| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Elisabeth Piccart, Christopher W Tschumi, Michael J Beckstea. Acute and subchronic PCP attenuate D2 autoreceptor signaling in substantia nigra dopamine neurons. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 29. issue 3. 2019-08-26. PMID:30686631. |
these findings suggest the effects of pcp on dopaminergic signaling in the midbrain could enhance burst firing and contribute to the development of schizophreniform behavior. |
2019-08-26 |
2023-08-13 |
Not clear |
| Francesca L'Episcopo, Cataldo Tirolo, Luca Peruzzotti-Jametti, Maria F Serapide, Nunzio Testa, Salvatore Caniglia, Beatrice Balzarotti, Stefano Pluchino, Bianca Marchett. Neural Stem Cell Grafts Promote Astroglia-Driven Neurorestoration in the Aged Parkinsonian Brain via Wnt/β-Catenin Signaling. Stem cells (Dayton, Ohio). vol 36. issue 8. 2019-08-13. PMID:29575325. |
during aging-one the most potent risk factors for parkinson's disease (pd)-both astrocytes and microglia undergo functional changes that ultimately hamper homoeostasis, defense, and repair of substantia nigra pars compacta (snpc) midbrain dopaminergic (mda) neurons. |
2019-08-13 |
2023-08-13 |
mouse |
| Yuji K Takahashi, Thomas A Stalnaker, Yasmin Marrero-Garcia, Ray M Rada, Geoffrey Schoenbau. Expectancy-Related Changes in Dopaminergic Error Signals Are Impaired by Cocaine Self-Administration. Neuron. vol 101. issue 2. 2019-08-12. PMID:30653935. |
these areas provide critical input to midbrain dopamine neurons regarding expected outcomes, suggesting that effects on learning may result from changes in dopaminergic error signaling. |
2019-08-12 |
2023-08-13 |
rat |
| Ryuhei Araki, Kazuko Hayashi, Teiji Saw. Dopamine D2-receptor Antagonist Droperidol Deepens Sevoflurane Anesthesia. Anesthesiology. vol 128. issue 4. 2019-08-06. PMID:29251645. |
although midbrain dopaminergic pathways are known to contribute to arousal and emergence from anesthesia, few reports exist regarding the anesthetic effects of dopamine d2 receptor antagonism in humans. |
2019-08-06 |
2023-08-13 |
Not clear |
| Bolton K H Chau, Huw Jarvis, Chun-Kit Law, Trevor T-J Chon. Dopamine and reward: a view from the prefrontal cortex. Behavioural pharmacology. vol 29. issue 7. 2019-08-02. PMID:30188354. |
these regions receive projections from midbrain dopamine (da) neurons and, in turn, project to other key dopaminergic regions such as the striatum. |
2019-08-02 |
2023-08-13 |
Not clear |
| Bolton K H Chau, Huw Jarvis, Chun-Kit Law, Trevor T-J Chon. Dopamine and reward: a view from the prefrontal cortex. Behavioural pharmacology. vol 29. issue 7. 2019-08-02. PMID:30188354. |
however, our current understanding of the role of da in reward-based processes is based mainly on studies of midbrain dopaminergic neurons and striatal da release from nonhuman animal models. |
2019-08-02 |
2023-08-13 |
Not clear |
| Pooja Jadiya, Snober S Mir, Aamir Nazi. Osmotic stress induced toxicity exacerbates Parkinson's associated effects via dysregulation of autophagy in transgenic C. elegans model. Cellular signalling. vol 45. 2019-07-31. PMID:29410282. |
pd, known to be associated with multiple genetic and environmental factors, is characterized by the aggregation of α-synuclein protein and loss of dopaminergic neurons in midbrain. |
2019-07-31 |
2023-08-13 |
caenorhabditis_elegans |
| Sumit Sarkar, Edward Lu, James Raymick, Joseph Hanig, Qiang G. ERK/MAP Kinase Activation is Evident in Activated Microglia of the Striatum and Substantia Nigra in an Acute and Chronically-Induced Mouse Model of Parkinson's Disease. Current neurovascular research. vol 15. issue 4. 2019-07-30. PMID:30468126. |
parkinson's disease (pd) is a debilitating, age-related disorder characterized by selective degeneration of dopaminergic neurons in the midbrain substantia nigra (snc). |
2019-07-30 |
2023-08-13 |
mouse |
| Sumit Sarkar, Edward Lu, James Raymick, Joseph Hanig, Qiang G. ERK/MAP Kinase Activation is Evident in Activated Microglia of the Striatum and Substantia Nigra in an Acute and Chronically-Induced Mouse Model of Parkinson's Disease. Current neurovascular research. vol 15. issue 4. 2019-07-30. PMID:30468126. |
dopaminergic neurons originating in the midbrain project to the striatum (caudate-putamen-cpu). |
2019-07-30 |
2023-08-13 |
mouse |
| Lifeng Qiu, Mei-Chih Liao, Allen K Chen, Shunhui Wei, Shaoping Xie, Shaul Reuveny, Zhi Dong Zhou, Walter Hunziker, Eng King Tan, Steve K W Oh, Li Zen. Immature Midbrain Dopaminergic Neurons Derived from Floor-Plate Method Improve Cell Transplantation Therapy Efficacy for Parkinson's Disease. Stem cells translational medicine. vol 6. issue 9. 2019-06-27. PMID:28650520. |
immature midbrain dopaminergic neurons derived from floor-plate method improve cell transplantation therapy efficacy for parkinson's disease. |
2019-06-27 |
2023-08-13 |
mouse |
| Petros Stathakos, Natalia Jimenez-Moreno, Lucy Crompton, Paul Nistor, Maeve A Caldwell, Jon D Lan. Imaging Autophagy in hiPSC-Derived Midbrain Dopaminergic Neuronal Cultures for Parkinson's Disease Research. Methods in molecular biology (Clifton, N.J.). vol 1880. 2019-06-24. PMID:30610703. |
imaging autophagy in hipsc-derived midbrain dopaminergic neuronal cultures for parkinson's disease research. |
2019-06-24 |
2023-08-13 |
human |
| Petros Stathakos, Natalia Jimenez-Moreno, Lucy Crompton, Paul Nistor, Maeve A Caldwell, Jon D Lan. Imaging Autophagy in hiPSC-Derived Midbrain Dopaminergic Neuronal Cultures for Parkinson's Disease Research. Methods in molecular biology (Clifton, N.J.). vol 1880. 2019-06-24. PMID:30610703. |
in pd, a class of dopaminergic neurons in the ventral midbrain (mdans) is affected. |
2019-06-24 |
2023-08-13 |
human |
| Fabiano Araújo Tofoli, Ana Teresa Silva Semeano, Ágatha Oliveira-Giacomelli, Maria Carolina Bittencourt Gonçalves, Merari F R Ferrari, Lygia Veiga Pereira, Henning Ulric. Midbrain Dopaminergic Neurons Differentiated from Human-Induced Pluripotent Stem Cells. Methods in molecular biology (Clifton, N.J.). vol 1919. 2019-06-14. PMID:30656624. |
midbrain dopaminergic neurons differentiated from human-induced pluripotent stem cells. |
2019-06-14 |
2023-08-13 |
mouse |
| Fabiano Araújo Tofoli, Ana Teresa Silva Semeano, Ágatha Oliveira-Giacomelli, Maria Carolina Bittencourt Gonçalves, Merari F R Ferrari, Lygia Veiga Pereira, Henning Ulric. Midbrain Dopaminergic Neurons Differentiated from Human-Induced Pluripotent Stem Cells. Methods in molecular biology (Clifton, N.J.). vol 1919. 2019-06-14. PMID:30656624. |
the work with midbrain dopaminergic neurons (mdan) differentiation might seem to be hard. |
2019-06-14 |
2023-08-13 |
mouse |
| Leah C Beauchamp, Jacky Chan, Lin W Hung, Benjamin S Padman, Laura J Vella, Xiang M Liu, Bradley Coleman, Ashley I Bush, Michael Lazarou, Andrew F Hill, Laura Jacobson, Kevin J Barnha. Ablation of tau causes an olfactory deficit in a murine model of Parkinson's disease. Acta neuropathologica communications. vol 6. issue 1. 2019-06-04. PMID:29976255. |
parkinson's disease is diagnosed upon the presentation of motor symptoms, resulting from substantial degeneration of dopaminergic neurons in the midbrain. |
2019-06-04 |
2023-08-13 |
mouse |
| Leah C Beauchamp, Jacky Chan, Lin W Hung, Benjamin S Padman, Laura J Vella, Xiang M Liu, Bradley Coleman, Ashley I Bush, Michael Lazarou, Andrew F Hill, Laura Jacobson, Kevin J Barnha. Ablation of tau causes an olfactory deficit in a murine model of Parkinson's disease. Acta neuropathologica communications. vol 6. issue 1. 2019-06-04. PMID:29976255. |
there is limited information about non-motor impairments and there is a need for directed research into these early pathogenic cellular pathways that precede extensive dopaminergic death in the midbrain. |
2019-06-04 |
2023-08-13 |
mouse |
| Vukasin M Jovanovic, Ahmad Salti, Hadas Tilleman, Ksenija Zega, Marin M Jukic, Hongyan Zou, Roland H Friedel, Nilima Prakash, Sandra Blaess, Frank Edenhofer, Claude Brodsk. BMP/SMAD Pathway Promotes Neurogenesis of Midbrain Dopaminergic Neurons The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 38. issue 7. 2019-06-03. PMID:29321139. |
bmp/smad pathway promotes neurogenesis of midbrain dopaminergic neurons the embryonic formation of midbrain dopaminergic (mda) neurons |
2019-06-03 |
2023-08-13 |
Not clear |
| Spyridon Theofilopoulos, Willy Antoni Abreu de Oliveira, Shanzheng Yang, Eylan Yutuc, Ahmed Saeed, Jonas Abdel-Khalik, Abbe Ullgren, Angel Cedazo-Minguez, Ingemar Björkhem, Yuqin Wang, William J Griffiths, Ernest Arena. 24( The Journal of biological chemistry. vol 294. issue 11. 2019-05-30. PMID:30655290. |
24( the liver x receptors lxrα/nr1h3 and lxrβ/nr1h2 are ligand-dependent nuclear receptors critical for midbrain dopaminergic (mda) neuron development. |
2019-05-30 |
2023-08-13 |
Not clear |
| Angel J Santiago-Lope. A Repulsive Environment Induces Neurodegeneration of Midbrain Dopaminergic Neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 38. issue 6. 2019-05-29. PMID:29438033. |
a repulsive environment induces neurodegeneration of midbrain dopaminergic neurons. |
2019-05-29 |
2023-08-13 |
Not clear |
| Krishnapriya Madhu Varier, Thangarajan Sumath. Hinokitiol Offers Neuroprotection Against 6-OHDA-Induced Toxicity in SH-SY5Y Neuroblastoma Cells by Downregulating mRNA Expression of MAO/α-Synuclein/LRRK2/PARK7/PINK1/PTEN Genes. Neurotoxicity research. vol 35. issue 4. 2019-05-23. PMID:30569287. |
parkinson's disease (pd) remarks its pathology by affecting the patient's movements and postural instability by dopaminergic loss in the substantia nigra of midbrain. |
2019-05-23 |
2023-08-13 |
Not clear |