement, motivation, learning, and cognition. |
2021-12-20 |
2023-08-13 |
rat |
| James A Conway, Edgar R Krame. Is activation of GDNF/RET signaling the answer for successful treatment of Parkinson's disease? A discussion of data from the culture dish to the clinic. Neural regeneration research. vol 17. issue 7. 2021-12-17. PMID:34916419. |
this prompted the idea to try gdnf/ret signaling as a therapeutic approach to treat parkinson's disease with the hallmark of dopaminergic cell death in the substantia nigra of the midbrain. |
2021-12-17 |
2023-08-13 |
Not clear |
| James A Conway, Edgar R Krame. Is activation of GDNF/RET signaling the answer for successful treatment of Parkinson's disease? A discussion of data from the culture dish to the clinic. Neural regeneration research. vol 17. issue 7. 2021-12-17. PMID:34916419. |
this suggests that it will be helpful to learn more about the basic biology of this fascinating but complicated gdnf/ret signaling system in the dopaminergic midbrain and about recent developments in the field to facilitate its use in the clinic. |
2021-12-17 |
2023-08-13 |
Not clear |
| Semra Smajić, Cesar A Prada-Medina, Zied Landoulsi, Jenny Ghelfi, Sylvie Delcambre, Carola Dietrich, Javier Jarazo, Jana Henck, Saranya Balachandran, Sinthuja Pachchek, Christopher M Morris, Paul Antony, Bernd Timmermann, Sascha Sauer, Sandro L Pereira, Jens C Schwamborn, Patrick May, Anne Grünewald, Malte Spielman. Single-cell sequencing of human midbrain reveals glial activation and a Parkinson-specific neuronal state. Brain : a journal of neurology. 2021-12-17. PMID:34919646. |
to date, parkinson's disease research has mainly focused on nigral dopaminergic neurons, although recent studies suggest disease-related changes also in non-neuronal cells and in midbrain regions beyond the substantia nigra. |
2021-12-17 |
2023-08-13 |
human |
| Kenan Steidel, Marina C Ruppert, Irina Palaghia, Andrea Greuel, Masoud Tahmasian, Franziska Maier, Jochen Hammes, Thilo van Eimeren, Lars Timmermann, Marc Tittgemeyer, Alexander Drzezga, David Pedrosa, Carsten Egger. Dopaminergic pathways and resting-state functional connectivity in Parkinson's disease with freezing of gait. NeuroImage. Clinical. vol 32. 2021-12-16. PMID:34911202. |
seed-to-voxel resting-state functional connectivity maps of the resulting dopamine depleted structures and dopaminergic midbrain regions were created and compared between both groups. |
2021-12-16 |
2023-08-13 |
Not clear |
| Min Hyung Seo, Sabina Lim, Sujung Ye. Association of decreased triadin expression level with apoptosis of dopaminergic cells in Parkinson's disease mouse model. BMC neuroscience. vol 22. issue 1. 2021-12-11. PMID:34736417. |
parkinson's disease (pd) represent a loss of dopaminergic neurons in the substantia nigra (sn) of the midbrain. |
2021-12-11 |
2023-08-13 |
mouse |
| Yasir H Siddiqu. Does Human Alpha-Synuclein Behave Like Prions? CNS & neurological disorders drug targets. vol 20. issue 6. 2021-12-09. PMID:33881974. |
its overexpression in the neurons leads to the formation of lewy bodies that damage the dopaminergic neurons in the subtantianigra of the midbrain and leads to the progression of parkinson's disease (pd). |
2021-12-09 |
2023-08-13 |
human |
| Manal T Hussein, Abdelraheim Attaai, Gamal Kamel, Doaa M Mokhta. Spatiotemporal expression of sonic hedgehog signalling molecules in the embryonic mesencephalic dopaminergic neurons. Gene expression patterns : GEP. vol 42. 2021-12-09. PMID:34767969. |
midbrain dopaminergic neurons (mda) play an important role in controlling the voluntary motor movement, reward, and emotion-based behaviour. |
2021-12-09 |
2023-08-13 |
Not clear |
| Giada Rossignoli, Karolin Krämer, Eleonora Lugarà, Haya Alrashidi, Simon Pope, Carmen De La Fuente Barrigon, Katy Barwick, Giovanni Bisello, Joanne Ng, John Counsell, Gabriele Lignani, Simon J R Heales, Mariarita Bertoldi, Serena Barral, Manju A Kuria. Aromatic l-amino acid decarboxylase deficiency: a patient-derived neuronal model for precision therapies. Brain : a journal of neurology. vol 144. issue 8. 2021-12-08. PMID:33734312. |
to characterize the underlying disease pathophysiology and guide precision therapies, we generated a patient-derived midbrain dopaminergic neuronal model of aadc deficiency from induced pluripotent stem cells. |
2021-12-08 |
2023-08-13 |
Not clear |
| Sanghyun Park, Jeong-Eun Yoo, Gyu-Bum Yeon, Jin Hee Kim, Jae Souk Lee, Sung Kyoung Choi, Young-Gi Hwang, Chan Wook Park, Myung Soo Cho, Jongwan Kim, Dokyun Na, Hyung Wook Kim, Dae-Sung Kim, Dong-Wook Ki. Trophoblast glycoprotein is a new candidate gene for Parkinson's disease. NPJ Parkinson's disease. vol 7. issue 1. 2021-12-08. PMID:34876581. |
parkinson's disease (pd) is a movement disorder caused by progressive degeneration of the midbrain dopaminergic (mda) neurons in the substantia nigra pars compacta (snc). |
2021-12-08 |
2023-08-13 |
mouse |
| Yan Xu, Shicong Wang, Longmao Chen, Ziqiang Shao, Min Zhang, Shuang Liu, Xinwen Wen, Yangding Li, Wenhan Yang, Fei Tang, Jing Luo, Li Fan, Cui Yan, Jun Liu, Kai Yua. Reduced midbrain functional connectivity and recovery in abstinent heroin users. Journal of psychiatric research. vol 144. 2021-12-07. PMID:34662755. |
dopaminergic pathways from the midbrain to striatum as well as cortex are involved in addiction. |
2021-12-07 |
2023-08-13 |
human |
| V Mesa-Infante, D Afonso-Oramas, J Salas-Hernández, J Rodríguez-Núñez, P Barroso-Chine. Long-term exposure to GDNF induces dephosphorylation of Ret, AKT, and ERK1/2, and is ineffective at protecting midbrain dopaminergic neurons in cellular models of Parkinson's disease. Molecular and cellular neurosciences. vol 118. 2021-12-07. PMID:34826608. |
long-term exposure to gdnf induces dephosphorylation of ret, akt, and erk1/2, and is ineffective at protecting midbrain dopaminergic neurons in cellular models of parkinson's disease. |
2021-12-07 |
2023-08-13 |
rat |
| Theodoros Tsetsenis, Julia K Badyna, Julianne A Wilson, Xiaowen Zhang, Elizabeth N Krizman, Manivannan Subramaniyan, Kechun Yang, Steven A Thomas, John A Dan. Midbrain dopaminergic innervation of the hippocampus is sufficient to modulate formation of aversive memories. Proceedings of the National Academy of Sciences of the United States of America. vol 118. issue 40. 2021-12-06. PMID:34580198. |
midbrain dopaminergic innervation of the hippocampus is sufficient to modulate formation of aversive memories. |
2021-12-06 |
2023-08-13 |
mouse |
| Theodoros Tsetsenis, Julia K Badyna, Julianne A Wilson, Xiaowen Zhang, Elizabeth N Krizman, Manivannan Subramaniyan, Kechun Yang, Steven A Thomas, John A Dan. Midbrain dopaminergic innervation of the hippocampus is sufficient to modulate formation of aversive memories. Proceedings of the National Academy of Sciences of the United States of America. vol 118. issue 40. 2021-12-06. PMID:34580198. |
here, we utilize anterograde and retrograde viral tracing methods to label midbrain dopaminergic projections to the dorsal hippocampus. |
2021-12-06 |
2023-08-13 |
mouse |
| Theodoros Tsetsenis, Julia K Badyna, Julianne A Wilson, Xiaowen Zhang, Elizabeth N Krizman, Manivannan Subramaniyan, Kechun Yang, Steven A Thomas, John A Dan. Midbrain dopaminergic innervation of the hippocampus is sufficient to modulate formation of aversive memories. Proceedings of the National Academy of Sciences of the United States of America. vol 118. issue 40. 2021-12-06. PMID:34580198. |
we identify a population of midbrain dopaminergic neurons near the border of the substantia nigra pars compacta and the lateral ventral tegmental area that sends direct projections to the dorsal hippocampus. |
2021-12-06 |
2023-08-13 |
mouse |
| Maxime Fougère, Cornelis Immanuel van der Zouwen, Joël Boutin, Kloé Neszvecsko, Philippe Sarret, Dimitri Ryczk. Optogenetic stimulation of glutamatergic neurons in the cuneiform nucleus controls locomotion in a mouse model of Parkinson's disease. Proceedings of the National Academy of Sciences of the United States of America. vol 118. issue 43. 2021-12-06. PMID:34670837. |
in parkinson's disease (pd), the loss of midbrain dopaminergic cells results in severe locomotor deficits, such as gait freezing and akinesia. |
2021-12-06 |
2023-08-13 |
mouse |
| Takashi Hanakaw. Thoughts on vigor in the motor and cognitive domains. The Behavioral and brain sciences. vol 44. 2021-12-02. PMID:34588072. |
functions of the basal ganglia-cortical circuits, which are regulated by the midbrain dopaminergic system, appear to underlie both movement vigor and cognitive vigor. |
2021-12-02 |
2023-08-13 |
Not clear |