| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Linfang Chen, Liujun Xue, Jinlong Zheng, Xiangyang Tian, Yingdong Zhang, Qiang Ton. PPARß/δ agonist alleviates NLRP3 inflammasome-mediated neuroinflammation in the MPTP mouse model of Parkinson's disease. Behavioural brain research. vol 356. 2019-04-16. PMID:29885849. |
our results show that gw501516 reduced movement impairment in pd mice; furthermore, it attenuated dopaminergic neurodegeneration in the midbrain and the depletion of dopamine in the striatum and it inhibited inflammatory reactions and nlrp3 inflammasome activation in the midbrain of pd mice. |
2019-04-16 |
2023-08-13 |
mouse |
| François-Xavier Blaudin de Thé, Hocine Rekaik, Eugenie Peze-Heidsieck, Olivia Massiani-Beaudoin, Rajiv L Joshi, Julia Fuchs, Alain Prochiant. Engrailed homeoprotein blocks degeneration in adult dopaminergic neurons through LINE-1 repression. The EMBO journal. vol 37. issue 15. 2019-04-16. PMID:29941661. |
we report that line-1 are expressed in substantia nigra ventral midbrain dopaminergic neurons, a class of neurons that degenerate in parkinson's disease. |
2019-04-16 |
2023-08-13 |
Not clear |
| Diana Lupu, Mukesh K Varshney, Daniel Mucs, José Inzunza, Ulf Norinder, Felicia Loghin, Ivan Nalvarte, Joëlle Rüeg. Fluoxetine Affects Differentiation of Midbrain Dopaminergic Neurons In Vitro. Molecular pharmacology. vol 94. issue 4. 2019-04-16. PMID:30115672. |
fluoxetine affects differentiation of midbrain dopaminergic neurons in vitro. |
2019-04-16 |
2023-08-13 |
mouse |
| Diana Lupu, Mukesh K Varshney, Daniel Mucs, José Inzunza, Ulf Norinder, Felicia Loghin, Ivan Nalvarte, Joëlle Rüeg. Fluoxetine Affects Differentiation of Midbrain Dopaminergic Neurons In Vitro. Molecular pharmacology. vol 94. issue 4. 2019-04-16. PMID:30115672. |
mouse neuronal precursors were differentiated into midbrain dopaminergic precursor cells (mdpcs) and concomitantly exposed to clinically relevant doses of flx. |
2019-04-16 |
2023-08-13 |
mouse |
| I L Kovalenko, D A Smagin, A G Galyamina, Yu L Orlov, N N Kudryavtsev. [Changes in the Expression of Dopaminergic Genes in Brain Structures of Male Mice Exposed to Chronic Social Defeat Stress: An RNA-seq Study]. Molekuliarnaia biologiia. vol 50. issue 1. 2019-04-11. PMID:27028825. |
whole-transcriptome analysis (rna-seq) has been used to analyze changes in the expression of dopaminergic genes that encode proteins involved in the synthesis, inactivation, and neurotransmission of dopamine in the striatum, ventral tegmental area, raphe nuclei of the midbrain, hypothalamus, and hippocampus of male mice subjected to chronic social defeat. |
2019-04-11 |
2023-08-13 |
mouse |
| W F Alsanie, V Penna, M Schachner, L H Thompson, C L Paris. Homophilic binding of the neural cell adhesion molecule CHL1 regulates development of ventral midbrain dopaminergic pathways. Scientific reports. vol 7. issue 1. 2019-04-11. PMID:28839197. |
homophilic binding of the neural cell adhesion molecule chl1 regulates development of ventral midbrain dopaminergic pathways. |
2019-04-11 |
2023-08-13 |
Not clear |
| W F Alsanie, V Penna, M Schachner, L H Thompson, C L Paris. Homophilic binding of the neural cell adhesion molecule CHL1 regulates development of ventral midbrain dopaminergic pathways. Scientific reports. vol 7. issue 1. 2019-04-11. PMID:28839197. |
abnormal development of ventral midbrain (vm) dopaminergic (da) pathways, essential for motor and cognitive function, may underpin a number of neurological disorders and thereby highlight the importance of understanding the birth and connectivity of the associated neurons. |
2019-04-11 |
2023-08-13 |
Not clear |
| Longping Yao, Yongyi Ye, Hengxu Mao, Fengfei Lu, Xiaozheng He, Guohui Lu, Shizhong Zhan. MicroRNA-124 regulates the expression of MEKK3 in the inflammatory pathogenesis of Parkinson's disease. Journal of neuroinflammation. vol 15. issue 1. 2019-04-08. PMID:29329581. |
parkinson's disease (pd) is the most prevalent neurodegenerative disorder that is characterised by selective loss of midbrain dopaminergic (da) neurons. |
2019-04-08 |
2023-08-13 |
Not clear |
| Enaam Chleilat, Lena Skatulla, Belal Rahhal, Manal T Hussein, Melanie Feuerstein, Kerstin Krieglstein, Eleni Rouss. TGF-β Signaling Regulates Development of Midbrain Dopaminergic and Hindbrain Serotonergic Neuron Subgroups. Neuroscience. vol 381. 2019-04-05. PMID:29689292. |
tgf-β signaling regulates development of midbrain dopaminergic and hindbrain serotonergic neuron subgroups. |
2019-04-05 |
2023-08-13 |
Not clear |
| Enaam Chleilat, Lena Skatulla, Belal Rahhal, Manal T Hussein, Melanie Feuerstein, Kerstin Krieglstein, Eleni Rouss. TGF-β Signaling Regulates Development of Midbrain Dopaminergic and Hindbrain Serotonergic Neuron Subgroups. Neuroscience. vol 381. 2019-04-05. PMID:29689292. |
molecular and functional diversity within midbrain dopaminergic (mda) and hindbrain serotonergic (5-ht) neurons has emerged as a relevant feature that could underlie selective vulnerability of neurons in clinical disorders. |
2019-04-05 |
2023-08-13 |
Not clear |
| Maroof M Adil, David V Schaffe. hPSC-derived Midbrain Dopaminergic Neurons Generated in a Scalable 3-D Biomaterial. Current protocols in stem cell biology. vol 44. 2019-04-01. PMID:29512105. |
hpsc-derived midbrain dopaminergic neurons generated in a scalable 3-d biomaterial. |
2019-04-01 |
2023-08-13 |
human |
| Maroof M Adil, David V Schaffe. hPSC-derived Midbrain Dopaminergic Neurons Generated in a Scalable 3-D Biomaterial. Current protocols in stem cell biology. vol 44. 2019-04-01. PMID:29512105. |
human pluripotent stem cell (hpsc)-derived midbrain dopaminergic (mda) neurons may facilitate the development of therapies for parkinson's disease via disease modeling, drug screening, and cell replacement therapy. |
2019-04-01 |
2023-08-13 |
human |
| Torsten Weiss, René Bernard, Hans-Gert Bernstein, Rüdiger W Veh, Gregor Laub. Agmatine modulates spontaneous activity in neurons of the rat medial habenular complex-a relevant mechanism in the pathophysiology and treatment of depression? Translational psychiatry. vol 8. issue 1. 2019-04-01. PMID:30250120. |
it is concluded that increased activity of the agmatinergic system in the medial habenula may strengthen midbrain dopaminergic activity. |
2019-04-01 |
2023-08-13 |
human |
| Asma Lamine-Ajili, Ahmed M Fahmy, Myriam Létourneau, David Chatenet, Patrick Labonté, David Vaudry, Alain Fournie. Effect of the pituitary adenylate cyclase-activating polypeptide on the autophagic activation observed in in vitro and in vivo models of Parkinson's disease. Biochimica et biophysica acta. vol 1862. issue 4. 2019-03-28. PMID:26769362. |
parkinson's disease (pd) is a neurodegenerative disorder that leads to destruction of the midbrain dopaminergic (da) neurons. |
2019-03-28 |
2023-08-13 |
Not clear |
| M A Hutchison, X Gu, M F Adrover, M R Lee, T S Hnasko, V A Alvarez, W L. Genetic inhibition of neurotransmission reveals role of glutamatergic input to dopamine neurons in high-effort behavior. Molecular psychiatry. vol 23. issue 5. 2019-03-27. PMID:28194005. |
these results provide genetic evidence that glutamatergic transmission onto dopaminergic neurons underlies incentive motivation, a willingness to exert high levels of effort to obtain reinforcers, and have important implications for understanding the normal function of the midbrain dopamine system. |
2019-03-27 |
2023-08-13 |
mouse |
| Angela Cruz-Hernandez, Zeynep Sena Agim, Paola C Montenegro, George P McCabe, Jean-Christophe Rochet, Jason R Canno. Selective dopaminergic neurotoxicity of three heterocyclic amine subclasses in primary rat midbrain neurons. Neurotoxicology. vol 65. 2019-03-27. PMID:29408373. |
selective dopaminergic neurotoxicity of three heterocyclic amine subclasses in primary rat midbrain neurons. |
2019-03-27 |
2023-08-13 |
rat |
| Angela Cruz-Hernandez, Zeynep Sena Agim, Paola C Montenegro, George P McCabe, Jean-Christophe Rochet, Jason R Canno. Selective dopaminergic neurotoxicity of three heterocyclic amine subclasses in primary rat midbrain neurons. Neurotoxicology. vol 65. 2019-03-27. PMID:29408373. |
using e17 rat primary midbrain cultures, we tested dopaminergic and non-dopaminergic neurotoxicity elicited by the following compounds: 2-amino-3-methylimidazo[4,5-f]quinoline (iq), 2-amino-3,4-dimethylimidazo[4,5-f]quinoline (meiq), 2-amino-3,8-dimethylmidazo[4,5-f]quinoxaline (meiqx), 2-amino-3,4,8-trimethylimidazo[4,5-f]quinoxaline (4,8-dimeiqx), phip, 1-methyl-9h-pyrido[3,4-b]indole (harmane), 9h-pyrido[3,4-b]indole (norharmane) and 2-amino-9h-pyrido[2,3-b]indole (aαc) at concentrations ranging from 100 nm-5 μm. |
2019-03-27 |
2023-08-13 |
rat |
| Su-Rong Yang, Zhen-Zhen Hu, Yan-Jia Luo, Ya-Nan Zhao, Huan-Xin Sun, Dou Yin, Chen-Yao Wang, Yu-Dong Yan, Dian-Ru Wang, Xiang-Shan Yuan, Chen-Bo Ye, Wei Guo, Wei-Min Qu, Yoan Cherasse, Michael Lazarus, Yu-Qiang Ding, Zhi-Li Huan. The rostromedial tegmental nucleus is essential for non-rapid eye movement sleep. PLoS biology. vol 16. issue 4. 2019-03-27. PMID:29652889. |
the rostromedial tegmental nucleus (rmtg), also called the gabaergic tail of the ventral tegmental area, projects to the midbrain dopaminergic system, dorsal raphe nucleus, locus coeruleus, and other regions. |
2019-03-27 |
2023-08-13 |
rat |
| Su-Rong Yang, Zhen-Zhen Hu, Yan-Jia Luo, Ya-Nan Zhao, Huan-Xin Sun, Dou Yin, Chen-Yao Wang, Yu-Dong Yan, Dian-Ru Wang, Xiang-Shan Yuan, Chen-Bo Ye, Wei Guo, Wei-Min Qu, Yoan Cherasse, Michael Lazarus, Yu-Qiang Ding, Zhi-Li Huan. The rostromedial tegmental nucleus is essential for non-rapid eye movement sleep. PLoS biology. vol 16. issue 4. 2019-03-27. PMID:29652889. |
electrophysiological experiments combined with optogenetics showed a direct inhibitory connection between the terminals of rmtg neurons and midbrain dopaminergic neurons. |
2019-03-27 |
2023-08-13 |
rat |
| Shane V Hegarty, Sean L Wyatt, Laura Howard, Elke Stappers, Danny Huylebroeck, Aideen M Sullivan, Gerard W O'Keeff. Zeb2 is a negative regulator of midbrain dopaminergic axon growth and target innervation. Scientific reports. vol 7. issue 1. 2019-03-25. PMID:28819210. |
zeb2 is a negative regulator of midbrain dopaminergic axon growth and target innervation. |
2019-03-25 |
2023-08-13 |
mouse |